LOCUS       NM_020656               4191 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus parvin, alpha (Parva), mRNA.
ACCESSION   NM_020656
VERSION     NM_020656.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4191)
  AUTHORS   Nicholson,L., Madawala,R., Lindsay,L. and Murphy,C.R.
  TITLE     alpha-Parvin and beta-parvin in the rat uterus during
            decidualisation and uterine receptivity
  JOURNAL   Histochem Cell Biol 151 (5), 395-406 (2019)
   PUBMED   30515554
  REMARK    GeneRIF: This study demonstrates that the changing balance and
            localisation of the two PARVA proteins are dependent on the time of
            uterine receptivity, suggesting a co-dependent role in the
            cytoskeletal re-organisation crucial to the changing conditions
            necessary for implantation and decidualisation.
REFERENCE   2  (bases 1 to 4191)
  AUTHORS   Rogg,M., Yasuda-Yamahara,M., Abed,A., Dinse,P., Helmstadter,M.,
            Conzelmann,A.C., Frimmel,J., Sellung,D., Biniossek,M.L., Kretz,O.,
            Grahammer,F., Schilling,O., Huber,T.B. and Schell,C.
  TITLE     The WD40-domain containing protein CORO2B is specifically enriched
            in glomerular podocytes and regulates the ventral actin
            cytoskeleton
  JOURNAL   Sci Rep 7 (1), 15910 (2017)
   PUBMED   29162887
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4191)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4191)
  AUTHORS   Moik,D., Bottcher,A., Makhina,T., Grashoff,C., Bulus,N., Zent,R.
            and Fassler,R.
  TITLE     Mutations in the paxillin-binding site of integrin-linked kinase
            (ILK) destabilize the pseudokinase domain and cause embryonic
            lethality in mice
  JOURNAL   J Biol Chem 288 (26), 18863-18871 (2013)
   PUBMED   23658024
REFERENCE   5  (bases 1 to 4191)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 4191)
  AUTHORS   LaLonde,D.P., Brown,M.C., Bouverat,B.P. and Turner,C.E.
  TITLE     Actopaxin interacts with TESK1 to regulate cell spreading on
            fibronectin
  JOURNAL   J Biol Chem 280 (22), 21680-21688 (2005)
   PUBMED   15817463
REFERENCE   7  (bases 1 to 4191)
  AUTHORS   Curtis,M., Nikolopoulos,S.N. and Turner,C.E.
  TITLE     Actopaxin is phosphorylated during mitosis and is a substrate for
            cyclin B1/cdc2 kinase
  JOURNAL   Biochem J 363 (Pt 2), 233-242 (2002)
   PUBMED   11931650
  REMARK    GeneRIF: Actopaxin is phosphorylated during mitosis and is a
            substrate for cyclin B1/cdc2 kinase.
REFERENCE   8  (bases 1 to 4191)
  AUTHORS   Tu,Y., Huang,Y., Zhang,Y., Hua,Y. and Wu,C.
  TITLE     A new focal adhesion protein that interacts with integrin-linked
            kinase and regulates cell adhesion and spreading
  JOURNAL   J Cell Biol 153 (3), 585-598 (2001)
   PUBMED   11331308
REFERENCE   9  (bases 1 to 4191)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
REFERENCE   10 (bases 1 to 4191)
  AUTHORS   Nikolopoulos,S.N. and Turner,C.E.
  TITLE     Actopaxin, a new focal adhesion protein that binds paxillin LD
            motifs and actin and regulates cell adhesion
  JOURNAL   J Cell Biol 151 (7), 1435-1448 (2000)
   PUBMED   11134073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 3, 2022 this sequence version replaced NM_020656.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228521.1, SRR26643298.4754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000001.1  175981725-175981920
            197-286             JAXUCZ010000001.1  176091585-176091674
            287-357             JAXUCZ010000001.1  176092414-176092484
            358-460             JAXUCZ010000001.1  176096237-176096339
            461-601             JAXUCZ010000001.1  176108874-176109014
            602-717             JAXUCZ010000001.1  176116372-176116487
            718-776             JAXUCZ010000001.1  176121001-176121059
            777-796             JAXUCZ010000001.1  176123351-176123370
            797-858             JAXUCZ010000001.1  176124621-176124682
            859-927             JAXUCZ010000001.1  176125169-176125237
            928-1029            JAXUCZ010000001.1  176127738-176127839
            1030-1102           JAXUCZ010000001.1  176128863-176128935
            1103-4191           JAXUCZ010000001.1  176136430-176139518
FEATURES             Location/Qualifiers
     source          1..4191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..4191
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /note="parvin, alpha"
                     /db_xref="GeneID:57341"
                     /db_xref="RGD:71021"
     exon            1..196
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1179
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /note="actopaxin"
                     /codon_start=1
                     /product="alpha-parvin"
                     /protein_id="NP_065707.3"
                     /db_xref="GeneID:57341"
                     /db_xref="RGD:71021"
                     /translation="MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAK
                     EVSEFQEEGMNAINLPLSPISFELDPEDTMLEENEVRTMVDPNSRNDPKLQELMKVLI
                     DWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTV
                     LEKINETLKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVV
                     QKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHL
                     NKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELM
                     QDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE"
     exon            197..286
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            287..357
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            358..460
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            461..601
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..717
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            718..776
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            777..796
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            797..858
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            859..927
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1029
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1102
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..4191
                     /gene="Parva"
                     /gene_synonym="Actp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctcagtc ccgccgccgc ccgccgcggc cgctcagctc cagctccgcg tcccgccgcc
       61 atggccacat ccccacagaa gtcaccctcg gtccccaaat ctcccacccc caagtcgcct
      121 ccgtcccgca agaaggatga ctcgttcttg gggaaacttg gagggacgct ggcccggagg
      181 aagaaagcca aggaagtatc cgagttccag gaggaaggaa tgaacgccat caacctgcct
      241 cttagcccca tctccttcga gctggacccc gaagacacca tgctggagga gaatgaggtg
      301 cggacaatgg tcgatccaaa ctcacgcaat gaccccaagc ttcaagagct gatgaaggtg
      361 ctcatcgact ggatcaatga cgtattggtg ggagaaagaa tcatcgtgaa ggacctcgct
      421 gaagatctct atgatggcca agtcctgcag aagctcttcg agaaactgga gagtgagaag
      481 ctcaacgtgg cagaggttac ccagtcggag atcgcccaga agcaaaagct acagactgta
      541 ctggagaaga tcaacgagac cctgaagctt cctcccagga gcatcaagtg gaacgtagac
      601 tctgttcatg ccaagaacct ggttgccatc ctccacctgc tggttgccct gtctcagtat
      661 ttccgggcac caatccgact cccagaccat gtttccatcc aagtggttgt ggtccagaaa
      721 cgggaaggga tccttcagtc tcggcaaatc caagaggaaa taactggtaa cacagaggcc
      781 ctttccggaa ggcatgaacg cgatgccttt gacacactgt ttgaccatgc accagacaaa
      841 ctcaatgtgg tgaagaagac cctcatcacg ttcgtgaaca agcacctgaa taaactgaac
      901 ttggaggtca cagaactgga gacgcagttt gcagatgggg tctacctggt gctgctcatg
      961 gggctcctgg agggctactt tgtacccctg cacagcttct tcctgacccc agacagcttt
     1021 gaacagaagg tcctgaatgt ttcctttgcc tttgaactca tgcaagatgg agggctggaa
     1081 aagcctaaac ctcggccaga agacattgtc aactgtgacc tgaagtccac gctgagagtg
     1141 ctgtacaacc tcttcaccaa gtaccggaat gtggagtgaa gacctgggct gcctcctgct
     1201 gcccagccac tctgaaggcc atctggacca gcttcccaac tgcctcaccc gcttactcct
     1261 gtctcttgtt ctaccctctc ccacaaaccc agcaaccacc cagagatagt ggacattaaa
     1321 atcagtaagg aagtgaccac taacctacat ctgtaggctc tggggactga accatcaatg
     1381 acttgggaaa ttgtctccat acaaattcag gccctagatg tttccacatg tgccatgggg
     1441 atcagtgcag cccccagagc ataggaataa agattagaat tagtccccac aataaagggg
     1501 agtctctcct gtgctccagt tcattaggct tgtgtctcat taaaggagat catccctccc
     1561 tcttacagac aaagaaactg aggcccagag atgtggaggc ttgctatcca ttagcatata
     1621 tttttcctct ctgggtaact tactggtcaa ctgcattcca ttctctgtgt gtcctaaaat
     1681 gcatgtgtgc ttgtgcagac cagccttacc tgcatacacc tgtgtcctct agcagacaag
     1741 acgctctgat ctcaccctag ggcaggccag gtcagggctg ggtgattcac actaaaattg
     1801 ccaaattgaa tctaactcaa ttaatactgt gtgtggcagg agcctcatcc ctcaaatcct
     1861 ttgtacaaat gaaaattacc cttaattcct tcagattggt aataagccca cgctccggtt
     1921 gcaagatgac atttgggaag ggttctgttt ggaattaata gagtgcccat tttgcagcct
     1981 ttttgcttga ttgcatgtaa tggatgtgcc ctatattttc ctgcaaaata agtactcaat
     2041 tcattatcgt taggcaaatg tagggtatgc ttgcacatgg caaagagctg ggtgcagacc
     2101 cattggagca tcgcctaaga agtagggctt gtcaacaggg acccttgaac tttaaaaaaa
     2161 agaacctcct ttttgctttc taattggtca tttaggccat cctggctaag tctgcccacg
     2221 tgcaattact ggctaattcc aggcgtggaa aatgtcagtc atttaactaa agctcatcta
     2281 gtttcctcac tccagtgact tgagggttgc tggtcatgta cctcttcatg caaacctggc
     2341 tttgaaggat agagttctgc tgtgccagtc tgccccaggg ccctacagag aaagcaaaga
     2401 ggctgatggg aaaagggagg gtcagaacta agggaacaag aaatgggggt gggagagctg
     2461 gatactaatc gcttaacatg taggggaaac cctcggagac acagcagcag atacagtact
     2521 taccccttgt gttctcccat tgagaagcta atgggatatc ttggggtaat gacccatgct
     2581 actgtcgtct tcacagaaca tctactgctg tcttaacagc ttgggttgcc tcttcccaaa
     2641 gtgcgtctgg aagtcgctcc ttgtcttagt tatgtttctc aatggaacaa aagaacctgg
     2701 tgaaaacagt ttaaggaaag gaggacttat tttggctcat gatctgaagg cacacagcct
     2761 gtcatggagg gcaagttatg gcagccatgg cgggaagagc atatagccaa cacccctcac
     2821 ttcccatgcc agaacaagga gagaacagac aaacaggggc tgagctagca aacctcaaag
     2881 ccctcctcca gtgaggctcc accccctaaa ggattcataa tttttcaaaa caccagctga
     2941 gaaccaaggg ttcataatga gcccatggag gaacattttc cacatgcaaa cgaaagcctc
     3001 tagaaaagcc ttccctagtt tgaggattca ctgacgtggc ttgctagact caggccttcc
     3061 agttgtccac agcattccct gcctgttctt gattctttct gtaccaacca tccagggcag
     3121 ctcagaatcc agcagcctta gacccaccgt gtctctccgc ggctgttcta aggattgtta
     3181 ttcagcacag tgagcatctg agatgtgagg gcgatgcacc gtcttccatc gatctatgtg
     3241 taagaacaga gttctttctt gcataattaa tgaaatacca tatttctcat taggattcat
     3301 gttggtctcc tgctctttta aattccttta gtaaattgag attgataact gttggatctc
     3361 tgtgagcagc actgaagtag aatgaaataa gagaccttca tccacttgaa ctttgctgtc
     3421 ggggttgtgc cttgctgctc cctgatactc aagccattaa tgcacaccac ccttcctaag
     3481 ggccctccat tggggttttg tattctccac agtaagaaac catatcagac cttggtaact
     3541 ttcttaatag catgacagtg tacccaacaa ctgggtattg ggactaaggc ctttgcctca
     3601 acccagcatc ccagagcttg tgtctggttt tataaagctg tcttctcgtg gagatgggtg
     3661 tttcccttta gattccagga ttgaatacat aagacacaat catggttttg aagaagaaag
     3721 ggaccttgcc attatgagta accaaatagc cttcaactcc tgacaaaaga gaggaaagaa
     3781 gaaactgaga caagatcatt ctggcttaca gttcaaggct acagggaagg atggagaggt
     3841 atggccacag gagtgtgggg cagccgctct cgtgtttgca ggcaggaagc agagaggtga
     3901 atgctggtgc tcaacctact gattttttat ttagtctggg accccaacct atgaaatggt
     3961 accaccacag ttaggatctt tcccccctca attaatcatc gttattctta atagtcaata
     4021 cataagaaaa acagaactca aaaagcaaaa aggatatctg attaaaaacc ctaagtatcc
     4081 acctcacctc ttccccattg gtctccactc tccatggaga tgactgtctt gatccatttc
     4141 ttctgcatga ttccagaaat accctgtgca aataaactct gaatgaacgt a
//
