LOCUS       NM_001419788            5724 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus poly(A) specific ribonuclease subunit PAN3
            (Pan3), mRNA.
ACCESSION   NM_001419788
VERSION     NM_001419788.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5724)
  AUTHORS   Wahle,E. and Winkler,G.S.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   2  (bases 1 to 5724)
  AUTHORS   Zheng,D., Ezzeddine,N., Chen,C.Y., Zhu,W., He,X. and Shyu,A.B.
  TITLE     Deadenylation is prerequisite for P-body formation and mRNA decay
            in mammalian cells
  JOURNAL   J Cell Biol 182 (1), 89-101 (2008)
   PUBMED   18625844
REFERENCE   3  (bases 1 to 5724)
  AUTHORS   Uchida,N., Hoshino,S. and Katada,T.
  TITLE     Identification of a human cytoplasmic poly(A) nuclease complex
            stimulated by poly(A)-binding protein
  JOURNAL   J Biol Chem 279 (2), 1383-1391 (2004)
   PUBMED   14583602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-803               JAXUCZ010000012.1  12630690-12631492   c
            804-925             JAXUCZ010000012.1  12612303-12612424   c
            926-992             JAXUCZ010000012.1  12610176-12610242   c
            993-1063            JAXUCZ010000012.1  12608335-12608405   c
            1064-1225           JAXUCZ010000012.1  12596268-12596429   c
            1226-1373           JAXUCZ010000012.1  12571851-12571998   c
            1374-1621           JAXUCZ010000012.1  12539282-12539529   c
            1622-1726           JAXUCZ010000012.1  12537085-12537189   c
            1727-1784           JAXUCZ010000012.1  12535776-12535833   c
            1785-1946           JAXUCZ010000012.1  12532629-12532790   c
            1947-2063           JAXUCZ010000012.1  12532275-12532391   c
            2064-2165           JAXUCZ010000012.1  12532087-12532188   c
            2166-2331           JAXUCZ010000012.1  12529407-12529572   c
            2332-2422           JAXUCZ010000012.1  12528271-12528361   c
            2423-2562           JAXUCZ010000012.1  12523425-12523564   c
            2563-2692           JAXUCZ010000012.1  12520587-12520716   c
            2693-2757           JAXUCZ010000012.1  12520154-12520218   c
            2758-2896           JAXUCZ010000012.1  12517412-12517550   c
            2897-5724           JAXUCZ010000012.1  12512835-12515662   c
FEATURES             Location/Qualifiers
     source          1..5724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..5724
                     /gene="Pan3"
                     /note="poly(A) specific ribonuclease subunit PAN3"
                     /db_xref="GeneID:360760"
                     /db_xref="RGD:1590880"
     exon            1..803
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..3037
                     /gene="Pan3"
                     /EC_number="3.1.13.4"
                     /note="PAN3 polyA specific ribonuclease subunit homolog;
                     PAB-dependent poly(A)-specific ribonuclease subunit PAN3;
                     PAN3 poly(A) specific ribonuclease subunit"
                     /codon_start=1
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3"
                     /protein_id="NP_001406717.1"
                     /db_xref="GeneID:360760"
                     /db_xref="RGD:1590880"
                     /translation="MNSGGGLPPPSAAASPSSSSLAAAVAVAVAASSGVGGVPGGPAA
                     GVKLKYCRYYAKDKTCFYGEECQFLHEDPASGAAPGLGLHSNSVPLALAAASGAGFPP
                     GALPGGGAGPPAGPKKPELGVPGAATAGGGLDGPRVAIPGMDGGALTDTSLTDSYFST
                     SFIGVNGFGSPVETKYPLMQRMTSSSSSPSLLNDSAKPYTGHDPLTSSASSLFNDFGA
                     LNISQRRKPRKYRLGMLEERLVPMGSKARKAKNPIGCLADRCKSGVPINMVWWNRVTE
                     NNLQTPNPTASEFIPKGGSTSRLSNVSQSNMSAFSQVFSHPSMGSPATAGLAPGMSLS
                     AGSSPLHSPKITPHTSPAPRRRSHTPNPASFMVPPSASTPANNPVPQTPSSGQVIQKE
                     TVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELI
                     NRHLITMAQIDQADLPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNS
                     KDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFSEPSLVFAYD
                     FHAGGETMMSRHFNDPNSDAYFTKRKWGQHDGPLPRQHAGLLPESLIWAYIVQLSSAL
                     RTIHTAGLACRVMDPTKILITSKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQAD
                     LISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVND
                     IMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTW
                     SETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLTSRDEKSV
                     LVVTYSDLKRCFENTFQELIAAANGQL"
     exon            804..925
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..992
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1063
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1225
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1373
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1621
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1726
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1784
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1946
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2063
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2165
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2331
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2422
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2562
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2692
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2757
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2896
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..5724
                     /gene="Pan3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcggcg accgtctcag gaagaggaaa atggaataaa caactcggag gaaccggagc
       61 gcgagacgac gagcggaggc agagtttaaa aacaaaccgg ctccctccgc cgtgccttac
      121 cccccagctt ccggtcgccg ccgcctcagg gtctcctgca gccccggcca cgcgcccacc
      181 gcggcgtccc gcgcggcccc tttaaggaca gcggagaggg agagggagaa tccctactcg
      241 ccgcccgccc ctccccctcc ccgggcggct ccggctccct cagcgggccc aacccgcccg
      301 cccggcttcc atccggctcc ggcggcggct ccttcccgcc ctcgtctatg gtggcggcgg
      361 cgggggacgc ggctgcggcg tggccatgaa cagtggcggc ggccttccgc ccccctcggc
      421 cgccgcctcc ccgtcgtcct cctcgctggc ggcggccgtg gcggtcgcgg tcgcggcctc
      481 gtcgggcgtc gggggcgtcc ccggcgggcc ggctgcgggc gtgaagctca agtactgccg
      541 ctactacgcc aaggacaaga cgtgcttcta cggagaggag tgtcagttcc tgcacgagga
      601 cccggcctcc ggcgcggctc cggggctcgg cctccatagc aacagcgtcc cgctggcgct
      661 ggcggccgcg tcgggggccg gctttcctcc cggagcgctc ccgggcgggg gagcggggcc
      721 gcccgcgggg cccaagaagc cggagctggg cgtcccgggg gcggcgacag cgggcggcgg
      781 actcgatgga ccgcgggtgg cgattcccgg aatggatgga ggtgctttaa ctgacacaag
      841 cctcacagat tcctatttca gcaccagctt cattggagtg aatggatttg gaagcccggt
      901 agaaacaaag tatcccttga tgcagagaat gactagtagt agcagctccc caagccttct
      961 aaatgacagt gccaagccat acacaggcca cgatcctctg acttcatctg cttcatcctt
     1021 gtttaatgac ttcggtgccc tcaacatctc ccagagaagg aagccaagga agtatcgcct
     1081 ggggatgctg gaggagaggc tagttccgat gggatccaag gcacgaaaag caaagaaccc
     1141 tattggctgc cttgctgaca ggtgtaaatc aggagtaccc atcaatatgg tttggtggaa
     1201 cagagtcaca gaaaacaatt tacagacacc aaatcctact gcaagcgaat ttatacctaa
     1261 aggaggatca acctccaggc tgagtaacgt gtcccagtca aatatgtctg ccttctctca
     1321 agttttctct cacccatcca tgggaagtcc tgctactgct ggattagcac caggaatgtc
     1381 actgtctgct ggatcttccc ctctccattc ccccaaaatt actccacaca cctctcctgc
     1441 tcctagaaga agaagccaca ctccaaaccc agcaagtttc atggtgccgc ctagtgcctc
     1501 cactcctgcc aataaccctg ttcctcagac tccgtcctct ggtcaagtga tccagaagga
     1561 gactgtcggg gggacgactt acttctatac agatacaact ccagcacctt tgactggaat
     1621 ggtatttcca aactatcata tttacccacc aactgcacct catgttgctt acatgcaacc
     1681 caaagcaaac gcaccttcct tcttcatggc cgacgagctc cgacaggagc tgatcaacag
     1741 acatttaata acaatggctc agattgatca agcagatctg ccagcagtcc ctacagaagt
     1801 tgacagctac catagtctgt tccctctaga accactgcca cccccaaacc ggatacagaa
     1861 atcaagtaat tttggatata tcacatcttg ctacaaagct gtaaatagca aagatgattt
     1921 gccatattgc cttcgaagga tacatggttt tcgtcttgtt aacacaaagt gcatggtgtt
     1981 ggttgatatg tggaaaaaaa ttcagcactc aaatattgta actctgcgtg aagtgtttac
     2041 cactaaagca ttttccgagc cttctcttgt gttcgcgtat gatttccatg ctggaggaga
     2101 aactatgatg agcagacact ttaatgaccc aaattctgac gcttacttca caaagagaaa
     2161 gtggggccag catgatggac cgctgcccag gcagcatgct gggttgttgc cagagtctct
     2221 catttgggca tatattgtcc agctgagttc tgctctgcgt accattcata cagcagggtt
     2281 ggcatgtaga gtaatggacc caacgaagat tctgataacc agcaaaacaa ggttacgagt
     2341 aaattgtgta ggagtttttg atgttttaac atttgataac agtcaaaata ataatccttt
     2401 ggcgttaatg gctcaatacc agcaagcaga tctgatatca ttaggaaaag ttgtgttggc
     2461 tttggcttgc aactctttgg caggaattca acgagaaaat ttacagaaag ccatggaatt
     2521 ggtgacaatc aactactcct ctgacctgaa gaacctcatc ttgtacttgt tgactgacca
     2581 aaacaggatg cggagtgtga atgacatcat gcccatgatt ggtgctcggt tttacactca
     2641 actggatgct gctcaaatga gaaatgatgt tatcgaggaa gaccttgcta aggaggttca
     2701 aaatggaaga ctgtttaggc ttctagcaaa attgggaaca atcaacgaga gaccagagtt
     2761 tcagaaggat ccaacttggt cagagactgg agaccggtat ttgttgaaac tcttcaggga
     2821 tcatcttttt catcaggtga cagaagcagg tgctccctgg atcgacctca gtcacatcat
     2881 ttcttgtctt aacaagctgg atgccggtgt gccagaaaag ataagcctga cctccaggga
     2941 cgagaagagc gtgctggtgg tgacgtacag tgacctaaaa cgctgcttcg aaaatacctt
     3001 tcaggaactg attgcggctg ccaatggtca gttgtagtat ttgctaaaag tgatgacagg
     3061 gcatggtgaa ggaccaagcc tatagccagt ttgcactacg gctgacctgt cctcccatct
     3121 cctgccacca ggggaatgag caggaaggag cgaagcttct cgcacgtggc tcaggtgctc
     3181 tgttacttga gaggaagaat gtctcacttt gtacgcactc tggctgccac tggcctccga
     3241 agaatttatt cagactaagg tcacctttcg gtgaatgatg ctcctgctcc tggttttcca
     3301 ctcgtgtatg cactaatctt aattttttta aagacttttc ctgacctttg acctcctgcc
     3361 acattgtatg cttactaagg gaattatttg caaggacact ggggaacagg aagggggcag
     3421 ctgattgctc gccactgaga gatgcagaat ttgctcttgg gggatggcca ggtcagtagt
     3481 tcctagaaat gccgtgtagt gcgtagtcag tccttaagag tgtcgtacgc aagctccagc
     3541 tgccggccac ccacgtgagc tcaaactgat gcttgtgctg tgtttaagag cactcagaga
     3601 gaatatccct gagttctcag atatgaattc ccgtttgttg atttaaatcc ttttccaggt
     3661 aacgatcgga gcagtaactg aaggagcagg cgctgctctt ctccaggttc atccagaggc
     3721 ttcttcagag aggcgtctgc ctgccagtca catacactta gattgacgta atttttaata
     3781 gcaaaatgaa attgtgctga aggcctgaaa gttgaggagt tacattactt tagggtcttt
     3841 ccagtttgct ttttcccttt gaactccagc tttataatgg tacttacact ggatctggac
     3901 tcactgtcga gagagaaggt gggctgagca cagcagtggc ctgatgcttt gcggcctggc
     3961 tctggaggac actttcctgc tgtgcctttg cactcactgc ttaacccaaa gtaacaggac
     4021 tttcggtcat ctgagaaggc catctcaaaa gttgcagttt tcttccttgg aactttctta
     4081 ctatttggac atgcagttgt cgccaaactc aagtatttgt gggacttgtg gtcacttcga
     4141 tactgaagac tgccaaatac attgggattt tctcctacac agccgccatg aagactccat
     4201 ctccttcccc gagccgcgtg ctgagcgcgc actgggtgtg caccgcagag ctgggaagaa
     4261 agtgtgggga ctcagagggt cgggacggac tcccaagcac ttgcaactga tgttactgtc
     4321 ttcgttttta acaagtacac ctatttgtat atttcagaga agtttttaac atttctctgt
     4381 ccacttttta taagctttaa aatgattttt ctctgccttg agatttgcat caagaaaaag
     4441 cacctttctt caccgaaagc tttgaggact agagacacac ttcacacgtc taacaagcac
     4501 gtctgcgtcc gcgagcggta gcatcagtcg ttaacaagaa aattaattat tgcatttgat
     4561 ctggatggat tttaaaagaa cataatgttc aatattcaaa ggataatgac catttgccac
     4621 catgatgttc cttttattta aagggaacaa gaactttgag tgtaacacac agaagtcttt
     4681 atcattagct catgtattga ggaagagcag ctgtcttttt atatgttttt tgacaaatca
     4741 tattgtaatt cttttgtaca aaaaagaact acttgtattc tagaagaaat atgaaatgct
     4801 taatttataa gcgggctgga gatttttttc caatattgtt ttctttgaaa atgaaagggg
     4861 atcatctatt ttagtttttg ggggcctggg aactttttga aaattttcat ttgtggacca
     4921 atgttatgtg aatgctaaag aagggcaggg gtaaaatagg gcttgaatct cttgttccgc
     4981 atagaccagc aaactcccct ctgcaaggca ggttcacatc acaaccccag agagtctgca
     5041 tcagaaacgc tagtttgctt cagcccctgg taacctcagg acttggtgtg ggtataaaag
     5101 gtagtcagct gaaagttttc ataagtaaat attgtcagcc agaaaacagt tggtgtcagg
     5161 taatgcacat ttttttagct ttgttttata tttattttca ttgggaatgg ttttcaaaag
     5221 aattcttgag ttctctgctt tgataggttt ctttctttct ttttttcttt tttccgtttt
     5281 tttgttttgc tttgcttttt tttctgggag ccctctgttc cacggtgtaa acccatatag
     5341 gaggttgtct gaaagttact attcagtgca taggaagagt ttactatctg agaatatcga
     5401 atgaaggacg tgaactcacc gtgacttcct gtgtgacaac acaacacgga aaggacaacc
     5461 ctgaaatcat gtggtgtcgc tcacctcagc tgtgtgccca tctccaatcc cgttagtgtg
     5521 tttacttcat tgcagatgcc tttgagggag ccctctattc tgctttgacc ttggttctgt
     5581 catggatagc aacattgtct ctaaaaagca ccagtatgtt taagttctaa tgtcacgatc
     5641 ccagtacctg tttctcatct ttaaccctgt tttcagtctc tatgtgtata gcagtatttt
     5701 ttaataaaga attacagaga taaa
//
