LOCUS       XM_002728025            9150 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus pappalysin 2 (Pappa2), mRNA.
ACCESSION   XM_002728025
VERSION     XM_002728025.5
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051348.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XM_002728025.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..9150
                     /gene="Pappa2"
                     /note="pappalysin 2; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 25 ESTs, 3 Proteins, and
                     99% coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:680415"
                     /db_xref="RGD:1591785"
     CDS             430..5796
                     /gene="Pappa2"
                     /codon_start=1
                     /product="pappalysin-2"
                     /protein_id="XP_002728071.2"
                     /db_xref="GeneID:680415"
                     /db_xref="RGD:1591785"
                     /translation="MMCWKVLRISLVVLAGWAFSTTNSELGWTRKKYLAQRAHLNQAL
                     LEGERCWLAYKVRRPRCAPQHHPFGVYPSHHENYLRSYPVGMQQTQYAEWSQRSTERQ
                     APSGVPRDLTENPAGVKRKSEQPAAPWVGDGPIGQSQLLRDDDTYLGKGGSKEALGEP
                     AIRGSSETAVSTITTFTYQKGPTAETQRKGQSKSRLPRQVQKRQAEDMTRDPQNTPQD
                     VQLWPKDPLKHGDSNSPLEGTIQNGGGASAQRAETFNPQGGLPVLYFSGKRERLLLRP
                     EVLAEIPREAFTVEAWVRPEGGQSNPAIIAGVFDNCSHTVNDKGWALGIRSGKDKGQR
                     DARFFFSLRTDRMKKATTVIGHSRYQPGTWTHVAATYDGQHMALYVDGTRVAASPDQS
                     GPLNSPFMASCRSLLLGGDNSENGHYFRGYLGTLVIWSTALSQLHLQHSPQHPSGVDE
                     LTTLILTATFDPLKEQWAPFRDETYPLMEVFQDSESQPEILSPLQPPPCGQTACDNVE
                     LISQYNTHGPLRREKVVRYQVVNICDDEGLHPIVSDLQIRRQHEALNQAFSRYNISWQ
                     LSVHRVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGFDGGDCRLQGRCYSWNRR
                     DGLCHMECNNMLNDFDDGDCCDPEVTDVRKTCFDPDSPKRAYMSVKELKEALQLNSTH
                     FLNVYFASSVREDLAGSATWPWDKDALSHLGGVVLNPAYYGMLGHTNIMIHEVGHVLG
                     LYHVFKGVSERESCDDPCRETVPSMETGDLCADTAPTPKSKLCRDPEPANDTCGFTLF
                     PRAPFNNYMSYTDDDCTDNFTPNQVARMHCYLDLVYQQWSESQKPTPIPIPPMVIGQT
                     HKSLTIHWLPPISGVVYDRTPDSMCGACTEDGTFRQYVYKASSGRVCDSSGYWTPEEA
                     VGPPDVDQPCEPSLQAWSPELHLNHMNMTVPCPAEGCSLELLFQHPVQADTLTLWVTY
                     LSVNSSKAFFDIEILLEHKESMHLGPLNTFCDMPLTIKLHVDEKVVGAKVYTFDERME
                     IDAALLTSRPSSSLCSGCRPVSYQVLREPPFSSGLPMVVTHPHRKFTDTEVIPGQVYQ
                     YQVQAEAGGELGEASPPLSHIHGGPYCGDGKVERSMGEMCDDGDLLNGDGCSRACELE
                     EGFNCAGEPSLCYRYEGDGICEAFEKKTSIIDCGLHTPEGYLDQWASQAYSYHEDKKK
                     CPVSLVTGEPHSLICTSRHPDSSPYHLFPGWFPCVFNLKKDQDAGREKSKDSLQKENE
                     IWLEVCFNKPGVAVAIFIFLASDGLNPGEHQQATVTPYLIDVSGNNHSLGTYGLSCQH
                     NPLVINVSHHANVNPQHTSTMLLNFSSPLVGISAVALRTSSQTISSSLSNCIPEQNHQ
                     GQSCAQRPCGEQGRCVPLLLDHTDMVNCTSSGPGHMECAITCQRGYVLQTSSGQYLRN
                     MQKEILLTCSSGHWNNNVNCKRLDCGVPDSSLVNYANFSCTEGTDFLKRCSISCVPPA
                     KLQGLNPWLTCLEDGLWSLPEVYCKLECEAPPVIPNAHLLRPHCLEGNHDVSTICKYE
                     CKPGYYVKESSGSQGKNKFLKIQCLDDGTWEQGSCVPVVCEPPPPVFEGMYDCTNGFK
                     LDSQCVLNCNQETERIPILCTKEGLWTQEFKLCENLQGECPPPTSELNSVEYKCGQGY
                     GIGAVCSPSCVIPPSDPVILPENVTTDTLEHWMEPVKVQSIVCTGRRQWHPDPSLVHC
                     IQSCEPFQADGWCDTINNRAYCNYDGGDCCSSTLSSKKVIPFAADCDSDECTCRDPKA
                     EENQ"
ORIGIN      
        1 gattattttg aatgaccaga tggggtggta tgtatctgag agaatttggc ttacgtccta
       61 cattctcttc tcttatcagt gaggagagga gttactgaag gaagaaaagg aaaccttggg
      121 tctctgggag gagtttcaaa ggaagaacac ttaacttcat tctgaaggac tgaaatcaat
      181 caggagaggt caaggaagaa ggtgagagaa accaaaagct acagaagcca ccggggctgg
      241 ctaaatcccc tggacaggta gtcaggaaag gcattcttct gtggctactt gagaaagttt
      301 ttggcttgtg aatcaaacag ttttcctggt gacttcaaat ccattgctgg ttgcttttcc
      361 atcttcccat cattcttgtg tggtacccag aagctgactt cgggttttaa ggagcaagct
      421 gaaggagata tgatgtgttg gaaggtcctg agaataagtc tggtggtcct ggctgggtgg
      481 gcattcagta ccaccaactc cgagctgggc tggactcgca agaaatacct ggcccagagg
      541 gcacacctga accaggcgct gttggaaggg gaacgctgtt ggctggcgta caaggttcga
      601 agacccagat gtgctccaca gcatcatccc tttggggtct acccaagcca ccatgaaaac
      661 tacctaaggt cctatcctgt ggggatgcag caaacacagt atgcagaatg gagtcagcga
      721 agcacagaga gacaggctcc aagtggtgtt cccagagacc tgactgaaaa cccagcagga
      781 gtgaagagaa agtctgagca gccagctgcc ccgtgggtag gggatggtcc tattgggcaa
      841 tcgcagctgc tgagagatga tgacacttat cttggcaagg gaggatctaa ggaggctcta
      901 ggtgagcctg caattcgggg aagctcagaa actgctgtct ccaccattac cacctttaca
      961 taccagaagg gacccacagc agagacccag aggaagggtc agtccaagtc taggcttcct
     1021 cgccaagtgc agaagaggca ggcagaagat atgaccagag acccccagaa tacccctcag
     1081 gatgttcagc tttggcctaa agaccccctt aagcacggag atagcaacag tccattggag
     1141 ggcacaatcc aaaatggtgg aggggcctct gcccagagag cagagacctt taacccccaa
     1201 ggaggattgc ctgtactgta tttctctggg aagagggagc ggctgttgct gcgtccagaa
     1261 gtgctggctg agattccccg ggaggcgttc acagtggaag cctgggtgag accagaggga
     1321 ggacagagca acccagccat cattgcaggt gtgtttgata actgctccca cacagtcaat
     1381 gacaagggct gggccctggg gatccgctca gggaaggaca aggggcaaag agatgctcgc
     1441 ttcttctttt ccctccgcac tgaccggatg aagaaagcca ctactgtgat tggtcacagc
     1501 cgctaccagc caggcacgtg gactcatgtg gcagccactt atgatggaca gcatatggct
     1561 ctgtatgtgg atggcactcg agtggctgct agtcctgacc agtctggtcc actgaatagc
     1621 cctttcatgg catcctgccg ctctctactt ctgggagggg acaactccga gaatgggcat
     1681 tacttccgtg gttacctggg cacactggtc atctggtcga ccgccctctc acaactccac
     1741 ctccagcaca gtccccagca tccaagtgga gtagatgagt tgaccacctt gatcctgaca
     1801 gccactttcg atcctctgaa ggaacagtgg gctcctttta gagatgaaac atatcccctg
     1861 atggaggttt tccaggactc tgagtcacag cccgagattc tgtcaccttt acagccccca
     1921 ccttgtgggc aaacagcttg cgacaatgtg gaactcatct cccagtacaa tacgcacggg
     1981 ccccttcgca gagagaaagt ggtccgctac caggtggtaa acatctgtga cgatgaggga
     2041 ctgcatccca ttgtgagtga tcttcagatc cgccggcagc atgaggccct gaaccaggcc
     2101 ttcagccgct acaatatcag ctggcagctg agtgtgcacc gggtccacaa ctccaccctg
     2161 cgccaccggg ttgtgcttgt taattgtgag cccagcaaga ttggcaatga ccattgtgac
     2221 cctgagtgtg agcatcccct caccggcttc gatgggggcg attgccgcct gcaggggcgc
     2281 tgctactcct ggaatcgcag ggatggcctt tgtcacatgg agtgcaacaa catgctgaat
     2341 gattttgatg atggggactg ctgcgatcct gaagtgactg atgtccgaaa gacttgcttt
     2401 gaccctgact cacccaagag ggcatacatg agtgtgaagg agctaaagga ggccttgcag
     2461 ctcaacagta ctcacttcct caatgtctac ttcgccagct cagttcggga agaccttgca
     2521 ggttctgcca catggccctg ggacaaggat gctctcagtc acctgggtgg tgtcgtcctc
     2581 aacccagcct attatggtat gcttggccac accaacatca tgatccatga ggtgggacat
     2641 gtcctgggtc tctaccatgt attcaaagga gtcagcgaaa gagaatcctg tgatgacccc
     2701 tgtagagaaa cagtgccatc catggagaca ggagacctgt gtgctgacac tgctcctaca
     2761 ccgaagagca agctctgtcg ggacccagag ccagctaatg acacctgcgg cttcaccctt
     2821 ttcccacggg ctccattcaa taactacatg agctacacag atgacgattg cactgacaac
     2881 ttcaccccca atcaggtggc ccggatgcat tgctacttgg atcttgtata tcagcaatgg
     2941 agtgaaagcc aaaagcccac ccccataccc ataccaccca tggttattgg tcaaacccac
     3001 aagtccctca ctatccattg gctgcctcct atcagcggag ttgtatatga caggacccct
     3061 gacagcatgt gtggtgcttg cactgaagat gggacattcc gtcagtatgt gtacaaggca
     3121 tcctctgggc gggtgtgtga ctcttccggt tactggaccc cagaggaggc tgtggggcct
     3181 cccgatgttg atcagccctg tgagcctagc ttgcaggcct ggagtcctga gctccacctg
     3241 aaccacatga atatgacggt gccctgccca gcagaaggct gcagcttgga gctgcttttc
     3301 caacacccgg tccaagcgga taccctcacc ctctgggtca cttacctctc cgtgaactct
     3361 tccaaggcct tctttgacat agagatcttg ctagaacaca aagaatctat gcatcttggg
     3421 cccttaaaca ctttttgtga tatgccgctc accatcaaac ttcacgtgga tgagaaggtc
     3481 gtgggagcga aagtctatac ctttgatgaa cgaatggaaa ttgatgctgc tctcttgact
     3541 tctaggccca gtagttcttt gtgttctgga tgcagacctg tgagttacca ggttctccga
     3601 gagcctcctt tttccagtgg cttgcccatg gtggtgacgc atccacatag gaagttcaca
     3661 gatacggagg tcatccccgg gcaggtgtat cagtaccaag ttcaagctga agctggaggg
     3721 gaacttggag aagcttcacc tcctctgagc catattcatg gaggccctta ctgtggagat
     3781 ggaaaggtag aaaggagtat gggagaaatg tgtgatgatg gagacttgtt gaatggagat
     3841 gggtgctcaa gagcatgtga actggaggaa ggcttcaatt gtgcagggga gccaagcctt
     3901 tgctaccggt atgagggaga tggtatttgt gaagcttttg aaaagaaaac cagcatcata
     3961 gactgtggcc ttcatactcc ggaaggatat ttggaccagt gggctagcca ggcttattcc
     4021 taccatgaag acaagaagaa gtgtcctgtt tccctggtaa caggagaacc tcattcattg
     4081 atttgtactt cacgccaccc ggattcatcc ccatatcatc tctttcctgg ctggtttccc
     4141 tgtgtcttca atctgaagaa agaccaggat gcaggcaggg agaagtcgaa agatagcctg
     4201 cagaaggaga atgaaatttg gctcgaagtg tgtttcaata agccaggagt tgcggtggca
     4261 attttcattt tcttggcatc tgatggcttg aaccctgggg agcaccagca ggcaacagtg
     4321 accccttacc tgattgatgt cagtggaaac aaccactctc ttggaaccta tggactgtca
     4381 tgccaacata atcctctggt tatcaatgtg agccaccatg cgaatgtcaa cccccaacat
     4441 acctccacca tgctgctgaa tttttcatcc ccactggtgg gcatctcagc agtggcacta
     4501 aggacatcct cccagactat ttcttcatct ctcagtaact gcatcccaga gcaaaatcat
     4561 cagggacaga gctgtgctca acgaccttgt ggagaacagg gaagatgtgt gccattgcta
     4621 cttgatcata cagacatggt gaattgtacc tccagtggcc caggtcacat ggagtgtgct
     4681 atcacttgtc aaagggggta tgtccttcag accagcagtg gacagtacct caggaacatg
     4741 cagaaagaga ttctcctcac ttgttcctct ggtcactgga acaacaatgt gaactgcaag
     4801 cgtcttgact gtggtgtccc agactcgtcc ttggtgaatt atgcaaactt ctcctgtacg
     4861 gagggtacag actttctgaa acgctgttcc atctcatgtg tcccaccagc caagctccaa
     4921 ggactgaacc catggctgac gtgtcttgaa gatggactct ggtctctccc tgaagtctac
     4981 tgcaagttgg aatgtgaagc tcctccagtt attccaaatg ctcatctgct ccggccacac
     5041 tgcctggaag gcaaccatga cgtgagcacc atctgcaaat atgaatgcaa accaggctac
     5101 tacgtgaagg agagctcagg aagtcaaggc aagaacaagt tcctgaagat ccaatgccta
     5161 gatgatggaa cctgggaaca agggagctgt gtccccgtgg tgtgtgagcc tcctcctcct
     5221 gtttttgaag gcatgtatga ctgtactaac ggcttcaagc tggacagcca gtgcgtcctc
     5281 aactgtaacc aggaaacaga aaggattccc atcctctgca cgaaagaggg gttgtggacc
     5341 caggaattca agttgtgtga aaacttgcaa ggagaatgcc caccacccac ttccgagctg
     5401 aattctgtgg agtacaagtg tggacaggga tatgggattg gtgcagtgtg ctccccatca
     5461 tgtgtaattc cccctagtga ccctgtgata ctaccggaga atgtgactac tgacactttg
     5521 gagcactgga tggaacctgt caaagtgcag agtatcgtgt gtaccggcag gcgtcagtgg
     5581 cacccagatc cctctctggt gcactgcatc cagtcatgtg agcctttcca agcagacggt
     5641 tggtgtgaca ctatcaataa ccgggcctac tgcaactatg atgggggaga ctgctgctcc
     5701 tccacactct cttccaagaa ggtcattcca tttgctgctg actgtgactc ggatgaatgc
     5761 acctgtcgag atcccaaggc agaagaaaac cagtaactca aggaccagag cccacttcct
     5821 ctgccctgga ggcagactaa aagagaggct cccatagcag gatgcaaagg gtgaatgaac
     5881 aatgcaggtc ccatggtgga aggagagtct agaacagagc ctttaagaaa tgcaagagaa
     5941 agtttgtagg tgccaattaa tgcattaagt agtccaagta gggagggatt ataggtaaac
     6001 atttctgtaa aaggacaact gattagaaat ggaaggagaa attgatggac aagacccctc
     6061 ccccatctgt actcaactcc gtccttctct caactcttaa tctcctcccc actctgcacg
     6121 ctgtcagtgg ctcagcccca cctaccatgt aaaccaatat caaagtatta gaaggtaagc
     6181 tgccaaggga ctcagtcaat ccccatcgca gatggactgt ctgtcatctt tccgggctca
     6241 tctactccag actgaccctt tgcctttctt ttgtgtggtc tctctcaaat aatgaggtta
     6301 gctatttctt tatgagtatt taaacataat tatataaata tattatatat tatatttttt
     6361 tgctgtttac taagctacag attatccatt gttccacaaa tgctgctgtg aagttcatgt
     6421 ccagagggat actgaagctt cgaggacaga aagaaaggtt cttttgcctt cctcccatag
     6481 ataggcttgg agggtcggat ggggagaaga gagttgatgg aattctggat gctggcctgt
     6541 cagttgatca tcattttatg acctgggagc tgggcctact gaagggagat agacttggca
     6601 tgctaagaac aaaaggcatg gaaagttaca aatgggaacc tatttggcag taggtccagg
     6661 agagatagac aatggtttct aagtatctat caaaaggagc atacaaactc ttctatgctt
     6721 ctcagaatgc acggttggaa ttggtaaaga ccagggtctt ttccacttct ccatgtatct
     6781 agtccaagtg tagctgccag ccagccagcc agccagccag ccagccagcc aaaaagtttg
     6841 tattaggtct cattctctga acatcaggct tacaggaact tacaccctct tcatacttgg
     6901 ccagttagtg tctcttcttg ctgcaagtct caaagcctgg ccatcgttca cagccacatc
     6961 accaactgtt gattttttct gagaaaagaa aatgctttgg aaatttggaa ttgggatggg
     7021 gtaggggagg gaagataaga tatgaaagaa ctgggaactg gaagagcaaa aggctgtcag
     7081 agaggtgaaa ggtcagagag gtgagaggtc aagattaaat gagatctgag aataagagga
     7141 tggaatgagt gaacaagccc ctgttctaag tctccaaaag aggccagaga tccttcgagc
     7201 aatgagataa atcttattca agtccaaggc atgaagtctg tggcccagta agcaacatgt
     7261 ggagcgaggg tgacacactg tggggagaaa gaagaatttc aacgatttcg ggtccatgtt
     7321 gtctttacca tttcttgttc agtagatgta tggtctatgc acagaacagt cacactaaca
     7381 cttctctgtc catgaatctt aagctcatat tttccattgg gtctggccta ggtatgtttt
     7441 cctataacag tttctgaatc acacatagaa agagagttag gacatagttt ctttctttta
     7501 acaatggtct tgtcctctta caaaggctct gagatctgtc tcccctaatt tttttctcca
     7561 gtggaaactt aagatcagga aaaacttgga gtcacttctg gtatttccaa aacctttcct
     7621 cctgtttctc ctactctttc atcatcaagg ctgaagcctt gaatctatag aatgagaaag
     7681 gaaacattat ttatcattat cagcacatta cccctgctct gcatgaagag caatattctg
     7741 tagtgattgg ggatatagca atatacatat agttacctgt gcatgagtgg aatgtgcaca
     7801 acaaagccat tgagaaaggc agtgttagtt ctctattcct agcaataagg taagcagtgc
     7861 ttaaatgctg cttactgact aggtcgctta ctgactaggt catgccatct gtcaagcaaa
     7921 acaattcata ttctggatcc tgataaattt aatatggaaa ggaccataga aaaacttata
     7981 ttagctacta aatatttcaa ttcatatttc tctggatcct gctaagttta aaatgaaaag
     8041 accaatagaa aagtttagat tctctactaa atacacacac accccacaac ccccccacac
     8101 cacacttctc cacacacaca caccctacac cataccatac acacacacac acacacacac
     8161 acacacacac acacacacac acaccacaaa ttgtttcctt ggagaagcat tcacattgct
     8221 ggaaatgtat caacttttac cttgggcaaa tcctgaaaga gacagaggca gagagatggc
     8281 aatagttacc ttacacagct cagtgcagtg aggctgtcac tcccaaaaac actcctgagc
     8341 tcagagtgcc caccagcgta catctatggt ctgtctcttc attaagtcca ttaagagtaa
     8401 cagagaggac atttctatcc catgcttcac tttaagatac tttgttcttt ttttggcaac
     8461 atttattcca ccctgggaag ccaagaggac cgtttctctt ggtgtgtgca aagctctcca
     8521 ggctgaaggc catttagcca taatcagcta gagacagagg caagcagtca tgtctagact
     8581 ttgtctctag gctccagtgt ttaaagaaac ttaagtctct aataaagaaa atgatcagag
     8641 atcccaggga caactcatgt ttgcccccag gtgattgtat tctgttctta gacatccatg
     8701 atgtcattca tcacactcca cagaggttcc tctgtctgct tctttcttcc atagtcacct
     8761 gtctgtttct tcttgttcct ggtaaccaga gttttgaggt ccacatggac aaaggggggc
     8821 tgacttcaat agttagtatg gcagccttca atcacaaata cagaaaagag ggcagcaggg
     8881 gcaatgagca gatcctggca aagaaggcag cgagtagagt cttggttctt tccttccctt
     8941 tccaacatta caaggccttg gtctttgaca catcgtctac tgtgtgtgat caccattgag
     9001 tgtgtcagtt agcacccaag gggacagttt gatggaaaac acagtgaaag gggctgatct
     9061 actgtattgt aatgtaaaac agctacattc agtattttat aagattataa aacattcatt
     9121 aaaaaatcag cacataaaat atgaagtgca
//
