LOCUS       NM_001108272            7044 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus pantothenate kinase 3 (Pank3), mRNA.
ACCESSION   NM_001108272 XM_001066086 XM_340785
VERSION     NM_001108272.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7044)
  AUTHORS   Yao,J., Subramanian,C., Rock,C.O. and Jackowski,S.
  TITLE     Human pantothenate kinase 4 is a pseudo-pantothenate kinase
  JOURNAL   Protein Sci 28 (6), 1031-1047 (2019)
   PUBMED   30927326
REFERENCE   2  (bases 1 to 7044)
  AUTHORS   Subramanian,C., Yun,M.K., Yao,J., Sharma,L.K., Lee,R.E.,
            White,S.W., Jackowski,S. and Rock,C.O.
  TITLE     Allosteric Regulation of Mammalian Pantothenate Kinase
  JOURNAL   J Biol Chem 291 (42), 22302-22314 (2016)
   PUBMED   27555321
REFERENCE   3  (bases 1 to 7044)
  AUTHORS   Alfonso-Pecchio,A., Garcia,M., Leonardi,R. and Jackowski,S.
  TITLE     Compartmentalization of mammalian pantothenate kinases
  JOURNAL   PLoS One 7 (11), e49509 (2012)
   PUBMED   23152917
REFERENCE   4  (bases 1 to 7044)
  AUTHORS   Leonardi,R., Zhang,Y.M., Yun,M.K., Zhou,R., Zeng,F.Y., Lin,W.,
            Cui,J., Chen,T., Rock,C.O., White,S.W. and Jackowski,S.
  TITLE     Modulation of pantothenate kinase 3 activity by small molecules
            that interact with the substrate/allosteric regulatory domain
  JOURNAL   Chem Biol 17 (8), 892-902 (2010)
   PUBMED   20797618
REFERENCE   5  (bases 1 to 7044)
  AUTHORS   Hong,B.S., Senisterra,G., Rabeh,W.M., Vedadi,M., Leonardi,R.,
            Zhang,Y.M., Rock,C.O., Jackowski,S. and Park,H.W.
  TITLE     Crystal structures of human pantothenate kinases. Insights into
            allosteric regulation and mutations linked to a neurodegeneration
            disorder
  JOURNAL   J Biol Chem 282 (38), 27984-27993 (2007)
   PUBMED   17631502
REFERENCE   6  (bases 1 to 7044)
  AUTHORS   Zhang,Y.M., Rock,C.O. and Jackowski,S.
  TITLE     Feedback regulation of murine pantothenate kinase 3 by coenzyme A
            and coenzyme A thioesters
  JOURNAL   J Biol Chem 280 (38), 32594-32601 (2005)
   PUBMED   16040613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 20, 2012 this sequence version replaced NM_001108272.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1323221.1,
                                           SRR26360186.2357978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000010.1  20733191-20733280
            91-443              JAXUCZ010000010.1  20740101-20740453
            444-697             JAXUCZ010000010.1  20741867-20742120
            698-874             JAXUCZ010000010.1  20744303-20744479
            875-998             JAXUCZ010000010.1  20747652-20747775
            999-1124            JAXUCZ010000010.1  20749502-20749627
            1125-7044           JAXUCZ010000010.1  20751098-20757017
FEATURES             Location/Qualifiers
     source          1..7044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..7044
                     /gene="Pank3"
                     /note="pantothenate kinase 3"
                     /db_xref="GeneID:360511"
                     /db_xref="RGD:1310531"
     exon            1..90
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1175
                     /gene="Pank3"
                     /EC_number="2.7.1.33"
                     /codon_start=1
                     /product="pantothenate kinase 3"
                     /protein_id="NP_001101742.1"
                     /db_xref="GeneID:360511"
                     /db_xref="RGD:1310531"
                     /translation="MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVES
                     LKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDK
                     NFSTLQTVLSATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAEC
                     YYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTF
                     LGLCSLLTGCESFEEALEMASKGDSTQADRLVRDIYGGDYERFGLPGWAVASSFGNMI
                     YKEKREAVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLL
                     AYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS"
     exon            91..443
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            444..697
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..874
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..998
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1124
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..7044
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttcacctc tcttcgctga gctctgcacc ggaggctacc cctcgcgcct tagaccgacg
       61 ccatgaagat caaggatgcc aaaaaaccct ctttcccatg gtttggcatg gacattggag
      121 gaacgctagt aaagctctca tattttgaac ctattgatat cacagcagag gaagaacaag
      181 aggaagttga gagcttaaaa agtattcgga aatatttgac ttctaatgta gcatatggat
      241 ctactggcat tcgggatgta catcttgaac tgaaggattt aacacttttt ggacgaagag
      301 gaaacttgca ctttatcaga tttccaaccc aggacctgcc tacttttatc caaatgggga
      361 gagataaaaa tttctcaacc ttacaaacgg tgctgagtgc tacaggaggt ggtgcttaca
      421 agtttgagaa agattttcgc acaattggaa acctccacct gcacaaactg gatgaacttg
      481 actgccttgt aaagggcttg ctgtacatag attctgtcag tttcaatggg caagcagaat
      541 gctattattt tgctaatgcc tcagaacctg agcgatgcca aaagatgcct tttaacctgg
      601 atgatcctta tccactgctg gtggtgaata ttggctcagg agtcagtatt ttagcagtcc
      661 attccaaaga caactataaa agagtgactg ggacaagcct tggagggggc acctttcttg
      721 gtttatgcag tttattgact ggctgtgaga gctttgaaga ggctctggag atggcatcca
      781 aaggtgacag cacccaagct gatagactgg tccgagatat ttacggagga gactatgaga
      841 gatttggtct gccaggttgg gctgtggcat ctagttttgg taatatgatt tataaggaaa
      901 aacgagaagc tgttagtaaa gaggatctgg caagagctac tttagtgact atcaccaata
      961 acattggatc cgtggctcga atgtgtgctg ttaatgagaa aataaatcga gttgtcttcg
     1021 ttggaaactt tttacgtgtc aatactctct ctatgaaact tctggcatat gctttggatt
     1081 actggtcaaa gggtcaattg aaagcattgt ttctagaaca tgagggatac tttggagctg
     1141 tcggtgcact tcttggactg ccaaatttca gctgaaacat cagagatctt cactaagaaa
     1201 tgtcatccag gaggaactga tccagaaact gcattcacta tttgtcattg ggaaccaaag
     1261 tataaaaact ccgatatttg tatgcatttt aagtgtcaga gcagtgagct cgtgggcttt
     1321 gccgcatgga aagacctaca acgggaagtg ggaagtgtcc ctcgttgatg tccccgtatg
     1381 tgcaggcgcc agtgtcccat cttagatgca ctgcagcctc tcggttgctg agcttccctc
     1441 catgatctcc tattgatttg atgcagccaa cattgtagta ctgtgtactc cgacacaaat
     1501 cttaaaatct cagaagtgtt tgtttatgca aaataatcaa ttctaaatat ttgtttgagt
     1561 ctgtttcatg tatgcttggt tactagtgag caggaagtaa cactctcatg atttattgta
     1621 ctggcaatca aagatcattt ctgtgactga gaaatgttaa ggcaatatta agtattaact
     1681 gtggtagttt tataacatat cctcagaaaa gcatgtcaac atgacctctg ctcataagta
     1741 cagttttctc tcacatgatg agttgaatac tgtgcttaaa catgaacctg aatttttcta
     1801 ttgaatccct aaagtttttg cacatatttg gtggcgctac agtttctttg tctcatgcat
     1861 taatcagtat atgtgttaaa atgtttactg tttttaaaat tgagggcata atcacatact
     1921 ttggagttta tcaaattaat taagtccttg gactgttcaa atggaatatg gttagagtga
     1981 gtggcattct gtgctctttc tctaccatgt atatctcagg cccaaacgtg catttctttc
     2041 ttcttctcgt tagatccgaa ctatggaagc tgatttttat cctgccataa gcagtagtag
     2101 caatgaacag aatcagatgc tgtctaaaag aaggttttgg aattacgtga ctctggggca
     2161 gtgctgctga attacaaatg gatcaatgtt tatgggtttt ggtcataaaa gcagtgcaga
     2221 tgcagaattt gtctttctgc tttgaattta ttcttaggtt tgaattcctg ttttttatgt
     2281 taaaatctct cagattttat atagacagta acattttgga tgccattagt tctagaaagt
     2341 tgagtctatg agggaaatgg atctgtatta atttccaata tttctggaaa tagccttaaa
     2401 gaggttagag attgtttaca tttcaaagaa tatttcagtg tagtttctga aaccccagtg
     2461 ttgacagttt ccagcaaact gtcaagaggc gcttggtaaa gacgggtctc tggagccagg
     2521 ggttgtggtt atgctttaat ctctgtactc ggcagacaga ggcaggcaaa tctcttgagt
     2581 taaaggccag tctgggccac agagtgagtt ccaggacatc cagggccaca tagggaaacc
     2641 ctgtttccag ggtaaaaaag acaggtctgt gtgtagttta tgtgcaagta tttaagattc
     2701 cgttttcttt acctaaaaat acaaacatac aaatagtatc tggggaggga ctccatgaca
     2761 gtagtgttcg cccaatagac tgctaggaac cttgcagtca gtccattcgg taaacatttt
     2821 aggtctacag tgatgtcagc cagtatttgc gtgcagatcg gtggccacta gttccaggtg
     2881 gaatgctact gcttccttgt tttaaaggtt tttgacttga gtgtgaagtt agaataattg
     2941 agtgatagaa actgtaggtc agcaactgta ggtttagggt tgtctttaag gattgaatag
     3001 tactcacgtt aatgatcact ttgctttggt ttatatagaa ctaacatttt gccatttgga
     3061 actgaaatta actactaaga tccatgtaaa gtgagccaac taggtcatac atttaccttt
     3121 cttcaagtgt aatctgtaat tactgaactt aataagaaca cagaatcata actgataaag
     3181 gctgacaaga ttctgatcta gtctatattg ctcttaagaa attcccagta tgcatgctgt
     3241 cctaagtgga ggttgcttct agtatcaatc aaactaatta aaggtctgtg ttcttaaaca
     3301 gtgccattta atagataaag tgtaaactat aattttatat tttctagtaa acgcattaaa
     3361 agctaacaag aaataggtga aggtcatttt agtactttta atttaccagt atatctaatg
     3421 tgttatttca gtgtgaaatt ggcacaaaaa attaaatggg agatgtgttt tgccctcttt
     3481 tatgttgttt atattattac tcagttgata tgtattttat acttaataac acatttcagt
     3541 tttggactga ccacctttca gctttcacag ccacatgtac agtttttcta aagctacttt
     3601 gttttgtttt tgcctgagcc agcctccagt gcatagcact ggtggccagt acctggccat
     3661 gtgaccagcc aagccctgag ctcaaaaaac atctacctgc ccctgcccct gcccctgccc
     3721 ccgcatgcgg agattaaagg tctgctagaa gtacttgcaa gagagcacta ttgtgtgtct
     3781 gtgaacatgg gccaaagaag gaggtgggga aagaatgata acttttttaa aaataaagac
     3841 aagaccatta tttgggccag tttattttac acagataagc tgttactgac tattccaaaa
     3901 atagtgtata ttgtcatcat gccatctctt gtgcagtgta tgggatactt ctaataaatg
     3961 atactgataa aatgatcgat aacgcatcct agtagttagc aatttccaca ctactgtatt
     4021 tccttcatgg aagcaaaatt aattccaggg acttaaagtt tctgagtttt gtgcagttaa
     4081 ttttgaaaaa accaagagac actttttatc tcactgtaca tacaaagagt ctttatagaa
     4141 atttcaaatg ctaagagcat cgtcagccat ggttttggtg gtaaaacacg cacacaaatc
     4201 taaaacacca cctatcccca aaaaggttgc cttttaacta gacctctcca ggcatctgta
     4261 tatacaccgg ccacagcata ccttcctcag ctactctgag taggtggggc tgtagaggat
     4321 ttctcttttg gttaaagtca ttgccaaggc taggccagta atacccatga taattgaaag
     4381 ccagccccct gaagggatcc tcattatttg caaatcctgg actcttcaga agctctaaat
     4441 ggatggtgcc ctcgaatgca tgtgctccct gcttgttagg tgcccattcc taaggacagt
     4501 gctgctttgt gggttacatt cttgagggag aaaagatcat ctggctacag tttctaaata
     4561 tcctttataa aactactttg ttagaaacaa agttcttatt tagtttgtct atcttctttt
     4621 gttgagcact ttatgtttgt tagtgttttg cattctcaaa tatagttcag aaattctagg
     4681 ctatgtaaag tgttgataaa gcgtaatgaa aattcgtgga catggagttc aactgcagtt
     4741 ctgtgctgga tgtaaaccaa taatggaaat actttttatc tgagatgatt gcctctaaat
     4801 gtctctgcta tcttttccca cctaagccct gagtgcactt cattctgaca gcagtgcagg
     4861 cctgctagct tctaccgtgt caccagttaa tctcttgttt ggtttttgct ttttgagact
     4921 gtgtctttct atgtagtcct gactgtcctg gaacttttgt catgtagacc aggtggcctc
     4981 aaactcagcc ccctcctctg cttcccaagg gctggtaata aaagaatgag ccgccacatc
     5041 cggcctgcat cacagaattt ttgttttata atctaacagg aattgtctca cagtatcagt
     5101 catataatga tgtaatcttt tttcctttga agtattatga tgaccagttc aatacagcat
     5161 gaagagtgtc ccaagtttgt gctgtctttt atcctacttg caaaattaaa atactcccca
     5221 ttgggcacac tgtgctgtct tacatattca gtacatggaa ttctgttttg atacaatgtt
     5281 ttacagtgtt ctggtcattg gcctagcttc ttcaagtgtt ctctttgtta accagaaatt
     5341 tggtggccac catgggaaat gacaccattg ctaggagcct gagtgaaacc cttgctccat
     5401 tcctggcagc gcttaagatg acttacacat ttcagatgct attaatgttc tagagttaat
     5461 tttagtgttt tatagtaata atttaataat ttctccgcct ttcactagta tgtgttgata
     5521 aatactttca aaaccagaaa aaaagaatta ctctctcact gctgcctgtg gtaaatattg
     5581 gaaagtatat gtgtacattc atgtgtaacg tcttgaattt tagctgttaa cctcaaaatt
     5641 atatagggat tgttactact ctgcatttgt gtaagaagaa aatgtccctc taaattcaga
     5701 gaagtgtatc tggaatttta gtagcccctc tctttgacct gtttttattt ctaatcattg
     5761 tgtatggtca caggtggggg cgaatacaga gctcttctga aattattgta tttgtctgac
     5821 atgttgcagc aacatttaca aaatgaaagt ggaatcacct gcccgcccgc ccgccggtcg
     5881 gaatggatta cagtcctacc tactaataag gcaggtagcc gaccttaaga tctcttctga
     5941 gctgagtgga gcaacctgtg tctgacagca ctgtcctaaa gtcagggcgg gctgacgctg
     6001 gaatcctgct gctggggatc tgatcttagt tcacaaacga gtctgtcttc taaacagttt
     6061 tggcttatag attctttttt ctgcagctgc tgttaattta atctttagag acctggtaaa
     6121 ggatgtaacg taacagaatg cgttttcact tttacataac cttaaagtac cacaagtgat
     6181 gtaagacagt ttgggattgc agttgtcttg gctctgagtg tcattgtgac tagctgtcca
     6241 caagacgtca cagtggctca ttcagtactt aattaaccct gctaagccat ttggaaagtg
     6301 gccagttttt tttttcctga atgatgcctt agagttgaca gcatttagaa ggaaaaataa
     6361 ctttataaaa tctaacgctc atgctgtagt gttcattcct acctataatc tctagtccct
     6421 gcagtgagaa gttcggatac ttggtcacag ttacccactg tgtttgagtt aagtgaactg
     6481 gcattttaac tgaagtgaaa ggcaagtttc ttcttaactc tgcccagttg tgaagaagtc
     6541 attccttcct aggtgtttct gtcccggctt agagcatctg ttacttaaac ctgtcactcc
     6601 agtgcaagtt gccttactct gttagctgca ttcttcctgt caggtccgag cttggtttat
     6661 gtttagattc ttctaatatt attaaatctt atgtaaaaat gtatgaggta ctacaaactt
     6721 tatgcataat aagactaagt tatagcctat tgtaacctat aaaacacttg ttgtaaatta
     6781 tctaatttat ttttccattt atgtacagtt tcttattgta aattgaaaaa tgtttgttgt
     6841 gccctcctct gtaaacattc ccttaatgct tatttgcatg aaagaatgtt gggttctact
     6901 catttgtact atgtagctgt aagctgggtt tgggtgtcta ccttttctgt agtttctaac
     6961 ttttttaatt tgttaatatt ctaaataagt gttagaatca tgctttttat accctacttt
     7021 ccaaataaat cctcttcttt acta
//
