LOCUS       NM_001108056            4047 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus poly (A) polymerase alpha (Papola), mRNA.
ACCESSION   NM_001108056 XM_001069675 XM_001069715 XM_001069753 XM_001069793
            XM_234508
VERSION     NM_001108056.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4047)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4047)
  AUTHORS   Kiefer,H., Mizutani,A., Iemura,S., Natsume,T., Ando,H., Kuroda,Y.
            and Mikoshiba,K.
  TITLE     Inositol 1,4,5-triphosphate receptor-binding protein released with
            inositol 1,4,5-triphosphate (IRBIT) associates with components of
            the mRNA 3' processing machinery in a phosphorylation-dependent
            manner and inhibits polyadenylation
  JOURNAL   J Biol Chem 284 (16), 10694-10705 (2009)
   PUBMED   19224921
REFERENCE   3  (bases 1 to 4047)
  AUTHORS   Lee,S.H., Choi,H.S., Kim,H. and Lee,Y.
  TITLE     ERK is a novel regulatory kinase for poly(A) polymerase
  JOURNAL   Nucleic Acids Res 36 (3), 803-813 (2008)
   PUBMED   18084034
REFERENCE   4  (bases 1 to 4047)
  AUTHORS   Murthy,K.G. and Manley,J.L.
  TITLE     The 160-kD subunit of human cleavage-polyadenylation specificity
            factor coordinates pre-mRNA 3'-end formation
  JOURNAL   Genes Dev 9 (21), 2672-2683 (1995)
   PUBMED   7590244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jul 21, 2011 this sequence version replaced NM_001108056.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083612.1, SRR26643296.18505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               JAXUCZ010000006.1  130446801-130447013
            214-387             JAXUCZ010000006.1  130459310-130459483
            388-454             JAXUCZ010000006.1  130460607-130460673
            455-536             JAXUCZ010000006.1  130465546-130465627
            537-646             JAXUCZ010000006.1  130467424-130467533
            647-700             JAXUCZ010000006.1  130468127-130468180
            701-812             JAXUCZ010000006.1  130469305-130469416
            813-902             JAXUCZ010000006.1  130470086-130470175
            903-1041            JAXUCZ010000006.1  130470267-130470405
            1042-1114           JAXUCZ010000006.1  130471871-130471943
            1115-1235           JAXUCZ010000006.1  130473161-130473281
            1236-1320           JAXUCZ010000006.1  130474122-130474206
            1321-1374           JAXUCZ010000006.1  130479196-130479249
            1375-1494           JAXUCZ010000006.1  130479725-130479844
            1495-1604           JAXUCZ010000006.1  130481433-130481542
            1605-1726           JAXUCZ010000006.1  130484565-130484686
            1727-1869           JAXUCZ010000006.1  130487169-130487311
            1870-1970           JAXUCZ010000006.1  130488752-130488852
            1971-2191           JAXUCZ010000006.1  130489375-130489595
            2192-2254           JAXUCZ010000006.1  130493296-130493358
            2255-2329           JAXUCZ010000006.1  130494870-130494944
            2330-4047           JAXUCZ010000006.1  130497183-130498900
FEATURES             Location/Qualifiers
     source          1..4047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..4047
                     /gene="Papola"
                     /note="poly (A) polymerase alpha"
                     /db_xref="GeneID:314417"
                     /db_xref="RGD:1308673"
     exon            1..213
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2425
                     /gene="Papola"
                     /EC_number="2.7.7.19"
                     /codon_start=1
                     /product="poly(A) polymerase alpha"
                     /protein_id="NP_001101526.1"
                     /db_xref="GeneID:314417"
                     /db_xref="RGD:1308673"
                     /translation="MPFPVTTQGSQQTQPPQRHYGITSPISLAAPKETDCLLTQKLIE
                     TLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGS
                     YRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLC
                     FDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNID
                     NFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVF
                     SKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTR
                     MVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVG
                     LVESKIRILVGSLEKNEFITLAHVNPQSFPAPKESPDREEFRTMWVIGLVFKKTENSE
                     NLSVDLTYDIQSFTDTVYRQAINSKMFELDMKIAAMHVKRKQLHQLLPSHVLQKRKKH
                     STEGVKLAALNDSSLDLSMDSDNSMSVPSPTSAMKTSPLNSSGSSQGRNSPAPAVTAA
                     SVTSIQASEVSVPQANSSESPGGPSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNP
                     SPRPSGNAATKVPNPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTET
                     KEQVGMETSAAPSEAAPASASLVASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR"
     exon            214..387
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            388..454
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            455..536
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            537..646
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            647..700
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            701..812
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            813..902
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1041
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1114
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1235
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1320
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1374
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1494
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1604
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1726
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1869
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1970
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2191
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2254
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2329
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..4047
                     /gene="Papola"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagaacgttg ctgtggtagc gctcgggcgc catgttagga cgaaggggaa ggaggagaag
       61 cgcttaaagc ggcggggcgc gggtgcagga ctgggttggc cctggggctg aggcaggccg
      121 ccgtccctcc cgcctcggtg gatcatgccc agggcggcag cggtcgcggg ggggaagtga
      181 ctgggcggtg ccggcgccgg agacgatgcc gtttccagtt acaacgcagg gatcacaaca
      241 aacgcagccg ccacagaggc actatggcat tacctctcct atcagcttag cagcccccaa
      301 ggagaccgac tgcctactca cacagaaact catcgagacg ctgaagccct ttggggtttt
      361 tgaagaagaa gaggaactgc agcgcaggat tttaattttg ggaaaattaa ataacctggt
      421 gaaagaatgg atacgagaaa tcagtgaaag caagaatctt ccacaatctg taattgaaaa
      481 tgttggagga aaaattttta catttggatc ctacagacta ggagtacata cgaaaggtgc
      541 tgatattgat gcgttgtgtg ttgcaccaag acatgttgat cgaagtgatt ttttcacctc
      601 attctatgat aaattgaaat tacaagaaga agtgaaagat ttaagagctg ttgaagaggc
      661 atttgtacca gttatcaaac tctgttttga tggaatagag attgatattt tgtttgcaag
      721 attagcactg cagactattc cagaagattt ggacctacga gatgacagtc tgcttaaaaa
      781 cctagatata agatgcataa gaagccttaa tggttgcagg gtaaccgatg agattttaca
      841 tctagtacca aacattgaca acttcaggtt aactctgaga gccatcaaac tgtgggccaa
      901 acggcacaac atctattcca atatattagg tttcctcggt ggtgtttcct gggctatgct
      961 agtagcaaga acttgccagc tttatccaaa tgcaatagca tcaactcttg tacataaatt
     1021 tttcttggta ttttctaaat gggaatggcc aaatccagtg ctattgaaac agcctgaaga
     1081 atgcaatctt aatttgcctg tgtgggaccc aagggtaaac cccagtgata ggtaccatct
     1141 tatgcctata attacaccag catacccaca acagaactcc acgtacaatg tgtccgtttc
     1201 aacacggatg gtcatggttg aggagtttaa acaaggtctt gctatcacag atgaaatttt
     1261 gctgagtaag gcagagtggt ccaaactttt tgaagctcca aacttctttc aaaagtacaa
     1321 gcattatatt gtacttctag caagtgcgcc cacggaaaag cagcgtctgg aatgggtggg
     1381 cttggtggaa tcaaaaattc gtatcctggt tggaagttta gagaagaatg agtttattac
     1441 actggctcat gtgaatcccc agtcatttcc agcccccaag gaaagtcctg atagggaaga
     1501 atttcgcaca atgtgggtga ttggtttagt gtttaaaaaa actgaaaact ctgagaatct
     1561 cagtgtggac ctcacctatg atatccagtc tttcacagac acagtttata ggcaagcaat
     1621 aaacagcaag atgtttgagt tggatatgaa gatcgcagca atgcatgtga agagaaagca
     1681 gctccaccag ctgctgccaa gtcatgtgct tcagaagagg aagaagcatt caacagaagg
     1741 agtcaagtta gcagctctga atgacagcag ccttgacttg tctatggaca gtgataacag
     1801 catgtctgtg ccttcaccca ccagtgctat gaagaccagt ccattgaaca gttctggcag
     1861 ctctcagggc agaaacagtc ctgctccagc tgtgaccgca gcatctgtga ccagcattca
     1921 ggcttctgag gtttctgtac cacaagcaaa ttccagtgaa agcccagggg gtccatcgag
     1981 cgaaagcatt cctcaaactg ccacacagcc agccatttct ccaccaccaa agcctacagt
     2041 ctccagagtt gtctcctcaa cacgactggt aaacccgtcg cctagacctt caggaaacgc
     2101 agcaacaaaa gtacctaatc ctatagtagg agtcaagaga acgtcctcac cccataaaga
     2161 agaaagtcct aagaaaacca aaacagaaga ggatgaaaca agtgaagatg ctaactgtct
     2221 tgctttgagt ggacatgata aaacagagac aaaggaacaa gttggcatgg agacaagtgc
     2281 ggctccgtca gaagctgctc cggcctcggc gtctctggtg gcctctcaga aaacatccag
     2341 tacagacctt tccgatatcc ctgctctccc tgcaaaccct attcctgtta tcaagaattc
     2401 aataaaactg agactgaatc ggtaaaacca cctcagggtc cataaacagt atctgccaac
     2461 tcaacccgtt gtctccagat gcttaaacaa aagaaagaaa gaaaaaagaa aggagaaagg
     2521 agattggagg gacaggacta gccctgactg actgggttta gtcttggtga cctcccttac
     2581 ttgggctcat cagcacttga tcagcagtcc aggttagtat ggaagccagg agtactgtta
     2641 ttattgtgtt agcaacagtt gcattaacta tttcagaaaa attactgcct ttaagaagga
     2701 aagaaaacaa aaccctcaag ctgcgtttgt atccataatt gacatccaga ttgggtttat
     2761 gtgtgatgat gcattgtttg gaaaattgca atacaaactg gcataagaac tccttattct
     2821 gatgatgcac ttttatgtat tttttttatt agaaagtaga actaatttta gattttcagc
     2881 ttaatggatt ttcaattttt ttcccaaaga attttcttta caattagtct ttaaattgga
     2941 ttccttgtgc agtggtgtac cattctgcct cagaaaggac agtaggacac ctagctcagt
     3001 ccttacgggc agctgtaacc cttagggtgc attgtcaatg ctaaggtata ctttggacac
     3061 tgaaagaaga attaggcgat acttggtttt gatgaggtta tgattaagaa gtatatattc
     3121 cttttattta tagagttgtt ttatagtgca tacaaatcag cagtcagcca acaagtgtgg
     3181 tctttgagct ttctcaagct ctgttctttt gccttcagtc tgttagtctt tgaaacaacg
     3241 acagtgcttt ctccccatcc cccttttttc ttttgcctgt ttttcccttt tgcttgaatg
     3301 cacaaggtaa ggcttatttc acagaaacca gaatgccagt attttcctaa gccatgacat
     3361 gtaaccgtga cctgtggcta cgtgacacag aacactaacg ttggtcccat ggctagaact
     3421 tgagaatgac tgaaagccat acccgtgaag catctccgga ggatggccat ttgatctctg
     3481 agaggacttt tgtacactcc acagaactcc tgttcctgtc ttacacaaag ttgattttca
     3541 attttaaaag tgggcaaaaa ggcattttct tccagatttt taaactaatt tttattttta
     3601 accagtttat caaaatttgt cagtgaattt tacatacaga aacattttaa aaatcattcc
     3661 tagtaagcac ttgacgttta gtcagctctc cacttttgaa tttttttgtt ctatcaaaaa
     3721 ttagaaactt cctttaaaga caatgatttc tcataattaa gtagcagaat tctcgtccat
     3781 cttgtgacgt gtgaggacgc cagaggttga taaggttcct cttgtcgatc tgggtagagc
     3841 aggcctgtag cagcagatct ttgtatgagc atggtttcca atccttcatc tcgctgcatt
     3901 ctatcacaca tttgtgcatt ttcacgtaac actgcaatta aactctcctg tcctcctaaa
     3961 ttaatttcca aagttggagt atagtctttc ccttcagctg tgcattaatt aaggctttct
     4021 ttaccactta cattgtttat atacagt
//
