LOCUS       NM_001270415            2872 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus poly(A)-specific ribonuclease (Parn), mRNA.
ACCESSION   NM_001270415 XM_001075629 XM_340740
VERSION     NM_001270415.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2872)
  AUTHORS   Shukla S, Schmidt JC, Goldfarb KC, Cech TR and Parker R.
  TITLE     Inhibition of telomerase RNA decay rescues telomerase deficiency
            caused by dyskerin or PARN defects
  JOURNAL   Nat Struct Mol Biol 23 (4), 286-292 (2016)
   PUBMED   26950371
REFERENCE   2  (bases 1 to 2872)
  AUTHORS   Moon DH, Segal M, Boyraz B, Guinan E, Hofmann I, Cahan P, Tai AK
            and Agarwal S.
  TITLE     Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of
            the telomerase RNA component
  JOURNAL   Nat Genet 47 (12), 1482-1488 (2015)
   PUBMED   26482878
REFERENCE   3  (bases 1 to 2872)
  AUTHORS   Boele J, Persson H, Shin JW, Ishizu Y, Newie IS, Sokilde R, Hawkins
            SM, Coarfa C, Ikeda K, Takayama K, Horie-Inoue K, Ando Y, Burroughs
            AM, Sasaki C, Suzuki C, Sakai M, Aoki S, Ogawa A, Hasegawa A, Lizio
            M, Kaida K, Teusink B, Carninci P, Suzuki H, Inoue S, Gunaratne PH,
            Rovira C, Hayashizaki Y and de Hoon MJ.
  TITLE     PAPD5-mediated 3' adenylation and subsequent degradation of miR-21
            is disrupted in proliferative disease
  JOURNAL   Proc Natl Acad Sci U S A 111 (31), 11467-11472 (2014)
   PUBMED   25049417
REFERENCE   4  (bases 1 to 2872)
  AUTHORS   Udagawa T, Swanger SA, Takeuchi K, Kim JH, Nalavadi V, Shin J,
            Lorenz LJ, Zukin RS, Bassell GJ and Richter JD.
  TITLE     Bidirectional control of mRNA translation and synaptic plasticity
            by the cytoplasmic polyadenylation complex
  JOURNAL   Mol Cell 47 (2), 253-266 (2012)
   PUBMED   22727665
  REMARK    GeneRIF: poly(A) polymerase Gld2, deadenylase PARN, and translation
            inhibitory factor neuroguidin (Ngd) are components of a dendritic
            CPEB-associated polyadenylation apparatus
REFERENCE   5  (bases 1 to 2872)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2872)
  AUTHORS   Berndt H, Harnisch C, Rammelt C, Stohr N, Zirkel A, Dohm JC,
            Himmelbauer H, Tavanez JP, Huttelmaier S and Wahle E.
  TITLE     Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent
            adenylation and PARN-dependent trimming
  JOURNAL   RNA 18 (5), 958-972 (2012)
   PUBMED   22442037
  REMARK    Erratum:[RNA. 2014 Aug;20(8):1349]
REFERENCE   7  (bases 1 to 2872)
  AUTHORS   Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA,
            Wang X, Linding R, Ong SE, Weaver D, Carr SA and Yaffe MB.
  TITLE     DNA damage activates a spatially distinct late cytoplasmic
            cell-cycle checkpoint network controlled by MK2-mediated RNA
            stabilization
  JOURNAL   Mol Cell 40 (1), 34-49 (2010)
   PUBMED   20932473
REFERENCE   8  (bases 1 to 2872)
  AUTHORS   Mauxion F, Faux C and Seraphin B.
  TITLE     The BTG2 protein is a general activator of mRNA deadenylation
  JOURNAL   EMBO J 27 (7), 1039-1048 (2008)
   PUBMED   18337750
REFERENCE   9  (bases 1 to 2872)
  AUTHORS   Ren YG, Kirsebom LA and Virtanen A.
  TITLE     Coordination of divalent metal ions in the active site of
            poly(A)-specific ribonuclease
  JOURNAL   J Biol Chem 279 (47), 48702-48706 (2004)
   PUBMED   15358788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000217.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001270415.3.
            
            On Oct 29, 2022 this sequence version replaced NM_001270415.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ123458.1, SRR8487231.19328.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JACYVU010000217.1  1240186-1240327     c
            143-220             JACYVU010000217.1  1239702-1239779     c
            221-300             JACYVU010000217.1  1238153-1238232     c
            301-368             JACYVU010000217.1  1236998-1237065     c
            369-450             JACYVU010000217.1  1236826-1236907     c
            451-511             JACYVU010000217.1  1230684-1230744     c
            512-656             JACYVU010000217.1  1221292-1221436     c
            657-722             JACYVU010000217.1  1217183-1217248     c
            723-761             JACYVU010000217.1  1216230-1216268     c
            762-804             JACYVU010000217.1  1214686-1214728     c
            805-885             JACYVU010000217.1  1212349-1212429     c
            886-942             JACYVU010000217.1  1211350-1211406     c
            943-1020            JACYVU010000217.1  1205622-1205699     c
            1021-1064           JACYVU010000217.1  1197546-1197589     c
            1065-1107           JACYVU010000217.1  1195499-1195541     c
            1108-1183           JACYVU010000217.1  1194281-1194356     c
            1184-1294           JACYVU010000217.1  1192151-1192261     c
            1295-1364           JACYVU010000217.1  1191528-1191597     c
            1365-1420           JACYVU010000217.1  1171620-1171675     c
            1421-1507           JACYVU010000217.1  1170413-1170499     c
            1508-1582           JACYVU010000217.1  1165044-1165118     c
            1583-1751           JACYVU010000217.1  1133612-1133780     c
            1752-1945           JACYVU010000217.1  1106250-1106443     c
            1946-2872           JACYVU010000217.1  1102416-1103342     c
FEATURES             Location/Qualifiers
     source          1..2872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..2872
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /note="poly(A)-specific ribonuclease"
                     /db_xref="GeneID:360464"
                     /db_xref="RGD:1565449"
     exon            1..142
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1998
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /EC_number="3.1.13.4"
                     /note="poly(A)-specific ribonuclease (deadenylation
                     nuclease)"
                     /codon_start=1
                     /product="poly(A)-specific ribonuclease PARN"
                     /protein_id="NP_001257344.1"
                     /db_xref="GeneID:360464"
                     /db_xref="RGD:1565449"
                     /translation="MEIIRSNFKINLPKVYQAIEEADFFAIDGEFSGISDGPSVTALT
                     SGFDTPEERYQKLKKHSMDFLLFQFGLCAFKYDHANSKHVTKSFNFYVFPKPFSRSSP
                     DVKFVCQSSSIDFLASQGFDFNKVFCSGIPYLNQEEERQLREQFDEKRSQANGAGALT
                     KCPVTIPEDQKKFIDQVIEKIEGFLQREEKRTLELNPCTGFQRKLIYQTLSWKYPKGI
                     HVETLETDKKERHIVISKVDEEERKRREQEKYAKEQEELNDAVGFSRVIHAIANSGKL
                     VVGHNMLLDVMHTIHQFYCPLPVDLNEFKEMTTCVFPRLLDTKLMASTQPFKDIINNT
                     SLAELEKRLKETPFDPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGS
                     LLSPPKTCVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWK
                     TSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVQIAVNTSKYAESYRIQTYAEYVGK
                     KQESKQVKRKWTEDSWKEVDRKRPHVPGPCYHTNSFTAAGIVGKRTLSPDPREAGVVD
                     RESEGISDPELEQTDYCADPLPEGRKKAKKLKRMKKEFSLAGSASDSPAVLFEVPDTW
                     "
     exon            143..220
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            221..300
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            301..368
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            369..450
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            451..511
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            512..656
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            657..722
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            723..761
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            762..804
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            805..885
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            886..942
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1020
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1064
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1107
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1183
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1294
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1364
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1420
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1507
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1582
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1751
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1945
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2872
                     /gene="Parn"
                     /gene_synonym="RGD1565449"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtgtccag cacggtctgt ttcgtggcgg tctcggacac ccccgccgct gcttttgcta
       61 cggaactctg cgcgtggacc ggcgccggcc tgggcggggc caaggttccg tctgcgccgc
      121 gggatggaga taatccggag caattttaag attaatcttc ccaaagtgta ccaggccata
      181 gaggaggctg acttcttcgc catcgatggg gagttttcag gaatcagtga tggaccctca
      241 gtaacagcat taacaagtgg ttttgacacc ccagaagaga gatatcagaa gcttaaaaag
      301 cattccatgg acttcttgct gtttcagttt ggcctctgtg cttttaagta tgaccacgcc
      361 aattccaagc atgtaacgaa gtcgtttaac ttctatgttt tccccaagcc tttcagtagg
      421 tcctcaccag atgtcaagtt tgtttgccag agctccagca ttgactttct ggcaagccaa
      481 ggatttgact ttaataaagt gttttgcagt ggaattccat atctgaacca ggaagaagaa
      541 agacagctga gagagcaatt tgatgaaaaa cgttctcagg ccaatggggc cggagctctg
      601 acaaaatgtc ctgtgacaat tcctgaggat cagaagaagt ttattgacca agtaatagag
      661 aagatagagg gtttcctaca gagagaagag aagaggactc tggaacttaa cccatgcact
      721 gggttccaaa gaaaacttat ttatcagact ttgagttgga agtatcccaa aggcattcat
      781 gttgagacat tagagactga caagaaggaa agacacatag ttatcagcaa agtggatgaa
      841 gaagaacgca aaaggagaga acaggagaag tacgcaaagg agcaggagga actgaatgat
      901 gctgtaggat tttcaagagt catccatgcg attgctaatt cggggaagct ggttgttgga
      961 cacaacatgc tcttggatgt catgcacact attcaccagt tctactgccc tctgcctgtg
     1021 gacctgaatg agtttaagga gatgacaaca tgtgtcttcc ccagactctt ggatactaaa
     1081 ttgatggcca gcacccagcc ctttaaggat atcattaaca atacatccct tgcagagttg
     1141 gaaaagcggt tgaaagagac accttttgac cctcctaaag ttgagagtgc ggaaggcttt
     1201 ccaagctacg acacagcttc tgagcagctg catgaggcag gttatgatgc gtacatcaca
     1261 ggactctgct tcatctccat ggcaaattac ttaggttctt tactcagtcc tccaaaaacg
     1321 tgtgtgtccg ccagatcaaa gctcatcgaa ccctttttta acaagttatt tcttatgagg
     1381 gtcatggata ttccctattt aaacttggaa gggccagact tgcagcctaa gcgggatcat
     1441 gttctccatg tgaccttccc taaagaatgg aaaaccagtg acctgtacca gctcttcagc
     1501 gcctttggta acattcagat atcctggatt gatgacacat cagccttcgt ttctctcagc
     1561 caaccagaac aagtacaaat tgctgttaat accagtaagt atgctgaaag ttatcggatc
     1621 cagacctacg ctgagtatgt gggaaagaag caggaaagca agcaggtcaa gaggaagtgg
     1681 acagaagaca gttggaagga ggtggacaga aagcggcccc acgtgccggg cccctgttac
     1741 cacaccaaca gcttcactgc agccggcata gttggaaaga gaactctgag tcccgaccct
     1801 cgggaagctg gagtggtgga cagagaatca gagggaatat ctgacccgga acttgaacag
     1861 acggattact gtgcagaccc cctcccagag ggaaggaaaa aggccaagaa gttaaaaaga
     1921 atgaagaaag agttttcctt ggcaggaagt gcctcagata gccctgctgt gctttttgaa
     1981 gtccccgaca cgtggtaatg acacacggtc atgggatgga gcacactgaa ggtgctgctg
     2041 cgacggcccc gcctacctgc ttagaagcca tgctgtagac acttaatcag atatggcatg
     2101 ggagagtttt ggaaccagtt tatttcctgc aaaagctact ttttactttt ttggctgtat
     2161 ctatcatccc ttttaatcta aactgacctt tggcacatgt catggttgag ggctgctgca
     2221 agtgtgtgtg tttattaact aattacttcc tgctcctgga aaacttgcct gccctggtga
     2281 atgttggtaa gtccacccaa ggagaagtca gctgcgaacc atgccaagag agccaagttc
     2341 tgaagtattc taggcagatt tctgctgagc ttctcctgcc tgaaatgtgc ctggccgtcc
     2401 tcccactgct gcctagaaac agcacgaagg cttgtctttt ccatggggat cttcctgtgc
     2461 taactcaggg tcatctcaac agatgccgag gctgtgagag cttgtcattt caagttactt
     2521 tccctcagac agggtgtggt gatgtgtggg tgaagctggt tcttctgttc ctatgcacaa
     2581 agctgtgttc acagtgcagc agcttctcct gtctttactg tatgtctttg tgtatctctg
     2641 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2701 tgacagtggc aggcctacag catgcatcaa gtcctcattc agacaggttt aagtggcaga
     2761 gtgctcctgc cggacactcc atagcagaca cttttggaca tgtaacgctt ttgtatcatg
     2821 aaaataaaag tgaaaaaata atttcaaaaa gattaaagaa aatttcctag aa
//
