LOCUS       NM_199397               2456 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus Pannexin 1 (Panx1), transcript variant 1, mRNA.
ACCESSION   NM_199397 XM_235835
VERSION     NM_199397.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2456)
  AUTHORS   Fukuyama,K., Motomura,E. and Okada,M.
  TITLE     Age-Dependent Activation of Pannexin1 Function Contributes to the
            Development of Epileptogenesis in Autosomal Dominant Sleep-related
            Hypermotor Epilepsy Model Rats
  JOURNAL   Int J Mol Sci 25 (3), 1619 (2024)
   PUBMED   38338895
  REMARK    GeneRIF: Age-Dependent Activation of Pannexin1 Function Contributes
            to the Development of Epileptogenesis in Autosomal Dominant
            Sleep-related Hypermotor Epilepsy Model Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2456)
  AUTHORS   Kurisu,R., Saigusa,T., Aono,Y., Hayashi,Y., Hitomi,S., Shimada,M.,
            Iwata,K. and Shinoda,M.
  TITLE     Pannexin 1 role in the trigeminal ganglion in infraorbital nerve
            injury-induced mechanical allodynia
  JOURNAL   Oral Dis 29 (4), 1770-1781 (2023)
   PUBMED   35029007
  REMARK    GeneRIF: Pannexin 1 role in the trigeminal ganglion in infraorbital
            nerve injury-induced mechanical allodynia.
REFERENCE   3  (bases 1 to 2456)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   4  (bases 1 to 2456)
  AUTHORS   Luetic,M., Kretzschmar,G., Grobe,M., Jercic,L., Bota,I., Ivic,V.,
            Balog,M., Zjalic,M., Vitlov Uljevic,M., Heffer,M., Gaspar,R.,
            Tabi,T., Vukojevic,K., Vari,S.G. and Filipovic,N.
  TITLE     Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet
  JOURNAL   Acta Histochem 123 (8), 151817 (2021)
   PUBMED   34808525
  REMARK    GeneRIF: Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet.
REFERENCE   5  (bases 1 to 2456)
  AUTHORS   Koyama,R., Iwata,K., Hayashi,Y., Hitomi,S., Shibuta,I.,
            Furukawa,A., Asano,S., Kaneko,T., Yonehara,Y. and Shinoda,M.
  TITLE     Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal
            Subnucleus Caudalis Is Involved in Tongue Cancer Pain
  JOURNAL   Int J Mol Sci 22 (21), 11404 (2021)
   PUBMED   34768835
  REMARK    GeneRIF: Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal
            Subnucleus Caudalis Is Involved in Tongue Cancer Pain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2456)
  AUTHORS   Boassa,D., Ambrosi,C., Qiu,F., Dahl,G., Gaietta,G. and Sosinsky,G.
  TITLE     Pannexin1 channels contain a glycosylation site that targets the
            hexamer to the plasma membrane
  JOURNAL   J Biol Chem 282 (43), 31733-31743 (2007)
   PUBMED   17715132
REFERENCE   7  (bases 1 to 2456)
  AUTHORS   Pelegrin,P. and Surprenant,A.
  TITLE     Pannexin-1 mediates large pore formation and interleukin-1beta
            release by the ATP-gated P2X7 receptor
  JOURNAL   EMBO J 25 (21), 5071-5082 (2006)
   PUBMED   17036048
  REMARK    GeneRIF: pannexin-1 is required for processing of caspase-1 and
            release of mature IL-1beta induced by P2X(7) receptor activation.
REFERENCE   8  (bases 1 to 2456)
  AUTHORS   Vanden Abeele,F., Bidaux,G., Gordienko,D., Beck,B., Panchin,Y.V.,
            Baranova,A.V., Ivanov,D.V., Skryma,R. and Prevarskaya,N.
  TITLE     Functional implications of calcium permeability of the channel
            formed by pannexin 1
  JOURNAL   J Cell Biol 174 (4), 535-546 (2006)
   PUBMED   16908669
  REMARK    Erratum:[J Cell Biol. 2013 May 27;201(5):777]
REFERENCE   9  (bases 1 to 2456)
  AUTHORS   Dvoriantchikova,G., Ivanov,D., Panchin,Y. and Shestopalov,V.I.
  TITLE     Expression of pannexin family of proteins in the retina
  JOURNAL   FEBS Lett 580 (9), 2178-2182 (2006)
   PUBMED   16616526
  REMARK    GeneRIF: Panx1 and Panx2 are abundantly expressed in the retina,
            and may therefore contribute to the electrical and metabolic
            coupling, or to signaling between retinal neurons
REFERENCE   10 (bases 1 to 2456)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
  REMARK    GeneRIF: the different expression patterns of pannexin 1 (Panx1)
            and pannexin 2 (Panx2) in the brain indicate that pannexins form
            cell type-specific gap junctions with distinct properties that may
            subserve different functions.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000008.1 and
            BM385439.1.
            
            On Jul 17, 2012 this sequence version replaced NM_199397.1.
            
            Summary: The protein encoded by this gene is a plasma membrane
            protein that is a structural component of gap junctions. The
            encoded protein acts as a homodimer or as a heterodimer with other
            isoforms or proteins. Two additional variants have been found, and
            the isoforms expressed from them are found in the cytoplasm. It is
            thought that these two isoforms could attenuate the actions of the
            membrane-bound protein. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ557015.1, SRR26643288.32796.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840110,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                JAXUCZ010000008.1  20171185-20171200   c
            17-18               BM385439.1         79-80
            19-615              JAXUCZ010000008.1  20170586-20171182   c
            616-755             JAXUCZ010000008.1  20150032-20150171   c
            756-976             JAXUCZ010000008.1  20137390-20137610   c
            977-1635            JAXUCZ010000008.1  20134554-20135212   c
            1636-2456           JAXUCZ010000008.1  20132611-20133431   c
FEATURES             Location/Qualifiers
     source          1..2456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..2456
                     /gene="Panx1"
                     /gene_synonym="px1"
                     /note="Pannexin 1"
                     /db_xref="GeneID:315435"
                     /db_xref="RGD:735204"
     exon            1..615
                     /gene="Panx1"
                     /gene_synonym="px1"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..1715
                     /gene="Panx1"
                     /gene_synonym="px1"
                     /note="isoform a is encoded by transcript variant 1;
                     pannexin-1"
                     /codon_start=1
                     /product="pannexin-1 isoform a"
                     /protein_id="NP_955429.1"
                     /db_xref="GeneID:315435"
                     /db_xref="RGD:735204"
                     /translation="MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVG
                     LPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLP
                     LWLHKFFPYILLLFAILLYLPALFWRFAAAPHLCSDLKFIMEELDKVYNRAIKAAKSA
                     RDLDLRDGPGPPGVTENVGQSLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLV
                     TFAVVLLACIYLSYYFSLSSLSDEFLCSIKSGVLRNDSTIPDSFQCKLIAVGIFQLLS
                     LINLLVYALLVPVVIYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFL
                     EENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDVIDGKVPMSLQTKGEDQ
                     GSQRMDFKDLDLSSETAANNGEKNSRQRLLNSSC"
     exon            616..755
                     /gene="Panx1"
                     /gene_synonym="px1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..976
                     /gene="Panx1"
                     /gene_synonym="px1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1635
                     /gene="Panx1"
                     /gene_synonym="px1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..2456
                     /gene="Panx1"
                     /gene_synonym="px1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggtttcc cccgcgtagg ttccggaaga gctcggttcc cgtagccgag cgcgcagtgc
       61 aggcgcgagc agctgtagcg gagagctagc tttgttcccg gcacgttgtt gtccctgcgc
      121 gctcaaggcg gccggagtcc tggtgtcgcg cgcgctgggg acccgcggga gctgagcacg
      181 gggtgtgatc gctgccgcca agacttcggg gctcgtgcgc cctgtgttgc ttggagcgat
      241 cccaggcggc tgcagctctc gtgcggtccc tgcgaggtag gcgcagcgac tgccaaggcg
      301 gtgcaatgct gggccggccc ggaagccgcg ctccgggtcg ttgacggcgc ggactcggcg
      361 cctctccccg gcttcccgca gcacccgcgc ctgccttcga ctgcccgtcc cgcggcaccc
      421 ggcgcgccgt gaccatggcc atcgcccacc tggccacgga gtacgtgttc tcggacttct
      481 tgctgaagga gcccaccgag cccaagttca aggggctgcg actggagctg gcagtggaca
      541 agatggtcac gtgcattgcc gtgggtctgc ctctgctgct catctcgctg gccttcgctc
      601 aggagatctc catcggtacc cagataagct gcttctcccc aagttccttc tcctggcgcc
      661 aggccgcctt cgtggactct tactgctggg ccgctgtaca gcagaaaaac tccctgcaga
      721 gtgagtctgg aaacctcccg ctgtggctgc acaagttctt cccctacatc ctgctactgt
      781 ttgccatact cctgtacctg cccgctctgt tctggcgctt tgcggcggct ccacacctct
      841 gctccgacct gaagtttatc atggaggagc ttgacaaagt ctataaccgc gccatcaagg
      901 ctgccaagag tgctcgtgat ttggacctga gagatggacc tggacctcca ggagtgactg
      961 agaatgtggg gcagagtctg tgggagatat ccgaaagcca cttcaagtac ccgatcgtgg
     1021 agcagtactt gaagacgaag aagaactcca gtcacctaat catgaaatac attagctgcc
     1081 ggctggtgac ctttgcggtg gtactgctgg cttgcatcta cttgagctac tacttcagcc
     1141 tctcctcgct ctccgacgag tttctgtgta gcatcaagtc gggcgtcctg aggaacgaca
     1201 gcaccatccc cgatagcttc cagtgcaagc tcatcgcggt cggcatcttc cagctgctca
     1261 gcctcattaa cctcctagtg tacgccctgc tggtccccgt ggtcatctac acgctcttcg
     1321 tcccgttccg gcagaagacg gacgtcctca aggtatacga gatcctgccc accttcgatg
     1381 ttctacattt caagtctgaa ggctacaacg acttgagcct ctacaacctt tttctggaag
     1441 agaacataag tgagctcaaa tcgtacaagt gtcttaaggt gctggagaac attaagagca
     1501 atgggcaggg catcgacccc atgttacttc tgacaaacct aggcatgatt aagatggacg
     1561 tcattgatgg aaaagtcccc atgtccctac agaccaaggg agaggaccag ggcagccaga
     1621 gaatggactt caaagatttg gacctgagca gcgagacggc agcgaacaat ggggagaaga
     1681 actctcgcca gcgacttctg aattcatcct gctaatggtt tcattcttga atttcaagcc
     1741 tgtgactcct gtggctgacc cacccctgtt ggaaccgtag ctagtttgca gtatatgttt
     1801 ttggtatcga tgtggtgtgt gtcctaagac ataatggccc acagcgttat ggaagaatag
     1861 ctaggaacgt ccttcaagac taaatatgga aacgagtaag tgctttgtct aaagccctcg
     1921 tcggagggct attaagagag agcacagagc cttctagagc cccagagaag caccgttctg
     1981 gactggcagt gctgggagac ctggagcttc tagagaacaa gcactttgtt ttgtgagata
     2041 ataataaacc tgtcaggatg taatttaata accccttctg tgtgcccttt ctgactgttg
     2101 gacaagaaga gcattcactg gcctaccagg gaaatcgacc tgttcgagtg cagctgtgcc
     2161 ctaaattggg tgtgacctgc cgtttgacct cagcacggac agcagcctga ggcagtgctg
     2221 actaaacccc agctatggag ccagagtcat gccatggtga ctctcagaag gaaggcttga
     2281 gaaaccttcc cagtgggaaa cctgagttta gatacctgag gcaggagaac gggattttac
     2341 tgacgcccat gtgaggcaca ctttgtccaa tgagggcaga acacggaact gacctagcag
     2401 tggccttggc catttgttta gatcagattg attaaattta agcccaactt ttaaaa
//
