LOCUS       NM_001106373            2701 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pantothenate kinase 1 (Pank1), mRNA.
ACCESSION   NM_001106373 XM_001080007 XM_215283
VERSION     NM_001106373.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Alfonso-Pecchio,A., Garcia,M., Leonardi,R. and Jackowski,S.
  TITLE     Compartmentalization of mammalian pantothenate kinases
  JOURNAL   PLoS One 7 (11), e49509 (2012)
   PUBMED   23152917
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Garcia,M., Leonardi,R., Zhang,Y.M., Rehg,J.E. and Jackowski,S.
  TITLE     Germline deletion of pantothenate kinases 1 and 2 reveals the key
            roles for CoA in postnatal metabolism
  JOURNAL   PLoS One 7 (7), e40871 (2012)
   PUBMED   22815849
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Nowell,C.S., Bredenkamp,N., Tetelin,S., Jin,X., Tischner,C.,
            Vaidya,H., Sheridan,J.M., Stenhouse,F.H., Heussen,R., Smith,A.J.
            and Blackburn,C.C.
  TITLE     Foxn1 regulates lineage progression in cortical and medullary
            thymic epithelial cells but is dispensable for medullary sublineage
            divergence
  JOURNAL   PLoS Genet 7 (11), e1002348 (2011)
   PUBMED   22072979
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Leonardi,R., Rehg,J.E., Rock,C.O. and Jackowski,S.
  TITLE     Pantothenate kinase 1 is required to support the metabolic
            transition from the fed to the fasted state
  JOURNAL   PLoS One 5 (6), e11107 (2010)
   PUBMED   20559429
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Hong,B.S., Senisterra,G., Rabeh,W.M., Vedadi,M., Leonardi,R.,
            Zhang,Y.M., Rock,C.O., Jackowski,S. and Park,H.W.
  TITLE     Crystal structures of human pantothenate kinases. Insights into
            allosteric regulation and mutations linked to a neurodegeneration
            disorder
  JOURNAL   J Biol Chem 282 (38), 27984-27993 (2007)
   PUBMED   17631502
REFERENCE   6  (bases 1 to 2701)
  AUTHORS   Zhang,Y.M., Rock,C.O. and Jackowski,S.
  TITLE     Feedback regulation of murine pantothenate kinase 3 by coenzyme A
            and coenzyme A thioesters
  JOURNAL   J Biol Chem 280 (38), 32594-32601 (2005)
   PUBMED   16040613
REFERENCE   7  (bases 1 to 2701)
  AUTHORS   Nishimura,H., Kim,E., Fujimori,T., Kashiwabara,S., Kuroiwa,A.,
            Matsuda,Y. and Baba,T.
  TITLE     The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha)
            gene, are localized on mouse chromosome 5
  JOURNAL   Gene 291 (1-2), 67-76 (2002)
   PUBMED   12095680
REFERENCE   8  (bases 1 to 2701)
  AUTHORS   Rock,C.O., Karim,M.A., Zhang,Y.M. and Jackowski,S.
  TITLE     The murine pantothenate kinase (Pank1) gene encodes two
            differentially regulated pantothenate kinase isozymes
  JOURNAL   Gene 291 (1-2), 35-43 (2002)
   PUBMED   12095677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 7, 2012 this sequence version replaced NM_001106373.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.5199.1,
                                           SRR26643429.5464.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000001.1  241806264-241806463 c
            201-553             JAXUCZ010000001.1  241770045-241770397 c
            554-807             JAXUCZ010000001.1  241756690-241756943 c
            808-984             JAXUCZ010000001.1  241751460-241751636 c
            985-1108            JAXUCZ010000001.1  241750827-241750950 c
            1109-1234           JAXUCZ010000001.1  241743924-241744049 c
            1235-2701           JAXUCZ010000001.1  241741083-241742549 c
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..2701
                     /gene="Pank1"
                     /note="pantothenate kinase 1"
                     /db_xref="GeneID:294088"
                     /db_xref="RGD:1304677"
     exon            1..200
                     /gene="Pank1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1294
                     /gene="Pank1"
                     /EC_number="2.7.1.33"
                     /codon_start=1
                     /product="pantothenate kinase 1"
                     /protein_id="NP_001099843.1"
                     /db_xref="GeneID:294088"
                     /db_xref="RGD:1304677"
                     /translation="MKLINGRKQTFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVEN
                     LKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPTCAMHMFIQMGSEK
                     NFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPEC
                     YYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTF
                     LGLCCLLTGCETFEEALDMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMM
                     SKEKRESISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLL
                     AYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDTQ"
     exon            201..553
                     /gene="Pank1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..807
                     /gene="Pank1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..984
                     /gene="Pank1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1108
                     /gene="Pank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1234
                     /gene="Pank1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..2701
                     /gene="Pank1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaagtgcg ttgtttcaca atctgaggct tgtatatata atggtagact gtaaagggta
       61 ccttccccac ctgatattct ggaatgtcag tttgtaggtg gagattgcga cttctttttc
      121 cttagcagag ccaagctcca ttcagctggt taccactttg tgggtgtctt taatgaagct
      181 tataaatggc aggaagcaaa cattcccgtg gtttggcatg gatattggtg gaaccctggt
      241 taagttggtt tactttgaac cgaaggatat cacggcagaa gaagagcagg aagaagtgga
      301 gaacctgaag agcatccgga agtatttgac ttctaacact gcctatggca aaactgggat
      361 ccgagacgtc catctggaac tgaaaaacct caccatgtgt gggcgcaaag ggaacctgca
      421 cttcatccgc ttccccacct gtgccatgca catgttcatc cagatgggca gcgagaagaa
      481 cttctccagc cttcacacca ccctctgtgc cacgggaggt ggggctttca agtttgagga
      541 ggacttcaga atgattgcgg acctgcagct gcataagctg gatgaactgg actgtttgat
      601 tcagggcctg ctttacgttg actcggttgg cttcaacggc aaaccagaat gctactattt
      661 cgaaaacccc acaaatcccg agttgtgtca aaaaaagcca tactgtttgg ataacccgta
      721 ccctatgttg ctggttaaca tgggctcagg tgtcagcatt ctggctgtgt actccaaaga
      781 caactacaaa agagtgacgg ggaccagtct tggaggtggg acattcctag gcctatgttg
      841 cttgctgact ggttgtgaga cctttgaaga agctctggac atggcagcta aaggcgacag
      901 caccaatgtt gataagctgg tgaaggacat ttacggagga gactatgaac gatttggcct
      961 tcaaggatct gccgtagcat caagctttgg caacatgatg agcaaagaaa agagagagtc
     1021 catcagcaaa gaagacctcg cccgagccac attggtcacc atcaccaaca acattggctc
     1081 cattgctcgg atgtgtgcac tgaatgagaa tatcgacaga gttgtatttg ttgggaactt
     1141 tctcagaatc aatatggtct cgatgaagtt gctggcatac gccatggact tttggtctaa
     1201 aggacagctg aaagcactgt ttttggaaca tgagggttac ttcggagctg ttggggccct
     1261 tttggaactg ttcaaaatga ctgacacgca gtagagaaac agccccttgt gaagaccgag
     1321 gactgatggc caatgccaga gaaggtgacg tctctgtggg gcagaaacca agccactatg
     1381 gtggatgaac ctgctgtatt tgtaaataac ctaaaatcct agaccttttg ctcttcgttt
     1441 caagcttatg atacaaaatg gggaatctaa gaattttttt ctgtatactg tattttttaa
     1501 aaaagaaaaa agaaattgtg cagcgtggcc aaacctacca atttcatgca ttaactttga
     1561 aaagttgtat gatgttcaag aggggcctga aatgagagcg ctgtccattt ttcttctggg
     1621 gtttactgat cagtgtggta atttaaactt catttagtaa ttactctagg agatttttgc
     1681 ctttacttaa tattttttca tgacgtttca tgatttgctg ttggtttcaa atgaaactac
     1741 gaatctggca tgttgcactg tgaacacttt ttgtttgttc tctctctctt taatcctttc
     1801 tgtttcgatg tcttaggaca gaaaaggaaa agaagtttcc cctcccccac ccctgttttt
     1861 tttgttcctc gtgatttctc tcctctctgt ccatatgctt tccttgttgt aaccgctcaa
     1921 tcaaggtgct gaccaattca acacaaagtt aaacacgtaa tttacggctc tgaaagtgtg
     1981 gccatgtgag aagactttaa aggaaggggt tgatgagagt ggcatacatt ggacgttata
     2041 tgcagtgcaa ttttatcttt gccttcttac ccctcatcac tagagtgtcc cactggcttt
     2101 acttcacact acactgaaat agtctgtgac ggcatgtcct catttgtgta cgccacgggg
     2161 agggcagcaa acccctgtgt aaatttggag gggctcccaa agctgatccg atcacaccgg
     2221 gcctagggca aaagtcctgg gttgagatgt tagaaatcat ggtctgtctt atatatgttc
     2281 gtacctagga agggtgtaac gagacatccc aagtaataac gttaaagcct gttttttttt
     2341 tttttatttc tattttagta tttaaactga gattggtact ttattccatt tctaaaacgt
     2401 agatataatt tatgatacac tcacatctat ggacattctg ggatgttttc gttaagatag
     2461 acgcgtcact ttcaaatgag ggtgttgtac acaaactgta acaggagagc taatggtctt
     2521 ttggattgag ggtacccttc caagggcttt ttgaaaggca atagagttac tccttggtca
     2581 gtcttcgcct ctctaccttg tggagcaccg cccttctttt ccataccctt gagccttgaa
     2641 gaagctgatg ctaatggaag aactcacttg tctggttgaa ataaagcccg tttgtgttgg
     2701 g
//
