LOCUS       NM_133531               2327 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus pantothenate kinase 4 (Pank4), mRNA.
ACCESSION   NM_133531 XM_346756
VERSION     NM_133531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Yao,J., Subramanian,C., Rock,C.O. and Jackowski,S.
  TITLE     Human pantothenate kinase 4 is a pseudo-pantothenate kinase
  JOURNAL   Protein Sci 28 (6), 1031-1047 (2019)
   PUBMED   30927326
REFERENCE   2  (bases 1 to 2327)
  AUTHORS   Xiang,R.L., Yang,Y.L., Zuo,J., Xiao,X.H., Chang,Y.S. and De Fang,F.
  TITLE     PanK4 inhibits pancreatic beta-cell apoptosis by decreasing the
            transcriptional level of pro-caspase-9
  JOURNAL   Cell Res 17 (11), 966-968 (2007)
   PUBMED   17971806
  REMARK    GeneRIF: PanK4 inhibits pancreatic beta-cell apoptosis by
            decreasing the transcriptional level of pro-caspase-9
REFERENCE   3  (bases 1 to 2327)
  AUTHORS   Li,Y., Chang,Y., Zhang,L., Feng,Q., Liu,Z., Zhang,Y., Zuo,J.,
            Meng,Y. and Fang,F.
  TITLE     High glucose upregulates pantothenate kinase 4 (PanK4) and thus
            affects M2-type pyruvate kinase (Pkm2)
  JOURNAL   Mol Cell Biochem 277 (1-2), 117-125 (2005)
   PUBMED   16132722
  REMARK    GeneRIF: PanK4 interacts with Pkm2 and thereby may modulate the
            glucose metabolism through regulating the activity of Pkm2.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF399873.1.
            
            On Feb 21, 2013 this sequence version replaced NM_133531.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF399873.1, FQ223969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132272
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2327              AF399873.1         1-2327
FEATURES             Location/Qualifiers
     source          1..2327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2327
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /note="pantothenate kinase 4"
                     /db_xref="GeneID:171053"
                     /db_xref="RGD:628857"
     exon            1..128
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..2326
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /EC_number="2.7.1.33"
                     /note="rPanK4; pantothenic acid kinase 4; hypothetical
                     protein Fang1; inactive pantothenic acid kinase 4;
                     pantothenate kinase 4 (inactive)"
                     /codon_start=1
                     /product="4'-phosphopantetheine phosphatase"
                     /protein_id="NP_598215.1"
                     /db_xref="GeneID:171053"
                     /db_xref="RGD:628857"
                     /translation="MAECRASGGGSGGDSLDKSITLPPDEIFRNLENAKRFAIDIGGS
                     LTKLAYYSTVQHKVAKVRSFDHPGKDAEQDHEPPYEISVQEEITARLHFIKFENTYME
                     ACLDFIRDHLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLK
                     NIPHEAFMYQKDSDPEFRFQTNHPNIFPYLLVNIGSGVSIVKVETEDRFEWIGGSSIG
                     GGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLIASSF
                     GKSATADREFSKEDMAKSLLHMISNDIGQLACLYAKLHGLDRVYFGGFFIRGHPVTMR
                     TITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDNPNQYSWGENYAASSGLMST
                     APELCPTQRARSGTFDLLEMDRLERPLVNLPLLLDPSSYVPDTVDLTDDALARQYWLT
                     CFEEALDGVVKRAVASQPESVDAAERAEKFRQKYWGKLQTLRHQPFAYGTLTVRSLLD
                     TREHCLNEFNFPDPYSKVKQKENGLALKCFQSVTRSLDSLGWEERQLALVKGLLAGNV
                     FDWGAKAVSDVLESDPQFGFEEAKRKLQERPWLVDSYTKWLQRLKGPPHKCALIFADN
                     SGIDIILGVFPFVRELLCRGIEVILACNSGPALNDVTYSESLIVAERIAAMDPIICTA
                     LREDRLLLVQTGSSPPCLDLSRLDKGLAVLVRERGADLVVIEGMGRAVHTNYHALLRC
                     ESLKLAVVKNAWLAERLGGQLFSVIFKYEVPAE"
     exon            129..211
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..426
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..610
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..703
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..857
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1039
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1121
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1222
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1378
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1491
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1579
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1731
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1787
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1837
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1942
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2043
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2112
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2327
                     /gene="Pank4"
                     /gene_synonym="Fang1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaatggcg gagtgccggg cgagtggcgg cgggagcggc ggggacagtc tggacaagag
       61 catcacgctg ccccccgacg agatcttccg aaacctggag aacgccaagc gcttcgccat
      121 tgatataggt ggatcactga ccaagttggc atactattcc acagtacagc acaaagtggc
      181 caaagtgagg tcttttgacc acccaggaaa ggacgcagaa caggaccatg agccgcccta
      241 tgagatctca gttcaggagg agatcacagc tcgtctgcat ttcatcaagt ttgagaacac
      301 ctacatggaa gcctgcctgg actttatcag agaccacctt gtcaacactg agaccaaggt
      361 catccaggcc acagggggtg gagcctacaa gttcaaggac ctcatcgagg agaagctgcg
      421 tctgaaggtg gacaaagagg atgtgatgac ctgcttgatt aaggggtgca acttcgtgct
      481 gaagaacatc ccacatgagg ccttcatgta ccagaaagac tcagacccag agtttcggtt
      541 tcagacaaat cacccgaaca tcttccccta cctcctagtc aacattggct ctggagtctc
      601 catcgtgaag gtggagacag aggaccggtt cgagtggatt ggtgggagct ccattggagg
      661 aggcaccttc tgggggcttg gggctctgct caccaaaaca aagaagtttg atgagctgct
      721 gcagctggct tccagaggcc ggcacgccaa tgttgacatg ctggtacaag acatctatgg
      781 aggggcccac cagaccctgg ggctgagcgg caatctcatc gcaagcagtt ttgggaagtc
      841 agccactgct gacagagagt tctccaaaga agacatggcc aagagcctgc tgcacatgat
      901 cagcaatgac attggacagc tcgcctgtct ctacgccaag cttcatggcc tagacagggt
      961 ctactttggg ggtttcttca tccggggtca ccctgtgacc atgcgcacca tcacctacag
     1021 cattaacttc ttctctaagg gtgaagtcca ggcactcttc ctgagacatg aaggctacct
     1081 gggagccatc ggggcatttt tgaaaggagc cgagcaagat aatcctaacc agtacagctg
     1141 gggtgagaac tacgcggcca gctccgggct gatgagcacg gcgccggagc tgtgcccgac
     1201 acagcgggca aggagcggca catttgacct gctggaaatg gaccgcctgg agagacccct
     1261 ggtcaacctg cccctcctcc tggacccatc ctcctatgtg cccgacacgg tagacctcac
     1321 tgacgatgct ctggcccgac agtactggct cacatgcttt gaggaggctc tggatggggt
     1381 ggtgaagcga gctgtggcca gccagccaga atccgtggat gcagctgaga gggcagagaa
     1441 gttccgtcag aagtactggg gcaaacttca gactctgagg caccagccct ttgcttatgg
     1501 gacgctgact gtgcgcagcc tgttggacac aagagagcac tgtttgaatg agttcaactt
     1561 cccagacccc tactccaagg tgaagcagaa agaaaacggc ctcgcgctaa agtgctttca
     1621 gagcgtgact cgctcgctgg actcactagg ctgggaggag cggcagctgg ccctggtgaa
     1681 ggggctgtta gctgggaatg tctttgactg gggagccaag gctgtgtctg acgtcctgga
     1741 atcggacccc cagtttgggt ttgaagaagc aaagagaaaa ttgcaagaac ggccctggct
     1801 ggtggattcc tacaccaagt ggctccagag gttaaagggg ccccctcata aatgtgcctt
     1861 aattttcgca gataacagtg gaatagacat cattttggga gtcttcccct ttgtcaggga
     1921 gctactctgt agagggatag aggtcatctt ggcatgcaac tcaggccctg ccctgaacga
     1981 tgtgacctac agtgagtctc tcattgtggc agaacgcatt gcagccatgg accccatcat
     2041 ctgcactgca ctcagagaag acaggctact gctggtgcag accggttcca gtcccccatg
     2101 cctagatctc agccgcctag ataagggact ggctgtgctg gtgcgggagc gtggtgccga
     2161 cctggtggtc atcgagggaa tgggccgtgc tgtccacacc aactaccatg ctttgctgcg
     2221 atgtgagagt ctcaagctgg ccgtggtgaa gaacgcctgg ctggctgagc gtctgggtgg
     2281 ccagctcttc agtgtcatct tcaagtacga ggtcccagcc gagtgag
//
