LOCUS       NM_199409               3376 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus pannexin 2 (Panx2), mRNA.
ACCESSION   NM_199409 XM_343309
VERSION     NM_199409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3376)
  AUTHORS   Liu,J., Liu,W., Li,H., Deng,Q., Yang,M., Li,X. and Liang,Z.
  TITLE     Identification of key genes and pathways associated with
            cholangiocarcinoma development based on weighted gene correlation
            network analysis
  JOURNAL   PeerJ 7, e7968 (2019)
   PUBMED   31687280
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3376)
  AUTHORS   Berchtold,L.A., Miani,M., Diep,T.A., Madsen,A.N., Cigliola,V.,
            Colli,M., Krivokapic,J.M., Pociot,F., Eizirik,D.L., Meda,P.,
            Holst,B., Billestrup,N. and Storling,J.
  TITLE     Pannexin-2-deficiency sensitizes pancreatic beta-cells to
            cytokine-induced apoptosis in vitro and impairs glucose tolerance
            in vivo
  JOURNAL   Mol Cell Endocrinol 448, 108-121 (2017)
   PUBMED   28390953
  REMARK    GeneRIF: Panx2 is an important regulator of the insulin secretory
            capacity and apoptosis in pancreatic beta-cells.
REFERENCE   3  (bases 1 to 3376)
  AUTHORS   Burns,A.R., Phillips,S.C. and Sokoya,E.M.
  TITLE     Pannexin protein expression in the rat middle cerebral artery
  JOURNAL   J Vasc Res 49 (2), 101-110 (2012)
   PUBMED   22301733
  REMARK    GeneRIF: pannexin 2 is expressed in both endothelium and smooth
            muscle of middle cerebral arteries.
REFERENCE   4  (bases 1 to 3376)
  AUTHORS   Bargiotas,P., Krenz,A., Hormuzdi,S.G., Ridder,D.A., Herb,A.,
            Barakat,W., Penuela,S., von Engelhardt,J., Monyer,H. and
            Schwaninger,M.
  TITLE     Pannexins in ischemia-induced neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 108 (51), 20772-20777 (2011)
   PUBMED   22147915
REFERENCE   5  (bases 1 to 3376)
  AUTHORS   Li,S., Bjelobaba,I., Yan,Z., Kucka,M., Tomic,M. and
            Stojilkovic,S.S.
  TITLE     Expression and roles of pannexins in ATP release in the pituitary
            gland
  JOURNAL   Endocrinology 152 (6), 2342-2352 (2011)
   PUBMED   21467198
  REMARK    GeneRIF: Overexpression of pannexins 1 and 2 in pituitary cells
            enhanced the release of ATP.
REFERENCE   6  (bases 1 to 3376)
  AUTHORS   Wang,X.H., Streeter,M., Liu,Y.P. and Zhao,H.B.
  TITLE     Identification and characterization of pannexin expression in the
            mammalian cochlea
  JOURNAL   J Comp Neurol 512 (3), 336-346 (2009)
   PUBMED   19009624
  REMARK    GeneRIF: Results show that pannexins 1, 2, and 3 are abundantly
            expressed in the mouse and rat cochlea and demonstrate distinct
            cellular distributions.
            Erratum:[J Comp Neurol. 2010 Apr 1;518(7):1156. Dosage error in
            article text]
REFERENCE   7  (bases 1 to 3376)
  AUTHORS   Zappala,A., Li Volti,G., Serapide,M.F., Pellitteri,R., Falchi,M.,
            La Delia,F., Cicirata,V. and Cicirata,F.
  TITLE     Expression of pannexin2 protein in healthy and ischemized brain of
            adult rats
  JOURNAL   Neuroscience 148 (3), 653-667 (2007)
   PUBMED   17692470
  REMARK    GeneRIF: We noted the expression of Px2 in astrocytes of reactive
            gliosis in the hippocampus after I/R injury.  Px2 mediates the
            formation of hemichannels for the release of signaling molecules
            devoted to influence the cellular metabolism .
REFERENCE   8  (bases 1 to 3376)
  AUTHORS   Dvoriantchikova,G., Ivanov,D., Panchin,Y. and Shestopalov,V.I.
  TITLE     Expression of pannexin family of proteins in the retina
  JOURNAL   FEBS Lett 580 (9), 2178-2182 (2006)
   PUBMED   16616526
  REMARK    GeneRIF: Panx1 and Panx2 are abundantly expressed in the retina,
            and may therefore contribute to the electrical and metabolic
            coupling, or to signaling between retinal neurons
REFERENCE   9  (bases 1 to 3376)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   10 (bases 1 to 3376)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
  REMARK    GeneRIF: the different expression patterns of pannexin 1 (Panx1)
            and pannexin 2 (Panx2) in the brain indicate that pannexins form
            cell type-specific gap junctions with distinct properties that may
            subserve different functions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ557016.1, BC112319.1 and BQ204587.1.
            
            On Dec 21, 2007 this sequence version replaced NM_199409.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               AJ557016.1         1-508
            509-509             BC112319.1         391-391
            510-2894            AJ557016.1         510-2894
            2895-3376           BQ204587.1         1-482               c
FEATURES             Location/Qualifiers
     source          1..3376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3376
                     /gene="Panx2"
                     /note="pannexin 2"
                     /db_xref="GeneID:362979"
                     /db_xref="RGD:735191"
     exon            1..549
                     /gene="Panx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..2348
                     /gene="Panx2"
                     /codon_start=1
                     /product="pannexin-2"
                     /protein_id="NP_955441.2"
                     /db_xref="GeneID:362979"
                     /db_xref="RGD:735191"
                     /translation="MHHLLEQSADMATALLAGEKLRELILPGSQDDKAGALAALLLQL
                     KLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE
                     LRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQE
                     IDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRG
                     RSNFLAKLYLARHVLILLLSVVPISYLCTYYATQKQNEFTCALGASPDGPVGSAGPTV
                     RVSCKLPSVQLQRIIAGVDIVLLCFMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTR
                     RQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNH
                     DTTPTVRDSGIQTVDPSINPAEPEGSAEPPVVKRPRKKMKWIPTSNPLPQPFKEQLAI
                     MRVENSKTEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGSGGDTGPSSAPPAASEKK
                     HTRHFSLDVHPYILGSKKAKTEAVPPALPASRSQEGGFLSQTEECGLGLAAAPTKDAP
                     LPEKEIPYPTESALPSGGPFHVCSPPTASAAASLSPSSLGKADPLTILSRNATHPLLH
                     ISTLYEAREEEEGGPCAPSDMGDLLSIPPPQQILIATFEEPRTVVSTVEF"
     exon            550..2013
                     /gene="Panx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..3360
                     /gene="Panx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtaaacagc ccccctccca ggcgggagcg ggccgcgcgg cccaggcagg atagccgccg
       61 ccgcccccgg gagggacgca gggcgcgggc cagctacagc gcacggcggg ggcggcggcg
      121 gcccggcgcc ctggcagctc gacccctctc gcggggcggc agacccccga gccccgccgc
      181 atccccgctg acatccctct tccagcgccc tgcgccccgc gcccccgtga cctcggtctc
      241 cgtcgccccc cgccgccctc tctggcgcgc ggccccgccc gcgccccccg cccgtacccc
      301 gccgggccgc gcccccgccc cccatgcacc acctcctgga gcagtcggcg gacatggcga
      361 ccgcgctgct ggcgggcgag aagctgaggg agctgatcct gcctggctcg caggacgaca
      421 aggcgggtgc gctggccgcg ctgctgctgc agctcaagct ggaactgccg ttcgaccgcg
      481 tggtcaccat cggcaccgtg ctggtaccca tcctgctggt caccctggtc ttcaccaaga
      541 acttcgcaga ggaaccaatt tactgttata ctccgcacaa cttcacccgt gaccaggcgc
      601 tgtacgcccg tggctactgc tggacagagc tgcgggatgc cctgcccggc gtggatgcca
      661 gcctgtggcc atcgctgttt gagcacaagt tcctgcccta cgcactgctg gcctttgccg
      721 ccatcatgta tgtgcccgca ctgggctggg agttcctggc ctccacgcgc ctcacctccg
      781 agctcaactt cctgcttcag gagatcgaca actgctacca ccgagccgcc gaaggtcgcg
      841 cccccaagat tgagaagcag atccagtcca aggggccagg catcacggag cgcgagaagc
      901 gggaaatcat tgagaacgct gagaaggaga agagccctga gcagaatttg tttgagaagt
      961 acctggagcg ccggggccgc agcaacttct tggccaagct gtacttggcg cggcacgtac
     1021 tgatcctgct actcagtgtg gtgcccatct cttacctatg cacatactac gccacccaga
     1081 agcagaacga gttcacctgc gccctgggcg cctcgcctga cgggccggtg ggtagcgccg
     1141 ggcccacggt gcgcgtcagc tgtaagctgc cctccgtgca gctgcagcgg atcattgcgg
     1201 gtgtggacat cgtattgctc tgcttcatga acctcatcat cctggtcaac ctcatccacc
     1261 tcttcatctt ccgcaagagc aacttcattt ttgacaagct gcacaaggtg ggtatcaaga
     1321 cgcgccggca gtggcgccgc tcgcagttct gcgacatcaa catcctggcc atgttctgta
     1381 acgagaaccg tgaccacatc aagtcgctta accggctgga cttcatcacc aacgagagcg
     1441 acctcatgta cgacaacgtg gtgcggcagc ttctggctgc cttggctcag tctaaccacg
     1501 acaccacgcc cacggttcgg gactcaggca tccagaccgt ggaccccagc atcaaccccg
     1561 cagagcctga gggctctgct gagccacccg tggtcaagcg gccccgtaag aaaatgaagt
     1621 ggatccccac cagcaacccg ctgccacagc ccttcaagga gcagctggcc attatgcgcg
     1681 tagaaaacag caagactgag aagcccaaac ctgtgcgcag gaagacagcc acggatacac
     1741 ttattgcccc gctgctggac gctggtgccc gggctgccca ccactacaag gggagtggag
     1801 gtgatacagg gccctcctct gccccgcctg ctgcctctga gaaaaagcat acccggcact
     1861 tctccttgga tgtgcatccc tatatcctag gcagcaagaa ggccaagact gaagcagtac
     1921 cccctgccct accagcctcc cggagccagg aaggtggctt cctgtcccag acagaggaat
     1981 gtgggctggg cttggctgca gcacccacca aagatgctcc gctccctgag aaggaaatcc
     2041 cataccccac agagtctgcc ctgccgtctg ggggcccatt ccatgtgtgc tcacccccca
     2101 cggcctctgc tgctgcttcc ctgtcaccga gcagcctggg caaggctgac cccctcacca
     2161 tcctgagccg aaacgccact caccccctgc tccacatcag cacgttgtac gaggcccggg
     2221 aagaggagga aggaggtccc tgtgcaccct cagacatggg cgacctcctc agcatacccc
     2281 caccccagca gatcctcatc gccaccttcg aggagccgag aacagttgtg agtactgtgg
     2341 agttttgagg ggcagggcct cccaggccac caaaacctct ctgcgagagc cagggatggc
     2401 ccagctgagc ctaggcatga gtagatccga actctgctca cccagtaccg cccacaaccc
     2461 ccagcctcct gtctgcatgc cacggggccc agccctcctt ccacctggct caccatggca
     2521 tccacaagtg caggccgggg ctcgagcaca aggtgggaga gggtgcctac cccagcatca
     2581 ggcacccccc tcagcatgct gggccacaag atgaagagtt tattttttta gtgggttttg
     2641 ttgtgggctg acacaactca gcacacccag ttgggcccag cctagggtaa gtgaggacgg
     2701 tgctggggaa ggtggtactg gcctcaggac agaccccagg ggtcactcac ttaagggcct
     2761 ggcccctaca gagggacctg ataccttcag gtggaggggg gactgagggc tgccccgggt
     2821 ccaaatcaac atgcactttc tccacgtagc ctgacacaca ctttattttt actatgacta
     2881 ctgtaactga cgagactatt tatccccagg agaattaggg tgcatttaaa gcagaggacg
     2941 atgtgtgtga gtggcctaag cagacgtggg tgtaaaagtc ccaagtaagc aggtgtgggt
     3001 acaagcacct gcccgagtga ctgagtttgc cagagatgca cagtgcccgt gcacgagtaa
     3061 acaagcgagc aggagacaag cctgctgtga gtgagcctga gtatgtgtga gtgtgcgagc
     3121 gagtgagcag cacccacgtg agcagtgggt gagagcaggc gtaggcgcca gggtacaaac
     3181 gagggaaggg atacaacgca ataaccacat ccccttcccg ggtccccagc tgctggctgg
     3241 accgcttccc atgggagtcc aggccccact ggccccaccc ctattacctc agccacgcgc
     3301 cacgtgaccg aagtattaac aaggtagcac tgagcatatc aataaatact attctgataa
     3361 aaaaaaaaaa aaaaaa
//
