LOCUS       NM_001106030            1817 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase 2 (Parp2), mRNA.
ACCESSION   NM_001106030 XM_001063825 XM_214157
VERSION     NM_001106030.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Huang,C., Zhang,X., Wang,S., Shen,A., Xu,T., Hou,Y., Gao,S.,
            Xie,Y., Zeng,Y., Chen,J., Lin,R., Zhang,Y., Wan,C. and Cai,Y.
  TITLE     PARP-2 mediates cardiomyocyte aging and damage induced by
            doxorubicin through SIRT1 Inhibition
  JOURNAL   Apoptosis 29 (5-6), 816-834 (2024)
   PUBMED   38281279
  REMARK    GeneRIF: PARP-2 mediates cardiomyocyte aging and damage induced by
            doxorubicin through SIRT1 Inhibition.
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Bilokapic,S., Suskiewicz,M.J., Ahel,I. and Halic,M.
  TITLE     Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin
  JOURNAL   Nature 585 (7826), 609-613 (2020)
   PUBMED   32939087
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Liu,K., Zhang,Y., Liu,L. and Yuan,Q.
  TITLE     miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid
            arthritis rats via PARP2
  JOURNAL   Biosci Rep 39 (1) (2019)
   PUBMED   30541899
  REMARK    GeneRIF: MiR-125 might attenuate RA development by regulating
            PI3K/Akt/mTOR signaling pathway via directly inhibiting PARP2
            expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Marton,J., Peter,M., Balogh,G., Bodi,B., Vida,A., Szanto,M.,
            Bojcsuk,D., Janko,L., Bhattoa,H.P., Gombos,I., Uray,K., Horvath,I.,
            Torok,Z., Balint,B.L., Papp,Z., Vigh,L. and Bai,P.
  TITLE     Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of
            muscular lipid homeostasis
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (11), 1399-1412
            (2018)
   PUBMED   30077797
  REMARK    GeneRIF: Results provide evidence for a new role for PARP2 as a
            lipid-modulated regulator of lipid metabolism.
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Bonfiglio,J.J., Fontana,P., Zhang,Q., Colby,T., Gibbs-Seymour,I.,
            Atanassov,I., Bartlett,E., Zaja,R., Ahel,I. and Matic,I.
  TITLE     Serine ADP-Ribosylation Depends on HPF1
  JOURNAL   Mol Cell 65 (5), 932-940 (2017)
   PUBMED   28190768
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Moroni,F., Formentini,L., Gerace,E., Camaioni,E.,
            Pellegrini-Giampietro,D.E., Chiarugi,A. and Pellicciari,R.
  TITLE     Selective PARP-2 inhibitors increase apoptosis in hippocampal
            slices but protect cortical cells in models of post-ischaemic brain
            damage
  JOURNAL   Br J Pharmacol 157 (5), 854-862 (2009)
   PUBMED   19422384
  REMARK    GeneRIF: Selective PARP-2 inhibitors increase apoptosis in
            hippocampal slices but protect cortical cells in models of
            post-ischaemic brain damage.
REFERENCE   7  (bases 1 to 1817)
  AUTHORS   Meder,V.S., Boeglin,M., de Murcia,G. and Schreiber,V.
  TITLE     PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in
            transcriptionally active nucleoli
  JOURNAL   J Cell Sci 118 (Pt 1), 211-222 (2005)
   PUBMED   15615785
REFERENCE   8  (bases 1 to 1817)
  AUTHORS   Benchoua,A., Couriaud,C., Guegan,C., Tartier,L., Couvert,P.,
            Friocourt,G., Chelly,J., Menissier-de Murcia,J. and Onteniente,B.
  TITLE     Active caspase-8 translocates into the nucleus of apoptotic cells
            to inactivate poly(ADP-ribose) polymerase-2
  JOURNAL   J Biol Chem 277 (37), 34217-34222 (2002)
   PUBMED   12065591
REFERENCE   9  (bases 1 to 1817)
  AUTHORS   Schreiber,V., Ame,J.C., Dolle,P., Schultz,I., Rinaldi,B.,
            Fraulob,V., Menissier-de Murcia,J. and de Murcia,G.
  TITLE     Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient
            base excision DNA repair in association with PARP-1 and XRCC1
  JOURNAL   J Biol Chem 277 (25), 23028-23036 (2002)
   PUBMED   11948190
REFERENCE   10 (bases 1 to 1817)
  AUTHORS   Ame,J.C., Rolli,V., Schreiber,V., Niedergang,C., Apiou,F.,
            Decker,P., Muller,S., Hoger,T., Menissier-de Murcia,J. and de
            Murcia,G.
  TITLE     PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose)
            polymerase
  JOURNAL   J Biol Chem 274 (25), 17860-17868 (1999)
   PUBMED   10364231
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474040.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063825.1, XM_214157.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1817
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /note="poly (ADP-ribose) polymerase 2"
                     /db_xref="GeneID:290027"
                     /db_xref="RGD:1310568"
     exon            1..74
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1711
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /EC_number="2.4.2.30"
                     /note="ADP-ribosyltransferase (NAD+, poly(ADP-ribose)
                     polymerase)-like 2; poly (ADP-ribose) polymerase family,
                     member 2"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase 2"
                     /protein_id="NP_001099500.1"
                     /db_xref="GeneID:290027"
                     /db_xref="RGD:1310568"
                     /translation="MAPRRRRSGCGRRVLNEAKRVDNGNRATDDSPPGKKVRTCQKKG
                     PAAGGEDTDRTKGKQDSVKTLLVKGRAPVDPECTSKVGKAHVYCEGDDVYDVMLNQTN
                     LQFNNNKYYLIQLLEDDAQQNFSVWMRWGRVGKTGQHSLVACSGDLNKAKEIFQKKFL
                     DKTKNNWEDRENFEKVPGKYDMLQMDYAASTEDENKTKQEETSKPESQLDLRVQELLK
                     LICNVQTMEEMMIEMKYDTKRAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEA
                     CNEFYTRIPHDFGLSIPPVIRTEKELSDKVKLLEALGDIEIALKLVKSERQGLEHPLD
                     QHYRNLRCALRPLDHESHEFKVISQYLQSTHAPTHKDYTMTLLEVFEVEKEGEKEAFR
                     KDLPNRMLLWHGSRLSNWVGILSHGLRVAPPEAPITGYMFGKGIYFADMSSKSANYCF
                     ASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGMGKMAPSPAHFITLNG
                     STVPLGPASDTGILNPEGYTLNYNEFIVYSPSQVHMRYLLKIQFNFLQLW"
     exon            75..212
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            213..283
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..334
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..431
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..507
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..610
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..761
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..900
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..964
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1099
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1227
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1327
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1426
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1551
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1817
                     /gene="Parp2"
                     /gene_synonym="Adprtl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcaaaggg tgatgacgtc gtccttcaag cgctatggcg ccgcggcggc ggagatctgg
       61 ctgtggaaga cgagtgctaa atgaagccaa gagagttgat aatggcaaca gagcaacaga
      121 tgactctcct cctggcaaga aagtgcgcac gtgccagaaa aaggggcctg cggctggagg
      181 ggaggacaca gacaggacaa aaggcaagca agactctgtg aagaccctgc tcgtaaaggg
      241 ccgagctcct gtggacccag agtgcacatc caaggtcgga aaggctcatg tgtattgtga
      301 aggagatgat gtctatgacg tcatgttaaa tcaaaccaat ctccagttca acaacaacaa
      361 gtactacctt atccagctgt tagaagatga tgcccagcag aacttcagtg tgtggatgag
      421 gtggggccga gttgggaaaa cagggcagca cagcttggtg gcttgttctg gtgacctcaa
      481 caaagcaaaa gaaatatttc agaaaaaatt ccttgacaaa actaaaaaca attgggagga
      541 tcgtgagaac tttgagaaag tacctggaaa atacgacatg ttgcagatgg actatgctgc
      601 cagcactgag gatgaaaata aaacaaaaca agaggaaact tcgaagccag agtcacagct
      661 ggatcttcga gtccaggagc tgctaaagtt gatctgtaac gtgcagacca tggaagagat
      721 gatgattgag atgaagtatg acaccaagag ggccccactc ggaaaactga cagtggcgca
      781 gatcaaggca ggctaccagt ctctcaagaa gattgaggat tgtatccgtg ctggccagca
      841 tgggcgagcg cttgttgagg catgtaatga attctacacc aggatccctc atgactttgg
      901 actctccatc cctcctgtaa tccggacaga gaaagaactg tcagacaaag taaaactgct
      961 ggaggcattg ggagacattg aaattgccct taagctggtg aagtcagagc gccaaggcct
     1021 agaacaccca ctggaccaac actatagaaa cctacgttgt gctttgcgtc ctctggacca
     1081 tgaaagtcat gagttcaaag tgatttccca gtacttacag tctacccatg ctcctacaca
     1141 taaggactat actatgacct tgctggaagt tttcgaagta gagaaggaag gggagaaaga
     1201 ggccttcaga aaggaccttc ctaacaggat gctgctctgg catggttcca ggctgagtaa
     1261 ctgggtgggg atcctgagcc acggacttag agtcgcccca cctgaggctc ccatcacagg
     1321 ttatatgttt gggaaaggaa tctactttgc tgacatgtcg tccaagagtg ccaattactg
     1381 ctttgcttct cgcctgaaga atacaggatt gcttcttctg tcagaggtag ctctgggtca
     1441 gtgtaatgaa ctgctggagg ccaaccctaa ggcagaagga ttgcttcagg gcaagcatag
     1501 caccaagggg atgggaaaga tggctcccag ccctgcccac ttcatcaccc tgaatgggag
     1561 tacagtgccc ttaggaccag caagtgacac aggaattctc aatccagagg ggtacaccct
     1621 caactacaat gagtttattg tttatagccc cagccaggtc catatgcgat accttctaaa
     1681 gattcaattt aattttctgc agctgtggtg aatgttgatc aaacaagcca gagagaatct
     1741 catcttcaaa caaaaaccaa gcaatacttt gttcttaaac tttttgatat tttgtttaat
     1801 aaaatcgtat aaatctt
//
