LOCUS       NM_001107781            4040 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus p21 (RAC1) activated kinase 5 (Pak5), mRNA.
ACCESSION   NM_001107781 XM_001080088 XM_230625
VERSION     NM_001107781.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4040)
  AUTHORS   Morris,D.W., Pearson,R.D., Cormican,P., Kenny,E.M.,
            O'Dushlaine,C.T., Perreault,L.P., Giannoulatou,E., Tropea,D.,
            Maher,B.S., Wormley,B., Kelleher,E., Fahey,C., Molinos,I.,
            Bellini,S., Pirinen,M., Strange,A., Freeman,C., Thiselton,D.L.,
            Elves,R.L., Regan,R., Ennis,S., Dinan,T.G., McDonald,C.,
            Murphy,K.C., O'Callaghan,E., Waddington,J.L., Walsh,D.,
            O'Donovan,M., Grozeva,D., Craddock,N., Stone,J., Scolnick,E.,
            Purcell,S., Sklar,P., Coe,B., Eichler,E.E., Ophoff,R., Buizer,J.,
            Szatkiewicz,J., Hultman,C., Sullivan,P., Gurling,H., Mcquillin,A.,
            St Clair,D., Rees,E., Kirov,G., Walters,J., Blackwood,D.,
            Johnstone,M., Donohoe,G., O'Neill,F.A., Kendler,K.S., Gill,M.,
            Riley,B.P., Spencer,C.C. and Corvin,A.
  CONSRTM   International Schizophrenia Consortium, SGENE+ Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     An inherited duplication at the gene p21 Protein-Activated Kinase 7
            (PAK7) is a risk factor for psychosis
  JOURNAL   Hum Mol Genet 23 (12), 3316-3326 (2014)
   PUBMED   24474471
REFERENCE   2  (bases 1 to 4040)
  AUTHORS   Furnari,M.A., Jobes,M.L., Nekrasova,T., Minden,A. and Wagner,G.C.
  TITLE     Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice
  JOURNAL   PLoS One 8 (4), e61321 (2013)
   PUBMED   23593460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4040)
  AUTHORS   Nekrasova,T., Jobes,M.L., Ting,J.H., Wagner,G.C. and Minden,A.
  TITLE     Targeted disruption of the Pak5 and Pak6 genes in mice leads to
            deficits in learning and locomotion
  JOURNAL   Dev Biol 322 (1), 95-108 (2008)
   PUBMED   18675265
REFERENCE   4  (bases 1 to 4040)
  AUTHORS   Cotteret,S., Jaffer,Z.M., Beeser,A. and Chernoff,J.
  TITLE     p21-Activated kinase 5 (Pak5) localizes to mitochondria and
            inhibits apoptosis by phosphorylating BAD
  JOURNAL   Mol Cell Biol 23 (16), 5526-5539 (2003)
   PUBMED   12897128
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_001107781.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080088.1, XM_230625.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4040
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /note="p21 (RAC1) activated kinase 5"
                     /db_xref="GeneID:311450"
                     /db_xref="RGD:1312009"
     exon            1..286
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            287..407
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            408..562
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            563..777
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..2730
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /EC_number="2.7.11.1"
                     /note="p21-activated kinase 7; serine/threonine-protein
                     kinase PAK 7; p21 (CDKN1A)-activated kinase 7;
                     p21-activated kinase 5; p21 protein (Cdc42/Rac)-activated
                     kinase 7; p21 (RAC1) activated kinase 7"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 5"
                     /protein_id="NP_001101251.1"
                     /db_xref="GeneID:311450"
                     /db_xref="RGD:1312009"
                     /translation="MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLA
                     DTANRPKPMVDPSCITPIQLAPMKTIVRGNKSCKESSINGLLEDFDNISVTRSNSLRK
                     ESPPTPDQGAASRIQGHSEENGFITFSQYSSESDTTTDYTTEKYRDRSLYGDDLDLYY
                     RGSHAAKQNGHAMKMKHGDAYYPEMKPLKSDLARFPVDYHTHLDSLSKASEYGDLKWD
                     YQRASSSSPLDYSFQLTPSRTAGTSRCSKESLAYSESDWGPSFDDYDRRPKSSYLHQT
                     SPQPAMRQRSKSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYD
                     RAQMVFSPPLSGSDTYPRGPTKLPQSQSKVGYSSSSHQYPGYHKASLYHHPSLQTSSQ
                     YISTASYLSSLSISSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLDN
                     FIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDM
                     YNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHR
                     DIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVD
                     IWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVR
                     EPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH"
     exon            778..1563
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2052
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2186
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2313
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2439
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2574
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..4040
                     /gene="Pak5"
                     /gene_synonym="PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggagcagc tgaatggtct cagcggacag tcttcctagg ggcaagtcag gcggcttggg
       61 catgctcagt agctgggaga ggtttgggag gagagtagaa agctttgact ctgcccccac
      121 cccctcctct agcccccgcc ccccttgccc cttcccagcc gtagtagttc cccagcgtgc
      181 gccagtggag agcaggaaca tggcgctcgg agcgatagaa cagatgtagc agcagcggaa
      241 aagcagatga ggtaccgcga cttcactgct gacagccagc caccagggag agtttgcact
      301 gacagagaag acagtgaaga ataggcttcc ctgtaggttg gctcttcagc ctgctcagca
      361 ctgccactgg agctttctta gcctcgctac agcctccgca tttgtagaaa tactctgtgg
      421 tgaaatgctt ctgtctgttg ccaaaatgaa cactgaagaa aaatgaagaa gactgaagaa
      481 ctccaacaaa aaatttgcac aacagaagta accaaaatct tctggagtct ttaattcatc
      541 cacagccatc gtaaagcaaa aagtttttac atcatgtttg ggaagaaaaa gaaaaagatc
      601 gaaatatccg gcccatctaa ctttgaacac agggttcata ctgggtttga tccacaagag
      661 cagaagttta ctggccttcc ccagcagtgg cacagcctgt tagcagacac agccaacagg
      721 cccaagccta tggtggatcc atcatgcatc acacccatac aactggctcc catgaagaca
      781 atcgtcagag gaaataaatc ctgcaaggaa agctctatca acggtctgct agaggatttc
      841 gacaacatct ccgtgactcg ctccaactcc ctaaggaaag aaagcccacc caccccagat
      901 cagggagcag ctagccgcat tcaaggccac tccgaagaaa acggcttcat tactttctca
      961 caatattcta gtgaatctga tactactacg gactacacaa ctgaaaagta tagagacagg
     1021 agtctctatg gagacgacct ggatctgtac tatagaggca gccatgcagc caagcaaaac
     1081 gggcatgcta tgaagatgaa acatggagat gcctactatc ctgagatgaa gcctttgaaa
     1141 tccgacctgg ccagattccc tgtcgactat cacacacact tggactcgct gagcaaagca
     1201 agtgagtacg gtgacctcaa gtgggattat cagcgagcct ccagtagctc ccctctggac
     1261 tactcattcc agctcacgcc ttccagaact gcagggacca gcaggtgctc caaggagagt
     1321 ctggcataca gtgaaagtga ttggggaccc agctttgatg actatgatag gaggccaaaa
     1381 tcatcctacc tgcatcagac aagccctcag ccagccatgc gccagagatc caagtcaggc
     1441 tcagggcttc aggaacccat gatgccattt ggagcaagtg catttaaaac tcatcctcaa
     1501 ggacactcgt acaactccta cacctaccct cgattgtctg agcccacaat gtgcattcca
     1561 aaggtggatt atgatcgagc acagatggtc ttcagtcctc cactgtcagg gtccgacacc
     1621 tatcccagag gccccaccaa actacctcaa agtcaaagca aagtgggcta ctcttcaagt
     1681 agccaccagt atcctgggta ccacaaagca tccctatacc atcatccgtc cctgcaaacc
     1741 agttctcagt acatctccac cgcttcttac ttgagctctc tcagtatctc ctcgagcacc
     1801 taccctccac ccagctgggg ctcctcttca gaccagcagc cctctagggt atcccatgaa
     1861 cagtttcgag ctgccctgca actggtggtc agcccaggag accccaggga atatttggat
     1921 aactttatta aaatcggaga agggtcgaca ggcatcgtgt gcattgcaac agagaagcac
     1981 acaggcaagc aagtggcggt gaagaaaatg gacctccgaa agcaacagag acgggaactc
     2041 ctttttaatg aggtcgtgat aatgcgtgat taccaccatg acaatgtagt tgacatgtat
     2101 aacagctacc ttgttggaga tgagctctgg gtggtcatgg agtttctaga aggtggtgcc
     2161 ttgacagaca tcgtcactca taccagaatg aatgaagaac agatagctac tgtctgcctg
     2221 tcagttctga aagcgctgtc ctaccttcat aaccaaggag tgattcacag ggacataaag
     2281 agtgactcca ttcttctgac aagcgatggc cggataaagt tatctgactt tggcttctgt
     2341 gctcaagttt ccaaagaggt gccaaagagg aagtcactgg tgggtacccc atactggatg
     2401 gctcctgagg tgatttccag gctaccttat gggacagagg tggacatctg gtccctcggg
     2461 ataatggtga tagagatgat tgatggtgag cctccctatt tcaatgagcc tcctctgcag
     2521 gccatgagga ggatccggga cagtttacct ccaagagtga aggacctgca caaggtttct
     2581 tccatgctcc gaggattcct agatcttatg ttggtgaggg agccctctca aagagccaca
     2641 gctcaagaac ttcttggaca tccattctta aaattggcag gcccgccatc ttgcatcgtt
     2701 cccctcatga gacaatatag gcatcactga gaggagtcac ataagatgca aagctaggca
     2761 aagacataaa aatgattcag gagaacatga ggagacccac aaaacatgca aagacctgtg
     2821 tattctaaac cagctgattg gtgggacagt gtgatgacct gaccggcagg gttcgacaga
     2881 ccagggcatc ttctagtgtc ttaaatagta ggcatctctc cactaacagc tggcatggtc
     2941 aattggagca tggctttaat aagtcattat tatacatttt cagcccttct tccagtgaat
     3001 cagaaggact cagtacaaac tccgttacga tatatcctag ccacatgcag ggtaccatat
     3061 aggattttct attattgaaa gaatactttt ctggcaaaaa aaaagataaa gaaaggaaga
     3121 aaagaaaata aaaagcactt tttttcttaa tggtagcagt gtaatgtatt ttgcaatgaa
     3181 tttgtaattt ttctgtacaa tagttttgat aatttatagt actttgatgt cacgtagcca
     3241 ttgtctcggt tgaagtaata cttgtttact agcaggcgtt tgaacaaagc ctttcctact
     3301 tttttatccc tttcagagaa ccaacgattc tttaggaact ttgaatacta aatgaccctc
     3361 agtcaccgtc agctttagca gaatatcttt cttatcttaa caagtgtctt atgtggtgga
     3421 ggaagagtta agggggatgg tggtggtgcg gacacttcac ttacccaacc aaatataacg
     3481 aaataacatt tgagccacag aattgccata tgattccttg agatgatgct aagtattttg
     3541 aaaaattaca tattcctgca aagattctgg taacaccatt ttttttcttt tgtagaacca
     3601 gatattaccc ttgatgcctc ccttcaaata ggtgtggcat cctcagtggc caaatttccc
     3661 tcccagggag taattttaat gctgggatct ttggactcag atccccaggt agaatgtttc
     3721 agtgagacca tggaaatgcc aggctcacaa agggagaatg aataaggcaa gttgtttggt
     3781 ccgtcactgt ttctaagact ctgtatgcta gcacaccaaa ctcttgtctg tatttacctt
     3841 catgccacag tattaatcac tgttattcat gtattgtgct gaaagtctga acggatgata
     3901 gaggatgaat tagcaagggg gtactttacc aagtatggtc taacttccgt ggtggccgtg
     3961 ttataatgtg tttctgacat aaggagagtt tgtgctgctg tctcgatctt cctgaatgtt
     4021 gataaaaatg aatgactact
//
