LOCUS       NM_173114               5036 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus prostate androgen-regulated mucin-like protein 1
            (Parm1), mRNA.
ACCESSION   NM_173114
VERSION     NM_173114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5036)
  AUTHORS   He,Z., Chang,T., Chen,Y., Wang,H., Dai,L. and Zeng,H.
  TITLE     PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial
            Hypertension via AKT/FOXO3A Axis
  JOURNAL   Int J Mol Sci 24 (7), 6385 (2023)
   PUBMED   37047359
  REMARK    GeneRIF: PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary
            Arterial Hypertension via AKT/FOXO3A Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5036)
  AUTHORS   Park,J.Y., Jang,H., Curry,T.E., Sakamoto,A. and Jo,M.
  TITLE     Prostate androgen-regulated mucin-like protein 1: a novel regulator
            of progesterone metabolism
  JOURNAL   Mol Endocrinol 27 (11), 1871-1886 (2013)
   PUBMED   24085821
  REMARK    GeneRIF: PARM1 contributes to ovulation and/or luteal function by
            acting as a novel regulator of progesterone metabolism.
REFERENCE   3  (bases 1 to 5036)
  AUTHORS   Isodono,K., Takahashi,T., Imoto,H., Nakanishi,N., Ogata,T.,
            Asada,S., Adachi,A., Ueyama,T., Oh,H. and Matsubara,H.
  TITLE     PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic
            reticulum stress-induced apoptosis in rat cardiac myocytes
  JOURNAL   PLoS One 5 (3), e9746 (2010)
   PUBMED   20305782
  REMARK    GeneRIF: PARM-1 is a novel ER transmembrane molecule involved in
            cardiac remodeling in hypertensive heart disease
            GeneRIF: PARM-1 is an ER protein in cardiac myocytes, whose
            expression is enhanced by ER stress and in the hearts of
            hypertensive heart disease model of Dahl salt-sensitive rats.
            PARM-1 has a protective role against ER stress-induced apoptosis in
            cardiac myocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5036)
  AUTHORS   Fladeby,C., Gupta,S.N., Barois,N., Lorenzo,P.I., Simpson,J.C.,
            Saatcioglu,F. and Bakke,O.
  TITLE     Human PARM-1 is a novel mucin-like, androgen-regulated gene
            exhibiting proliferative effects in prostate cancer cells
  JOURNAL   Int J Cancer 122 (6), 1229-1235 (2008)
   PUBMED   18027867
REFERENCE   5  (bases 1 to 5036)
  AUTHORS   Cornet,A.M., Hanon,E., Reiter,E.R., Bruyninx,M., Nguyen,V.H.,
            Hennuy,B.R., Hennen,G.P. and Closset,J.L.
  TITLE     Prostatic androgen repressed message-1 (PARM-1) may play a role in
            prostatic cell immortalisation
  JOURNAL   Prostate 56 (3), 220-230 (2003)
   PUBMED   12772192
REFERENCE   6  (bases 1 to 5036)
  AUTHORS   Bruyninx,M., Hennuy,B., Cornet,A., Houssa,P., Daukandt,M.,
            Reiter,E., Poncin,J., Closset,J. and Hennen,G.
  TITLE     A novel gene overexpressed in the prostate of castrated rats:
            hormonal regulation, relationship to apoptosis and to acquired
            prostatic cell androgen independence
  JOURNAL   Endocrinology 140 (10), 4789-4799 (1999)
   PUBMED   10499539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 5, 2020 this sequence version replaced NM_173114.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.51171.1,
                                           SRR26643295.48456.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840115,
                                           SAMN12840119 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000014.1  16861301-16861570   c
            271-954             JAXUCZ010000014.1  16785955-16786638   c
            955-1033            JAXUCZ010000014.1  16766385-16766463   c
            1034-5036           JAXUCZ010000014.1  16752541-16756543   c
FEATURES             Location/Qualifiers
     source          1..5036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..5036
                     /gene="Parm1"
                     /gene_synonym="CIPAR-1; Cipar1; PARM-1"
                     /note="prostate androgen-regulated mucin-like protein 1"
                     /db_xref="GeneID:286894"
                     /db_xref="RGD:708342"
     exon            1..270
                     /gene="Parm1"
                     /gene_synonym="CIPAR-1; Cipar1; PARM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1118
                     /gene="Parm1"
                     /gene_synonym="CIPAR-1; Cipar1; PARM-1"
                     /note="prostate androgen-regulated mucin-like protein 1
                     homolog; prostatic androgen-repressed message 1 protein;
                     castration-induced prostatic apoptosis-related protein 1;
                     prostatic androgen-repressed message-1"
                     /codon_start=1
                     /product="prostate androgen-regulated mucin-like protein 1
                     homolog precursor"
                     /protein_id="NP_775137.2"
                     /db_xref="GeneID:286894"
                     /db_xref="RGD:708342"
                     /translation="MVCKALITLCIFAAGLRVQGSPTPTLLPVSLTTKSTAPMATWTT
                     SAQHTAMATTPVASATHNASVLRTTAASLTSQLPTHPREEAVTSPPLKREVNSTDSSP
                     AGFSSNSSGIHLAPTPEEHSLGSPETSVPATGSQSPTLLFSQGPTSASTSPATSPSEP
                     LSASVTSNHSSTVNNIQPTGAPMAPASPTEEHSSSHTPTSHVTEPVPKEKSPQDTEPG
                     KVICESETTTPFLIMQEVENALSSGSIAAITVTVIAVVLLVFGAAAYLKIRHSSYGRL
                     LDDHDYGSWGNYNNPLYDDS"
     exon            271..954
                     /gene="Parm1"
                     /gene_synonym="CIPAR-1; Cipar1; PARM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1033
                     /gene="Parm1"
                     /gene_synonym="CIPAR-1; Cipar1; PARM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..5036
                     /gene="Parm1"
                     /gene_synonym="CIPAR-1; Cipar1; PARM-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagtgcgc ctggcgccgc agggcacaca gctgactctc cgcgccacct ccgcttcgcc
       61 ttgcgccgcc agacaccgaa gcttcctgga ctgatcgtgc ggggcttcag tacgtccctg
      121 ctcctcccgt agcccaccgg gtggaagagg agctgccggt gccccggagc acttggtcag
      181 tctcaggaaa ctcttcccta gtcgcatcca gctcggtacc gagtaacatg gtctgcaagg
      241 cgctcatcac cctctgcatc ttcgccgcag gattgagggt acagggttca ccaacaccaa
      301 ccctattgcc tgtctctctt acgacaaaaa gtacagcacc tatggccacc tggactacct
      361 ctgctcaaca cactgctatg gccaccaccc ctgtagccag tgccactcac aacgcctcag
      421 ttctccgcac gactgctgca tccctgacat ctcagctccc cactcaccct agagaagagg
      481 ctgtcaccag tccgcctttg aagagggagg tcaacagcac agactcctca cctgccgggt
      541 tctcctcaaa cagcagtggc atccacttgg cacccacacc tgaggaacac agtctcggca
      601 gtcctgaaac aagtgtgcca gctactgggt cacagtcacc cacactcctg ttttctcaag
      661 gtccaacctc agcatccaca tccccagcaa cttccccttc cgagcctctc tccgcttccg
      721 ttacctctaa ccacagctct actgtgaaca acatccagcc cacaggagct ccaatggcac
      781 ctgcatcacc aacagaagag cacagttcta gtcacacccc cacttcccat gtcacagagc
      841 ccgtgcccaa ggagaaatca ccccaagaca ctgagcctgg caaagtgatc tgtgagtctg
      901 agaccaccac ccccttcctg atcatgcagg aagtcgagaa tgccttaagt tcaggcagca
      961 tcgccgccat caccgtgaca gtcattgctg tggtgttgct ggtgtttgga gctgcggcat
     1021 atctgaagat caggcattcc tcctacggaa ggctgctgga tgaccatgac tacgggtcct
     1081 ggggaaacta caacaaccct ctctatgatg actcttaaca aaggaaggtg gctgaggaca
     1141 agaaataact gtcctttatt tataagtgct tatccagtag aattaataac aagtacctga
     1201 tgtacactga acgacaatcg caagccctct tttgttggtt tggttgtttt tgctttcctt
     1261 cctctctcct ccggctgcta ctacaatgtc ccccttctgg tacaaaagaa ccattgcgta
     1321 aaggccagcg gaggccgatt tgcagctgac gtgggccatc tttgcactga ccaagccaga
     1381 tatcatgagg tgggggggct gcagaacccc tatcacggga accactctgg aaatgaccta
     1441 ggaaaggggc tcggagttgc ttggttgggg atttaatttt aggtgatctt ttggtttggg
     1501 ttatttctta aagttctcga caggaaatta cattaaatat cagcgaggag aaaggaataa
     1561 atcccaggag gctgccaccc tgtgtggaag aagcagggac ttcttgattc ctttctaacc
     1621 cttgtttgcc aggttgtatc tgacaggatg ccggcttagt cctataagca gatatacaat
     1681 tctcagctgc ctaacagatg aaaggtaaaa gaggccttgc ccaggaggag agcagcaggc
     1741 aagggcagag cagcacagca ggctgtcagt cagcaaactc aaccagctct ccccatccag
     1801 gccaccggaa ggcgacaggg atcccaaccc gatagctttc aagaaagtta taggtccaag
     1861 agtgaagcgg agaggtgatc ttgaagaaca ggcagggaga gactgcagag actaagggat
     1921 gggggaagaa gggagagacg aaagcttaca tgcaccaagg accctcttga agcaagcagg
     1981 agtcggctct ccatggtagt gggagatatc aaaatcttgg aggaacacca tagaactcta
     2041 acccataaag caactgcctc actgccttgc tatctgtgtt gagtaatggc tgtatgctat
     2101 cccctccccc cccaaaaaaa agctaagaga ggccctactc tatctgcagt tgttcatcca
     2161 aagcactcac ttccatagga tggagacatc cagaactatc tgtttgctct ccctaacgct
     2221 taaccttccc catccttcct tttaatacgt aaataccccc aggcgtgcag tctcaactcc
     2281 cgtacaacca gttctgagga gagatcatcc ttctttgtca gctctttttc tttcacttat
     2341 gacccaccag gaggtgtttg agtatctctc ataccacccc cacccccacc cgaggtgtct
     2401 agtagcaatt tttttattgt gactttgttc cttgggagtg ctagttaggg gtagagacta
     2461 tggatcctgc taaacaccct acctggcaca ggacaaccgt ccactccgaa gaatttccta
     2521 gctgaaaaca tcaaaggctg agattgagac cattcaccgc aatgcccttg tgacgtaaag
     2581 caaacaaacg aacaggcatc aggaagaccc tttcatgttt aacaaagtga aaaatggatt
     2641 tcttccccca aagtgtttag tttgctgccc gatgggttgg cttctggtat gcactgttgt
     2701 tgcctcatgt aggtcgaaga gagctttatt acagggctac cccgctgttc ttttgaagca
     2761 gctgacacct agtatctgaa gtcctgattt catggaggag gaaatctaca tcacaaacta
     2821 tgttacattg tcctgtgatg tcagaggaaa caactatcca ttttaattcc tcagatggat
     2881 ctggccgcca tgactcggtt gaggaaaaca ctctcaattg ctatcttgaa cctctccggt
     2941 gtagagtcca cagattgggg tacctcccac aacctgccac gccaggcttt gacgaaaatc
     3001 cttcctaaat ttcagaagtg ccaaaaggag agatcagtcc tggaagttag cctgtaagca
     3061 gagtgggtag caaggaatga ggttacggaa attaagatat ccctgaatag gaaacacctg
     3121 atacacagac agacagacag acagacagac acacacacac acacacacac acacacacac
     3181 acacacacac acactgtgca cagcaagggt atgccctctg gccacacttg gcctgaacaa
     3241 ctgtccctcc ttcctaccct gaccccggtt ctccggttag gcgaaggaca aaccagtaca
     3301 caccaggatt ctgcacgtca ctgtcctcca tcagtctaaa acacttttga cacatgacac
     3361 aaagctctct atgaaacacc ttaggggaag tgtacttcag ataggtaaaa taaatcctag
     3421 gccagaggaa ccggcttctt cctaagccct cttacctgtt agaaaccaga gacacagcaa
     3481 gaaatttctc atacagaagg atgccagtgt atatgagctt gtgattgcca gtgctctgat
     3541 tagcctctaa ttgctttcgg caaaacacaa agctgtcata tacaacaagg taaccggcag
     3601 tatcctctca aagctcaaga atgaccctag cctatttact ataaagtgtg tcagtgtgag
     3661 aatgtacttt gccaaatgta tttttctgct tttgaattgg ccaaaagatt tcagtatatt
     3721 tattctacaa acattactac acacacgcat gcgcatgcac acacgcacgc acacacacac
     3781 tcacatctga tatatatata tatgtatata tgccaataat tgacctttac ctcagggaga
     3841 gttagtttaa atctacacaa gggaaattag tggtccccct aagtagatcc aaacagtcat
     3901 accccatcat ggatcggtct ggccagaatg ttttggagag aaagtcagag caaaaagaaa
     3961 gctaggagct tcttctccgt gggctctaaa cgatccaaga atggtaggca actatgcttt
     4021 ctttccccat ggccccgatg ggcccctctc ctccctgcac atctgtgtct tcatctataa
     4081 aatgggggtg atgctttcat agtggcctta ccccttccta cctcacagac gtgttgtgag
     4141 gattaatgaa attgtgtcta cagtgttttc aaccggagaa aaactattta tggacacttc
     4201 aagtattacg tagatatata agtgatctca gtttcttact tgctgttaga ctagtgtgct
     4261 ggttttactt cctttatgaa actacagtca atgtcatggc cacctcagat ggctatcaga
     4321 gctctgaact tccctcctgt gcaccgggct gatgcaggtt taactgttcc tggaactaca
     4381 gaggatatct cccctccaac tgagaagatg gcccaggaca caggtctcag agacctgcat
     4441 taggatccag gtcaggatgg cacatgtcaa cattgcggaa gaaggcctcg gacttccaca
     4501 ccccgagctc tcagaggact tagactatgg gctgatgcca tctatttgcc cttcatcttg
     4561 cttgcaaggg tgcatggttg gatcctatgc atcttgaaaa atgaattttg tgattggtct
     4621 ggatgctaat ttgcacgtcg attcaccttc tttgccttta accttctttt gagggcaaat
     4681 ggatgtacca tttcaacttt gatctcggag gcattagctc atattgactc gttggcgcat
     4741 tggtctctag gagtaagtta gccgacgtcg tttgaagatg ggaaggtgtg caacttcttt
     4801 gatatttgat gacgtcatat ctgcatttgt tgtaagacat attgcatacc aattataact
     4861 ctgccaatta aagtggttaa aagcttctgt gtagctgtgg tgattcacgt tttgagatgt
     4921 tttgttgccc aggctgctgg gtttgttttt gtcagtcata ttaaacagct ctgacttgtt
     4981 cttaaagaaa tcgtatccct cacccccacc ccatcaataa ataataattt ctgtag
//
