LOCUS       NM_031339               3974 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus poly (ADP-ribose) glycohydrolase (Parg), mRNA.
ACCESSION   NM_031339
VERSION     NM_031339.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3974)
  AUTHORS   Wright,R.H., Lioutas,A., Le Dily,F., Soronellas,D., Pohl,A.,
            Bonet,J., Nacht,A.S., Samino,S., Font-Mateu,J., Vicent,G.P.,
            Wierer,M., Trabado,M.A., Schelhorn,C., Carolis,C., Macias,M.J.,
            Yanes,O., Oliva,B. and Beato,M.
  TITLE     ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for
            chromatin remodeling
  JOURNAL   Science 352 (6290), 1221-1225 (2016)
   PUBMED   27257257
REFERENCE   2  (bases 1 to 3974)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   3  (bases 1 to 3974)
  AUTHORS   Rosenthal,F., Feijs,K.L., Frugier,E., Bonalli,M., Forst,A.H.,
            Imhof,R., Winkler,H.C., Fischer,D., Caflisch,A., Hassa,P.O.,
            Luscher,B. and Hottiger,M.O.
  TITLE     Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases
  JOURNAL   Nat Struct Mol Biol 20 (4), 502-507 (2013)
   PUBMED   23474714
REFERENCE   4  (bases 1 to 3974)
  AUTHORS   Kim,I.K., Kiefer,J.R., Ho,C.M., Stegeman,R.A., Classen,S.,
            Tainer,J.A. and Ellenberger,T.
  TITLE     Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a
            flexible tyrosine clasp as a substrate-binding element
  JOURNAL   Nat Struct Mol Biol 19 (6), 653-656 (2012)
   PUBMED   22609859
  REMARK    GeneRIF: The study reports the crystal structures of Parg and its
            complex with a substrate mimic that reveal an open
            substrate-binding site and a unique 'tyrosine clasp' enabling
            endoglycosidic cleavage of branched PAR chains.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3974)
  AUTHORS   Williams,B.L., Hornig,M., Yaddanapudi,K. and Lipkin,W.I.
  TITLE     Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation
            in neonatal bornavirus infection
  JOURNAL   J Virol 82 (4), 1748-1758 (2008)
   PUBMED   18057239
REFERENCE   6  (bases 1 to 3974)
  AUTHORS   Lu,X.C., Massuda,E., Lin,Q., Li,W., Li,J.H. and Zhang,J.
  TITLE     Post-treatment with a novel PARG inhibitor reduces infarct in
            cerebral ischemia in the rat
  JOURNAL   Brain Res 978 (1-2), 99-103 (2003)
   PUBMED   12834903
REFERENCE   7  (bases 1 to 3974)
  AUTHORS   Mennella,M.R., Roma,G. and Farina,B.
  TITLE     Active poly(ADPribose) metabolism in DNAase- and salt-resistant rat
            testis chromatin with high transcriptional activity/competence
  JOURNAL   J Cell Biochem 89 (4), 688-697 (2003)
   PUBMED   12858335
REFERENCE   8  (bases 1 to 3974)
  AUTHORS   Shimokawa,T., Masutani,M., Nagasawa,S., Nozaki,T., Ikota,N.,
            Aoki,Y., Nakagama,H. and Sugimura,T.
  TITLE     Isolation and cloning of rat poly(ADP-ribose) glycohydrolase:
            presence of a potential nuclear export signal conserved in
            mammalian orthologs
  JOURNAL   J Biochem 126 (4), 748-755 (1999)
   PUBMED   10502684
REFERENCE   9  (bases 1 to 3974)
  AUTHORS   Bernardi,R., Rossi,L., Poirier,G.G. and Scovassi,A.I.
  TITLE     Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear
            extracts from mammalian cells
  JOURNAL   Biochim Biophys Acta 1338 (1), 60-68 (1997)
   PUBMED   9074616
REFERENCE   10 (bases 1 to 3974)
  AUTHORS   Quesada,P., Atorino,L., Cardone,A., Ciarcia,G. and Farina,B.
  TITLE     Poly(ADPribosyl)ation system in rat germinal cells at different
            stages of differentiation
  JOURNAL   Exp Cell Res 226 (1), 183-190 (1996)
   PUBMED   8660954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031339.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019366.1, SRR26643295.52021.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               JAXUCZ010000016.1  7442878-7443227
            351-417             JAXUCZ010000016.1  7449039-7449105
            418-1389            JAXUCZ010000016.1  7449681-7450652
            1390-1573           JAXUCZ010000016.1  7451476-7451659
            1574-1696           JAXUCZ010000016.1  7455123-7455245
            1697-1780           JAXUCZ010000016.1  7455351-7455434
            1781-1855           JAXUCZ010000016.1  7461149-7461223
            1856-1948           JAXUCZ010000016.1  7489315-7489407
            1949-2106           JAXUCZ010000016.1  7493277-7493434
            2107-2186           JAXUCZ010000016.1  7501791-7501870
            2187-2247           JAXUCZ010000016.1  7505507-7505567
            2248-2323           JAXUCZ010000016.1  7509538-7509613
            2324-2471           JAXUCZ010000016.1  7513850-7513997
            2472-2550           JAXUCZ010000016.1  7523542-7523620
            2551-2659           JAXUCZ010000016.1  7526534-7526642
            2660-2765           JAXUCZ010000016.1  7537154-7537259
            2766-2894           JAXUCZ010000016.1  7548580-7548708
            2895-3974           JAXUCZ010000016.1  7549503-7550582
FEATURES             Location/Qualifiers
     source          1..3974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3974
                     /gene="Parg"
                     /note="poly (ADP-ribose) glycohydrolase"
                     /db_xref="GeneID:83507"
                     /db_xref="RGD:620387"
     exon            1..350
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..3049
                     /gene="Parg"
                     /EC_number="3.2.1.143"
                     /codon_start=1
                     /product="poly(ADP-ribose) glycohydrolase"
                     /protein_id="NP_112629.2"
                     /db_xref="GeneID:83507"
                     /db_xref="RGD:620387"
                     /translation="MSAGPGCEPCTKRPRWGAAGTSAPTASDSRSFPGRQKRVLDPKD
                     APVQFRVPPSSSACVSGRAGPHRGSVTSFVFKQKPITTWMDTKGPKTAESESKENNNT
                     RTDPMMSSVQKDNFYPHKVEKLGNVPQLNLDKSPTEKSTPYLNQQQTAGVCKWHSAGE
                     RAEQLSASEPSAVTQAPKQLSNANIDQSPPTDGHSDTDHEEDRDNQQFLTPVKLANAK
                     QTVGDGQARSNCKCSASCQCGQDCAGCQREEADVIPESPLSDVGAEDIGTGSKNDNKL
                     TGQESGLGDSPPFEKESEPESPMDVDNSKTSCQDSEADEEASPVFDEQDDQDDRSSQT
                     ANKLSSRQAREVDGDLRKRYLTKGSEIRLHFQFEGGSNAGTSDLNAKPSGNSSSLNVD
                     GRSSKQHGKRDSKITDHFVRIPKSEDKRKEQCEVRHQRAERKIPKYVPPNLPPDKKWL
                     GTPIEEMRKMPRCGVRLPLLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVK
                     MPCSEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDF
                     TALVDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQE
                     QIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRV
                     TEKKPTGLVTFTRQSLEDFPEWERCDKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVG
                     GGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWA
                     RSHEDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPPE
                     NLSAVATGNWGCGAFGGDARLKALIQLLAAAAAERDVVYFTFGDSELMRDIYSMHTFL
                     TERKLNVGKVYRLLLRYYREECRDCSSPGPDTKLYPFIYHAAESSAETSDQPGQRTGT
                     "
     exon            351..417
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            418..1389
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1573
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1696
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1780
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1855
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1948
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2106
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2186
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2247
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2323
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2471
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2550
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2659
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2765
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2894
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3974
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgggccg ctgcagagag ggaatggtgc ggggggcgcc gagaaggagg cgcactccgt
       61 ccctctcagg gttggtgaat gaggctctcc gcccgggccg gcccggggac tgtgcgctgc
      121 gggtcccagc atgagtgcgg gccccggctg tgagccctgc acgaagcggc cccgctgggg
      181 tgccgctgga acttctgcgc cgactgcctc ggactcccgg agcttccctg gcaggcagaa
      241 gcgcgttctc gaccctaagg acgctcccgt acagttcagg gtcccaccgt cctcgtcagc
      301 ctgcgtctcg gggcgggcgg gaccgcacag aggcagcgtc acctcgtttg ttttcaaaca
      361 aaagcctatt accacttgga tggatactaa aggacccaag acagctgaat cagaaagtaa
      421 agaaaacaac aataccagga ctgaccccat gatgagttct gtgcagaaag ataactttta
      481 cccacataag gtagagaaat tgggaaatgt tcctcaacta aatcttgata aatcacccac
      541 tgagaagagc acgccgtatt tgaaccaaca gcagactgca ggcgtgtgca agtggcacag
      601 tgcaggggag cgtgcagagc agctctcggc cagcgagcct tcagcagtga ctcaggcacc
      661 aaagcagctt agtaatgcga acattgatca gtcaccccca actgatggcc acagtgacac
      721 cgatcatgag gaagacagag acaatcaaca gttccttacg cccgtgaagc ttgcaaatgc
      781 aaagcaaaca gtaggggatg ggcaagccag gagcaactgt aagtgcagtg cgtcttgtca
      841 gtgtgggcaa gactgtgcag gctgtcagcg ggaggaggcc gatgtcatac cagagagtcc
      901 tttgtcagat gttggcgctg aggacattgg aactggatca aaaaatgaca acaagttgac
      961 tggacaagaa agtggcctcg gtgattcacc tccgtttgag aaagaaagtg agcctgagtc
     1021 accaatggat gtagacaact cgaaaaccag ttgtcaagat tcagaagcag atgaagaagc
     1081 aagtccagtc tttgatgagc aagacgacca agacgaccgc tcttcccaga cagcaaataa
     1141 actttcaagt cgccaagcaa gagaagttga cggcgatctt aggaaacgct atttgactaa
     1201 gggaagtgaa attagattgc atttccagtt tgaaggaggg agtaatgctg ggaccagtga
     1261 tttaaatgcc aagccatctg gaaactcttc tagccttaat gtagacggta gaagttccaa
     1321 gcagcatgga aaaagggatt ctaaaattac agatcatttt gtgagaattc ccaagtcaga
     1381 ggacaaaaga aaagaacaat gtgaagtcag acatcaaaga gcagaaagga agatccctaa
     1441 atacgttcca cctaaccttc ctccagataa gaagtggttg ggaactccta ttgaggaaat
     1501 gagaaaaatg cctcggtgtg gggtccgcct gcctctctta agaccgtctg caagccacac
     1561 agtaactgtc cgggtagacc ttctgagagc aggagaggtt ccaaaaccgt ttccaacaca
     1621 ttacaaagat ttgtgggata ataagcacgt taaaatgcct tgttcagaac aaaacttgta
     1681 ccctgtggaa gatgagaatg gtgagcgaac tgcagggagt aggtgggagc tcattcagac
     1741 cgcactcctc aacaaattca cgcgacccca gaacctgaag gatgctattc tgaagtacaa
     1801 tgtggcatat tctaagaaat gggactttac agctttggtt gatttctggg ataaggtact
     1861 tgaagaagca gaagcccaac atttgtatca gtccatttta cccgacatgg tgaaaattgc
     1921 actctgtctg ccaaatattt gcacccagcc aataccactt ctgaaacaga agatgaacca
     1981 ttctgtcacg atgtcacagg aacagatcgc cagtcttctg gctaatgctt tcttctgcac
     2041 attcccccga cggaatgcca agatgaaatc ggagtattct agttacccag acattaactt
     2101 caatcggttg tttgaaggac gttcatcaag gaaaccagag aaactgaaaa cactcttctg
     2161 ctactttcga agagtcacag agaaaaaacc tactggattg gtgacgttta caagacagag
     2221 tcttgaagat tttccagaat gggaaagatg tgacaaacct ctgacacgct tacatgtcac
     2281 ttacgagggt accatagaag gcaacggccg aggcatgctc caggtggatt ttgcgaatcg
     2341 ttttgttgga ggtggtgtaa ctggtgcagg acttgtacaa gaagaaatcc gatttttaat
     2401 caatcctgag ttgattgttt cacggctctt cactgaggtg ctggatcaca atgaatgtct
     2461 tattatcaca ggtactgaac agtacagtga atacacgggc tatgctgaaa cttatcgttg
     2521 ggcccggagc cacgaagatg ggagtgagaa ggatgattgg cagcgacgct gcacggagat
     2581 cgtcgccatt gatgcacttc acttcagacg ctacctcgat cagtttgtgc ctgagaaagt
     2641 gagacgtgag cttaacaagg cttactgtgg attcctccgt cctggcgttc ctcctgagaa
     2701 cctctctgca gtggccacag gaaactgggg ctgtggtgcc tttgggggcg atgctagatt
     2761 aaaagcctta atacagttac tggccgctgc tgccgctgaa cgcgatgtgg tttatttcac
     2821 tttcggggac tcagagttga tgagagacat ttacagcatg cacactttcc tcactgagag
     2881 gaaactgaat gtcgggaaag tgtacaggtt actgcttaga tactacaggg aagagtgcag
     2941 agactgctcc agccctggac cagacaccaa gctctatcca ttcatatacc atgctgccga
     3001 gtccagtgca gagacctccg accagccagg acagaggacg ggcacctgag gacccaagat
     3061 gagacttcct cgcagagaga catcccgttt gagatgtggg atgaactgac ttaatctgat
     3121 ctaaatctgt atataatcca catttgtaat caaggatgca gtgtctccta tatatgcact
     3181 tgtcacttgt ccaccccgat tgacatgggc ttagacgtgg tttctcccat ttttcttctc
     3241 cttcagtctt tattctttta ttttcctttg ttttgccaac ctgacttctt gggaaaaccc
     3301 atgaaaggtt acactcagct tttaggactt tctcctcctg tctgtatact gctttggtgg
     3361 ctagcagata ccatcacgcc tggaggaagt taaaatccag aaatctgagt ttgctacaga
     3421 ttttcctgtg agcttctcac tcccaaccct tgttagtctt gcgttttcta cattttgaat
     3481 tttgaaagtt gaagtttttc ttatgttact taatgccaat atcttaggct aaaagtattt
     3541 tctacttaag acagactaat ttccagtttc tcttttgaaa cattgtccct ataagaaacg
     3601 gttttttttg tttgtttttt ttttgtttgt ttgtttgttt tttttggttt tttttttgtt
     3661 ttgttttgtt ttttttttgt cctttcccca gtgctctttt agaagctgac caagaggaaa
     3721 gaaactgtag aatgaaagga ttttcctcgt atggtataaa gaaaccaagt tcaagagcat
     3781 tgaggctttt gtttttctca agatttgttt ttcctttgaa actaggatga atgtttgttc
     3841 tgtggtgctt agagcatttc atgtaaccaa aggtgggggc tggaagcttc gtgctatctg
     3901 tacatatgga catttctctg gcagtgaata ttagagttaa taaatttcat taataaatca
     3961 tttgttagaa tctc
//
