LOCUS       NM_001277250             872 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus Parkinsonism associated deglycase (Park7),
            transcript variant 2, mRNA.
ACCESSION   NM_001277250
VERSION     NM_001277250.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Liu,H., Wang,X., He,K., Chen,Z., Li,X., Ren,J., Zhao,X., Liu,S.,
            Zhou,T. and Chen,H.
  TITLE     Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1 pathway by
            binding PTEN to induce autophagy and exacerbate myocardial
            ischemia-reperfusion injury
  JOURNAL   Eur J Pharmacol 971, 176496 (2024)
   PUBMED   38508437
  REMARK    GeneRIF: Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1
            pathway by binding PTEN to induce autophagy and exacerbate
            myocardial ischemia-reperfusion injury.
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Li,W., Leng,Y., Xiong,Y., Li,W., Cai,Y., Xue,R., Chen,R., Lei,S.,
            Xia,Z. and Xia,Z.
  TITLE     DJ-1 preserves ischemic postconditioning-induced cardioprotection
            in STZ-induced type 1 diabetic rats: role of PTEN and DJ-1
            subcellular translocation
  JOURNAL   Cell Commun Signal 22 (1), 252 (2024)
   PUBMED   38698453
  REMARK    GeneRIF: DJ-1 preserves ischemic postconditioning-induced
            cardioprotection in STZ-induced type 1 diabetic rats: role of PTEN
            and DJ-1 subcellular translocation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Lin,J., Wang,L., Wu,Y., Xiang,Q., Zhao,Y., Zheng,X., Jiang,S.,
            Sun,Z., Fan,D. and Li,W.
  TITLE     Involvement of DJ-1 in the pathogenesis of intervertebral disc
            degeneration via hexokinase 2-mediated mitophagy
  JOURNAL   Exp Mol Med 56 (3), 747-759 (2024)
   PUBMED   38531963
  REMARK    GeneRIF: Involvement of DJ-1 in the pathogenesis of intervertebral
            disc degeneration via hexokinase 2-mediated mitophagy.
REFERENCE   4  (bases 1 to 872)
  AUTHORS   Sarkar,A. and Singh,M.P.
  TITLE     A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of
            Mitochondrial Function in Cypermethrin-Induced Parkinsonism
  JOURNAL   Mol Neurobiol 61 (2), 953-970 (2024)
   PUBMED   37674036
  REMARK    GeneRIF: A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the
            Regulation of Mitochondrial Function in Cypermethrin-Induced
            Parkinsonism.
REFERENCE   5  (bases 1 to 872)
  AUTHORS   Bisoyi,P., Ratna,D., Kumar,G., Mallick,B.N. and Goswami,S.K.
  TITLE     In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome,
            Including Mitochondrial Electron Transporters that are Comodulated
            Under Oxidative Stress
  JOURNAL   Cell Mol Neurobiol 43 (7), 3061-3080 (2023)
   PUBMED   37165139
  REMARK    GeneRIF: In the Rat Midbrain, SG2NA and DJ-1 have Common
            Interactome, Including Mitochondrial Electron Transporters that are
            Comodulated Under Oxidative Stress.
            Review article
            Erratum:[Cell Mol Neurobiol. 2023 Oct;43(7):3081. doi:
            10.1007/s10571-023-01369-x.. PMID: 37278863]
REFERENCE   6  (bases 1 to 872)
  AUTHORS   Klinefelter,G.R., Welch,J.E., Perreault,S.D., Moore,H.D.,
            Zucker,R.M., Suarez,J.D., Roberts,N.L., Bobseine,K. and Jeffay,S.
  TITLE     Localization of the sperm protein SP22 and inhibition of fertility
            in vivo and in vitro
  JOURNAL   J Androl 23 (1), 48-63 (2002)
   PUBMED   11780923
REFERENCE   7  (bases 1 to 872)
  AUTHORS   Takahashi,K., Taira,T., Niki,T., Seino,C., Iguchi-Ariga,S.M. and
            Ariga,H.
  TITLE     DJ-1 positively regulates the androgen receptor by impairing the
            binding of PIASx alpha to the receptor
  JOURNAL   J Biol Chem 276 (40), 37556-37563 (2001)
   PUBMED   11477070
REFERENCE   8  (bases 1 to 872)
  AUTHORS   Hod,Y., Pentyala,S.N., Whyard,T.C. and El-Maghrabi,M.R.
  TITLE     Identification and characterization of a novel protein that
            regulates RNA-protein interaction
  JOURNAL   J Cell Biochem 72 (3), 435-444 (1999)
   PUBMED   10022524
REFERENCE   9  (bases 1 to 872)
  AUTHORS   Wagenfeld,A., Gromoll,J. and Cooper,T.G.
  TITLE     Molecular cloning and expression of rat contraception associated
            protein 1 (CAP1), a protein putatively involved in fertilization
  JOURNAL   Biochem Biophys Res Commun 251 (2), 545-549 (1998)
   PUBMED   9792810
REFERENCE   10 (bases 1 to 872)
  AUTHORS   Welch,J.E., Barbee,R.R., Roberts,N.L., Suarez,J.D. and
            Klinefelter,G.R.
  TITLE     SP22: a novel fertility protein from a highly conserved gene family
  JOURNAL   J Androl 19 (4), 385-393 (1998)
   PUBMED   9733139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and FM055257.1.
            
            Transcript Variant: This variant (2) includes an alternate
            penultimate exon, compared to variant 1, resulting in a novel 3'
            coding region and 3' UTR. The encoded isoform (2) is shorter,
            compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same
            isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR755577.1, FM076944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JAXUCZ010000005.1  166655155-166655184 c
            31-621              FM055257.1         1-591
            622-872             JAXUCZ010000005.1  166643486-166643736 c
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..872
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /note="Parkinsonism associated deglycase"
                     /db_xref="GeneID:117287"
                     /db_xref="RGD:621808"
     exon            1..98
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /inference="alignment:Splign:2.1.0"
     exon            99..205
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..685
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /EC_number="3.5.1.124"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein DJ-1; contraception-associated protein 1;
                     parkinson disease protein 7 homolog; fertility protein
                     SP22; Parkinson disease (autosomal recessive, early onset)
                     7; protein deglycase DJ-1; parkinson protein 7; maillard
                     deglycase; protein/nucleic acid deglycase DJ-1"
                     /codon_start=1
                     /product="Parkinson disease protein 7 homolog isoform 2"
                     /protein_id="NP_001264179.1"
                     /db_xref="GeneID:117287"
                     /db_xref="RGD:621808"
                     /translation="MASKRALVILAKGAEEMETVIPVDIMRRAGIKVTVAGLAGKDPV
                     QCSRDVVICPDTSLEEAKTQGPYDVVVLPGGNLGAQNLSESALVKEILKEQENRKGLI
                     AAICAGPTALLAHEVGFGCKVTSHPLAKDKMMNGSHYSYSESRVEKDGLILTSRGPGT
                     SFEFALAIVEALSGKDMANQVKAPLVLKD"
     exon            206..307
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /inference="alignment:Splign:2.1.0"
     exon            308..367
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /inference="alignment:Splign:2.1.0"
     exon            368..437
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /inference="alignment:Splign:2.1.0"
     exon            438..524
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /inference="alignment:Splign:2.1.0"
     exon            525..872
                     /gene="Park7"
                     /gene_synonym="CAP1; DJ-1; Dj1; SP22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatgcgtgt tgtgtacaaa tctgtgcgac tgagccgggt acggtgttcc tgcgggactg
       61 tctgtggctt cgcgtgggtg gaggaggcgc ggctgcaggt ctttaagaaa tagaaatggc
      121 atccaaaaga gctctggtca tcctagccaa aggagcagag gagatggaga cagtgattcc
      181 tgtggacatc atgcggcgag ctgggattaa agtcaccgtt gcaggcttgg ctgggaagga
      241 ccccgtgcag tgtagccgtg atgtagtgat ttgtccggat accagtctgg aagaagcaaa
      301 aacacaggga ccatacgatg tggttgttct tccaggagga aatctgggtg cacagaactt
      361 atctgagtcg gctttggtga aggagatcct caaggagcag gagaacagga agggcctcat
      421 agctgccatc tgtgcgggtc ctacggccct gctggctcac gaagtaggct ttggatgcaa
      481 ggttacatcg cacccattgg ctaaggacaa aatgatgaac ggcagtcact acagctactc
      541 agagagccgt gtggagaagg acggcctcat cctcaccagc cgtgggcctg ggaccagctt
      601 cgagtttgcg ctggccattg tggaggcact cagtggcaag gacatggcta accaagtgaa
      661 ggccccgctt gttctcaaag actagagccc aagccctgga ccctggaccc ccaggctgag
      721 caggcattgg aagcccacta gtgtgtccac agcccagtga acctcaggaa ctaacgtgtg
      781 aagtagcccg ctgctcagga atctcgccct ggctctgtac tattctgagc cttgctagta
      841 gaataaacag ttccccaagc tcctgacggc ta
//
