LOCUS       NM_001395706            4461 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus poly(A) specific ribonuclease subunit PAN2
            (Pan2), transcript variant 2, mRNA.
ACCESSION   NM_001395706 XM_006240783
VERSION     NM_001395706.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4461)
  AUTHORS   Wahle,E. and Winkler,G.S.
  TITLE     RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3
            complexes
  JOURNAL   Biochim Biophys Acta 1829 (6-7), 561-570 (2013)
   PUBMED   23337855
REFERENCE   2  (bases 1 to 4461)
  AUTHORS   Zheng,D., Ezzeddine,N., Chen,C.Y., Zhu,W., He,X. and Shyu,A.B.
  TITLE     Deadenylation is prerequisite for P-body formation and mRNA decay
            in mammalian cells
  JOURNAL   J Cell Biol 182 (1), 89-101 (2008)
   PUBMED   18625844
REFERENCE   3  (bases 1 to 4461)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   4  (bases 1 to 4461)
  AUTHORS   Uchida,N., Hoshino,S. and Katada,T.
  TITLE     Identification of a human cytoplasmic poly(A) nuclease complex
            stimulated by poly(A)-binding protein
  JOURNAL   J Biol Chem 279 (2), 1383-1391 (2004)
   PUBMED   14583602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 30, 2021 this sequence version replaced XM_006240783.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000007.1  1313655-1313792
            139-537             JAXUCZ010000007.1  1314410-1314808
            538-707             JAXUCZ010000007.1  1319693-1319862
            708-828             JAXUCZ010000007.1  1319947-1320067
            829-906             JAXUCZ010000007.1  1320224-1320301
            907-1174            JAXUCZ010000007.1  1320655-1320922
            1175-1517           JAXUCZ010000007.1  1321639-1321981
            1518-1614           JAXUCZ010000007.1  1322183-1322279
            1615-1731           JAXUCZ010000007.1  1324038-1324154
            1732-1851           JAXUCZ010000007.1  1324259-1324378
            1852-1980           JAXUCZ010000007.1  1324628-1324756
            1981-2180           JAXUCZ010000007.1  1324857-1325056
            2181-2329           JAXUCZ010000007.1  1325223-1325371
            2330-2436           JAXUCZ010000007.1  1325488-1325594
            2437-2535           JAXUCZ010000007.1  1325757-1325855
            2536-2606           JAXUCZ010000007.1  1325954-1326024
            2607-2748           JAXUCZ010000007.1  1326128-1326269
            2749-2919           JAXUCZ010000007.1  1326550-1326720
            2920-2979           JAXUCZ010000007.1  1326890-1326949
            2980-3070           JAXUCZ010000007.1  1327391-1327481
            3071-3228           JAXUCZ010000007.1  1328595-1328752
            3229-3372           JAXUCZ010000007.1  1328847-1328990
            3373-3552           JAXUCZ010000007.1  1329116-1329295
            3553-3646           JAXUCZ010000007.1  1329872-1329965
            3647-3844           JAXUCZ010000007.1  1331137-1331334
            3845-4461           JAXUCZ010000007.1  1331636-1332252
FEATURES             Location/Qualifiers
     source          1..4461
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4461
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /note="poly(A) specific ribonuclease subunit PAN2"
                     /db_xref="GeneID:408200"
                     /db_xref="RGD:1303301"
     exon            1..138
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            139..537
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..3879
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /EC_number="3.1.13.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PAB-dependent poly(A)-specific ribonuclease subunit 2;
                     ubiquitin specific peptidase 52; ubiquitin specific
                     protease 52; PAN2 polyA specific ribonuclease subunit
                     homolog; PAN deadenylation complex subunit 2; PAN2 poly(A)
                     specific ribonuclease subunit; PAB1P-dependent
                     poly(A)-specific ribonuclease; poly(A)-nuclease
                     deadenylation complex subunit 2; PAN2-PAN3 deadenylation
                     complex catalytic subunit Pan2; inactive ubiquitin
                     carboxyl-terminal hydrolase 52; PAB-dependent
                     poly(A)-specific ribonuclease subunit PAN2;
                     PAB1P-dependent poly(A)-nuclease; PAN deadenylation
                     complex catalytic subunit 2"
                     /codon_start=1
                     /product="PAN2-PAN3 deadenylation complex catalytic
                     subunit Pan2 isoform 2"
                     /protein_id="NP_001382635.1"
                     /db_xref="GeneID:408200"
                     /db_xref="RGD:1303301"
                     /translation="MNFEGLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNVELDPEGV
                     ALEALPVQESVHIMEGVYSELHSVVAEVGVPVSVSHFDLQEEMLWVGSHGGHATSFFG
                     PALERYSSFQVNGSDDIRQIQSLENGILFLTKNNLKYMARGGLIIFDYLLDESEDMHS
                     LLLADNNTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKV
                     SLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMR
                     AITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANPADIFHVNPVGPLLM
                     TFDVSASKQALAFGDSEGCVHLWTDSPEPSFNPYSRETEFALPCLVDSLPALDWSQDL
                     LPLSLIPVPLTTDALLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRL
                     RNQIPYRLKESDHEFDNFSQVTESPTGREEEPLHTVSKKYRKVTIKYSKLGLEDFDFK
                     HYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHML
                     DLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLH
                     QDMQELEVPQAYRGAGGSSFCSSGDSIIGQLFSCEMENCSLCRCGSETVRASSTLLFT
                     LSYPEGSICDKTGKNYDFAQVLKRSICLEQNTQAWCDSCEKYQPTIQTRNIRHLPDIL
                     VINCEVNSSKEADFWRLQAEVAFKIAVKKFGGEVKSKEFALADRKELRSPEGFLCCSS
                     MEELKNVWLPFSIRMKMTKNKGLDVCNWADEHELSSLGTPSQWGPARAEEEHGVYVYD
                     LMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKYEAVQF
                     DMNWKVPAILYYVKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNE
                     MPQVGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFI
                     DDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHG
                     LQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDAR
                     TALQLYRKYLELSKNGAEPESFHKVLKGLYEKGRKMDWKVPEPESQSSPKNAAVFPSV
                     LAL"
     exon            538..707
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            708..828
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            829..906
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1174
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1517
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1614
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1731
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1851
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1980
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2180
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2329
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2436
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2535
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2606
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2748
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2919
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..2979
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3070
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3228
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3372
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3552
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3646
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3844
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4461
                     /gene="Pan2"
                     /gene_synonym="Usp52"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcttgtg ttaggttgag ccagaggcgg gggagtagta gggaaactgg aatttcccgc
       61 ggagctgacg gcgctttctc taccccctac tcgtttgaat tccacgcgct ccaaaatatc
      121 cgccatggag aaatcttggc caggatgtcc attctaggtt cactggtgct gtcctgctga
      181 aggctgggtc aggcgtctgt aggaaccgtg gcaagggagg gtgtgaccca ggtctgacca
      241 gcggccatta tcgtcatgaa ctttgagggt ctggatcctg gactggccga attctcccca
      301 gctatgcatt ctaccctgga cccagtcctg gatgcccacc tgaatccaag tttgctacag
      361 aatgtggagc tggacccaga gggagtggct ttggaggccc ttcctgtcca ggagtcagtg
      421 cacataatgg aaggtgtcta ctctgagttg cacagcgtgg tggctgaagt gggagtgcct
      481 gtgtctgtct cccactttga tttgcaggag gagatgctgt gggtggggag ccacgggggc
      541 catgccactt ccttcttcgg tcccgctctg gagcgctact cgtcctttca ggtcaatggc
      601 agtgatgaca ttcggcaaat ccagagcctg gagaacggta tccttttcct caccaagaac
      661 aacctcaagt acatggcccg tggggggctc atcatctttg actatttgct ggatgagagt
      721 gaggacatgc acagtctcct cctggcggac aacaacactc tgcttgttgg tgggctgcag
      781 aaccacgtcc tggagatcga tctaaacact gtccaggaga ctcagaagta tgcagtcgag
      841 acacccggag tcaccatcat gagacagaca aatcgcttct tcttctgtgg ccacacatct
      901 ggcaaggttt ccctgcgaga cctccgtagt tttaaagtgg aacatgaatt tgatgccttc
      961 tcagggagtc tgtccgactt tgatgttcat ggcaacctgc tggctgcctg cggcttttcc
     1021 agccgcctta ccggcctggc ctgtgaccgt ttcctcaagg tgtatgacct gcgcatgatg
     1081 cgtgccatca ccccacttca agtgcacgtg gatccagcct tcttgcgttt catccccact
     1141 tacacatccc gccttgctat catttcccaa tcaggtcagt gccagttttg tgaacccaca
     1201 ggcctggcca acccagctga catcttccat gtgaatcccg tgggacctct gctaatgaca
     1261 tttgatgtgt cagccagcaa gcaggccctg gcctttgggg attccgaggg ctgtgtgcat
     1321 ctctggactg actcccccga gccgtccttc aacccctact cccgagagac tgaattcgct
     1381 ctgccctgtc ttgtggactc attgcctgcg ctggactgga gccaggatct gctgccgctt
     1441 tccctcattc ccgtcccact taccactgac gcgctgctct ccgactggcc ggctgccaac
     1501 tctgcccctg ctcccaggcg agcaccacct gtggatgcag aaatccttcg aaccatgaag
     1561 aaagtgggct tcattggcta cgcccccaac ccccgcacca ggctgcgcaa ccagattccc
     1621 tatcgactaa aggagtcaga ccatgaattt gacaacttca gccaagtcac agagtcaccg
     1681 acagggcgag aagaggagcc tctccacaca gtttctaaga aataccggaa ggtaaccatc
     1741 aaatattcca agctgggact ggaagacttt gacttcaaac actacaataa gactctgttt
     1801 gctgggttag agcctcacat ccccaatgcc tactgtaact gcatgatcca ggtgctctat
     1861 ttcttggagc ctgttcgctg tctgatccag aaccaccttt gccagaagga gttctgcctg
     1921 gcatgtgagc tgggctttct cttccacatg ctggacctct ctcgtggcga cccttgtcag
     1981 ggcagtaatt tcctccgagc tttccggacc attcctgagg cctcagcact gggtctcatc
     2041 ctggctgact cagatgaggc ttcaggcaag ggcagcctgg ccaggctcat ccagaggtgg
     2101 aaccgcttca tcctcactca gctgcatcag gatatgcagg agctggaagt accccaggct
     2161 tatcgaggtg ctgggggcag cagtttctgc tcatcagggg attccatcat cgggcagctg
     2221 ttcagctgtg agatggagaa ctgtagcctc tgccgctgtg gcagtgagac tgtgcgggcc
     2281 tcgtccaccc tgctcttcac actctcctac cctgagggta gcatctgtga taaaaccggc
     2341 aagaactatg actttgctca ggtgctgaag cgaagtattt gcctggagca gaacacacag
     2401 gcctggtgtg acagctgtga gaagtaccag cctacaattc agacccgcaa catccgacat
     2461 ctgccagata ttcttgtcat taattgtgaa gtgaatagct caaaagaggc tgatttctgg
     2521 agactgcaag ctgaggttgc cttcaaaata gcagtgaaga agttcggcgg ggaagtaaag
     2581 agcaaggagt ttgctttagc tgatcggaag gaactgagga gtcccgaggg ctttctgtgt
     2641 tgttcctcca tggaagagct gaagaacgtc tggcttccat tttccatccg catgaagatg
     2701 accaagaaca aaggactgga cgtgtgcaac tgggctgatg agcatgagct tagcagcctg
     2761 ggtaccccct cacagtgggg tccagccagg gcagaggagg agcatggtgt ctatgtctat
     2821 gacctgatgg ctactgtggt acacatcctg gactcacgaa caggaggcag cttggtagct
     2881 cacatcaaag tcggcgagac ctaccaccag cgcaaggagg gagtgactca ccagcagtgg
     2941 tatctcttca atgacttcct tattgaacct attgataagt atgaagctgt gcaatttgat
     3001 atgaactgga aagtacctgc tatcctgtat tacgtcaaaa ggaatctcaa ttccagatac
     3061 aacctgaaca tcaagaaccc tattgaggct agcgtgctgc tggcagaagc ctcactggca
     3121 cggaaacaac ggaaaacaca cactaccttt atcccactga tgctgaatga gatgccacag
     3181 gttggggacc tggtaggcct tgatgccgag tttgtcactc ttaatgagga agaagcagag
     3241 ttacgaagtg atggcaccaa gtccaccatt aagccaagcc agatgtcagt agcaaggatc
     3301 acctgtgttc ggggccaagg gcctaacgag ggtatcccct tcattgatga ctacatctcc
     3361 acacaggagc aggtagtaga ctacttgact cagtactcgg ggataaagcc aggagacctg
     3421 gatgccaaaa tttcctcaaa gcacctcaca actctcaagt cgacttactt aaagcttcgc
     3481 tttctcattg acattggagt caagtttgtg ggccacggtc tgcagaagga cttccgggtc
     3541 atcaacctca tggtacccaa ggaccaagtt ctcgacacag tctacctgtt ccacatgccc
     3601 cgaaaacgaa tgatttccct acgattcctt gcttggtact ttctcgacct gaagattcaa
     3661 ggtgagaccc atgacagtat tgaggatgcc cgcacagccc ttcagctcta ccgaaagtac
     3721 ctggagctaa gcaagaacgg cgctgagccc gagtccttcc acaaggtgct caagggcctc
     3781 tatgagaagg gccggaagat ggactggaag gtgccagagc cagaaagcca gagcagccca
     3841 aagaatgcag ctgtcttccc ctcagtgctg gcactgtgag ctgccttccc tctcagtgcc
     3901 cgctccccag aactgagagg tggcttctca atcggcttta ccctgtccac ttccagaact
     3961 ggatctgctc agggtctaca gatggtgcta ttaatagaac tggaaagcag caagattgtt
     4021 gcaaaggttc caactgccag attcccctta tccaaactgt gcaaacagtg ggccagaagc
     4081 aaagcctaag ggacccaggt gcagtgactg cccttggtaa tagatcctgg gtaactcatc
     4141 ctctacacaa gagctctacc cagactctca gctcagccag ctagggaaat gaagtcctgg
     4201 acagtcacag ggtaccgaga tccagacagt tcaagcatcc agctgcttga caaacagtgg
     4261 ctgggtggac cagcttgtag agtctccatg ggccaatcaa accagtgtgg aggaagctga
     4321 tctactggct tcattcctga tcacatctga gaagtatctg tcttccatac attctatctg
     4381 gagtttcatt ttatttttta aaaaatttgc ttaaaacagc atgttttata aaataaaaaa
     4441 tatttttatc tcattagaaa a
//
