LOCUS       NM_001108034            2703 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein associated with LIN7 1, MAGUK p55 family
            member (Pals1), mRNA.
ACCESSION   NM_001108034 XM_001080868 XM_234328
VERSION     NM_001108034.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2703)
  AUTHORS   Kim,J.Y., Song,J.Y., Karnam,S., Park,J.Y., Lee,J.J., Kim,S. and
            Cho,S.H.
  TITLE     Common and distinctive localization patterns of Crumbs polarity
            complex proteins in the mammalian eye
  JOURNAL   Gene Expr Patterns 17 (1), 31-37 (2015)
   PUBMED   25636444
REFERENCE   2  (bases 1 to 2703)
  AUTHORS   Monastyrskaya,K., Sanchez-Freire,V., Hashemi Gheinani,A.,
            Klumpp,D.J., Babiychuk,E.B., Draeger,A. and Burkhard,F.C.
  TITLE     miR-199a-5p regulates urothelial permeability and may play a role
            in bladder pain syndrome
  JOURNAL   Am J Pathol 182 (2), 431-448 (2013)
   PUBMED   23201090
REFERENCE   3  (bases 1 to 2703)
  AUTHORS   Ozcelik,M., Cotter,L., Jacob,C., Pereira,J.A., Relvas,J.B.,
            Suter,U. and Tricaud,N.
  TITLE     Pals1 is a major regulator of the epithelial-like polarization and
            the extension of the myelin sheath in peripheral nerves
  JOURNAL   J Neurosci 30 (11), 4120-4131 (2010)
   PUBMED   20237282
REFERENCE   4  (bases 1 to 2703)
  AUTHORS   Ishiuchi,T., Misaki,K., Yonemura,S., Takeichi,M. and Tanoue,T.
  TITLE     Mammalian Fat and Dachsous cadherins regulate apical membrane
            organization in the embryonic cerebral cortex
  JOURNAL   J Cell Biol 185 (6), 959-967 (2009)
   PUBMED   19506035
REFERENCE   5  (bases 1 to 2703)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2703)
  AUTHORS   Wong,E.W., Mruk,D.D., Lee,W.M. and Cheng,C.Y.
  TITLE     Par3/Par6 polarity complex coordinates apical ectoplasmic
            specialization and blood-testis barrier restructuring during
            spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (28), 9657-9662 (2008)
   PUBMED   18621709
REFERENCE   7  (bases 1 to 2703)
  AUTHORS   Stucke,V.M., Timmerman,E., Vandekerckhove,J., Gevaert,K. and
            Hall,A.
  TITLE     The MAGUK protein MPP7 binds to the polarity protein hDlg1 and
            facilitates epithelial tight junction formation
  JOURNAL   Mol Biol Cell 18 (5), 1744-1755 (2007)
   PUBMED   17332497
REFERENCE   8  (bases 1 to 2703)
  AUTHORS   van Rossum,A.G., Aartsen,W.M., Meuleman,J., Klooster,J.,
            Malysheva,A., Versteeg,I., Arsanto,J.P., Le Bivic,A. and
            Wijnholds,J.
  TITLE     Pals1/Mpp5 is required for correct localization of Crb1 at the
            subapical region in polarized Muller glia cells
  JOURNAL   Hum Mol Genet 15 (18), 2659-2672 (2006)
   PUBMED   16885194
REFERENCE   9  (bases 1 to 2703)
  AUTHORS   Kantardzhieva,A., Gosens,I., Alexeeva,S., Punte,I.M., Versteeg,I.,
            Krieger,E., Neefjes-Mol,C.A., den Hollander,A.I., Letteboer,S.J.,
            Klooster,J., Cremers,F.P., Roepman,R. and Wijnholds,J.
  TITLE     MPP5 recruits MPP4 to the CRB1 complex in photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 46 (6), 2192-2201 (2005)
   PUBMED   15914641
REFERENCE   10 (bases 1 to 2703)
  AUTHORS   Kamberov,E., Makarova,O., Roh,M., Liu,A., Karnak,D., Straight,S.
            and Margolis,B.
  TITLE     Molecular cloning and characterization of Pals, proteins associated
            with mLin-7
  JOURNAL   J Biol Chem 275 (15), 11425-11431 (2000)
   PUBMED   10753959
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234328.4, XM_001080868.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC168247.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2703
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2703
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /note="protein associated with LIN7 1, MAGUK p55 family
                     member"
                     /db_xref="GeneID:314259"
                     /db_xref="RGD:1308071"
     exon            1..94
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            95..618
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2279
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /note="MAGUK p55 subfamily member 5; membrane protein,
                     palmitoylated 5 (MAGUK p55 subfamily member 5); membrane
                     palmitoylated protein 5; protein associated with Lin-7 1;
                     protein associated with LIN7 1, MAGUK family member"
                     /codon_start=1
                     /product="protein PALS1"
                     /protein_id="NP_001101504.1"
                     /db_xref="GeneID:314259"
                     /db_xref="RGD:1308071"
                     /translation="MTTSYMNGHVTEESDSGIKNLGLASPEEHPKHREMAVDCPGDLG
                     TRLMPVRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNP
                     IFDTEEGIVLESPHYAVKILEVEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNRDFQ
                     NAFKIHNAVTVHMNKASPPFPLIANVQDLVQEVQTVLKPVHQKEGQELTALLNAPHIQ
                     ALLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKIVRIEKARDIPLGATVRNEMD
                     SVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIP
                     SQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQA
                     YREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
                     NANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFA
                     SAVPHTTRNRRDHEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQV
                     INSGKICLLSLRAQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREI
                     IEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR"
     exon            619..827
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            828..905
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1052
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1214
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1292
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1476
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1548
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1620
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1788
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1991
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2102
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2703
                     /gene="Pals1"
                     /gene_synonym="Mpp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttttgcag aataagaaag ctaacctgaa tattgggggg aaagacagag aagagaaaca
       61 aggattgaag acgaggtttt ccagtttgca taatatttgc ctcatggata catttcatag
      121 cattattatg tgatatgaga agttattttt cttttttgaa gtaacatgga ttttatacta
      181 cagaatcaag agaattggct ttataggaaa ttttgatata taaaaagtga tagaggtttt
      241 tatagataac catgacaaca tcgtatatga atgggcatgt gacagaggaa tcagacagcg
      301 gaataaaaaa tcttggtctt gcatcaccag aggaacatcc gaaacacaga gagatggctg
      361 ttgactgccc tggagatttg ggcaccagat tgatgccagt gcgaagaagt gcacagttag
      421 agcgcattcg acagcaacag gaggatatga gacgtaggcg tgaagaagaa gggaaaaagc
      481 aagaacttga cctaaattct tccatgagac ttaagaaact agctcaaatt cctccgaaga
      541 ctggaataga taaccctata tttgacacag aagaaggaat tgttttagaa agtcctcact
      601 atgctgtgaa aatattagaa gttgaagact tgttctcttc acttaaacat atccagcaca
      661 ctttggttga ttctcagagc caggaggata tttcactgct tttacagctt gtacaaaata
      721 gagattttca gaatgcattc aagatacaca atgctgtcac agtgcacatg aacaaggcca
      781 gccctccgtt tcctcttatc gccaatgtac aagaccttgt acaagaggta caaactgtct
      841 taaagccagt ccatcagaag gaaggacaag aattaactgc tttgttaaat gctccacata
      901 ttcaggcact tttactggcc catgataagg ttgctgagca ggaaatgcag ctagagccca
      961 taacagatga gagagtctat gaaagtatcg gccattatgg gggagaaact gtaaaaatag
     1021 ttcgtataga aaaggctcgg gatattccat tgggtgccac ggttcgtaat gagatggatt
     1081 ctgtcatcat aagtcggata gtgaaaggag gcgcggcaga gaagagcggg cttctgcacg
     1141 aaggagacga agtcctagag atcaatggca tcgaaatccg gggcaaggac gtcaatgagg
     1201 tttttgactt gttgtctgat atgcacggta cgttgacatt tgttctgatt cctagtcaac
     1261 agatcaagcc tcctcccgcc aaagaaactg taatccacgt gaaagctcat tttgactatg
     1321 acccctcaga tgacccttat gttccctgtc gagagttagg actgtctttt caaaaaggag
     1381 atatacttca tgtgattagt caagaagatc cgaattggtg gcaggcctat agagaaggag
     1441 acgaagacaa tcagcctcta gctggacttg ttccagggaa aagttttcag cagcaaaggg
     1501 aagccatgaa gcaaactata gaagaagata aggagccaga aaaatcagga aaactatggt
     1561 gtgcaaagaa gaataaaaag aagaggaaaa aggttttata taatgccaat aaaaatgatg
     1621 attatgacaa tgaagagatc ctaacgtatg aagaaatgtc actttaccat cagccagcaa
     1681 ataggaaaag acctatcatc ttgattggtc cccagaactg tggccagaat gaactgcgcc
     1741 agagactcat gaacaaagaa aaagaccgct ttgcatctgc agttcctcat acaactcgga
     1801 ataggcgaga ccacgaagta gctgggagag attaccactt tgtttcacgg caagcatttg
     1861 aagcagatat agcagctggc aagttcattg aacatggtga atttgagaaa aacctgtatg
     1921 gaaccagcat agattctgta cgacaagtaa tcaactctgg caaaatatgt cttttaagtc
     1981 ttcgagcaca gtccttgaag accctccgga attcagattt gaaaccatac atcatcttca
     2041 ttgcaccacc ttcacaagag agacttcggg cgttgttagc caaggaaggc aagaacccaa
     2101 agccggaaga attaagggag attattgaga agacgagaga gatggaacag aacaacggcc
     2161 actacttcga cactgcgatt gtgaattcag atcttgataa agcctatcag gaactgctta
     2221 ggcttattaa caaactggac accgagcctc agtgggtgcc atccacctgg ctaaggtgaa
     2281 ggaaatggct gttctgtgtc atcatgatga gctttatttg ataaaccgcc aacaggaaga
     2341 tggccttaac gctgagagtt aatctcctac actagtgaga aaggcccgtt aggcaatttg
     2401 tacacaacac ttcctgcaca ttgctttagg gggccttgac ttgtttggag atttaaaatg
     2461 gaaactttct tcagagcatt tctgatttat gttttcacct ttcttgcctc ttggtcagat
     2521 gtctataaaa aaaaatgtat atatatacgt aatataccat tgtctcactt aggtatgaat
     2581 actaacatta tttaacattt aacttaaatg acttcatggg attattgaga gaaggggctg
     2641 tgcttctgtg cactgagaat aacagtattt tcttaaactg atttagtcat cagaaatatt
     2701 tct
//
