LOCUS       NM_001035249            1343 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus presenilin associated, rhomboid-like (Parl),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001035249 XM_001055224 XM_001061991 XM_001062047 XM_001062100
VERSION     NM_001035249.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   Wu,H. and Chen,Q.
  TITLE     Hypoxia activation of mitophagy and its role in disease
            pathogenesis
  JOURNAL   Antioxid Redox Signal 22 (12), 1032-1046 (2015)
   PUBMED   25526784
  REMARK    Review article
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   Borengasser,S.J., Faske,J., Kang,P., Blackburn,M.L., Badger,T.M.
            and Shankar,K.
  TITLE     In utero exposure to prepregnancy maternal obesity and postweaning
            high-fat diet impair regulators of mitochondrial dynamics in rat
            placenta and offspring
  JOURNAL   Physiol Genomics 46 (23), 841-850 (2014)
   PUBMED   25336449
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Canzoneri,R., Lacunza,E., Isla Larrain,M., Croce,M.V. and Abba,M.C.
  TITLE     Rhomboid family gene expression profiling in breast normal tissue
            and tumor samples
  JOURNAL   Tumour Biol 35 (2), 1451-1458 (2014)
   PUBMED   24185965
REFERENCE   4  (bases 1 to 1343)
  AUTHORS   Yoshioka,H., Katsu,M., Sakata,H., Okami,N., Wakai,T., Kinouchi,H.
            and Chan,P.H.
  TITLE     The role of PARL and HtrA2 in striatal neuronal injury after
            transient global cerebral ischemia
  JOURNAL   J Cereb Blood Flow Metab 33 (11), 1658-1665 (2013)
   PUBMED   23921894
REFERENCE   5  (bases 1 to 1343)
  AUTHORS   Greene,A.W., Grenier,K., Aguileta,M.A., Muise,S., Farazifard,R.,
            Haque,M.E., McBride,H.M., Park,D.S. and Fon,E.A.
  TITLE     Mitochondrial processing peptidase regulates PINK1 processing,
            import and Parkin recruitment
  JOURNAL   EMBO Rep 13 (4), 378-385 (2012)
   PUBMED   22354088
REFERENCE   6  (bases 1 to 1343)
  AUTHORS   Andrew,T., Maniatis,N., Carbonaro,F., Liew,S.H., Lau,W.,
            Spector,T.D. and Hammond,C.J.
  TITLE     Identification and replication of three novel myopia common
            susceptibility gene loci on chromosome 3q26 using linkage and
            linkage disequilibrium mapping
  JOURNAL   PLoS Genet 4 (10), e1000220 (2008)
   PUBMED   18846214
REFERENCE   7  (bases 1 to 1343)
  AUTHORS   Powell,B.L., Wiltshire,S., Arscott,G., McCaskie,P.A., Hung,J.,
            McQuillan,B.M., Thompson,P.L., Carter,K.W., Palmer,L.J. and
            Beilby,J.P.
  TITLE     Association of PARL rs3732581 genetic variant with insulin levels,
            metabolic syndrome and coronary artery disease
  JOURNAL   Hum Genet 124 (3), 263-270 (2008)
   PUBMED   18758826
REFERENCE   8  (bases 1 to 1343)
  AUTHORS   Cipolat,S., Rudka,T., Hartmann,D., Costa,V., Serneels,L.,
            Craessaerts,K., Metzger,K., Frezza,C., Annaert,W., D'Adamio,L.,
            Derks,C., Dejaegere,T., Pellegrini,L., D'Hooge,R., Scorrano,L. and
            De Strooper,B.
  TITLE     Mitochondrial rhomboid PARL regulates cytochrome c release during
            apoptosis via OPA1-dependent cristae remodeling
  JOURNAL   Cell 126 (1), 163-175 (2006)
   PUBMED   16839884
REFERENCE   9  (bases 1 to 1343)
  AUTHORS   Walder,K., Kerr-Bayles,L., Civitarese,A., Jowett,J., Curran,J.,
            Elliott,K., Trevaskis,J., Bishara,N., Zimmet,P., Mandarino,L.,
            Ravussin,E., Blangero,J., Kissebah,A. and Collier,G.R.
  TITLE     The mitochondrial rhomboid protease PSARL is a new candidate gene
            for type 2 diabetes
  JOURNAL   Diabetologia 48 (3), 459-468 (2005)
   PUBMED   15729572
REFERENCE   10 (bases 1 to 1343)
  AUTHORS   Sik,A., Passer,B.J., Koonin,E.V. and Pellegrini,L.
  TITLE     Self-regulated cleavage of the mitochondrial intramembrane-cleaving
            protease PARL yields Pbeta, a nuclear-targeted peptide
  JOURNAL   J Biol Chem 279 (15), 15323-15329 (2004)
   PUBMED   14732705
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105907.1.
            
            On or before Nov 18, 2006 this sequence version replaced
            XM_001055224.1, XM_001062100.1, XM_001061991.1, XM_001062047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105907.1, FQ214115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1343
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /note="presenilin associated, rhomboid-like"
                     /db_xref="GeneID:287979"
                     /db_xref="RGD:1306191"
     exon            1..161
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1176
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /EC_number="3.4.21.105"
                     /note="presenilins-associated rhomboid-like protein,
                     mitochondrial; mitochondrial intramembrane-cleaving
                     protease PARL; presenilin-associated rhomboid-like
                     protein, mitochondrial"
                     /codon_start=1
                     /product="presenilin-associated rhomboid-like protein,
                     mitochondrial precursor"
                     /protein_id="NP_001030326.1"
                     /db_xref="GeneID:287979"
                     /db_xref="RGD:1306191"
                     /translation="MALYSWVQRGWRCGQTWAPLLGGGYRELSATQARQLLGRRFNLL
                     LQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPVRTLLKPFFF
                     TVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSL
                     SDGQRTVTGIIAANALVFCLWRVPSLHRTMIRYFTSNPASKVLCSPMLLSTFSHFSLF
                     HMAANMYVLWSFSTSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASG
                     AIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHL
                     GGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK"
     exon            162..357
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            358..498
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            499..547
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            548..643
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            644..793
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            794..864
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            865..966
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1064
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1318
                     /gene="Parl"
                     /gene_synonym="Psarl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggttagtga ggtcgggcca tggtggggca gaggttgtta agatggcgtt gtatagttgg
       61 gtacagcgag gctggcgctg cggtcagacg tgggcgcctc tcttgggtgg cggctaccgg
      121 gagctctctg cgacccaggc ccggcagctg cttggacgca ggtttaacct acttcttcag
      181 caaaaatgtg gatttagaaa agcaccgagg aaggtggagc ctcgaaggtc agacacaggg
      241 tcaagtggag aagcatacaa gagaagtgcc ttgatcccac ccctggagga aacagtcttt
      301 tacccttccc cctaccctgt aagaacactc ctgaagccct ttttcttcac cgttgggttc
      361 acaggctgtg catttggttc agctgctatt tggcagtatg aatcactcaa gtccagggtt
      421 cagagttatt ttgatggcat aaaagctgac tggttggata gcatacggcc acaaaaggaa
      481 ggaaacctca gaaaggagat taacaagtgg tggaatagcc taagtgatgg ccagcggact
      541 gtgacaggta tcatagctgc gaatgccctc gtattctgct tatggagagt gccgtccctg
      601 catcgaacca tgatcagata ctttacatcc aacccagcat caaaggttct ttgttcccca
      661 atgctgcttt ccacgttcag tcatttctcc ttattccaca tggcagctaa catgtatgtt
      721 ttgtggagct tctcaactag catcgtgaac attctgggtc aggagcagtt tgtggcagtg
      781 tacctgtctg caggtgttat ttcgaatttt gtcagttatg tgtgcaaagt tgccacagga
      841 agatacggac cttcacttgg tgcgtcaggc gcaatcatga ctgtgcttgc agctgtctgc
      901 accaagatcc cggaggggag actcgccatc atcttcctcc ctgttttcac cttcactgca
      961 ggcaatgcct taaaagccat cattgccatg gatacagctg ggatgatcct gggatggaag
     1021 ttttttgatc atgcagcaca tcttggggga gccctctttg gaatatggta tatcacgtat
     1081 ggacatgaac tcatttggaa gaacagggag cctctagtga aaatctggca cgaaataagg
     1141 actaatggcc ccaagaaagg aggtggctct aagtgaggca aagctggcct gtctggtggt
     1201 gcatctgatc cttgttgctc ggaagtctca gcatcggtca ccccggtgat ttaaatgtcc
     1261 tcagtacgtc tccttcaaaa attatggcag agttgtgaaa taaatgttta tatctctaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaa
//
