LOCUS       NM_001398772            1742 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus polyamine oxidase (Paox), mRNA.
ACCESSION   NM_001398772 XM_006230524
VERSION     NM_001398772.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Wang,K., Huang,Q., Zhao,G., Yang,J., Yang,K. and Huang,Y.
  TITLE     Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175
            affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese
            Han non-small-cell lung cancer patients
  JOURNAL   J Cell Biochem 120 (9), 14804-14812 (2019)
   PUBMED   31016788
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Gudkova,O.O., Latyshko,N.V. and Shandrenko,S.G.
  TITLE     Amine oxidases as important agents of pathological processes of
            rhabdomyolysis in rats
  JOURNAL   Ukr Biochem J 88 (1), 79-87 (2016)
   PUBMED   29227084
  REMARK    GeneRIF: Amine oxidases are important mediators of pathological
            processes of rhabdomyolysis in rats.
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Bjelakovic,G., Pavlovic,D., Kocic,G., Stojanovic,I.,
            Jevtovic-Stoimenov,T., Nikolic,J., Sokolovic,D. and Basic,J.
  TITLE     Dexamethasone decreases the spermidine and spermine concentrations
            and polyamine oxidase activity in rat thymus
  JOURNAL   J Basic Clin Physiol Pharmacol 24 (1), 67-72 (2013)
   PUBMED   23425626
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Jarvinen,A., Keinanen,T.A., Grigorenko,N.A., Khomutov,A.R.,
            Uimari,A., Vepsalainen,J., Narvanen,A., Alhonen,L. and Janne,J.
  TITLE     Guide molecule-driven stereospecific degradation of
            alpha-methylpolyamines by polyamine oxidase
  JOURNAL   J Biol Chem 281 (8), 4589-4595 (2006)
   PUBMED   16354669
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Wallace,H.M., Fraser,A.V. and Hughes,A.
  TITLE     A perspective of polyamine metabolism
  JOURNAL   Biochem J 376 (Pt 1), 1-14 (2003)
   PUBMED   13678416
  REMARK    Review article
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Wu,T., Yankovskaya,V. and McIntire,W.S.
  TITLE     Cloning, sequencing, and heterologous expression of the murine
            peroxisomal flavoprotein, N1-acetylated polyamine oxidase
  JOURNAL   J Biol Chem 278 (23), 20514-20525 (2003)
   PUBMED   12660232
REFERENCE   8  (bases 1 to 1742)
  AUTHORS   Vujcic,S., Liang,P., Diegelman,P., Kramer,D.L. and Porter,C.W.
  TITLE     Genomic identification and biochemical characterization of the
            mammalian polyamine oxidase involved in polyamine back-conversion
  JOURNAL   Biochem J 370 (Pt 1), 19-28 (2003)
   PUBMED   12477380
REFERENCE   9  (bases 1 to 1742)
  AUTHORS   Cattaruzza,M., Schafer,K. and Hecker,M.
  TITLE     Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes
            smooth muscle cell proliferation
  JOURNAL   J Biol Chem 277 (8), 6582-6589 (2002)
   PUBMED   11748220
REFERENCE   10 (bases 1 to 1742)
  AUTHORS   Van den Munckhof,R.J., Denyn,M., Tigchelaar-Gutter,W.,
            Schipper,R.G., Verhofstad,A.A., Van Noorden,C.J. and Frederiks,W.M.
  TITLE     In situ substrate specificity and ultrastructural localization of
            polyamine oxidase activity in unfixed rat tissues
  JOURNAL   J Histochem Cytochem 43 (11), 1155-1162 (1995)
   PUBMED   7560898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006230524.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.4953.1,
                                           SRR26360194.884283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000001.1  204349326-204349525
            201-687             JAXUCZ010000001.1  204349937-204350423
            688-887             JAXUCZ010000001.1  204351128-204351327
            888-1140            JAXUCZ010000001.1  204352812-204353064
            1141-1253           JAXUCZ010000001.1  204355585-204355697
            1254-1411           JAXUCZ010000001.1  204356492-204356649
            1412-1742           JAXUCZ010000001.1  204357810-204358140
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1742
                     /gene="Paox"
                     /note="polyamine oxidase"
                     /db_xref="GeneID:293589"
                     /db_xref="RGD:1561125"
     exon            1..200
                     /gene="Paox"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1555
                     /gene="Paox"
                     /EC_number="1.5.3.13"
                     /note="putative GTP-binding protein; polyamine oxidase
                     (exo-N4-amino); GTP-binding protein-like"
                     /codon_start=1
                     /product="peroxisomal N(1)-acetyl-spermine/spermidine
                     oxidase"
                     /protein_id="NP_001385701.1"
                     /db_xref="GeneID:293589"
                     /db_xref="RGD:1561125"
                     /translation="MAARGPRVLVVGGGIAGLGAVQRLCHHRAAPHLRVLEATACAGG
                     RIRSERCFGGVVELGAHWIHGPSQGNPVFQLAAEFGLLGEKELSEENQLVETGGHVAL
                     PSVSCTSSGTSVSLELVTEMGSLFYGLIDRTREFLNESETPMASVGEFLKKEISQQVA
                     NWTEDENTKRLKLAVLNTFFNIECCVSGTHSMDLVALAPFGEYTVLPGLDCTLSGGYQ
                     GLTNCILASLPKEVMVFDKPVKTIHWNGSFQEAAFPGETFPVLVECEDGARLPAHHVI
                     VTVPLGFLKEHQDTFFEPPLPAKKAEAIRKLGFGTNNKIFLEFEEPFWEPDCQFIQVV
                     WEDTSPLQDSPLSLQDTWFKKLIGFLVLPSFESSHVLCAFIAGLQSEFMETLSDEEVL
                     LSLTQVLRRVTGNPQLPAAKSVLRSRWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLPA
                     DGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREADRLIGLWDSQAEQSRPRL"
     exon            201..687
                     /gene="Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            688..887
                     /gene="Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1140
                     /gene="Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1253
                     /gene="Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1411
                     /gene="Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1742
                     /gene="Paox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcct acggccacgg gtcagaagta ctctgagcta gccatggctg cccgcggccc
       61 gcgggtgttg gtggtgggcg gcggcatcgc ggggttgggc gctgtgcaga ggctttgcca
      121 ccaccgggct gctccacacc tgcgggtcct ggaggctacc gcctgcgccg ggggccgcat
      181 ccgttcagaa cgctgcttcg gtggtgtagt ggagctgggt gcacactgga tccatgggcc
      241 ctcccagggc aatcctgtct tccagctggc tgcggagttc gggctcctgg gggagaaaga
      301 attatcggaa gagaaccagc tggtggagac aggagggcac gtggccctac cctccgtgag
      361 ctgtaccagt tctggaacaa gtgtgagcct ggagctggtg acagagatgg gcagtttgtt
      421 ctatggactg atagaccgga cccgagaatt cctgaatgaa tcggagaccc caatggccag
      481 tgttggcgag ttcttgaaga aggagataag tcagcaggtg gctaattgga ctgaggatga
      541 gaacaccaaa aggctcaagc tggctgtcct gaataccttc ttcaacatag agtgttgtgt
      601 gagcggtacc cacagcatgg acctggtggc ccttgcaccg ttcggggagt acacagtatt
      661 gccggggctg gattgcacct tgtctggcgg ctaccaagga cttaccaact gcatactggc
      721 ttccttgccc aaggaggtga tggtttttga caagccagtg aagaccattc actggaatgg
      781 gtccttccag gaagctgctt ttccagggga gaccttcccc gtgttggtag agtgtgaaga
      841 tggtgcccgc ctgcctgcgc atcatgtcat cgtcacggtg ccattaggtt ttcttaaaga
      901 acatcaagat accttctttg agccaccact gcctgccaaa aaggcagaag ccatcagaaa
      961 actaggcttt ggtaccaaca acaaaatctt cttggagttc gaggagcctt tctgggagcc
     1021 tgactgccag ttcatccagg tggtgtggga agatacatca cccctacagg actcgcccct
     1081 ctcactccaa gacacctggt tcaagaagct cattggattt ttggtcctgc cttcttttga
     1141 gtcttcacat gtgctctgtg catttattgc tgggctccag tcggagttta tggagactct
     1201 gtcagatgaa gaagtgcttc tgtctctaac ccaagtactc cggagggtga caggaaaccc
     1261 acaattgcca gcagccaaga gcgtgctgag gtctcgatgg cacagtgccc catacacccg
     1321 agggtcctac agctatgtgg ctgtgggcag cactggcgat gacctagatc tgatggctca
     1381 gcctctccca gcagatggaa ctggcaccca gctccaggta ctctttgctg gggaagccac
     1441 acatcggaca ttttattcta ccacacacgg agccctcctg tctggctgga gggaagctga
     1501 tcgcctcatt ggtctgtggg actcacaggc ggagcagtcc cggcccaggc tgtgagtgcc
     1561 tgctgctctg ctctaccact cgggctgacc aagctctcag tctggtttga ggtttgggga
     1621 tcttactggt agctttaatt ttgggaaagt ggccttgttt cacatatctg ttggagtctg
     1681 gcttggtctg accattgatg ccctgctaac tgttgtacac ataaagcaat taacactgcc
     1741 tg
//
