LOCUS       NP_001093606             125 aa            linear   ROD 26-FEB-2024
DEFINITION  mitochondrial import inner membrane translocase subunit TIM16
            [Rattus norvegicus].
ACCESSION   NP_001093606
VERSION     NP_001093606.2
DBSOURCE    REFSEQ: accession NM_001100136.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 125)
  AUTHORS   Schulz C, Schendzielorz A and Rehling P.
  TITLE     Unlocking the presequence import pathway
  JOURNAL   Trends Cell Biol 25 (5), 265-275 (2015)
   PUBMED   25542066
  REMARK    Review article
REFERENCE   2  (residues 1 to 125)
  AUTHORS   Mehawej C, Delahodde A, Legeai-Mallet L, Delague V, Kaci N,
            Desvignes JP, Kibar Z, Capo-Chichi JM, Chouery E, Munnich A,
            Cormier-Daire V and Megarbane A.
  TITLE     The impairment of MAGMAS function in human is responsible for a
            severe skeletal dysplasia
  JOURNAL   PLoS Genet 10 (5), e1004311 (2014)
   PUBMED   24786642
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 125)
  AUTHORS   Tagliati F, Gagliano T, Gentilin E, Minoia M, Mole D, Delgi Uberti
            EC and Zatelli MC.
  TITLE     Magmas overexpression inhibits staurosporine induced apoptosis in
            rat pituitary adenoma cell lines
  JOURNAL   PLoS One 8 (9), e75194 (2013)
   PUBMED   24069394
  REMARK    Erratum:[PLoS One. 2013 Sep 27;8(9):null. PMID: 24116255]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 125)
  AUTHORS   Tagliati F, Gentilin E, Buratto M, Mole D, degli Uberti EC and
            Zatelli MC.
  TITLE     Magmas, a gene newly identified as overexpressed in human and mouse
            ACTH-secreting pituitary adenomas, protects pituitary cells from
            apoptotic stimuli
  JOURNAL   Endocrinology 151 (10), 4635-4642 (2010)
   PUBMED   20719856
REFERENCE   5  (residues 1 to 125)
  AUTHORS   Sinha D, Joshi N, Chittoor B, Samji P and D'Silva P.
  TITLE     Role of Magmas in protein transport and human mitochondria
            biogenesis
  JOURNAL   Hum Mol Genet 19 (7), 1248-1262 (2010)
   PUBMED   20053669
REFERENCE   6  (residues 1 to 125)
  AUTHORS   Elsner S, Simian D, Iosefson O, Marom M and Azem A.
  TITLE     The mitochondrial protein translocation motor: structural
            conservation between the human and yeast Tim14/Pam18-Tim16/Pam16
            co-chaperones
  JOURNAL   Int J Mol Sci 10 (5), 2041-2053 (2009)
   PUBMED   19564938
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 125)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   8  (residues 1 to 125)
  AUTHORS   Peng J, Huang CH, Short MK and Jubinsky PT.
  TITLE     Magmas gene structure and evolution
  JOURNAL   In Silico Biol 5 (3), 251-263 (2005)
   PUBMED   15984936
REFERENCE   9  (residues 1 to 125)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (residues 1 to 125)
  AUTHORS   Jubinsky PT, Short MK, Mutema G and Witte DP.
  TITLE     Developmental expression of Magmas in murine tissues and its
            co-expression with the GM-CSF receptor
  JOURNAL   J Histochem Cytochem 51 (5), 585-596 (2003)
   PUBMED   12704206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG379323.1, AA933157.1 and BE098288.1.
            
            On Feb 5, 2008 this sequence version replaced NP_001093606.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220566.1, BP495337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..125
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     Protein         1..125
                     /product="mitochondrial import inner membrane translocase
                     subunit TIM16"
                     /note="mitochondria-associated granulocyte macrophage CSF
                     signaling molecule; mitochondria-associated protein
                     involved in granulocyte-macrophage colony-stimulating
                     factor signal transduction; presequence translocase
                     associated motor 16 homolog"
                     /calculated_mol_wt=13640
     Region          1..125
                     /region_name="Pam16"
                     /note="pfam03656"
                     /db_xref="CDD:252088"
     CDS             1..125
                     /gene="Pam16"
                     /gene_synonym="Magmas"
                     /coded_by="NM_001100136.2:75..452"
                     /db_xref="GeneID:679907"
                     /db_xref="RGD:1598163"
ORIGIN      
        1 makylaqiiv mgvqvvgraf aralrqefaa sqaaadargr aghqsaaasn lsglslqeaq
       61 qilnisklsp eevqknyehl fkvndksvgg sfylqskvvr akerldeelr iqaqedrekg
      121 qtpkt
//
