LOCUS       NM_001108623            2870 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase family, member 12
            (Parp12), mRNA.
ACCESSION   NM_001108623 XM_001067057 XM_003749716 XM_003753877 XM_342663
VERSION     NM_001108623.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Sep 4, 2019 this sequence version replaced
            XM_003749716.3, XM_003753877.3, NM_001108623.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            orthologous transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.19003.1,
                                           SRR26643293.22568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000004.1  68850130-68850541   c
            413-548             JAXUCZ010000004.1  68846087-68846222   c
            549-849             JAXUCZ010000004.1  68843116-68843416   c
            850-945             JAXUCZ010000004.1  68838986-68839081   c
            946-1069            JAXUCZ010000004.1  68834019-68834142   c
            1070-1265           JAXUCZ010000004.1  68822230-68822425   c
            1266-1407           JAXUCZ010000004.1  68818387-68818528   c
            1408-1504           JAXUCZ010000004.1  68815177-68815273   c
            1505-1580           JAXUCZ010000004.1  68810613-68810688   c
            1581-1711           JAXUCZ010000004.1  68809555-68809685   c
            1712-1863           JAXUCZ010000004.1  68808514-68808665   c
            1864-2870           JAXUCZ010000004.1  68806100-68807106   c
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2870
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /note="poly (ADP-ribose) polymerase family, member 12"
                     /db_xref="GeneID:362343"
                     /db_xref="RGD:1308628"
     exon            1..412
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2189
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /EC_number="2.4.2.30"
                     /note="zinc finger CCCH type domain containing 1; poly
                     ADP-ribose polymerase 12"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP12"
                     /protein_id="NP_001102093.2"
                     /db_xref="GeneID:362343"
                     /db_xref="RGD:1308628"
                     /translation="MAQAAVAVAEVTQLLCAAGGALELAELRRRLRTSLGADALERLL
                     RDRGRFVVASREGTGPATAAAAASERVVVAVSSLRLCRAHQGPKQGCTGLCAQLHLCK
                     FLIYGNCKFLRTGKNCRNGHNLKTDHNLSVLRTHGIDHLTYTELCQLLLQNDPSLLPD
                     ICLHYNKGDGHFGSCSFQKQCIKLHICQYFLQGECKFGTSCKRSHEFTNSENLEKLEK
                     LGLSSDLVSRLLSTYRNAYDIKNKGSALSKVSSSPAGPQGTSERKDSSVSPGTLSQEE
                     SEQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDGGEWKDLDNMELIENAYCNPSKDR
                     IVYTESAAGFHFDNLDFNSMKLGHTLARRLSTASSVTKPPHFILTTEWAWYWMDEFGS
                     WQEYGRQGTGHPVTTISSSDVEKAYLSFCVPGADAQAAILKFQAGKHNYELDFKAFLQ
                     KNLVYGTVRKVCRRPKYVSPQDVQMKQSCNTKLHGTKSIPDYWDPAALPDLGFKRITL
                     SSSSEEYQKVWNLFNRTLPFYFVQKIERIQNLGLWEVYQWQKGQMQKQNGGKEVDERQ
                     LFHGTSTNFVDAICQQNFDWRVCGLHGTSYGKGSYFARDAAYSHHYSKSDTHSHTMFL
                     ARVLVGDFVRGSTSFVRPPAKEGQSNAFYDSCVNSMSDPTIFVVFEKHQVYPEYLIQY
                     STSSKPPAGPSIFVALGNLFTSRQ"
     exon            413..548
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..849
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..945
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1069
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1265
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1407
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1504
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1580
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1711
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1863
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2870
                     /gene="Parp12"
                     /gene_synonym="Zc3hdc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcgaaac agtggggctg ggcctgtgaa caacgctgtc gtccgtgcta agcctcggtc
       61 cgacagccat ggcccaggcc gcggtggcgg tggcagaggt gacccagttg ctgtgcgcgg
      121 cggggggcgc cttggagttg gcggagctga ggcgccgctt gcgaaccagc ctgggcgccg
      181 acgcgctgga gcggctgctg cgggaccgcg ggcgcttcgt ggtggcctcg cgggagggca
      241 cgggcccggc gaccgcggcg gcggcggcct cggagcgcgt ggtagtggct gtgtcgtcgc
      301 tgcgtctgtg ccgcgcgcac cagggcccca agcagggctg caccgggctc tgcgcgcagt
      361 tgcatctctg caagtttctc atctacggta actgcaagtt cctgaggacc gggaagaact
      421 gtaggaatgg tcacaacttg aagactgatc acaacctgag tgtgctgagg actcatggta
      481 ttgaccacct cacgtatact gagctttgcc aactcttact tcagaatgac ccttcgcttt
      541 taccagatat ctgcctacac tataacaaag gtgatggaca cttcggctct tgctccttcc
      601 agaagcagtg cattaaactc catatctgcc agtacttctt acagggagag tgcaagtttg
      661 gcactagctg taagaggtcc cacgagttca ctaactcaga gaatctggag aaattagaaa
      721 agttgggttt aagttctgac ctggtgagca ggctactctc tacttaccgg aatgcatatg
      781 acatcaagaa taagggctca gccctcagca aagtgtcctc ttctcctgca ggcccacagg
      841 ggacttctga aagaaaagac agttcagtgt ccccaggcac tcttagccag gaggagagtg
      901 agcagatttg cttgtaccat attcggaaga gttgtagctt ccaagataag tgccatcggg
      961 tacattttca tttgccatat cggtggcaat tcttggatgg aggtgaatgg aaggatctgg
     1021 acaacatgga gcttattgaa aatgcttatt gcaatcccag taaagacagg attgtataca
     1081 cagagtcagc cgctggcttc cactttgata atctggactt taactccatg aagcttggtc
     1141 acactctggc tcgccgactc tccacagctt cctcggtcac caagccccca cacttcatcc
     1201 tcactactga gtgggcttgg tactggatgg atgagtttgg ttcttggcag gagtacggac
     1261 gacagggcac agggcaccct gtgaccacca tcagcagcag tgatgtggaa aaggcttact
     1321 tgtcattctg tgttccgggg gctgatgccc aggcagccat cttgaagttc caggctggaa
     1381 agcacaacta tgagttagac ttcaaagcct ttctgcagaa gaaccttgtg tatggcactg
     1441 tcagaaaggt ttgtcgcaga cccaagtatg tgtctcccca ggatgtgcag atgaagcagt
     1501 cctgcaatac taagttacac ggcacgaaga gcattccaga ctactgggac cctgcagccc
     1561 tgccggacct gggatttaag aggatcactc tgagttcctc ctcagaagag tatcagaagg
     1621 tatggaacct cttcaaccgt acactacctt tctactttgt tcagaagatc gagcggatcc
     1681 agaacctggg cctgtgggaa gtctaccagt ggcagaaagg ccagatgcag aagcagaatg
     1741 gggggaagga agtagatgag aggcagctgt ttcatgggac tagcaccaac ttcgtggacg
     1801 ccatctgcca gcagaacttt gactggcggg tctgtggtct gcacggtaca tcctatggca
     1861 aagggagcta ctttgcgaga gatgccgcct attcgcacca ctacagcaaa tctgacacac
     1921 actcccacac catgttcctg gcccgggtgc tggtgggaga cttcgtcagg ggcagcactt
     1981 cctttgtccg ccctccagcc aaggaaggcc agagcaatgc tttctatgac agctgcgtga
     2041 acagcatgtc cgacccgact atctttgtag tttttgagaa gcaccaggtc taccctgagt
     2101 acctcatcca atactctacc tcctccaagc ccccagctgg cccctccatc tttgttgccc
     2161 tgggcaactt gttcaccagc cgacagtaag catggccagt ttgcattagg catttctgcc
     2221 acatctgtct ggtggagcta tttggaaagg tttttttttt tctttttctt ttttaagcaa
     2281 aacttttaat gaactcttgt ttattgttag cttctcagtg aaattacatt ttccccctag
     2341 tgctgggaat ggaacatggg gccttgtgct tactagaaaa gcactctacc actgagctag
     2401 atgcccccag tccttttaaa atgtttttat tatgaggcag gattttgcta aattctatta
     2461 tgccttagtc tcctgagcag ctgggattaa aagcctatat taccaggcct gacttgaagc
     2521 cacaatctta atccttggct gataacaatt ttaggtttta ggtcctttta ggttggctta
     2581 tgatcttagc agtagtgatt gtgagcccaa gtttgactta taataatgtt agcattgcat
     2641 ttttaactct ttgctgactt tgatgtttgt taagaccaag cacagaattt ataatgctgt
     2701 tttatggatt tgttttaact gtgaagagtt tatgtctcta taacaattct ggttttggag
     2761 ggtcttatgg tccattttgc atttgtcaga ggagcatagt ggcctttatg gaagggggga
     2821 ctacagggaa ggcctcggca ttgctgtcac tcttgccccc tgctttggaa
//
