LOCUS       NM_001395059            2549 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus 3'-phosphoadenosine 5'-phosphosulfate synthase 1
            (Papss1), mRNA.
ACCESSION   NM_001395059 XM_039102097
VERSION     NM_001395059.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Kurogi,K., Davidson,G., Mohammed,Y.I., Williams,F.E., Liu,M.Y.,
            Sakakibara,Y., Suiko,M. and Liu,M.C.
  TITLE     Ethanol sulfation by the human cytosolic sulfotransferases: a
            systematic analysis
  JOURNAL   Biol Pharm Bull 35 (12), 2180-2185 (2012)
   PUBMED   23207770
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Harjes,S., Scheidig,A. and Bayer,P.
  TITLE     Expression, purification and crystallization of human
            3'-phosphoadenosine-5'-phosphosulfate synthetase 1
  JOURNAL   Acta Crystallogr D Biol Crystallogr 60 (Pt 2), 350-352 (2004)
   PUBMED   14747722
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Singh,B. and Schwartz,N.B.
  TITLE     Identification and functional characterization of the novel
            BM-motif in the murine phosphoadenosine phosphosulfate (PAPS)
            synthetase
  JOURNAL   J Biol Chem 278 (1), 71-75 (2003)
   PUBMED   12414806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 1, 2021 this sequence version replaced XM_039102097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166793.1, SRR22582416.1381303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000002.1  222714430-222714593
            165-279             JAXUCZ010000002.1  222730321-222730435
            280-515             JAXUCZ010000002.1  222733015-222733250
            516-654             JAXUCZ010000002.1  222733709-222733847
            655-773             JAXUCZ010000002.1  222736465-222736583
            774-887             JAXUCZ010000002.1  222753314-222753427
            888-999             JAXUCZ010000002.1  222755366-222755477
            1000-1205           JAXUCZ010000002.1  222757811-222758016
            1206-1341           JAXUCZ010000002.1  222759398-222759533
            1342-1610           JAXUCZ010000002.1  222770386-222770654
            1611-1840           JAXUCZ010000002.1  222776638-222776867
            1841-2549           JAXUCZ010000002.1  222787767-222788475
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..2549
                     /gene="Papss1"
                     /note="3'-phosphoadenosine 5'-phosphosulfate synthase 1"
                     /db_xref="GeneID:295443"
                     /db_xref="RGD:1308081"
     exon            1..164
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1979
                     /gene="Papss1"
                     /EC_number="2.7.7.4"
                     /codon_start=1
                     /product="bifunctional 3'-phosphoadenosine
                     5'-phosphosulfate synthase 1"
                     /protein_id="NP_001381988.1"
                     /db_xref="GeneID:295443"
                     /db_xref="RGD:1308081"
                     /translation="MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVV
                     GTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFS
                     PEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDA
                     PLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVE
                     LLQERDIVPVDASYEVKELYVPENKLHLAKTDAEALPALKINKVDMQWVQVLAEGWAT
                     PLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATQEDKERLDGCTAFALVYEGRR
                     VAILRNPEFFEHRKEERCARQWGTTCRSHPYIKMILEQGDWLIGGDLQVLDRIYWNDG
                     LDQYRLTPAELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLL
                     LHPLGGWTKDDDVPLMWRMKQHAAVLEEGILNPETTVVAIFPSPMMYAGPTEVQWHCR
                     ARMVAGANFYIVGRDPAGMPHPETGKDLYEPTHGAKVLTMAPGLITLEIVPFRVAAYN
                     KKKKRMDYYDSDHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLVEYYKSLEKA
                     "
     exon            165..279
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..515
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..654
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..773
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..887
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..999
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1205
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1341
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1610
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1840
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2549
                     /gene="Papss1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggtgcag gctccgcccc ttctccctgc tccgccccgc ccccggcctc tcttaccact
       61 cggcctcggg gcgctcagca actgagcatc cgcgttccac ggccatggag attcctggga
      121 gtctgtgcaa gaaagtcaag ctgagcaata acgcacagaa ctgggggatg cagagagcaa
      181 ccaacgtcac ctatcaagca caccatgtca gccggaataa gagaggtcag gtggtgggga
      241 ccagaggtgg cttccgtggt tgcacagttt ggctgacagg attgtctgga gcagggaaga
      301 cgaccgtgag catggctctg gaggagtacc tggtttgcca tggcattccg tgctacactt
      361 tggatggcga caacatccgt caaggcctca ataagaacct tggcttcagt cctgaggaca
      421 gagaggagaa tgttcgccgc atagcagagg tggcaaagct gttcgcagac gctggcctcg
      481 tgtgcatcac aagcttcata tcgccctaca cgcaggaccg caacaatgct cggcagattc
      541 atgagggtgc gagcttaccc ttcttcgagg tttttgtcga tgctcctctg catgtttgtg
      601 aacagaggga cgtcaaagga ctctacaaga aagcacgggc cggagaaata aaaggcttca
      661 ctgggatcga ctctgagtat gagaaaccag aggccccgga actggtgctg aaaacggatt
      721 cttgtgatgt caacgactgt gtccagcagg tcgtggagct tctgcaggaa cgggacattg
      781 tccctgtgga tgcctcctat gaggtgaaag agctgtatgt gccggagaac aaacttcact
      841 tggccaaaac tgatgcagaa gccttaccag cactgaaaat caacaaagtg gacatgcagt
      901 gggtgcaggt tctggcagaa ggctgggcga ctcctctgaa cggcttcatg agggagaggg
      961 aatacttgca gtgccttcat tttgactgtc ttctggatgg aggcgtcatc aacttatccg
     1021 tgcctatagt cctgacagct acgcaggagg acaaggagag gctggacggc tgcacagcgt
     1081 tcgctctggt gtatgagggc cgccgtgtgg ccatcctccg gaatccggaa ttttttgagc
     1141 accggaaaga ggagcgttgc gcccgacagt ggggaacaac gtgcaggagc cacccctaca
     1201 tcaagatgat tctggaacaa ggggattggc tgattggagg agatcttcaa gtcctggacc
     1261 ggatttactg gaacgatggc cttgatcagt accgtcttac ccctgcggag ctcaagcaga
     1321 agtttaaaga tatgaatgct gatgctgtct ttgcgtttca gttgcgcaac ccagtgcaca
     1381 atggacacgc tctgctaatg caggacaccc acaagcagct tctagagagg ggctaccggc
     1441 gtccagtcct cctcctccat ccgcttggtg gctggacgaa ggatgatgat gtccctctga
     1501 tgtggcgtat gaagcaacat gctgcagtgc tggaggaggg catcctgaat cctgaaacaa
     1561 ctgtggtggc cattttccca tctcctatga tgtatgctgg gccgaccgag gtccagtggc
     1621 actgcagggc tcggatggtg gcaggggcca atttttatat tgttggacga gaccctgctg
     1681 gcatgcctca tccggagaca gggaaggacc tctatgagcc aacccacggt gccaaagtgc
     1741 tgacgatggc ccccggcctg atcaccttgg aaatcgttcc cttccgagtc gcagcttaca
     1801 acaagaagaa gaagcggatg gactactatg actcggatca ccacgaagac ttcgaattta
     1861 tttcaggaac caggatgcgc aaactggcac gtgaaggcca gaaacctcca gagggcttca
     1921 tggcccccaa ggcgtggact gtgctggtgg agtactacaa gtccttagag aaagcctaac
     1981 ttcctgagcc aggcactctg ccagggatgc agggctgagc aacacagggg accacgcagt
     2041 cactgacagc acttctctgt gggtgtctgt ctggacacac ttcctgaaat caggccgttt
     2101 ccctccatgt gcatcagctt tgttttgcct ttgagttctg ttttgaacta gtgtaacacc
     2161 gctctggttc taatgtatct tttccactta ttgttaatat tcttataata cgattttaaa
     2221 aatctcgcct ttttatattg tatttatgct tctgtcttag gattttccaa gctgatttat
     2281 tagttataac cagtaataca cacatcatct agcttctcgt cctttaagaa agggggaaaa
     2341 tcactaaaca gtaaagttgg ctagaccttg ttcgaggagt tttacaaatt ttacaaacta
     2401 tctgtagcga ttaggttttt ttattttaca tcataaatgt aaaccgttcc ctctctccct
     2461 gtacccctac atgctgaggt attcttgcaa tctgtgttaa gtgctgaatg aatgccttga
     2521 ttcaataaaa ttaatttttg gcttattta
//
