LOCUS       NM_001106513            1854 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus pantothenate kinase 2 (Pank2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001106513 XM_001081198 XM_215826
VERSION     NM_001106513.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Brunetti,D., Dusi,S., Morbin,M., Uggetti,A., Moda,F., D'Amato,I.,
            Giordano,C., d'Amati,G., Cozzi,A., Levi,S., Hayflick,S. and
            Tiranti,V.
  TITLE     Pantothenate kinase-associated neurodegeneration: altered
            mitochondria membrane potential and defective respiration in Pank2
            knock-out mouse model
  JOURNAL   Hum Mol Genet 21 (24), 5294-5305 (2012)
   PUBMED   22983956
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Leoni,V., Strittmatter,L., Zorzi,G., Zibordi,F., Dusi,S.,
            Garavaglia,B., Venco,P., Caccia,C., Souza,A.L., Deik,A.,
            Clish,C.B., Rimoldi,M., Ciusani,E., Bertini,E., Nardocci,N.,
            Mootha,V.K. and Tiranti,V.
  TITLE     Metabolic consequences of mitochondrial coenzyme A deficiency in
            patients with PANK2 mutations
  JOURNAL   Mol Genet Metab 105 (3), 463-471 (2012)
   PUBMED   22221393
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Alfonso-Pecchio,A., Garcia,M., Leonardi,R. and Jackowski,S.
  TITLE     Compartmentalization of mammalian pantothenate kinases
  JOURNAL   PLoS One 7 (11), e49509 (2012)
   PUBMED   23152917
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Garcia,M., Leonardi,R., Zhang,Y.M., Rehg,J.E. and Jackowski,S.
  TITLE     Germline deletion of pantothenate kinases 1 and 2 reveals the key
            roles for CoA in postnatal metabolism
  JOURNAL   PLoS One 7 (7), e40871 (2012)
   PUBMED   22815849
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Leonardi,R., Zhang,Y.M., Lykidis,A., Rock,C.O. and Jackowski,S.
  TITLE     Localization and regulation of mouse pantothenate kinase 2
  JOURNAL   FEBS Lett 581 (24), 4639-4644 (2007)
   PUBMED   17825826
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Kuo,Y.M., Duncan,J.L., Westaway,S.K., Yang,H., Nune,G., Xu,E.Y.,
            Hayflick,S.J. and Gitschier,J.
  TITLE     Deficiency of pantothenate kinase 2 (Pank2) in mice leads to
            retinal degeneration and azoospermia
  JOURNAL   Hum Mol Genet 14 (1), 49-57 (2005)
   PUBMED   15525657
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Zhou,B., Westaway,S.K., Levinson,B., Johnson,M.A., Gitschier,J. and
            Hayflick,S.J.
  TITLE     A novel pantothenate kinase gene (PANK2) is defective in
            Hallervorden-Spatz syndrome
  JOURNAL   Nat Genet 28 (4), 345-349 (2001)
   PUBMED   11479594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001106513.2.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_001081198.1, XM_215826.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1531136.1,
                                           SRR26643298.18650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000003.1  138936508-138936790
            284-636             JAXUCZ010000003.1  138949408-138949760
            637-890             JAXUCZ010000003.1  138955237-138955490
            891-1067            JAXUCZ010000003.1  138959027-138959203
            1068-1191           JAXUCZ010000003.1  138962655-138962778
            1192-1317           JAXUCZ010000003.1  138968165-138968290
            1318-1854           JAXUCZ010000003.1  138970817-138971353
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1854
                     /gene="Pank2"
                     /note="pantothenate kinase 2"
                     /db_xref="GeneID:296167"
                     /db_xref="RGD:1305169"
     exon            1..283
                     /gene="Pank2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1368
                     /gene="Pank2"
                     /EC_number="2.7.1.33"
                     /note="pantothenate kinase 2 (Hallervorden-Spatz
                     syndrome)"
                     /codon_start=1
                     /product="pantothenate kinase 2, mitochondrial"
                     /protein_id="NP_001099983.1"
                     /db_xref="GeneID:296167"
                     /db_xref="RGD:1305169"
                     /translation="MGAGRFGAPMERQGRAAATSAAAGESADSEVRRREPLRRRASSA
                     APSESGPAESLRRERPGSLGGSVSAARPRGEGLRKRRPLFPWFGLDIGGTLVKLVYFE
                     PKDITAEEEKEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRF
                     PTHDMPAFIQMGRDKNFSSLHTVFCATGGGSYKFEQDFLTIGDLQLRKLDELDCLIKG
                     ILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKD
                     NYKRVTGTSLGGGTFFGLCCLLTGCSTFEEALEMASRGDSTKVDKLVRDIYGGDYERF
                     GLPGWAVASSFGNMMSKEKREAASKEDLARATLITITNNIGSIARMCALNENINQVVF
                     VGNFLRVNTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELLKIP"
     exon            284..636
                     /gene="Pank2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..890
                     /gene="Pank2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1067
                     /gene="Pank2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1191
                     /gene="Pank2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1317
                     /gene="Pank2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1854
                     /gene="Pank2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcctggc tcgggcggca gcggcggctg ttgcggatgg gagcgggccg gtttggcgcg
       61 cctatggagc gccagggcag ggctgccgcc acctcagccg cggccggcga gtctgcggac
      121 tccgaagtgc ggaggcggga gccgctcagg cgccgggcga gtagcgcggc tccgtcagag
      181 tcagggccgg cagagagctt gagacgggag cggcccggct ccctcggcgg ctctgtctcg
      241 gccgcccgcc cgcgcggcga gggcctccgg aagaggcggc cgctttttcc gtggtttggc
      301 ttggatattg gaggaaccct ggtcaagctg gtttattttg aacctaaaga catcactgct
      361 gaagaagaaa aggaggaagt ggagagtctg aaaagcattc ggaagtacct gacctccaat
      421 gtggcttatg ggtcgacagg aattcgggac gtgcaccttg agctgaagga cctgactctg
      481 tgtggacgca aaggcaatct gcactttata cgctttccca ctcatgacat gcctgctttt
      541 attcaaatgg gcagagataa aaacttctca agtctccaca ctgtcttttg tgccactgga
      601 ggtggatcat acaaatttga gcaggatttt ctcacaatag gtgaccttca gcttcgaaaa
      661 ctggatgaac tagattgctt aataaaagga attttataca ttgactcagt tggattcaat
      721 ggacggtcac agtgctatta tttcgaaaac cctgctgatt ctgaaaaatg tcagaaatta
      781 ccatttgatt tgaaaaatcc ataccctctg cttctggtga acatcggctc aggggttagc
      841 atcttagccg tgtattccaa ggataattat aagagggtca caggcaccag tcttggagga
      901 ggaactttct ttggtctctg ctgtcttctt accggctgta gtacttttga agaagctctt
      961 gagatggcgt ctcgtggaga tagcaccaaa gtggacaaat tagttcgaga catttatgga
     1021 ggagactatg agagatttgg attgccaggc tgggctgtgg cttcaagttt tggaaacatg
     1081 atgagcaagg agaagagaga ggctgctagc aaggaagacc ttgccagagc aactttgatc
     1141 accatcacca acaacattgg ctccatagca agaatgtgtg ctcttaatga aaacattaac
     1201 caggttgtat ttgtcggcaa tttcctgaga gtcaacacaa tcgccatgcg gcttctggcg
     1261 tatgctctgg attactggtc caaggggcag ctcaaagcac tgttttcaga gcacgagggt
     1321 tattttggag ctgttggcgc actccttgag ctgttgaaga taccctgact tacccagagg
     1381 acttcctgac atctgtggat atatatatat tttttaagag actcaagttt tatgatcgtg
     1441 tactattcaa atcagagcaa gaaacaaatg tatttttcta agacatcaag ataaattctt
     1501 aaagttttgt ctaacttagc attcagtaag gatatcatcc cccccccaca cacacacaca
     1561 attcacaccc ccacccccac ctcatctagg cagtgtggag atttgctgtt tataaggtgt
     1621 tcttcagggt agcataaatc cctgaggtac tttggaatcc cagcatcacc cactggatat
     1681 gcgtggagct gtgtggaccc ccaccagcag ctgactgctt gtgctgttga agtgtgtgag
     1741 agtctatcag tctcatcagt atgcctttgg aggttgcctt ccttttcggg ttgggccatg
     1801 tttacctgtg ttcacacact tgaattgaaa ttggttattt caagcttctg caaa
//
