LOCUS       NM_001107244            3725 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus poly(A) polymerase gamma (Papolg), mRNA.
ACCESSION   NM_001107244 XM_001057482 XM_001057530 XM_001057584 XM_223690
VERSION     NM_001107244.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3725)
  AUTHORS   Gruber AR, Martin G, Keller W and Zavolan M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 3725)
  AUTHORS   Yang Q, Nausch LW, Martin G, Keller W and Doublie S.
  TITLE     Crystal structure of human poly(A) polymerase gamma reveals a
            conserved catalytic core for canonical poly(A) polymerases
  JOURNAL   J Mol Biol 426 (1), 43-50 (2014)
   PUBMED   24076191
REFERENCE   3  (bases 1 to 3725)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3725)
  AUTHORS   Topalian SL, Kaneko S, Gonzales MI, Bond GL, Ward Y and Manley JL.
  TITLE     Identification and functional characterization of neo-poly(A)
            polymerase, an RNA processing enzyme overexpressed in human tumors
  JOURNAL   Mol Cell Biol 21 (16), 5614-5623 (2001)
   PUBMED   11463842
REFERENCE   5  (bases 1 to 3725)
  AUTHORS   Perumal K, Sinha K, Henning D and Reddy R.
  TITLE     Purification, characterization, and cloning of the cDNA of human
            signal recognition particle RNA 3'-adenylating enzyme
  JOURNAL   J Biol Chem 276 (24), 21791-21796 (2001)
   PUBMED   11287430
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473996.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057584.1, XM_001057530.1, XM_223690.4, XM_001057482.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..3725
                     /gene="Papolg"
                     /note="poly(A) polymerase gamma"
                     /db_xref="GeneID:305586"
                     /db_xref="RGD:1310337"
     exon            1..250
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..2453
                     /gene="Papolg"
                     /EC_number="2.7.7.19"
                     /codon_start=1
                     /product="poly(A) polymerase gamma"
                     /protein_id="NP_001100714.1"
                     /db_xref="GeneID:305586"
                     /db_xref="RGD:1310337"
                     /translation="MKEMSANTMLDSQRQQKHYGITSPISLACPKEIDHIYTQKLIDA
                     MKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDISESKNLPPSVVATVGGKIFTFGSY
                     RLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGVRNLRAVEDAFVPVIKFEF
                     DGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKET
                     FRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFS
                     KWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRT
                     VMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLEWVGL
                     VESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKANNYVSMWFLGIIFRRVENAES
                     VNIDLTYDIQSFTDTVYRQANNINMLKDGMKIEATHVKKKQLHHYLPAEILQKKKKSL
                     SDVSRSSGGLQSKRSSLDSNCLDSSRDTDSGTPFNSPGSAHKPSNPDSPTGDAERSNA
                     EPMAVIVEKLPSVPPAQGLSIPVIGAKGDAAVKAVSSPAVCTIPTVVGRSVIPRVTTP
                     HNPVQGQPHLNGISNITKNVTPKRSHSPPTDGTAKRLKDIEKFIRLESAFKESRAAED
                     RKRKPMDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPASNIRVIKNSIRLTLNR"
     exon            251..412
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            413..479
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            480..561
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            562..671
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            672..725
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            726..837
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            838..927
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1066
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1139
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1260
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1345
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1399
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1519
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1629
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1751
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1921
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2010
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2231
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2297
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2354
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..3725
                     /gene="Papolg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcctgg gaagcagcgc catattggcg gcggccgcgc tgtattgtca taaatagagc
       61 cggtttttgt ggtgttttca ctactcggtt gaatgcctcg gctgtagaga gtggggaagt
      121 gagcgagcaa gcgagctata agcgagcgaa aggaagtgga cagaggaagg aagagagggc
      181 aagaacagga ccccaaagcg aaagacactg gctggagaga gacgcaggaa gcgatgaaag
      241 agatgtctgc aaacactatg ctggacagcc agcgtcaaca aaagcattat ggaattacct
      301 ctccaattag tttggcatgt cctaaagaaa ttgatcatat ttatacacag aaattaattg
      361 atgccatgaa accatttgga gtatttgaag atgaggaaga attgaaccac aggctggttg
      421 ttcttggtaa attgaacaat ttagtaaaag aatggatttc tgacatcagt gaaagtaaga
      481 atctcccacc ttctgttgtg gctactgttg gtggtaaaat tttcacattt ggatcttaca
      541 ggcttggagt acacaccaaa ggagctgata ttgatgcact ttgtgtagcc ccaagacatg
      601 tggagagatc agattttttt cagtcctttt ttgaaaaatt gaaacatcaa gatggtgtta
      661 gaaacttaag agctgtagaa gatgcttttg tacctgtcat aaaatttgaa tttgatggta
      721 ttgaaattga tctagtcttt gcaagactgg caatacaaac catatcagat aatttagatc
      781 taagagatga ctctcgcctg agaagcctcg atatacggtg cattcgaagt ttaaatggat
      841 gtagagttac tgatgaaatt ttgcacttag tgccaaataa agaaactttt agacttactc
      901 taagagcagt caaattatgg gcaaagcgcc gtggtattta ttccaatatg ctggggttcc
      961 ttggtggtgt ctcctgggca atgctggtag ccagaacttg ccaactgtac ccaaacgcag
     1021 cagcttcaac cttagtccac aagttcttct tagttttctc caaatgggaa tggccaaatc
     1081 ctgtgctgct gaagcaacca gaagaaagca acttgaattt gcctgtctgg gacccgcggg
     1141 taaatccatc agacaggtat catcttatgc caataattac ccctgcctac ccacaacaga
     1201 attctacgta taatgtgtct acatcaactc gaacagtaat ggtagaagaa tttaaacaag
     1261 gtcttgcagt tacagatgaa attcttcaag ggaaatcaga ttggtccaaa ctattagaac
     1321 caccaaattt ctttcaaaaa tacagacatt atatagtgct gactgccagt gcatcgacag
     1381 aggagaatca tctggaatgg gttggattag tagaatctaa aatccgtgta cttgttggaa
     1441 acttggaacg gaatgaattt attactctcg cccatgtgaa tccccagtca ttcccaggaa
     1501 ataaggaaca tcataaagcc aacaattacg tatcaatgtg gttcctcggg ataatttttc
     1561 ggagagtaga aaatgcagaa agtgttaaca tagacttgac atatgatata cagtcattta
     1621 ctgacacagt gtacaggcag gcgaacaaca tcaatatgct gaaggacggg atgaagattg
     1681 aggccactca cgtaaagaaa aaacagcttc accattacct acccgcggag attcttcaga
     1741 agaagaaaaa gagtctttct gatgtgagtc ggagttcagg gggccttcag tccaaaagat
     1801 cgtctctgga tagcaattgt ctggacagct cccgagacac tgacagtgga actcccttta
     1861 attctcccgg gtctgcacat aaaccttcca acccagacag ccccacagga gacgcagaga
     1921 ggagtaacgc ggagcccatg gctgtgattg tggagaagct gccaagtgtt ccccccgcgc
     1981 aggggctgtc cattccagtc attggtgcaa agggtgacgc tgcagtcaaa gccgtgtcct
     2041 ccccagccgt gtgcaccatt cctactgtag taggacggag cgtcattcct agagtcacta
     2101 caccccacaa ccctgtccag ggacaaccac atctaaatgg gatatcaaat attactaaga
     2161 atgttacacc caaaagatcc cactcaccac ctacagatgg gactgctaag aggttgaaag
     2221 acatagaaaa gttcattcga cttgagtcag catttaagga gtcccgtgct gccgaggaca
     2281 ggaaaagaaa gccaatggat gcgattggtg gagaatctat gcccattcca actattgata
     2341 catcacgcaa aaagcgacta cccagtaaag aactgccaga ctcatcatct ccagttccag
     2401 caagcaacat ccgagtcatc aagaactcca tccgcctgac ccttaatcgg taatagcagt
     2461 gccacttccc tgaggtgagc atgcggtcat gaggtgcacc gagggcagcc agtcttcaac
     2521 ggagagccag ctgccgtgca gataggtggc ggggacagtc gtcagcctac tcacctcgga
     2581 gtgaggtgac ggagctgctc tcactgattg ctgggcacac tgaggacacc tgctagtgaa
     2641 cgtcacctac aatattatgg ctttgcattt tgaggtttta ctgccttaac ttttgatgtt
     2701 tgtttctgtt atgggaacca gttcttggcc acttggactc tgataaaaac aagtcctgaa
     2761 ctgtttggtt tttttttttc tttttttttt tttttaagtc ttgtgttgta atcattgtat
     2821 agaactgaaa aagttaaaac caaaaaaaaa aaaaaaaaaa aaaaaacccg tcttgtaatt
     2881 ttctaaatgt ttgtgtgttt actttagcat tgaagccact ttgtgaagct cgaggttggt
     2941 gaatgtgagg tgtctcttct gctcctttgt ttgtgtagat gtctattttg tttatttaaa
     3001 ttattttttc caaactggca catcaatatt taaactattt tttgtgcttt tgtccagatg
     3061 ttgcatagtt accgggaggc ttagtccagt gacgacacag gaactgggca ccgtaaatgt
     3121 tttgcctccc atggaggcct tcaaaatgca tctttattaa aaatcaaacc aaccaggata
     3181 ctgaaagtca gtatatgaat ggtgaaattg ttacatatcg tactatctca tgacattctt
     3241 gttagttgat tgtcttttct acagaggaag aattcattcc accatcaatg ataagatccc
     3301 ttcaagtata gcagacttgt atttttgaag tataaaagta actcagcatg acagcccctc
     3361 accataattc ccacagttgc caacagtttc ttcatggatt aggcatgcag aaataagcag
     3421 tggatttcat ggaaacctca aggcattttt tggatgacat tgttaccaac cgttaattgg
     3481 ctcaggacct ttgtagtttt tatttaacta tatgagttgt ctttttttac actgcttttt
     3541 tcagtgcatt tcttaatatt tttttaagtt tcatgaatgc atgctcagtt tattaaaaat
     3601 ccacaaccat gtaatcttgt aatctgttga ctccgtgttt tgtaaatgaa gtcgtatgta
     3661 ttttcagagt atttttgtat gtactgtaag atatcatctt ttcaaagaga aactttaaaa
     3721 ccttt
//
