LOCUS       NM_199398               2489 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus pannexin 3 (Panx3), mRNA.
ACCESSION   NM_199398 XM_236034
VERSION     NM_199398.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2489)
  AUTHORS   Xiao,J., Li,Y., Zhang,J., Xu,G. and Zhang,J.
  TITLE     Pannexin 3 activates P2X7 receptor to mediate inflammation and
            cartilage matrix degradation in temporomandibular joint
            osteoarthritis
  JOURNAL   Cell Biol Int 47 (7), 1183-1197 (2023)
   PUBMED   37021698
  REMARK    GeneRIF: Pannexin 3 activates P2X7 receptor to mediate inflammation
            and cartilage matrix degradation in temporomandibular joint
            osteoarthritis.
REFERENCE   2  (bases 1 to 2489)
  AUTHORS   Li,S., Bjelobaba,I., Yan,Z., Kucka,M., Tomic,M. and
            Stojilkovic,S.S.
  TITLE     Expression and roles of pannexins in ATP release in the pituitary
            gland
  JOURNAL   Endocrinology 152 (6), 2342-2352 (2011)
   PUBMED   21467198
  REMARK    GeneRIF: Pituitary gland expresses mRNA and protein transcripts of
            pannexins 1 and 2 but not pannexin 3.
REFERENCE   3  (bases 1 to 2489)
  AUTHORS   Turmel,P., Dufresne,J., Hermo,L., Smith,C.E., Penuela,S.,
            Laird,D.W. and Cyr,D.G.
  TITLE     Characterization of pannexin1 and pannexin3 and their regulation by
            androgens in the male reproductive tract of the adult rat
  JOURNAL   Mol Reprod Dev 78 (2), 124-138 (2011)
   PUBMED   21337450
  REMARK    GeneRIF: In the testis, Panx1 localized to the basal compartment of
            the seminiferous epithelium, while Panx3 was expressed in Leydig
            cells. In the ED, both Panxs were expressed in the apical region of
            ciliated cells.
REFERENCE   4  (bases 1 to 2489)
  AUTHORS   Celetti,S.J., Cowan,K.N., Penuela,S., Shao,Q., Churko,J. and
            Laird,D.W.
  TITLE     Implications of pannexin 1 and pannexin 3 for keratinocyte
            differentiation
  JOURNAL   J Cell Sci 123 (Pt 8), 1363-1372 (2010)
   PUBMED   20332104
  REMARK    GeneRIF: Panx1 and Panx3 are coexpressed in the mammalian
            epidermis, and the regulation of Panx1 plays a key role in
            keratinocyte differentiation.
REFERENCE   5  (bases 1 to 2489)
  AUTHORS   Bhalla-Gehi,R., Penuela,S., Churko,J.M., Shao,Q. and Laird,D.W.
  TITLE     Pannexin1 and pannexin3 delivery, cell surface dynamics, and
            cytoskeletal interactions
  JOURNAL   J Biol Chem 285 (12), 9147-9160 (2010)
   PUBMED   20086016
  REMARK    GeneRIF: although Panx1 and Panx3 share a common endoplasmic
            reticulum to Golgi secretory pathway to Cx43, their ultimate cell
            surface residency appears to be independent of cell contacts and
            the need for intact microtubules
REFERENCE   6  (bases 1 to 2489)
  AUTHORS   Wang,X.H., Streeter,M., Liu,Y.P. and Zhao,H.B.
  TITLE     Identification and characterization of pannexin expression in the
            mammalian cochlea
  JOURNAL   J Comp Neurol 512 (3), 336-346 (2009)
   PUBMED   19009624
  REMARK    GeneRIF: Results show that pannexins 1, 2, and 3 are abundantly
            expressed in the mouse and rat cochlea and demonstrate distinct
            cellular distributions.
            Erratum:[J Comp Neurol. 2010 Apr 1;518(7):1156. Dosage error in
            article text]
REFERENCE   7  (bases 1 to 2489)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 3, 2020 this sequence version replaced NM_199398.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ557017.1, SRR21887622.695159.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050766, SAMN17050767
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               JAXUCZ010000008.1  45565895-45566378   c
            485-627             JAXUCZ010000008.1  45563471-45563613   c
            628-842             JAXUCZ010000008.1  45559303-45559517   c
            843-2489            JAXUCZ010000008.1  45555501-45557147   c
FEATURES             Location/Qualifiers
     source          1..2489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2489
                     /gene="Panx3"
                     /note="pannexin 3"
                     /db_xref="GeneID:315567"
                     /db_xref="RGD:735137"
     exon            1..484
                     /gene="Panx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1482
                     /gene="Panx3"
                     /codon_start=1
                     /product="pannexin-3"
                     /protein_id="NP_955430.1"
                     /db_xref="GeneID:315567"
                     /db_xref="RGD:735137"
                     /translation="MSLAHTAAEYMLSDALLPDRRGSRLKGLRLELPLDKMVKFVTVG
                     FPLLLMSLAFAQEFSSGSPISCFSPSNFSVRQAVFVDSSCWDSLAHYKQDEAGQYTVK
                     SLWPHKALPYSLLALAVAMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQH
                     MLKIRQKSSDPHVFWDELEKARKERYFEFPLLERYLACKQRSHWLVATYLLRNALLLL
                     FTSATYLYLGHFHLDVFFQEEFSCSIKTGLLHEETHVPELITCRLTSLSVFQIVSVSS
                     VAIYTVLVPVIIYNLTRLCRWDKRLLSIYEMLPAFDLLSRKMLGCPINDLNVILLFLR
                     ANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTQHTYDEHP
                     "
     exon            485..627
                     /gene="Panx3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..842
                     /gene="Panx3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..2489
                     /gene="Panx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccacagt gcttcgtctg ttgggagaca atctaggcaa gcaccctggc accagacaca
       61 agtaaagcct gaccctcctc cagtaaagac ccatcaaggc tatgccctcc tctaattgcc
      121 agggcgtctg gcttagagcc tgggcaatta tgtagagaac cactgcctgg tactagcaca
      181 gatctgtgag gctggtgctg cgacatagct gcctgaagct gtcacatcac cccactgtac
      241 ctagattgct aagagtagca gtgtcctctg tattccccca aagcccccat actcagcagc
      301 atcatgtcac tcgcacacac agcggcagag tacatgctct ccgatgccct gctgcctgac
      361 cgcaggggct ctcggctcaa agggctgcgt ctggaactgc cgctggataa gatggtcaag
      421 ttcgttactg tgggctttcc cttgctgctg atgtctctgg ctttcgccca ggagttctca
      481 tcagggtctc cgatcagctg cttctctccc agcaacttca gtgtcagaca ggctgtgttt
      541 gtggacagct cctgctggga ctcactggct cactataaac aggatgaggc tggacagtac
      601 acggtgaaat ctctctggcc tcacaaggct ctcccctact ctctactggc cctggctgtg
      661 gccatgtatc tgccagtgct gctctggcaa tatgcagctg tgccagccct cagctcagac
      721 ctgttattca tcatcagtga gctggacaag tcttacaacc gctccatccg cctggtacag
      781 cacatgctga agatccggca gaagagctct gaccctcatg tcttctggga tgagctagag
      841 aaggcccgga aggaacggta ctttgaattt cccttgctag agcggtacct ggcatgcaag
      901 cagcgctccc attggctagt ggccacctac ctcctgagga acgccctttt actcctcttc
      961 acctcagcca cttacctgta ccttggccac ttccatttag acgtcttctt tcaggaagaa
     1021 ttcagctgct ccatcaagac aggcctactc catgaggaga cccacgtgcc agagctgatc
     1081 acatgcaggc tgacctccct gtctgtattc cagattgtga gtgtctccag tgtagcaata
     1141 tacaccgtac tggtcccagt gataatatac aacctcacgc ggctgtgccg gtgggacaaa
     1201 cgactcctct ccatctacga gatgctccca gcttttgatc tcctcagtag aaagatgcta
     1261 gggtgcccca tcaatgacct caatgtgatc cttcttttcc tccgagctaa tatctctgag
     1321 ctcatctctt ttagctggct gagtgtctta tgtgtgttga aggatacaac cacccagaaa
     1381 cacaacattg acacagtggt cgattttatg accttattgg ctggcttaga accctcaaaa
     1441 cctaaacatc tcacccaaca tacgtatgat gaacacccat agtttaaaaa aaaaagaggc
     1501 ataagagata agttttatag aaagtaagtc tccttcttca caagctatgt agagtaaaag
     1561 aaaaataata atgatgtctg cattaaattg ttaagattag acttaactga aatatcctgt
     1621 atttataaga agataaaaat caatgcatgg aagttcaagg tgaagtctga aagtgaagag
     1681 tcaaagagct gaaaaatcag tctagagaat tctgaggaca gtaaacgcta aacgatcaag
     1741 ttgaagcaaa gtgcaaacat tgaacacaga acaattctga aggccattta tggaaggaaa
     1801 ttctcacaag acccacccac tctagaagtc atgcttgcct ctgcacaatg ggcaggcaga
     1861 gcaacttagt aagagattaa taaggatatg accccctgaa acactttgat ttggcctgcc
     1921 catcctgctt tgtggacatt ttcagccttg ccaagcaccc catggcctgc taatgagaca
     1981 agaaatagtg atggctttaa cttgtaatct gctcttggaa cataggacag aggcaaaggc
     2041 cacgagttga ctctgtaagt cagttacgtt ttttatgata ttaactgagg attcttttcc
     2101 atgagggctc atattatagc ctatgaagcc cttctaaagt cttaatgagt ctaggtatgt
     2161 tcttaatagt ccaagggata ctacacgttc actgacagcc aactagtgaa ggccagtggg
     2221 ttagacctga tttcaatgcc tgggacccaa atggtgaaaa gggagaactg attctccaag
     2281 gctagcccct gatcgccata tacaaaacaa agtaaacaaa taaaaaagta ttaagcaaga
     2341 tgaacgtgaa agtcatattg atccacttct gtaattcacc gttcacggct ccctccttgc
     2401 atctaactgt caaagctttg ctctgattca aaagacagtg ctctaccccc aataccatgg
     2461 tgactcttaa taaatatttt taaactata
//
