LOCUS       NM_001014093            2336 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase family, member 16
            (Parp16), mRNA.
ACCESSION   NM_001014093 XM_236347
VERSION     NM_001014093.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2336)
  AUTHORS   Yang,D., Wang,Q., Wei,G., Wu,J., Zhu,Y.C., Zhu,Q., Ni,T., Liu,X.
            and Zhu,Y.Z.
  TITLE     Smyd3-PARP16 axis accelerates unfolded protein response and
            vascular aging
  JOURNAL   Aging (Albany NY) 12 (21), 21423-21445 (2020)
   PUBMED   33144524
  REMARK    GeneRIF: Smyd3-PARP16 axis accelerates unfolded protein response
            and vascular aging.
REFERENCE   2  (bases 1 to 2336)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   3  (bases 1 to 2336)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2336)
  AUTHORS   Jwa,M. and Chang,P.
  TITLE     PARP16 is a tail-anchored endoplasmic reticulum protein required
            for the PERK- and IRE1alpha-mediated unfolded protein response
  JOURNAL   Nat Cell Biol 14 (11), 1223-1230 (2012)
   PUBMED   23103912
  REMARK    Erratum:[Nat Cell Biol. 2013 Jan;15(1):123]
REFERENCE   5  (bases 1 to 2336)
  AUTHORS   Di Paola,S., Micaroni,M., Di Tullio,G., Buccione,R. and Di
            Girolamo,M.
  TITLE     PARP16/ARTD15 is a novel endoplasmic-reticulum-associated
            mono-ADP-ribosyltransferase that interacts with, and modifies
            karyopherin-ss1
  JOURNAL   PLoS One 7 (6), e37352 (2012)
   PUBMED   22701565
REFERENCE   6  (bases 1 to 2336)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 2336)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085908.1.
            
            [WARNING] On Mar 13, 2025 this sequence was replaced by
            NM_001014093.2.
            
            On Apr 20, 2005 this sequence version replaced XM_236347.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2336
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /note="poly (ADP-ribose) polymerase family, member 16"
                     /db_xref="GeneID:315760"
                     /db_xref="RGD:1306243"
     exon            1..11
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            12..294
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1089
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /EC_number="2.4.2.30"
                     /note="poly [ADP-ribose] polymerase 16; PARP-16;
                     ADP-ribosyltransferase diphtheria toxin-like 15; mono
                     [ADP-ribose] polymerase PARP16"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP16"
                     /protein_id="NP_001014115.1"
                     /db_xref="GeneID:315760"
                     /db_xref="RGD:1306243"
                     /translation="MQLSNRAAARESVSRDVLAADLRCSLFASALQSYKRDSVLRPFP
                     ASYARHDCKDFEALLADTGRLPNLKELLQSSRDTDKQTWDLVSWILSSKILTIHSAEK
                     AEFEKIQQLTGAPHTPVPIPDFLFEIEYFDPANARFYETKGGRDLIYAFHGSRLENFH
                     SIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGRGWQHSLLGQTLSCVAVCEVI
                     DHPDVKCQTKKKDSKEIDRSRARIKHSEGGDVPPKYFVVTNNQLLRVKYLLVYSQKQP
                     KRASSQLSWLCSHWFMVAMSLYLLLLLIVSVTNSSAFQHFWNRLKR"
     exon            295..432
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            433..639
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            640..811
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            812..953
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2314
                     /gene="Parp16"
                     /gene_synonym="ARTD15; LRRGT00109; RGD1306243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcccgga gctccacccc cgggctggga aacctggcag cagacggtcc aaggtccccc
       61 gggcccaggc cccgcactgc ccctccttgc ctcctcccga ccacgcgcta cgagcccggg
      121 atgcagctct ccaacagggc ggcagccagg gagtcggtga gccgcgacgt gctggccgcg
      181 gacctccgct gcagcctctt cgcctcagcg ctgcagagct acaagcggga ctcggtgctg
      241 cggcccttcc ccgcctccta cgcccgccac gactgtaagg acttcgaggc cctgcttgcg
      301 gacactggca ggttacctaa cttgaaggaa cttctgcagt cctccaggga cacagacaaa
      361 cagacctggg acctggtgag ctggattcta tcctccaaga tcctgacaat ccacagtgca
      421 gagaaggccg agtttgaaaa gatccagcag ctgaccggtg cacctcacac acctgtcccc
      481 atcccagatt tcctttttga aattgagtac tttgacccgg ccaatgccag attctatgag
      541 accaaaggag ggcgagacct gatctatgcc ttccatggca gccgcctaga gaacttccat
      601 tccatcattc acaacggcct gcattgtcac ctgaacaaga cttctctgtt tggagagggg
      661 acctacctca caagtgactt gagcctggcc ctcatttata gtcctcacgg ccgtgggtgg
      721 cagcatagcc tccttggcca gacccttagc tgtgtagctg tgtgtgaggt catcgaccat
      781 ccagatgtca agtgccaaac caagaagaag gattccaagg aaatcgaccg cagcagagct
      841 cgaatcaagc acagcgaagg gggagatgtc ccccctaagt actttgtagt cactaacaac
      901 cagcttctgc gggtgaagta cctactggtg tattcccaga agcagcccaa gagggcctcg
      961 agccagcttt cctggctgtg cagccattgg ttcatggtcg cgatgtccct ctatctgctg
     1021 ctgctgctca tcgtcagtgt caccaactcc tctgccttcc agcacttctg gaatcgcctg
     1081 aagagatgat ccctggtgct tggagtgggg ccactcaccg tgtgccttat gggcgctcgt
     1141 cctctacctc ctgcatgtca catccagtca ggtcgagtct gggaaccagt tgcggggtgc
     1201 acagggcgat gtttatatgc cataagtgta ctgattacct tgttggtgtg ctcagacaca
     1261 gtccagtcag cggggaccct ggcccctcac ttgctggctt caggggtatc ctaccatctg
     1321 cttcttccga aacagtctag ggaggtggct ctccagccag ggccaaagga agaagtcctg
     1381 ctgcatttaa aagcaaagtg tccaagctgt ccgcggtgtg tttgtaatag cccagatgga
     1441 ggcctcctga cgttaatgcc tctggaagac agaacatgtg caacgggaac gataaatcac
     1501 caggcggctg ccttgttttg actcaagaca cccaagaggg acagtcgtgt ttctcataaa
     1561 aatatcagtg ggaccgtttg ggaattccat cggctttagt ctgcgggtgc aaaacatttt
     1621 aacagttttc tcagatcaac aacagtctct gccacagctg tactcccctg cctcctcaac
     1681 cacacaggag gaggagccac aggcgggata acaaaatgca gatttgacaa ctagcaactc
     1741 tgtcatcttt ttctaaaaat gaccaactgc tgattacagc tcaaatggaa ccaaatgttt
     1801 gtgtttctgt ttctttgttg tttgtttgac caattagcct ctatgagcca aatagagagg
     1861 gagctgtgtg agccttgagc accgagtggc tggatccaca gcctctgtct ggttttgcta
     1921 tggagaaggg tccaagccat aggctcgcta gggtcctcat tcccacgaag ctgccttgat
     1981 aaacaacact ctaggctttc aggggccctg atggccttca aggcagaggc ctgcctcagt
     2041 gggccacaga tctccacagg ccgagcctct gtccaaggag cctgagcttg agttgaaagc
     2101 agagcccccc ggccgttcgt gctgtgttgt ttattctctc cttcctgcca gtcttcaatg
     2161 gcgaagaact ctgtctactg gcaatgggat ttccatagag aaggaggaaa tcatttttcc
     2221 ccctatgatt tgtaaagctt gtgaagaagc cactatcatg atttttaaac caagtagtga
     2281 gatgtttaaa aaccaataaa gatattttcc taaaaaaaaa aaaaaaaaaa aaaaaa
//
