LOCUS       NM_013063               3571 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus poly (ADP-ribose) polymerase 1 (Parp1), mRNA.
ACCESSION   NM_013063
VERSION     NM_013063.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Wen,J.J., Dejesus,J.E., Radhakrishnan,G.L. and Radhakrishnan,R.S.
  TITLE     PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory
            Response and Cardiac Function
  JOURNAL   J Am Coll Surg 236 (4), 783-802 (2023)
   PUBMED   36728307
  REMARK    GeneRIF: PARP1 Inhibition and Effect on Burn Injury-Induced
            Inflammatory Response and Cardiac Function.
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Chen,Q., Zhang,E., Wang,C., Zhang,P. and Huang,L.
  TITLE     PARP-1 Inhibition Repressed Imbalance of Th17 and Treg Cells in
            Preterm Rats with Intrauterine Infection-Induced Acute Respiratory
            Distress Syndrome by Reducing the Expression Level of IL-6
  JOURNAL   J Healthc Eng 2022, 1255674 (2022)
   PUBMED   35190759
  REMARK    GeneRIF: PARP-1 Inhibition Repressed Imbalance of Th17 and Treg
            Cells in Preterm Rats with Intrauterine Infection-Induced Acute
            Respiratory Distress Syndrome by Reducing the Expression Level of
            IL-6.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3571)
  AUTHORS   Wang,L., Wang,P., Xu,S., Li,Z., Duan,D.D., Ye,J., Li,J., Ding,Y.,
            Zhang,W., Lu,J. and Liu,P.
  TITLE     The cross-talk between PARylation and SUMOylation in C/EBPbeta at
            K134 site participates in pathological cardiac hypertrophy
  JOURNAL   Int J Biol Sci 18 (2), 783-799 (2022)
   PUBMED   35002525
  REMARK    GeneRIF: The cross-talk between PARylation and SUMOylation in
            C/EBPbeta at K134 site participates in pathological cardiac
            hypertrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3571)
  AUTHORS   Zhao,R., Jin,X., Li,A., Xu,B., Shen,Y., Wang,W., Huang,J., Zhang,Y.
            and Li,X.
  TITLE     Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent
            Cells via DPP4 Targeting and PARP1 Activation
  JOURNAL   Adv Sci (Weinh) 9 (1), e2104128 (2022)
   PUBMED   34738744
  REMARK    GeneRIF: Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate
            Senescent Cells via DPP4 Targeting and PARP1 Activation.
REFERENCE   5  (bases 1 to 3571)
  AUTHORS   Kuchmerovska,T., Guzyk,M., Tykhonenko,T., Yanitska,L.,
            Pryvrotska,I. and Diakun,K.
  TITLE     The parp-1 and bax genes as potential targets for treatment of the
            heart functioning impairments induced by type 1 diabetes mellitus
  JOURNAL   Endocr Regul 55 (2), 61-71 (2021)
   PUBMED   34020532
  REMARK    GeneRIF: The parp-1 and bax genes as potential targets for
            treatment of the heart functioning impairments induced by type 1
            diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3571)
  AUTHORS   Endres,M., Wang,Z.Q., Namura,S., Waeber,C. and Moskowitz,M.A.
  TITLE     Ischemic brain injury is mediated by the activation of
            poly(ADP-ribose)polymerase
  JOURNAL   J Cereb Blood Flow Metab 17 (11), 1143-1151 (1997)
   PUBMED   9390645
REFERENCE   7  (bases 1 to 3571)
  AUTHORS   Beneke,S., Meyer,R. and Burkle,A.
  TITLE     Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly
            (ADP-ribose) polymerase
  JOURNAL   Biochem Mol Biol Int 43 (4), 755-761 (1997)
   PUBMED   9385436
  REMARK    Erratum:[Biochem Mol Biol Int 1998 May;44(6):1273]
REFERENCE   8  (bases 1 to 3571)
  AUTHORS   Marsischky,G.T., Wilson,B.A. and Collier,R.J.
  TITLE     Role of glutamic acid 988 of human poly-ADP-ribose polymerase in
            polymer formation. Evidence for active site similarities to the
            ADP-ribosylating toxins
  JOURNAL   J Biol Chem 270 (7), 3247-3254 (1995)
   PUBMED   7852410
REFERENCE   9  (bases 1 to 3571)
  AUTHORS   Potvin,F., Thibodeau,J., Kirkland,J.B., Dandenault,B., Duchaine,C.
            and Poirier,G.G.
  TITLE     Structural analysis of the putative regulatory region of the rat
            gene encoding poly(ADP-ribose) polymerase
  JOURNAL   FEBS Lett 302 (3), 269-273 (1992)
   PUBMED   1601134
REFERENCE   10 (bases 1 to 3571)
  AUTHORS   Thibodeau,J., Gradwohl,G., Dumas,C., Clairoux-Moreau,S., Brunet,G.,
            Penning,C., Poirier,G.G. and Moreau,P.
  TITLE     Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase
            catalytic domain and analysis of mRNA levels during the cell cycle
  JOURNAL   Biochem Cell Biol 67 (9), 653-660 (1989)
   PUBMED   2508731
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085765.1.
            
            On Nov 15, 2004 this sequence version replaced NM_013063.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085765.1, U94340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..3571
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /note="poly (ADP-ribose) polymerase 1"
                     /db_xref="GeneID:25591"
                     /db_xref="RGD:2053"
     exon            1..182
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..3107
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /EC_number="2.4.2.30"
                     /note="poly[ADP-ribose] synthetase 1; NAD(+)
                     ADP-ribosyltransferase 1; ADPRT 1; DNA
                     ADP-ribosyltransferase PARP1; protein
                     poly-ADP-ribosyltransferase PARP1; poly[ADP-ribose]
                     synthase 1; ADP-ribosyltransferase (NAD+; poly
                     (ADP-ribose) polymerase); poly(ADP-ribose) polymerase
                     PARP-1; poly (ADP-ribose) polymerase family, member 1;
                     ADP-ribosyltransferase diphtheria toxin-like 1"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase 1"
                     /protein_id="NP_037195.1"
                     /db_xref="GeneID:25591"
                     /db_xref="RGD:2053"
                     /translation="MAEATERLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMF
                     DGKVPHWYHFSCFWKVGHSIRQPDTEVDGFSELRWDDQQKVKKTAEAGGVAGKGQHGG
                     GGKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQMRLSKKMLDPEKPQLGMIDRWYHP
                     TCFVKNRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAVKSEGKRKCDEVDGIDE
                     VAKKKSKKGKDKESSKLEKALKAQNELVWNIKDELKKACSTNDLKELLIFNQQQVPSG
                     ESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEW
                     VTPKEFREISYLKKLKIKKQDRLFPPESSAPAPPAPPVSITSAPTAVNSSAPADKPLS
                     NMKILTLGKLSQNKDEAKAMIEKLGGKLTGSANKASLCISTKKEVEKMSKKMEEVKAA
                     NVRVVCEDFLQDVSASAKSLQELLSAHSLSSWGAEVKVEPGEVVVPKGKSAAPSKKSK
                     GAVKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGT
                     NSYYKLQLLESDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGN
                     AWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLAVKPGTKSKLPKPVQELVGMIFDVESM
                     KKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAVSQGSSESQILDLSNRFYTLI
                     PHDFGMKKPPLLNNTDSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLK
                     TDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHN
                     RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGD
                     PIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTAPDPSASITLDGVEVPLG
                     TGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW"
     exon            183..348
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..464
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..679
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..782
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..899
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1076
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1224
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1365
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1605
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1674
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1807
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2003
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2132
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2216
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2339
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2468
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2567
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2720
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2848
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2910
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3025
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3536
                     /gene="Parp1"
                     /gene_synonym="Adprt; ARTD1; Parp-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacacgtta gcggagcgga ccggcggcgg cgtctgcctg ccgctgcggc acgagaggga
       61 ggatggcgga ggccacggag aggctttacc gagtggagta cgctaagagc gggcgcgcct
      121 cttgcaagaa atgcagcgag agtatcccca aggactcgct ccgcatggcc atcatggtgc
      181 agtcacccat gttcgatgga aaagtcccac actggtatca cttctcctgc ttctggaagg
      241 tgggccactc catccggcag cctgacacag aggtggacgg gttctctgag ctgcggtggg
      301 atgaccagca gaaggtcaag aagaccgcag aggctggagg cgtggcaggc aaaggccagc
      361 atggaggtgg cggcaaggcg gagaagacgc tgggcgactt tgcggcagag tatgccaagt
      421 ccaacaggag cacatgcaag ggctgcatgg agaagataga gaagggtcag atgcgcctgt
      481 ccaagaagat gctggatcca gagaagccgc aactgggtat gattgaccgc tggtaccatc
      541 caacttgctt tgtcaagaac cgggacgagc tgggcttccg gcctgagtac agtgccagcc
      601 agctcaaggg ctttagcctc ctctctgcag aagacaaaga agctctgaag aagcagctcc
      661 cggcagtcaa gagtgaagga aagagaaaat gtgacgaggt ggatggaata gatgaagtag
      721 ccaaaaagaa atctaaaaaa ggaaaggaca aggagagtag taaactggaa aaggcgctca
      781 aggctcagaa cgagctggtc tggaatatca aagatgagct gaagaaagcc tgctccacca
      841 acgacctgaa ggagttgctc atcttcaacc agcagcaagt accatctgga gagtccgcaa
      901 tcctggaccg agttgctgat ggcatggcgt ttggggccct tctgccctgc aaggagtgtt
      961 caggacagct ggtttttaag agcgacgctt attactgtac tggggatgtc actgcctgga
     1021 ccaagtgcat ggtcaagaca cagaatccca gccgaaagga atgggtaact ccaaaggaat
     1081 tccgagaaat atcctacctc aagaaattaa agatcaaaaa gcaggaccgg ctgttccctc
     1141 cagagagcag cgccccagca ccaccagcac ctcccgtctc gatcacctcc gcacccacag
     1201 ctgtgaactc ctctgcacca gcagacaaac ccctgtctaa catgaagatc ctgactcttg
     1261 gtaagctctc ccagaacaag gacgaagcaa aggccatgat tgagaaactc ggaggcaagc
     1321 tgacaggatc tgccaacaag gcctccttgt gtatcagcac taagaaggag gtggagaaga
     1381 tgagtaagaa gatggaggaa gtgaaagcag ccaatgttcg agtcgtgtgt gaggacttcc
     1441 tccaggatgt gtctgcctca gctaagagcc tccaagagct gctctcagcc catagcttgt
     1501 cctcgtgggg ggctgaggtg aaggtagagc ctggtgaagt ggtggtcccc aaggggaagt
     1561 cagctgcacc ctccaagaag agcaagggtg ctgtcaagga ggaaggtgtc aacaagtctg
     1621 aaaagaggat gaaactaact ctgaagggag gagcagccgt tgatcctgac tctggtctgg
     1681 aacactctgc acatgtcctg gagaaaggcg ggaaggtgtt cagtgccacg cttggcctgg
     1741 tggacattgt gaaagggact aactcctatt acaaactgca acttctggag tccgacaagg
     1801 agagcaggta ttggatcttc cggtcctggg gccgagtggg cacagttatc ggcagtaaca
     1861 agcttgagca gatgccgtcc aaagaggatg ctgttgaaca cttcatgaag ttatacgaag
     1921 agaagactgg aaatgcctgg cactcgaaaa acttcacaaa gtatcccaag aagttctacc
     1981 ctctggagat tgactatggc caggacgaag aggcagtaaa gaagctggcg gtgaagcctg
     2041 gcactaagtc gaagctgccg aagccggtgc aggagctcgt cgggatgatc ttcgacgtgg
     2101 agagcatgaa gaaggccttg gtggagtacg agattgacct tcagaagatg cccttgggga
     2161 aactgagcag aaggcagatc caggccgcct actctatcct cagtgaggtc cagcaggcag
     2221 tgtcccaagg cagcagtgaa tctcagatcc tggatctctc caatcgcttc tacaccctca
     2281 tcccccatga ctttggaatg aagaagcccc cacttctgaa caacacagac agtgtgcagg
     2341 ccaaggtgga gatgctggac aacctcctgg acatcgaggt tgcctatagt cttctcaggg
     2401 gtgggtctga tgacagcagt aaggacccca tcgatgtcaa ctatgagaag ctcaaaactg
     2461 acattaaggt ggttgacaga gattctgaag aggctgaggt catcaggaag tatgtgaaga
     2521 acactcacgc gaccacgcac aatgcctatg acctggaagt gatagacatc tttaagatag
     2581 agcgagaggg agagagccaa cgctacaagc ccttcaggca gcttcacaac cggagactgc
     2641 tgtggcacgg gtccaggacc accaacttcg caggcatcct gtcacagggt ctgcggatag
     2701 ccccacctga agcacctgtg acaggctaca tgtttgggaa aggaatctac tttgctgata
     2761 tggtgtccaa aagtgcgaac tactgccaca cgtctcaggg agacccgatt ggcttaatac
     2821 tgttgggaga agttgccctt ggaaacatgt acgaactcaa gcatgcttct cacatcagca
     2881 agttacccaa gggcaagcac agtgtcaaag gtttgggcaa aaccgcccct gacccttcgg
     2941 ccagcatcac cctggatggt gtagaggttc cgctgggaac agggattccg tctggtgtta
     3001 atgacacctg cctgctgtat aacgagtaca ttgtctacga cattgctcag gtgaatctga
     3061 agtacctact gaaactgaag ttcaatttca agacctcctt gtggtagagt gaaggcgggc
     3121 tttgccagca cccggggcct aggggataat gcccctagtg cctctgcacc aaacaccaca
     3181 acacctcagc catgctgccg cctcagggtg gcaccctcac cgaatctcct taggaaggac
     3241 tttacacaga taggttgcgc tggagtggga cggctgtttg tggtttgtcc aaccaggcac
     3301 agccgtgaca gacagctggc agtagaggga aagttgggga gaggtttttg ttgtttgcct
     3361 agactagtcc tgagggaaga aaccgccacg tcacagtcac aatgtctgcc ttactggctt
     3421 ccccagggaa ggaaaatgtg cttcctccct tctttcaagg gttcatcttt ggtttgattt
     3481 tggcaaaatg ttaagcattt attttgagct aaaaaataaa aactaatttc atactaaaaa
     3541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
