LOCUS       NP_001178532            1110 aa            linear   ROD 30-MAR-2024
DEFINITION  partner and localizer of BRCA2 [Rattus norvegicus].
ACCESSION   NP_001178532 XP_215047
VERSION     NP_001178532.1
DBSOURCE    REFSEQ: accession NM_001191603.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1110)
  AUTHORS   Girard,E., Eon-Marchais,S., Olaso,R., Renault,A.L., Damiola,F.,
            Dondon,M.G., Barjhoux,L., Goidin,D., Meyer,V., Le Gal,D.,
            Beauvallet,J., Mebirouk,N., Lonjou,C., Coignard,J., Marcou,M.,
            Cavaciuti,E., Baulard,C., Bihoreau,M.T., Cohen-Haguenauer,O.,
            Leroux,D., Penet,C., Fert-Ferrer,S., Colas,C., Frebourg,T.,
            Eisinger,F., Adenis,C., Fajac,A., Gladieff,L., Tinat,J.,
            Floquet,A., Chiesa,J., Giraud,S., Mortemousque,I., Soubrier,F.,
            Audebert-Bellanger,S., Limacher,J.M., Lasset,C.,
            Lejeune-Dumoulin,S., Dreyfus,H., Bignon,Y.J., Longy,M., Pujol,P.,
            Venat-Bouvet,L., Bonadona,V., Berthet,P., Luporsi,E., Maugard,C.M.,
            Nogues,C., Delnatte,C., Fricker,J.P., Gesta,P., Faivre,L.,
            Lortholary,A., Buecher,B., Caron,O., Gauthier-Villars,M.,
            Coupier,I., Servant,N., Boland,A., Mazoyer,S., Deleuze,J.F.,
            Stoppa-Lyonnet,D., Andrieu,N. and Lesueur,F.
  TITLE     Familial breast cancer and DNA repair genes: Insights into known
            and novel susceptibility genes from the GENESIS study, and
            implications for multigene panel testing
  JOURNAL   Int J Cancer 144 (8), 1962-1974 (2019)
   PUBMED   30303537
REFERENCE   2  (residues 1 to 1110)
  AUTHORS   Parplys,A.C., Zhao,W., Sharma,N., Groesser,T., Liang,F.,
            Maranon,D.G., Leung,S.G., Grundt,K., Dray,E., Idate,R.,
            Ostvold,A.C., Schild,D., Sung,P. and Wiese,C.
  TITLE     NUCKS1 is a novel RAD51AP1 paralog important for homologous
            recombination and genome stability
  JOURNAL   Nucleic Acids Res 43 (20), 9817-9834 (2015)
   PUBMED   26323318
REFERENCE   3  (residues 1 to 1110)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   4  (residues 1 to 1110)
  AUTHORS   Bowman-Colin,C., Xia,B., Bunting,S., Klijn,C., Drost,R.,
            Bouwman,P., Fineman,L., Chen,X., Culhane,A.C., Cai,H., Rodig,S.J.,
            Bronson,R.T., Jonkers,J., Nussenzweig,A., Kanellopoulou,C. and
            Livingston,D.M.
  TITLE     Palb2 synergizes with Trp53 to suppress mammary tumor formation in
            a model of inherited breast cancer
  JOURNAL   Proc Natl Acad Sci U S A 110 (21), 8632-8637 (2013)
   PUBMED   23657012
REFERENCE   5  (residues 1 to 1110)
  AUTHORS   Bouwman,P., Drost,R., Klijn,C., Pieterse,M., van der Gulden,H.,
            Song,J.Y., Szuhai,K. and Jonkers,J.
  TITLE     Loss of p53 partially rescues embryonic development of Palb2
            knockout mice but does not foster haploinsufficiency of Palb2 in
            tumour suppression
  JOURNAL   J Pathol 224 (1), 10-21 (2011)
   PUBMED   21404276
REFERENCE   6  (residues 1 to 1110)
  AUTHORS   Dray,E., Etchin,J., Wiese,C., Saro,D., Williams,G.J., Hammel,M.,
            Yu,X., Galkin,V.E., Liu,D., Tsai,M.S., Sy,S.M., Schild,D.,
            Egelman,E., Chen,J. and Sung,P.
  TITLE     Enhancement of RAD51 recombinase activity by the tumor suppressor
            PALB2
  JOURNAL   Nat Struct Mol Biol 17 (10), 1255-1259 (2010)
   PUBMED   20871616
REFERENCE   7  (residues 1 to 1110)
  AUTHORS   Rantakari,P., Nikkila,J., Jokela,H., Ola,R., Pylkas,K.,
            Lagerbohm,H., Sainio,K., Poutanen,M. and Winqvist,R.
  TITLE     Inactivation of Palb2 gene leads to mesoderm differentiation defect
            and early embryonic lethality in mice
  JOURNAL   Hum Mol Genet 19 (15), 3021-3029 (2010)
   PUBMED   20484223
REFERENCE   8  (residues 1 to 1110)
  AUTHORS   Sy,S.M., Huen,M.S., Zhu,Y. and Chen,J.
  TITLE     PALB2 regulates recombinational repair through chromatin
            association and oligomerization
  JOURNAL   J Biol Chem 284 (27), 18302-18310 (2009)
   PUBMED   19423707
REFERENCE   9  (residues 1 to 1110)
  AUTHORS   Sy,S.M., Huen,M.S. and Chen,J.
  TITLE     PALB2 is an integral component of the BRCA complex required for
            homologous recombination repair
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 7155-7160 (2009)
   PUBMED   19369211
REFERENCE   10 (residues 1 to 1110)
  AUTHORS   Jones,S., Hruban,R.H., Kamiyama,M., Borges,M., Zhang,X.,
            Parsons,D.W., Lin,J.C., Palmisano,E., Brune,K., Jaffee,E.M.,
            Iacobuzio-Donahue,C.A., Maitra,A., Parmigiani,G., Kern,S.E.,
            Velculescu,V.E., Kinzler,K.W., Vogelstein,B., Eshleman,J.R.,
            Goggins,M. and Klein,A.P.
  TITLE     Exomic sequencing identifies PALB2 as a pancreatic cancer
            susceptibility gene
  JOURNAL   Science 324 (5924), 217 (2009)
   PUBMED   19264984
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XP_215047.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.4311.1,
                                           SRR26643298.5035.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     Protein         1..1110
                     /product="partner and localizer of BRCA2"
                     /calculated_mol_wt=120412
     Region          761..1108
                     /region_name="PALB2_WD40"
                     /note="Partner and localizer of BRCA2 WD40 domain;
                     pfam16756"
                     /db_xref="CDD:435563"
     CDS             1..1110
                     /gene="Palb2"
                     /gene_synonym="RGD1304759"
                     /coded_by="NM_001191603.1:1..3333"
                     /db_xref="GeneID:293452"
                     /db_xref="RGD:1304759"
ORIGIN      
        1 meelsgkpls caekeklkek laflrkeytk tlarlqrakr aekvknskka iedcvpqqei
       61 spqlsrsepi nkgfpcdasl qsdhldeetg enisqildgd pqsfncesgq evlhtpragd
      121 iqgqflhsts spdgkkgqsa fpgttkklrk rssvlqekdd ffdtsslvlp grhqkrqetv
      181 ssknprapei ekthllclks qtpdppalvt eidgggrliv psgksergid tpvrgnnvsr
      241 ettvpsctas dsnhsghlel tppnsgckit tqgpassinl vaqdkkttif tdnpvvykpv
      301 sagsqlpgsp nscsvndlth snlpanttpn srslkspdni vdgrnenlee deivglsenl
      361 spaavsppst esqihsctml egllfpaeyy vrttrrmsdc qrkialeavi qshlgvkkke
      421 rkkknkatkn lvlsseetdq sesgmldtsi ghssseslsq klispvevss plgpannrsk
      481 katarppgrg hrekrtsact stlghhqllf ppcaalavnr trgkftkhkc qnrdviihdf
      541 elpdedfgpl kleklksyse kliespdskn cgeslptegk havleelqid seteglevel
      601 tvlpgeachp gptlrwqpvs kglsssivlf tptdtaapnn sdrstaslcs pafpvlgrtp
      661 afgsqatgen isaeagqpcs tsrpshlget nslvnknkqc dssacspkld tslqvsgrqg
      721 qatcdsdsgp qatplpiesf tfredqlcgs aclelhehst eqteiadlpa cdslspgnlq
      781 lvselknpss scsvdvsamw weragtkepc iitacedvvs lwkpldsmqw ekvhtwhfte
      841 vpvlqivpvp diyslicval gsleireira llcssgdece kqvllqsgdi kamlgltkrr
      901 lvsstgtfcn qqiqimtfae dgsskdeqll mppdetiltf aevhgmqeal lgtttvnsiv
      961 iwnlktgqll kkmhiddsyq tcvchrayse mgllfivlsh pcakesqafg spvfqllain
     1021 pmtaqsvgvl lcslpqgqag rflegdvkdh vaaavltsgt iaiwdlllgh ctallppvsd
     1081 qswslvkwsg tdshllagqk dgnifiyryf
//
