LOCUS       NM_001106498            2729 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus p21 (RAC1) activated kinase 6 (Pak6), mRNA.
ACCESSION   NM_001106498 XM_001080745 XM_230519
VERSION     NM_001106498.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2729)
  AUTHORS   Zhou Q, Feng X, Ye F, Lei F, Jia X and Feng D.
  TITLE     miR-27a promotion resulting from silencing of HDAC3 facilitates the
            recovery of spinal cord injury by inhibiting PAK6 expression in
            rats
  JOURNAL   Life Sci 260, 118098 (2020)
   PUBMED   32679145
  REMARK    GeneRIF: miR-27a promotion resulting from silencing of HDAC3
            facilitates the recovery of spinal cord injury by inhibiting PAK6
            expression in rats.
REFERENCE   2  (bases 1 to 2729)
  AUTHORS   Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie
            BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hubner CA,
            Pieler T and Zimmer G.
  TITLE     The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics
            of Migrating POA-Derived Interneurons Fated for the Murine Cerebral
            Cortex
  JOURNAL   Cereb Cortex 27 (12), 5696-5714 (2017)
   PUBMED   29117290
REFERENCE   3  (bases 1 to 2729)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2729)
  AUTHORS   Liu W, Liu H, Liu Y, Xu L, Zhang W, Zhu Y, Xu J and Gu J.
  TITLE     Prognostic significance of p21-activated kinase 6 expression in
            patients with clear cell renal cell carcinoma
  JOURNAL   Ann Surg Oncol 21 Suppl 4, S575-S583 (2014)
   PUBMED   24715215
REFERENCE   5  (bases 1 to 2729)
  AUTHORS   Furnari MA, Jobes ML, Nekrasova T, Minden A and Wagner GC.
  TITLE     Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice
  JOURNAL   PLoS One 8 (4), e61321 (2013)
   PUBMED   23593460
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2729)
  AUTHORS   Zhao W, Yang J, Shi W, Wu X, Shao B, Wu Q, Chen J and Ni L.
  TITLE     Upregulation of p21-activated Kinase 6 in rat brain cortex after
            traumatic brain injury
  JOURNAL   J Mol Histol 42 (3), 195-203 (2011)
   PUBMED   21541790
  REMARK    GeneRIF: after injury, the expression of PAK6 was increased
            significantly in the astrocytes and neurons
REFERENCE   7  (bases 1 to 2729)
  AUTHORS   Nekrasova T, Jobes ML, Ting JH, Wagner GC and Minden A.
  TITLE     Targeted disruption of the Pak5 and Pak6 genes in mice leads to
            deficits in learning and locomotion
  JOURNAL   Dev Biol 322 (1), 95-108 (2008)
   PUBMED   18675265
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by
            NM_001106498.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080745.1, XM_230519.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2729
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2729
                     /gene="Pak6"
                     /note="p21 (RAC1) activated kinase 6"
                     /db_xref="GeneID:296078"
                     /db_xref="RGD:1306213"
     exon            1..442
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            443..525
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            526..631
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            632..840
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..2682
                     /gene="Pak6"
                     /EC_number="2.7.11.1"
                     /note="p21-activated kinase 6; p21 (CDKN1A)-activated
                     kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 6"
                     /protein_id="NP_001099968.1"
                     /db_xref="GeneID:296078"
                     /db_xref="RGD:1306213"
                     /translation="MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL
                     DTLRRPKPVVDPSRITRVQLQPMKTVVRGSSVPTEGYISGLLNDIQKLSAISSNTLRG
                     RSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSERTDPHGVYLSCNGGTPAGHRQTPW
                     PEPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGTSPPMATGRRGVK
                     VTKHSSEEARPQSCLVGSAIGRPGGEGSPSPKTQESSLKHRLFRSMFLSTPATGSASS
                     SKPVPLPQNKLNSAFRPPQKDSSSNLVAKAQSLPSDQPTGTFSPLTTSDTSSPQKSLR
                     TAPATGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALGGEDTGIVTHEQFKA
                     ALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLF
                     NEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVCE
                     AVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPY
                     WMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS
                     YKVSPVLRDFLERMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC"
     exon            841..1494
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1992
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2126
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2253
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2379
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2514
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2729
                     /gene="Pak6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccactgtca ctgagtcacc cacccaccct ggcttttctt ccttcctcct ttgcatctga
       61 ttatttgggg agctgaaaac ttggaggtgt ccctgaggcc cgccccttct aactctcccc
      121 gccctacctc ggcttggagg aagatggaac tcgccgggaa gctgccacta ccctctaagg
      181 acatggaagg cacggaggga gccagaggtg cccatggaga gacctcagct ggcagaatac
      241 aatagcagac atggtgttca ggctgcccgt gtgtcctctg aaggttctgg gagagaaggg
      301 gagtctggtc cacaccgact ggagtccttc tgggttgcct ttgagctcac ctctcaaggg
      361 gatctttctg taaaacgtgt ggcttccaga gtcattggta tttggagagc aaggctggac
      421 tggcataggc aggcctgtgc aggtagcagc aagctctggg ctccagacaa gcaccaacct
      481 gcagagggag agggtgaggt cccactgccc agaaggagtg ccaaggtcgg cagaggactg
      541 gccctgtaag gtcctgggat cttccctcac ctccatgctc tagagagctg accgcagaag
      601 ggagaaagga gagacgagaa ggccacagaa ggcaccatgt tccgaaagaa gaagaagaaa
      661 cgccctgaga tatcagcccc acagaacttc cagcaccgtg ttcacacctc atttgacccc
      721 aaggaaggca agttcgtggg cctgccccca caatggcaga acatcctgga tactctgagg
      781 cggcccaagc ctgtggtgga tccttctcga atcacacggg tgcagttgca gcccatgaag
      841 acggtagtac ggggcagctc agtgcccaca gagggctaca tctccgggct gctcaatgac
      901 attcagaagt tgtcagctat cagctccaac actctgcgtg gacgcagccc caccagccgg
      961 cggcgggcac agtccctggg gctgctagga gatgatcagt gggcggctga cccggatatg
     1021 tacctccaaa gtcctcagtc tgagcgcact gatccccatg gcgtctacct cagctgtaat
     1081 gggggcacac cagcaggtca caggcaaacg ccatggccag aaccacagag cccacaggcc
     1141 ctgcccaatg gcatggctgc caaggcacag tcgctgggcc ccgctgagtt ccagggtgcc
     1201 tcccaacgct gcctgcagct gggtgcctgc ctacagagtt ccccacctgg tacctcaccc
     1261 cctatggcca cagggaggcg tggggtgaag gttaccaagc atagctcgga agaggctcga
     1321 ccacaatctt gcctggtggg ctcagccatt ggcagaccag gtggagaagg cagccccagc
     1381 cctaagaccc aggaaagcag cctcaagcac cggctcttcc gcagcatgtt cctgtccact
     1441 cccgccacag gctctgcaag cagcagcaag ccggtccctc tgccacagaa caagctcaat
     1501 tctgctttcc gaccaccaca aaaagattcc tcttcaaacc tggtagccaa ggcccagtcc
     1561 ttgccctcag atcagcccac ggggaccttc agtcctctga ccacctcaga taccagcagt
     1621 ccccagaagt ccctccgcac agccccagcc actggtccac ttccaggccg gtcttctcca
     1681 gcaggctccc cccgcacccg gcatgcccag atcagcacca gcaatctata cctgccccag
     1741 gaccccacag tggccaaggg ggccctgggt ggcgaagaca caggcatcgt aacacatgag
     1801 cagttcaaag ctgcgctcag gatggtggtg gaccagggtg accctcggct gctgctggac
     1861 agctatgtga agattgggga gggctccacg ggcattgtgt gtctggcccg ggagaagcat
     1921 tcaggtcgcc aggtagcagt caagatgatg gacctcagaa agcagcaacg cagggaactg
     1981 ctctttaatg aggtggtgat catgcgtgac taccagcacc tcaatgtggt ggagatgtac
     2041 aagagttacc tggtaggaga ggagctgtgg gtgctgatgg agttcctgca gggcggggcc
     2101 ctcacagaca tcatctccca agtcagactc aatgaggaac agattgctac tgtgtgtgaa
     2161 gctgtgcttc aggccttggc ttacctgcac gcccagggtg tcatccaccg agacatcaag
     2221 agtgattcca tcctgctgac ccttgatggc agggtgaagc tctcagactt tgggttctgt
     2281 gctcagatca gcaaagatgt ccccaagaga aagtctctcg taggaactcc atactggatg
     2341 gctcctgagg tgatctccag atccctgtac gctactgagg tggatatctg gtctctgggc
     2401 atcatggtga ttgagatggt ggatggagaa cccccttact tcagcgactc cccagtgcaa
     2461 gccatgaaga ggctccggga cagcccccca cccaagctaa agaactctta caaggtctct
     2521 ccagtgctgc gagacttcct ggaacgaatg ctggtacggg aaccccaaga gagagccaca
     2581 gcccaggagc tcctggatca cccctttctg ctgcagacgg ggctgcccga gtgtctggtg
     2641 cctctgatac agctctaccg caagcagacc tccacctgct gagcccacgc ccagggtgca
     2701 cctgccacct ctgtccacag gccaaggac
//
