LOCUS       NM_001008328            2123 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase family, member 3
            (Parp3), mRNA.
ACCESSION   NM_001008328 XM_217264
VERSION     NM_001008328.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Zarkovic G, Belousova EA, Talhaoui I, Saint-Pierre C, Kutuzov MM,
            Matkarimov BT, Biard D, Gasparutto D, Lavrik OI and Ishchenko AA.
  TITLE     Characterization of DNA ADP-ribosyltransferase activities of PARP2
            and PARP3: new insights into DNA ADP-ribosylation
  JOURNAL   Nucleic Acids Res 46 (5), 2417-2431 (2018)
   PUBMED   29361132
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Barkauskaite E, Jankevicius G and Ahel I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Robert I, Gaudot L, Rogier M, Heyer V, Noll A, Dantzer F and
            Reina-San-Martin B.
  TITLE     Parp3 negatively regulates immunoglobulin class switch
            recombination
  JOURNAL   PLoS Genet 11 (5), e1005240 (2015)
   PUBMED   26000965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, Ahel I and Chang
            P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Beck C, Boehler C, Guirouilh Barbat J, Bonnet ME, Illuzzi G, Ronde
            P, Gauthier LR, Magroun N, Rajendran A, Lopez BS, Scully R, Boussin
            FD, Schreiber V and Dantzer F.
  TITLE     PARP3 affects the relative contribution of homologous recombination
            and nonhomologous end-joining pathways
  JOURNAL   Nucleic Acids Res 42 (9), 5616-5632 (2014)
   PUBMED   24598253
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Fernandez-Marcelo T, Frias C, Pascua I, de Juan C, Head J, Gomez A,
            Hernando F, Jarabo JR, Diaz-Rubio E, Torres AJ, Rouleau M, Benito M
            and Iniesta P.
  TITLE     Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of
            telomerase activity
  JOURNAL   J Exp Clin Cancer Res 33 (1), 19 (2014)
   PUBMED   24528514
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson
            A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F and
            Dantzer F.
  TITLE     Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular
            response to DNA damage and mitotic progression
  JOURNAL   Proc Natl Acad Sci U S A 108 (7), 2783-2788 (2011)
   PUBMED   21270334
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   Rulten SL, Fisher AE, Robert I, Zuma MC, Rouleau M, Ju L, Poirier
            G, Reina-San-Martin B and Caldecott KW.
  TITLE     PARP-3 and APLF function together to accelerate nonhomologous
            end-joining
  JOURNAL   Mol Cell 41 (1), 33-45 (2011)
   PUBMED   21211721
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Loseva O, Jemth AS, Bryant HE, Schuler H, Lehtio L, Karlberg T and
            Helleday T.
  TITLE     PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the
            absence of DNA
  JOURNAL   J Biol Chem 285 (11), 8054-8060 (2010)
   PUBMED   20064938
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085863.1.
            
            On Dec 16, 2004 this sequence version replaced XM_217264.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085863.1, SRR8487230.57586.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093048 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2123
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /note="poly (ADP-ribose) polymerase family, member 3"
                     /db_xref="GeneID:300985"
                     /db_xref="RGD:1305189"
     exon            1..115
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            116..299
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1703
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /EC_number="2.4.2.30"
                     /note="ADP-ribosyltransferase (NAD+, poly (ADP-ribose
                     polymerase)-like 3; poly [ADP-ribose] polymerase 3; poly
                     (ADP-ribosyl) transferase-like 3"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP3"
                     /protein_id="NP_001008329.1"
                     /db_xref="GeneID:300985"
                     /db_xref="RGD:1305189"
                     /translation="MAPKRKSSMQTEGSKKQRQGTGEEGSFRSTAEALRAAPAGNRII
                     RVDPPCPLSGNPGIQVHEDYDCTLNQTNIGNNNNKFYIIQLLEEGGRFSCWNRWGRVG
                     EVGQSKMNHFGCLEDAKKDFKKKFWEKTKNKWEERDHFVAHPNKYTLIEVQGEAETQE
                     AVVKVDGPVRTVFKPCSLDPATQKLITNIFSKEMFKNAMTLMNLDVKKMPLGKLSKQQ
                     IARGFEALEALEEAMKNPTGDGQSLEELSSCFYTVIPHNFGRSRPPPINSPDILQAKK
                     DMLLVLADIELAQTLQAAPGEEEKVEEVPHPLDRDYQLLKCQLQLLDPGESEYKAIQT
                     YLEQTGNGYRRPDLQHVWKVNREGEGDRFQAHSKLGNRRLLWHGTNVAVVAAILTSGL
                     RIMPHSGGRVGKGIYFASENSKSASYVTAMRCGSHQVGYMFLGEVALGKVHHITMDDP
                     SLKSPPPGFDSVIARGQTEPDPAQDIELQLDGQPVVVPQGRPVACPSFKSSSFSQSEY
                     LIYKESQCRLRYLLEIHL"
     exon            300..425
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            426..614
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..735
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..962
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1112
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1199
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1377
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1533
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..2100
                     /gene="Parp3"
                     /gene_synonym="Adprtl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaagggtca ctagatggga gcccagactt ggaacttgtt tcttaggagg cacactcagc
       61 attcctaata ccagacagaa taacagccac ctcttcaagg ttccgtttct tttcggagag
      121 ccatggctcc aaaacggaaa tcttccatgc aaaccgaggg ctccaagaag caacgacagg
      181 gcacagggga ggaaggcagc ttccggtcca ctgccgaggc tctcagagca gctcctgctg
      241 gtaatcgcat catccgtgtg gatcccccat gtccactcag cgggaacccc ggaattcagg
      301 tccacgagga ctacgactgt accctgaacc agaccaacat cggtaacaac aataataagt
      361 tttacatcat ccagctgctg gaggagggcg gtcgcttctc ctgctggaat cgctggggcc
      421 gagtgggaga ggtgggccag agcaagatga accacttcgg ctgcctggaa gatgcaaaga
      481 aggactttaa gaagaaattt tgggagaaga ctaaaaacaa atgggaggag agagaccatt
      541 tcgtggccca tcccaacaag tacacactta tagaagttca gggagaagca gagacccaag
      601 aggctgtagt gaaggtggac ggcccagtga ggactgtgtt taagccctgc tccctagacc
      661 ctgccaccca gaaactcatc accaacatct tcagcaaaga gatgttcaag aacgctatga
      721 ccctcatgaa cctggatgtg aagaagatgc ccttgggaaa gttgagcaaa cagcagattg
      781 ctcgtggctt cgaggccttg gaagctctag aggaggccat gaaaaacccc acaggggacg
      841 gccagagcct ggaagagctg tcctcctgtt tctacactgt catcccacac aacttcggcc
      901 gtagccgacc tccacccatc aactcccctg acattcttca ggccaagaag gacatgttgc
      961 tggtgctagc ggacatcgag ctggcgcaga ccttgcaggc agcccctggt gaggaggaga
     1021 aagtagaaga ggtaccccat ccactggatc gagactacca gctcctcaag tgccagcttc
     1081 aactgctgga ccctggggag tccgagtaca aggccataca gacctactta gaacagactg
     1141 gcaacggcta cagacgccca gacctgcagc atgtttggaa agtgaaccga gaaggggagg
     1201 gagacaggtt ccaggcccac tccaaactgg gcaatcggag gctgctgtgg catggcacca
     1261 acgtggccgt ggtggctgcc atactgacca gtgggctcag aatcatgccg cattcaggtg
     1321 gtcgtgttgg caagggtatc tattttgcct cggagaacag caagtcagct agctatgtta
     1381 ctgccatgcg ctgtgggagc caccaggtgg gctacatgtt cctgggcgag gtggccctcg
     1441 gcaaagtgca ccacatcacc atggatgatc ccagcttgaa gagtccaccc cctggctttg
     1501 acagcgtcat cgcccgaggc caaacagagc ctgatccagc ccaggacatt gaactacagc
     1561 tggatgggca gcccgtggtg gtgcctcaag gccgacctgt ggcatgccca tccttcaaaa
     1621 gctccagctt cagccagagt gagtacctca tctacaagga gagccagtgc cgtctgcgct
     1681 acctgctgga gattcacctc tgagctgctt gccctcccca ggtcctgccc tggcgggcca
     1741 cgatcttcac cctcctctct ctgactctca tatcatatca ctttgtctgc ctcccaagaa
     1801 tacagcatgt gccaggcaca ctggcacaca cccgtagcct cagctacttg gggcggaggc
     1861 aagaaaaaca ctttaccctg agatttggag tccagcctag gctacacagt aagacatgtc
     1921 tcaaaaaaaa ttacaacggt taagagccct gactgctctt ccagaggtcc tgagttcagt
     1981 tcccagcaac cacatggtgg ctcacagcca tctgtaatgg gtctgatgcc ctcttctggt
     2041 gtgtctgagg acagcaacat tgtactcaca tataataaat aaataaatct ttaaaaagaa
     2101 aaaaaaaaaa aaaaaaaaaa aaa
//
