LOCUS       NM_001108609            3294 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus par-6 family cell polarity regulator beta
            (Pard6b), mRNA.
ACCESSION   NM_001108609 XM_001072588 XM_342589
VERSION     NM_001108609.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Tao H, Inoue K, Kiyonari H, Bassuk AG, Axelrod JD, Sasaki H, Aizawa
            S and Ueno N.
  TITLE     Nuclear localization of Prickle2 is required to establish cell
            polarity during early mouse embryogenesis
  JOURNAL   Dev Biol 364 (2), 138-148 (2012)
   PUBMED   22333836
REFERENCE   2  (bases 1 to 3294)
  AUTHORS   Hengst U, Deglincerti A, Kim HJ, Jeon NL and Jaffrey SR.
  TITLE     Axonal elongation triggered by stimulus-induced local translation
            of a polarity complex protein
  JOURNAL   Nat Cell Biol 11 (8), 1024-1030 (2009)
   PUBMED   19620967
  REMARK    GeneRIF: Results identify a new role for local translation and the
            PAR complex in axonal outgrowth.
REFERENCE   3  (bases 1 to 3294)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 3294)
  AUTHORS   Wong EW, Mruk DD, Lee WM and Cheng CY.
  TITLE     Par3/Par6 polarity complex coordinates apical ectoplasmic
            specialization and blood-testis barrier restructuring during
            spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (28), 9657-9662 (2008)
   PUBMED   18621709
REFERENCE   5  (bases 1 to 3294)
  AUTHORS   Suzuki A and Ohno S.
  TITLE     The PAR-aPKC system: lessons in polarity
  JOURNAL   J Cell Sci 119 (Pt 6), 979-987 (2006)
   PUBMED   16525119
  REMARK    Review article
REFERENCE   6  (bases 1 to 3294)
  AUTHORS   Vinot S, Le T, Ohno S, Pawson T, Maro B and Louvet-Vallee S.
  TITLE     Asymmetric distribution of PAR proteins in the mouse embryo begins
            at the 8-cell stage during compaction
  JOURNAL   Dev Biol 282 (2), 307-319 (2005)
   PUBMED   15950600
REFERENCE   7  (bases 1 to 3294)
  AUTHORS   Hurd TW, Gao L, Roh MH, Macara IG and Margolis B.
  TITLE     Direct interaction of two polarity complexes implicated in
            epithelial tight junction assembly
  JOURNAL   Nat Cell Biol 5 (2), 137-142 (2003)
   PUBMED   12545177
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342589.3, XM_001072588.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3294
                     /gene="Pard6b"
                     /note="par-6 family cell polarity regulator beta"
                     /db_xref="GeneID:362279"
                     /db_xref="RGD:1308205"
     exon            1..302
                     /gene="Pard6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1355
                     /gene="Pard6b"
                     /note="par-6 (partitioning defective 6) homolog beta"
                     /codon_start=1
                     /product="partitioning defective 6 homolog beta"
                     /protein_id="NP_001102079.1"
                     /db_xref="GeneID:362279"
                     /db_xref="RGD:1308205"
                     /translation="MNRGHRHGVSSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFY
                     GLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVSTANPLLRVFIQKKEEADYS
                     AFGTDTLIRKKNVLSNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRL
                     YKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEV
                     NGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGY
                     PQQAGASLEPEDQDSDEDDIIIEGSGEPQQIPKATPEALSLESLTQIELSFESGQNGF
                     SPLQDTSLVAVPSSLDTESESRAPDQKLLEEDGTIITL"
     exon            303..525
                     /gene="Pard6b"
                     /inference="alignment:Splign:2.1.0"
     exon            526..3294
                     /gene="Pard6b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgccgc cgcctccgag cctcgctggg agggacccgt gtccccgcct gccgcactgc
       61 cagtccgacc ctcaggccgc cacggagcag cgggcacagc gctgcgcgga ccttagcagg
      121 tgccgtgacg aagcgccgtg ctgcgcttcg agtcccgagc ccgcgctccg cggccccgct
      181 gcccgcgctc ccgaggacgg gccccagacg aggccgccgc cggccgggcg ctcagcatga
      241 accgtggcca caggcacggg gtgagcagcg gctgcctggg caccatggag gtgaagagca
      301 agttcggagc tgagtttcgg cggttttctc tggaaagatc caagcccgga aagtttgagg
      361 agttttatgg actgctgcaa cacgttcaca agatccccaa cgttgacgtg ctagtgggct
      421 acgcagacat ccacggggac ttgctgccca taaacaatga tgacaactac cacaaggccg
      481 tttccactgc caacccactg ctcagggtct ttatacagaa gaaggaagaa gccgactaca
      541 gcgcctttgg cacggacacc ctgatcagga agaagaacgt gctgagcaac gtgctgcgcc
      601 ccgacaacca caggaagaag ccgcacatcg tcatcagcat gccgcaggac ttccggcccg
      661 tgtcatccat catcgatgtg gacatcctcc cggagacgca ccgcagggtc cgtctgtaca
      721 agtacggcac agagaagccc ctgggcttct acatccggga cggctccagc gtccgtgtga
      781 cgccgcatgg tttagagaaa gttcccggga tcttcatctc caggctcgtc cccgggggcc
      841 tggcccagag cacgggcctg ctggctgtca atgacgaagt tctagaagta aatggtatag
      901 aagtgtcagg caagagcctg gaccaggtga ctgacatgat gatagccaac agccgtaacc
      961 tcatcatcac ggtgcggccg gccaaccaga ggaacaacgt ggtgcgtaac agtcggactt
     1021 ccggcagctc cggccagtcc accgacaaca gcctcctggg ctacccacag caggcagggg
     1081 ccagcttgga gccagaggac caggacagcg atgaggacga cattatcatt gaaggcagtg
     1141 gtgagccgca gcagatcccg aaggccaccc ccgaggccct gagcctggag tccctgacgc
     1201 agatcgagct cagcttcgag tcggggcaga atgggttctc ccctctccag gacacgagcc
     1261 tggtggctgt ccccagcagc ctggacaccg agtcggaaag ccgagctccg gatcagaaac
     1321 tcttagagga agacggaaca atcataacgt tgtgagtcgc caagctgtct gtcctctgag
     1381 tgaggatgtg agggacggtg tgtgagtgta gcacaagact gatgctgtgg acctccgggc
     1441 cgtgatactc cacgacagcc ttagtgcggc tgggatgggg tggggcgtct accatgccgg
     1501 tgagtgtgag caggccacag agcgggtgct gcttctctga ctgagacctg cctggagccg
     1561 ggctgcggtg gccagtgtct gcctgcctgc agggcccgct ctttgccctc tgtgaagtct
     1621 gattgtctgt tagccactgg gaacctcagt tcttagattc ccagcgttga tgttttctga
     1681 ctttaaaatg ctcctctgtt aactgtgaca atttattttt tccatgtgca gtttttgttc
     1741 tgtcttcctg ttttctaagc cgttagccgg ccatgtttag gggccccctc cctggccctg
     1801 gagtcacctg ttgtcctcac cctggggctt tacagttgca gggtgtcata gtcctttgcc
     1861 ccctgtccag ggtgtgagtg agtgtgagtg tgtacatgtg tgtgagtgag tgagtgtgag
     1921 atgcagtgca gttagctggc tcccacactc ttccagtgta ccaggcagtg tggatcgttt
     1981 tggataaaaa ggcccccggg ttaagagact tacacatggt acagatgtgc actttgtttt
     2041 cttcctgggg attctagggt gctgcctgca tttggggaag cccgcatcag ttcaccactc
     2101 acaggggtgg tgattatttg agtctattta ttctttcccg tgcgtccatt caggatgagg
     2161 gaaccgcagt tgtcttccct tacctgcccc cttgtgttgc ctgcacagcc actgagatcc
     2221 atacgcgtgg gctcagactg ccccgaggcc ctgaggcgga cagttattta tttcctaacc
     2281 tgacagtggg cgagcgtggg cacctcccag ctctgaacta tgactccaag atgaaggact
     2341 ttatcctccg tagtaggagc cggcagaaat gaagtcttga tccagtgaag ggcgccggac
     2401 gccatcgata ctcaacgtgg tatctgcaag cgcatggctg aggctgggtg cagtgaccca
     2461 gccagcgaat gttgaattca ctgagtccct cctctcatgg cacggccact tactgacagc
     2521 atccccctct gacactgtgc accatgcagt gcagccctag ggtggaaagc agccataggc
     2581 acagaaggct cagttgcaca cacattcgcg gtgcatgggc tcaacgttgt aagtagagat
     2641 atttcacatg ctacctctct ctctctctct ctctctcttt tctctctctt tttttttttt
     2701 taacagagtt ttaacattag aacttttctc ttggggaaga aacacttcag ggcttgactt
     2761 ttgtacaaat tttaactgta aaatgcagaa tttctcttct gtctgaaaat ggagatcgct
     2821 gctggtgtgg attttaattt aaaagataat agtgttaaca acgaggtcct agcaatgaag
     2881 ggagtggtca gtagacctcc gtgagccagt ggatcttggc tatgggggtc ccatcccgtt
     2941 ggctcagttc ttgaggctcc ttagaacaca gacgtaagtg tcagcggctt agcgtgcata
     3001 tctgttgtcc cggatgtcga gcctcactgt gaattctgtt ctgtcctcag tcatcaactc
     3061 tgtcaaccag atgctgtgct gttgtgaacc gtgaattttc taattaaatt ttacatgcta
     3121 taacatgatt tttttacatg aatgatactt tgtttaaact actaaatgtc agtattttac
     3181 tacaatttta ttataaaaat gtacattatc actaaatgaa ctttgatttt gaaaatcaag
     3241 ttagctttag ttccacatta ttttttacaa ataaaaacgg acttgtataa aggc
//
