LOCUS       NM_001100136             524 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus presequence translocase associated motor 16
            (Pam16), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001100136
VERSION     NM_001100136.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Schulz C, Schendzielorz A and Rehling P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Mehawej C, Delahodde A, Legeai-Mallet L, Delague V, Kaci N,
            Desvignes JP, Kibar Z, Capo-Chichi JM, Chouery E, Munnich A,
            Cormier-Daire V and Megarbane A.
  TITLE     The impairment of MAGMAS function in human is responsible for a
            severe skeletal dysplasia
  JOURNAL   PLoS Genet 10 (5), e1004311 (2014)
   PUBMED   24786642
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 524)
  AUTHORS   Tagliati F, Gagliano T, Gentilin E, Minoia M, Mole D, Delgi Uberti
            EC and Zatelli MC.
  TITLE     Magmas overexpression inhibits staurosporine induced apoptosis in
            rat pituitary adenoma cell lines
  JOURNAL   PLoS One 8 (9), e75194 (2013)
   PUBMED   24069394
  REMARK    Erratum:[PLoS One. 2013 Sep 27;8(9):null. PMID: 24116255]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 524)
  AUTHORS   Tagliati F, Gentilin E, Buratto M, Mole D, degli Uberti EC and
            Zatelli MC.
  TITLE     Magmas, a gene newly identified as overexpressed in human and mouse
            ACTH-secreting pituitary adenomas, protects pituitary cells from
            apoptotic stimuli
  JOURNAL   Endocrinology 151 (10), 4635-4642 (2010)
   PUBMED   20719856
REFERENCE   5  (bases 1 to 524)
  AUTHORS   Sinha D, Joshi N, Chittoor B, Samji P and D'Silva P.
  TITLE     Role of Magmas in protein transport and human mitochondria
            biogenesis
  JOURNAL   Hum Mol Genet 19 (7), 1248-1262 (2010)
   PUBMED   20053669
REFERENCE   6  (bases 1 to 524)
  AUTHORS   Elsner S, Simian D, Iosefson O, Marom M and Azem A.
  TITLE     The mitochondrial protein translocation motor: structural
            conservation between the human and yeast Tim14/Pam18-Tim16/Pam16
            co-chaperones
  JOURNAL   Int J Mol Sci 10 (5), 2041-2053 (2009)
   PUBMED   19564938
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 524)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   8  (bases 1 to 524)
  AUTHORS   Peng J, Huang CH, Short MK and Jubinsky PT.
  TITLE     Magmas gene structure and evolution
  JOURNAL   In Silico Biol 5 (3), 251-263 (2005)
   PUBMED   15984936
REFERENCE   9  (bases 1 to 524)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 524)
  AUTHORS   Jubinsky PT, Short MK, Mutema G and Witte DP.
  TITLE     Developmental expression of Magmas in murine tissues and its
            co-expression with the GM-CSF receptor
  JOURNAL   J Histochem Cytochem 51 (5), 585-596 (2003)
   PUBMED   12704206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG379323.1, AA933157.1 and BE098288.1.
            
            On Feb 5, 2008 this sequence version replaced NM_001100136.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220566.1, BP495337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BG379323.1         474-539             c
            67-391              AA933157.1         1-325
            392-524             BE098288.1         326-458
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..524
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /note="presequence translocase associated motor 16"
                     /db_xref="GeneID:679907"
                     /db_xref="RGD:1598163"
     exon            1..77
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..452
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /note="mitochondria-associated granulocyte macrophage CSF
                     signaling molecule; mitochondria-associated protein
                     involved in granulocyte-macrophage colony-stimulating
                     factor signal transduction; presequence translocase
                     associated motor 16 homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit TIM16"
                     /protein_id="NP_001093606.2"
                     /db_xref="GeneID:679907"
                     /db_xref="RGD:1598163"
                     /translation="MAKYLAQIIVMGVQVVGRAFARALRQEFAASQAAADARGRAGHQ
                     SAAASNLSGLSLQEAQQILNISKLSPEEVQKNYEHLFKVNDKSVGGSFYLQSKVVRAK
                     ERLDEELRIQAQEDREKGQTPKT"
     exon            78..162
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /inference="alignment:Splign:2.1.0"
     exon            163..299
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /inference="alignment:Splign:2.1.0"
     exon            300..365
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /inference="alignment:Splign:2.1.0"
     exon            366..522
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaccagcc acccttgagc tggtcccact gggtcgggaa gcggcacccg tccccgtaaa
       61 gtggagcggc cgccatggcc aagtacctgg cccagatcat tgtgatgggt gtgcaggtgg
      121 tgggcagagc ctttgccagg gccctgaggc aggagtttgc agcaagccag gcagccgctg
      181 atgctcgagg ccgtgctggg caccagtctg cagctgcatc caatctctct ggcctcagcc
      241 tccaggaagc ccagcagatt ctcaacatct ctaagctgag ccctgaggag gtgcagaaga
      301 attatgaaca cctgtttaag gtgaatgata agtccgtggg tggctctttc tacctgcagt
      361 caaaggttgt ccgtgcaaag gaacgcctag atgaggaact ccgaatacaa gcccaggaag
      421 acagagagaa agggcagacg cccaaaacgt gactgctggg ctctccacac ccacccattg
      481 cctcataatt tatagcctag taataaatgt cttttcgtgt ttaa
//
