LOCUS       NM_001012020            2349 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus poly(A) polymerase beta (Papolb), mRNA.
ACCESSION   NM_001012020 XM_221938
VERSION     NM_001012020.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Gruber AR, Martin G, Keller W and Zavolan M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Choi HS, Lee SH, Kim H and Lee Y.
  TITLE     Germ cell-specific gene 1 targets testis-specific poly(A)
            polymerase to the endoplasmic reticulum through protein-protein
            interactions
  JOURNAL   FEBS Lett 582 (8), 1203-1209 (2008)
   PUBMED   18325338
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Lee YJ, Lee Y and Chung JH.
  TITLE     An intronless gene encoding a poly(A) polymerase is specifically
            expressed in testis
  JOURNAL   FEBS Lett 487 (2), 287-292 (2000)
   PUBMED   11150526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079046.1 and CR458765.1.
            
            On Oct 19, 2005 this sequence version replaced NM_001012020.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC079046.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2344              BC079046.1         1-2344
            2345-2349           CR458765.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2349
                     /gene="Papolb"
                     /note="poly(A) polymerase beta"
                     /db_xref="GeneID:304300"
                     /db_xref="RGD:1310946"
     exon            1..2347
                     /gene="Papolb"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2131
                     /gene="Papolb"
                     /EC_number="2.7.7.19"
                     /note="poly (A) polymerase beta (testis specific)"
                     /codon_start=1
                     /product="poly(A) polymerase beta"
                     /protein_id="NP_001012020.1"
                     /db_xref="GeneID:304300"
                     /db_xref="RGD:1310946"
                     /translation="MMPFAVTTQGAQQPAPAPKQYGISSPISLAAPKDTDRELTQKLI
                     ETLQPFGVFEEEEELQRRILILQKLNNLVKEWIREISESRNLPQAVIENVGGKIFTFG
                     SYRLGVHTKGADIDALCVAPRHVDRNDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKL
                     CFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNI
                     DSFRLTLRAIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVRKFFLV
                     FSEWEWPNPVLLKEPEERNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVST
                     RMVMIEEFKQGLAITHEILLNKAEWSKLFEAPSFFQKYKHYIVLLASAPTEKQHLEWV
                     GLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENVDKEEFRTMWVIGLVLKKPENS
                     EILSIDLTYDIQSFTDTVYRQAINSKMFEMDMKIAAMHLRRKELHQLLPNHVLQKKET
                     HLTEGVRLTAVNDSSLLLSIDSENSMTAPSPTGTIKTGPLTANPQGRNSPALAVMAAS
                     VTNIQFPDVSLQHVNPIESSGIALSESIAQIPSQPTISPPPKPTMTRVVSSTHLVNHP
                     SRPSGNTATNIPNPILGV"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Papolb"
     polyA_site      2347
                     /gene="Papolb"
ORIGIN      
        1 cgcgaccgct gaggagcccg gcgccatgtt ggcccggagg ggtaccaggg gaagcgcttg
       61 aggcggcggg ctcggagcgg agcgggggcc gacagggccg gccggcagga gcccgcccct
      121 cgcgccttcg gatcatgagc cgagcagagg ccaccgaggt agcggtggcg gggcaggtgc
      181 cctggcggcg cgggagctag agatgatgcc atttgcggtg accacccaag gagcacaaca
      241 accggctccc gccccgaagc agtacggcat atcgtccccc atcagcctgg ccgcccccaa
      301 ggacacagac cgcgaactca cccagaagct gatcgagacc ctccagccct tcggggtgtt
      361 tgaagaggaa gaggaactgc agcgcaggat tttaattttg cagaaattaa ataatctggt
      421 gaaggaatgg atccgagaaa tcagtgaaag caggaatctt ccacaagctg taattgagaa
      481 tgttgggggg aaaattttta cgttcggctc ttaccgacta ggagtacaca cgaaaggtgc
      541 agatatcgat gcgttgtgcg ttgcaccaag acacgtggat cgaaatgact ttttcacctc
      601 cttctatgac aaattgaaac tacaggagga agtaaaagat ttaagagcgg ttgaggaggc
      661 ctttgtgccg gttatcaaac tgtgttttga tggaatagag attgatattt tgtttgcaag
      721 attagcattg cagactattc cggaagattt ggacctacga gatgatagtc tgcttaaaaa
      781 tttagatatt aggtgcataa gaagccttaa tggttgccgg gtaactgatg aaattttaca
      841 cctagtacca aacattgaca gcttcaggtt aacactgaga gccatcaaat tatgggccaa
      901 atgccacaac atctattcca atatattggg tttccttgga ggtgtttcct gggctatgct
      961 ggtagcaaga acttgccagc tttatccaaa tgcaatagca tccactcttg tacgaaaatt
     1021 tttcttggta ttttctgagt gggaatggcc aaatccagtc ttgttaaaag aaccagaaga
     1081 acgaaatctt aacttgcctg tatgggaccc aagagtgaat cctagtgaca ggtaccatct
     1141 tatgcctata attacaccag catacccaca gcagaactcc acatacaatg tgtctgtgtc
     1201 aaccaggatg gtcatgattg aggagtttaa gcaagggctt gctatcacac atgaaattct
     1261 gctgaataag gcagaatggt ccaaactttt tgaagctcca agcttttttc agaaatataa
     1321 gcattatatt gtactactgg caagtgcacc aacagagaaa caacatttag agtgggtggg
     1381 cttggtggaa tcaaagatcc gaatcctggt tgggagcctg gaaaagaatg aattcattac
     1441 tctggcacat gtgaatcccc agtcatttcc agcacctaaa gaaaatgttg acaaagaaga
     1501 atttcgtact atgtgggtga ttgggttagt gttgaaaaag ccagaaaatt ctgaaattct
     1561 cagtattgat ctcacttatg atattcagtc tttcacagat acagtgtaca gacaagcaat
     1621 aaatagtaag atgtttgaga tggatatgaa gattgctgca atgcatctaa gaagaaagga
     1681 acttcatcag ctacttccaa atcatgttct tcagaaaaag gaaacacatt taacagaagg
     1741 tgtaagattg acagctgtga atgatagcag ccttctcttg tctatagaca gtgaaaacag
     1801 catgactgca ccttcaccta ctggcactat aaagacaggc ccactgactg caaaccctca
     1861 gggcagaaac agtcctgctc tggctgttat ggcagcatcc gtgaccaaca tacagtttcc
     1921 tgacgtttcc ttgcagcacg tgaaccccat agaaagttca gggattgcac tgagtgaaag
     1981 cattgctcag attccctcac agccgaccat ctcaccacca cctaagccta ccatgaccag
     2041 agttgtttct tcgacacatc tggtaaacca tccatctaga ccttcaggaa atacagcaac
     2101 aaacataccc aatcctatac taggagtcta gaagacattc tcacctgata agaaaggaac
     2161 aagaaaccca acagaaggga aggaaccaga tagacgagtc cagcttagac actactcaga
     2221 cagcagcttc tctgttggcc tctcaggaaa cacctgggaa cagataagcc cggtatccct
     2281 gtttttccta gagatcctat tcctttaatt gagagttcaa taaaacagat tgaatggata
     2341 gaaaccaaa
//
