LOCUS       NM_001191603            3571 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus partner and localizer of BRCA2 (Palb2), mRNA.
ACCESSION   NM_001191603 XM_215047
VERSION     NM_001191603.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Girard,E., Eon-Marchais,S., Olaso,R., Renault,A.L., Damiola,F.,
            Dondon,M.G., Barjhoux,L., Goidin,D., Meyer,V., Le Gal,D.,
            Beauvallet,J., Mebirouk,N., Lonjou,C., Coignard,J., Marcou,M.,
            Cavaciuti,E., Baulard,C., Bihoreau,M.T., Cohen-Haguenauer,O.,
            Leroux,D., Penet,C., Fert-Ferrer,S., Colas,C., Frebourg,T.,
            Eisinger,F., Adenis,C., Fajac,A., Gladieff,L., Tinat,J.,
            Floquet,A., Chiesa,J., Giraud,S., Mortemousque,I., Soubrier,F.,
            Audebert-Bellanger,S., Limacher,J.M., Lasset,C.,
            Lejeune-Dumoulin,S., Dreyfus,H., Bignon,Y.J., Longy,M., Pujol,P.,
            Venat-Bouvet,L., Bonadona,V., Berthet,P., Luporsi,E., Maugard,C.M.,
            Nogues,C., Delnatte,C., Fricker,J.P., Gesta,P., Faivre,L.,
            Lortholary,A., Buecher,B., Caron,O., Gauthier-Villars,M.,
            Coupier,I., Servant,N., Boland,A., Mazoyer,S., Deleuze,J.F.,
            Stoppa-Lyonnet,D., Andrieu,N. and Lesueur,F.
  TITLE     Familial breast cancer and DNA repair genes: Insights into known
            and novel susceptibility genes from the GENESIS study, and
            implications for multigene panel testing
  JOURNAL   Int J Cancer 144 (8), 1962-1974 (2019)
   PUBMED   30303537
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Parplys,A.C., Zhao,W., Sharma,N., Groesser,T., Liang,F.,
            Maranon,D.G., Leung,S.G., Grundt,K., Dray,E., Idate,R.,
            Ostvold,A.C., Schild,D., Sung,P. and Wiese,C.
  TITLE     NUCKS1 is a novel RAD51AP1 paralog important for homologous
            recombination and genome stability
  JOURNAL   Nucleic Acids Res 43 (20), 9817-9834 (2015)
   PUBMED   26323318
REFERENCE   3  (bases 1 to 3571)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   4  (bases 1 to 3571)
  AUTHORS   Bowman-Colin,C., Xia,B., Bunting,S., Klijn,C., Drost,R.,
            Bouwman,P., Fineman,L., Chen,X., Culhane,A.C., Cai,H., Rodig,S.J.,
            Bronson,R.T., Jonkers,J., Nussenzweig,A., Kanellopoulou,C. and
            Livingston,D.M.
  TITLE     Palb2 synergizes with Trp53 to suppress mammary tumor formation in
            a model of inherited breast cancer
  JOURNAL   Proc Natl Acad Sci U S A 110 (21), 8632-8637 (2013)
   PUBMED   23657012
REFERENCE   5  (bases 1 to 3571)
  AUTHORS   Bouwman,P., Drost,R., Klijn,C., Pieterse,M., van der Gulden,H.,
            Song,J.Y., Szuhai,K. and Jonkers,J.
  TITLE     Loss of p53 partially rescues embryonic development of Palb2
            knockout mice but does not foster haploinsufficiency of Palb2 in
            tumour suppression
  JOURNAL   J Pathol 224 (1), 10-21 (2011)
   PUBMED   21404276
REFERENCE   6  (bases 1 to 3571)
  AUTHORS   Dray,E., Etchin,J., Wiese,C., Saro,D., Williams,G.J., Hammel,M.,
            Yu,X., Galkin,V.E., Liu,D., Tsai,M.S., Sy,S.M., Schild,D.,
            Egelman,E., Chen,J. and Sung,P.
  TITLE     Enhancement of RAD51 recombinase activity by the tumor suppressor
            PALB2
  JOURNAL   Nat Struct Mol Biol 17 (10), 1255-1259 (2010)
   PUBMED   20871616
REFERENCE   7  (bases 1 to 3571)
  AUTHORS   Rantakari,P., Nikkila,J., Jokela,H., Ola,R., Pylkas,K.,
            Lagerbohm,H., Sainio,K., Poutanen,M. and Winqvist,R.
  TITLE     Inactivation of Palb2 gene leads to mesoderm differentiation defect
            and early embryonic lethality in mice
  JOURNAL   Hum Mol Genet 19 (15), 3021-3029 (2010)
   PUBMED   20484223
REFERENCE   8  (bases 1 to 3571)
  AUTHORS   Sy,S.M., Huen,M.S., Zhu,Y. and Chen,J.
  TITLE     PALB2 regulates recombinational repair through chromatin
            association and oligomerization
  JOURNAL   J Biol Chem 284 (27), 18302-18310 (2009)
   PUBMED   19423707
REFERENCE   9  (bases 1 to 3571)
  AUTHORS   Sy,S.M., Huen,M.S. and Chen,J.
  TITLE     PALB2 is an integral component of the BRCA complex required for
            homologous recombination repair
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 7155-7160 (2009)
   PUBMED   19369211
REFERENCE   10 (bases 1 to 3571)
  AUTHORS   Jones,S., Hruban,R.H., Kamiyama,M., Borges,M., Zhang,X.,
            Parsons,D.W., Lin,J.C., Palmisano,E., Brune,K., Jaffee,E.M.,
            Iacobuzio-Donahue,C.A., Maitra,A., Parmigiani,G., Kern,S.E.,
            Velculescu,V.E., Kinzler,K.W., Vogelstein,B., Eshleman,J.R.,
            Goggins,M. and Klein,A.P.
  TITLE     Exomic sequencing identifies PALB2 as a pancreatic cancer
            susceptibility gene
  JOURNAL   Science 324 (5924), 217 (2009)
   PUBMED   19264984
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_215047.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.4311.1,
                                           SRR26643298.5035.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000001.1  186120068-186120115 c
            49-108              JAXUCZ010000001.1  186117275-186117334 c
            109-202             JAXUCZ010000001.1  186116731-186116824 c
            203-1615            JAXUCZ010000001.1  186114701-186116113 c
            1616-2286           JAXUCZ010000001.1  186110973-186111643 c
            2287-2358           JAXUCZ010000001.1  186110384-186110455 c
            2359-2520           JAXUCZ010000001.1  186107598-186107759 c
            2521-2606           JAXUCZ010000001.1  186105072-186105157 c
            2607-2768           JAXUCZ010000001.1  186103126-186103287 c
            2769-2885           JAXUCZ010000001.1  186101785-186101901 c
            2886-2973           JAXUCZ010000001.1  186100256-186100343 c
            2974-3122           JAXUCZ010000001.1  186099062-186099210 c
            3123-3571           JAXUCZ010000001.1  186096312-186096760 c
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..3571
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /note="partner and localizer of BRCA2"
                     /db_xref="GeneID:293452"
                     /db_xref="RGD:1304759"
     CDS             1..3333
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /codon_start=1
                     /product="partner and localizer of BRCA2"
                     /protein_id="NP_001178532.1"
                     /db_xref="GeneID:293452"
                     /db_xref="RGD:1304759"
                     /translation="MEELSGKPLSCAEKEKLKEKLAFLRKEYTKTLARLQRAKRAEKV
                     KNSKKAIEDCVPQQEISPQLSRSEPINKGFPCDASLQSDHLDEETGENISQILDGDPQ
                     SFNCESGQEVLHTPRAGDIQGQFLHSTSSPDGKKGQSAFPGTTKKLRKRSSVLQEKDD
                     FFDTSSLVLPGRHQKRQETVSSKNPRAPEIEKTHLLCLKSQTPDPPALVTEIDGGGRL
                     IVPSGKSERGIDTPVRGNNVSRETTVPSCTASDSNHSGHLELTPPNSGCKITTQGPAS
                     SINLVAQDKKTTIFTDNPVVYKPVSAGSQLPGSPNSCSVNDLTHSNLPANTTPNSRSL
                     KSPDNIVDGRNENLEEDEIVGLSENLSPAAVSPPSTESQIHSCTMLEGLLFPAEYYVR
                     TTRRMSDCQRKIALEAVIQSHLGVKKKERKKKNKATKNLVLSSEETDQSESGMLDTSI
                     GHSSSESLSQKLISPVEVSSPLGPANNRSKKATARPPGRGHREKRTSACTSTLGHHQL
                     LFPPCAALAVNRTRGKFTKHKCQNRDVIIHDFELPDEDFGPLKLEKLKSYSEKLIESP
                     DSKNCGESLPTEGKHAVLEELQIDSETEGLEVELTVLPGEACHPGPTLRWQPVSKGLS
                     SSIVLFTPTDTAAPNNSDRSTASLCSPAFPVLGRTPAFGSQATGENISAEAGQPCSTS
                     RPSHLGETNSLVNKNKQCDSSACSPKLDTSLQVSGRQGQATCDSDSGPQATPLPIESF
                     TFREDQLCGSACLELHEHSTEQTEIADLPACDSLSPGNLQLVSELKNPSSSCSVDVSA
                     MWWERAGTKEPCIITACEDVVSLWKPLDSMQWEKVHTWHFTEVPVLQIVPVPDIYSLI
                     CVALGSLEIREIRALLCSSGDECEKQVLLQSGDIKAMLGLTKRRLVSSTGTFCNQQIQ
                     IMTFAEDGSSKDEQLLMPPDETILTFAEVHGMQEALLGTTTVNSIVIWNLKTGQLLKK
                     MHIDDSYQTCVCHRAYSEMGLLFIVLSHPCAKESQAFGSPVFQLLAINPMTAQSVGVL
                     LCSLPQGQAGRFLEGDVKDHVAAAVLTSGTIAIWDLLLGHCTALLPPVSDQSWSLVKW
                     SGTDSHLLAGQKDGNIFIYRYF"
     exon            1..48
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            49..108
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            109..202
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            203..1615
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..2286
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2358
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2520
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2606
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2768
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2885
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2973
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3122
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3571
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaagagc tttccgggaa gcccctcagt tgtgcggaga aggaaaagtt gaaggaaaag
       61 ctagcatttt tgagaaagga atacaccaag acacttgctc gcctacagcg tgccaaaaga
      121 gctgagaagg ttaagaactc taagaaagca atagaagatt gtgtgcccca gcaggaaatc
      181 tccccacagc taagccgctc tgaacctata aataaaggct ttccttgtga cgcttcgtta
      241 caaagcgacc atcttgatga ggagactgga gaaaacatct ctcagatact tgatggtgat
      301 cctcagtcct ttaactgtga aagtggccaa gaagtcttac atacaccaag agcaggtgac
      361 atccaaggac aatttttaca tagcaccagc agccctgatg gtaagaaagg gcagagtgca
      421 tttccaggga caacaaagaa gctgcggaag agatcatctg ttttacagga aaaggacgat
      481 ttctttgaca ctagttctct tgtgctccct ggtaggcacc aaaaaagaca ggaaacagtc
      541 agtagcaaga atcctagggc cccagaaatt gaaaagactc accttttatg tctgaagtct
      601 caaactcctg accctccagc ccttgttaca gaaattgatg gagggggtag attaattgta
      661 ccatctggca aatcagaaag aggtattgat acacctgtga gaggaaacaa tgtctctagg
      721 gagactacag ttccttcatg tactgcttca gacagcaatc atagtggaca ccttgaactt
      781 acacctccta acagtggctg taaaattact actcagggcc ccgcttcatc cataaacctg
      841 gtggcacaag acaaaaaaac gactattttt acagataacc cagtagtata taaacctgtg
      901 agtgctggca gtcagctgcc aggaagtcct aattcgtgtt ctgtaaatga cctcactcac
      961 agtaacttgc cagcaaatac taccccaaac tctagatctt taaaatctcc tgataacatt
     1021 gttgatggga gaaatgaaaa tcttgaggaa gatgaaattg ttggtctatc tgagaacctc
     1081 agcccagcag cagtctctcc tccctccaca gaaagtcaaa tacattcttg tacgatgctt
     1141 gaaggccttc tgtttcctgc agagtactat gttagaacaa cccgtcgtat gtcagattgt
     1201 cagaggaaaa tagctctgga agctgtaatt caaagtcatt tgggtgtcaa gaagaaagag
     1261 cgtaaaaaga aaaacaaagc aactaaaaat ctagtcctct ccagtgaaga aactgaccaa
     1321 agtgaaagtg gtatgttgga caccagcata ggacactcaa gttcagaaag cctctctcag
     1381 aaactaatct caccagttga ggtcagctct cctctgggac ctgccaacaa cagatctaag
     1441 aaagccactg cacggccacc aggtagaggg cacagagaga aacgaacatc agcctgcacc
     1501 tccacactgg gtcaccatca gctgcttttc cctccttgtg ccgccctggc tgttaacagg
     1561 accaggggca aattcacaaa gcataagtgt cagaacagag acgtgattat tcatgacttt
     1621 gaattacccg atgaagactt tgggcctctt aaacttgaaa aattgaagtc ctactcagaa
     1681 aaactgattg agtctcctga ctcaaaaaac tgtggtgaga gtcttcctac agaaggaaaa
     1741 catgctgttc tggaggaact gcagatagat tcggaaacag agggcttgga agtggaactc
     1801 actgttctac caggagaagc atgccatcca gggccaaccc tgagatggca gccagtgagc
     1861 aagggccttt cttcatccat agtgcttttc actcctacag acaccgctgc acctaacaac
     1921 agtgacaggt ctactgcttc cctgtgctca cctgctttcc ccgtcttagg caggactcca
     1981 gcttttggct cccaagcaac cggtgagaat atatctgctg aagctggaca gccttgctct
     2041 acatcccgac cttctcactt gggagaaaca aacagtcttg ttaataagaa taaacagtgc
     2101 gacagttcag cctgctcacc aaaactggat accagcctgc aagtgtcagg taggcaagga
     2161 caagctacct gtgacagtga ctctggcccc caagcaacac ctctacccat tgagtcattc
     2221 actttcagag aagatcagct ttgtggaagt gcatgcctcg agttacatga acattccacc
     2281 gaacagactg aaattgcaga tctccctgct tgtgacagtt taagcccagg caacctacag
     2341 ttggtttcag agttaaagaa tccttccagt tcctgctctg tggatgtgag cgccatgtgg
     2401 tgggaaagag ctggtactaa ggagccatgt atcataactg cttgtgaaga tgtagtttct
     2461 ctttggaaac cgttggattc tatgcagtgg gagaaagttc atacctggca cttcacagag
     2521 gttccagtat tacaaatagt tccagtgcct gatatttaca gtcttatatg tgtagctttg
     2581 ggaagtttgg aaatcagaga aatcagggcg ttgctgtgct cctctggtga tgaatgtgaa
     2641 aagcaagtcc tcctgcaatc tggagacata aaagctatgc ttggcctgac aaagaggaga
     2701 ctggttagta gcactgggac cttttgcaat caacaaatac aaatcatgac atttgctgaa
     2761 gatggaagca gcaaagatga acagcttctg atgcctcctg atgagactat actgactttc
     2821 gctgaggtcc acgggatgca ggaagccctg cttggtacta ccactgtgaa cagcattgtg
     2881 atctggaatt taaaaactgg ccaactcctg aaaaagatgc acattgatga ctcttaccaa
     2941 acttgtgtct gtcacagagc ctattctgag atggggctcc tgtttattgt tctgagtcat
     3001 ccttgtgcca aagagagcca ggcctttggc agccccgtgt ttcagctgct ggcaattaac
     3061 cctatgacag ctcagagtgt gggtgttctg ctgtgctccc ttcctcaggg gcaggctgga
     3121 aggttcctgg aaggggatgt gaaagatcat gttgcagcag cagtcctgac ttctgggaca
     3181 attgccattt gggatttgct tctgggtcac tgcacggctc tcctcccacc tgtctctgac
     3241 cagagttggt ctttggttaa atggtcaggt acagattctc acctgttagc cggacaaaag
     3301 gatggaaata tattcatata ccgctacttt taagaggcaa ataggtgttt cctctatttt
     3361 ttttttttta agaatacaat atcttaatga cattttatgt gattacttga atgtatttcc
     3421 cacaaactta attttattct gatggtggca ctactgactg aacgtttgct tatacttact
     3481 ttcaggttaa tggttttaag tcattctttg cacatctgct attacagctg tacatatgca
     3541 gtaaatgtta ataaatattt attttgatac a
//
