LOCUS       NM_001106238            2857 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus p21 (RAC1) activated kinase 4 (Pak4), mRNA.
ACCESSION   NM_001106238 XM_001073813 XM_001073846 XM_001073872 XM_218388
VERSION     NM_001106238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2857)
  AUTHORS   Ramos-Alvarez,I., Lee,L. and Jensen,R.T.
  TITLE     Group II p21-activated kinase, PAK4, is needed for activation of
            focal adhesion kinases, MAPK, GSK3, and beta-catenin in rat
            pancreatic acinar cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 318 (3), G490-G503 (2020)
   PUBMED   31984786
  REMARK    GeneRIF: In pancreatic acinar cells, activation of focal adhesion
            kinases (p125(FAK),PYK2) and its accompanying adapter proteins,
            p130CAS/paxillin; Mek1/2, p44/42, GSK3, and beta-catenin are
            mediated by PAK4.
REFERENCE   2  (bases 1 to 2857)
  AUTHORS   Pan,S., Wu,Z., Liu,X., Chen,J., Wang,H., Liu,D., Fei,A., Chen,L.
            and Gao,C.
  TITLE     Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury
  JOURNAL   Biomed Res Int 2017, 8314276 (2017)
   PUBMED   29445744
  REMARK    GeneRIF: In summary, PAK4 is a key regulator in the
            pathophysiological process of acute lung injury (ALI) and can be a
            useful target for ALI treatment.
REFERENCE   3  (bases 1 to 2857)
  AUTHORS   Won,S.Y., Park,M.H., You,S.T., Choi,S.W., Kim,H.K., McLean,C.,
            Bae,S.C., Kim,S.R., Jin,B.K., Lee,K.H., Shin,E.Y. and Kim,E.G.
  TITLE     Nigral dopaminergic PAK4 prevents neurodegeneration in rat models
            of Parkinson's disease
  JOURNAL   Sci Transl Med 8 (367), 367ra170 (2016)
   PUBMED   27903866
  REMARK    GeneRIF: PAK4 activity was markedly decreased in postmortem brain
            tissue from Parkinson's disease (PD) patients and in rodent models
            of PD. Expression of constitutively active PAK4(S445N/S474E)
            (caPAK4) protected DA neurons in both the 6-hydroxydopamine and
            alpha-synuclein rat models of PD and preserved motor function.
REFERENCE   4  (bases 1 to 2857)
  AUTHORS   Baskaran,Y., Ang,K.C., Anekal,P.V., Chan,W.L., Grimes,J.M.,
            Manser,E. and Robinson,R.C.
  TITLE     An in cellulo-derived structure of PAK4 in complex with its
            inhibitor Inka1
  JOURNAL   Nat Commun 6, 8681 (2015)
   PUBMED   26607847
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2857)
  AUTHORS   Liu,W., Yang,Y., Liu,Y., Liu,H., Zhang,W., Xu,L., Zhu,Y. and Xu,J.
  TITLE     p21-Activated kinase 4 predicts early recurrence and poor survival
            in patients with nonmetastatic clear cell renal cell carcinoma
  JOURNAL   Urol Oncol 33 (5), 205 (2015)
   PUBMED   25744653
REFERENCE   6  (bases 1 to 2857)
  AUTHORS   Dolan,B.M., Duron,S.G., Campbell,D.A., Vollrath,B.,
            Shankaranarayana Rao,B.S., Ko,H.Y., Lin,G.G., Govindarajan,A.,
            Choi,S.Y. and Tonegawa,S.
  TITLE     Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the
            small-molecule PAK inhibitor FRAX486
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), 5671-5676 (2013)
   PUBMED   23509247
REFERENCE   7  (bases 1 to 2857)
  AUTHORS   Fiedler,J., Jazbutyte,V., Kirchmaier,B.C., Gupta,S.K., Lorenzen,J.,
            Hartmann,D., Galuppo,P., Kneitz,S., Pena,J.T., Sohn-Lee,C.,
            Loyer,X., Soutschek,J., Brand,T., Tuschl,T., Heineke,J., Martin,U.,
            Schulte-Merker,S., Ertl,G., Engelhardt,S., Bauersachs,J. and
            Thum,T.
  TITLE     MicroRNA-24 regulates vascularity after myocardial infarction
  JOURNAL   Circulation 124 (6), 720-730 (2011)
   PUBMED   21788589
REFERENCE   8  (bases 1 to 2857)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   9  (bases 1 to 2857)
  AUTHORS   Liu,Y., Chen,N., Cui,X., Zheng,X., Deng,L., Price,S., Karantza,V.
            and Minden,A.
  TITLE     The protein kinase Pak4 disrupts mammary acinar architecture and
            promotes mammary tumorigenesis
  JOURNAL   Oncogene 29 (44), 5883-5894 (2010)
   PUBMED   20697354
REFERENCE   10 (bases 1 to 2857)
  AUTHORS   Belmonte,M.A., Santos,M.F., Kihara,A.H., Yan,C.Y. and
            Hamassaki,D.E.
  TITLE     Light-Induced photoreceptor degeneration in the mouse involves
            activation of the small GTPase Rac1
  JOURNAL   Invest Ophthalmol Vis Sci 47 (3), 1193-1200 (2006)
   PUBMED   16505058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218388.3, XM_001073872.1, XM_001073813.1, XM_001073846.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168940.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2857
                     /gene="Pak4"
                     /note="p21 (RAC1) activated kinase 4"
                     /db_xref="GeneID:292756"
                     /db_xref="RGD:1307705"
     exon            1..109
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            110..182
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            183..447
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2025
                     /gene="Pak4"
                     /EC_number="2.7.11.1"
                     /note="p21-activated kinase 4; p21 (CDKN1A)-activated
                     kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 4"
                     /protein_id="NP_001099708.1"
                     /db_xref="GeneID:292756"
                     /db_xref="RGD:1307705"
                     /translation="MFGKKKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIE
                     ESARRPKPLIDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRR
                     ESPPPPARAHQENGMLEERAALARMAPDKAGGRGRATGHSEAGSGSGDRRRVGPEKRP
                     KSSREGPGGPQEVSRDKRPLSGPDVSTPQPGSLASETKLAAGRPFNTYPRADTDHPPR
                     GTQGEPHTMAPNGPSAIGLAAPQSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPARA
                     LAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGST
                     GIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDE
                     LWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILL
                     THDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVI
                     EMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAA
                     ELLKHPFLTKAGPPASIVPLMRQHRNR"
     exon            448..906
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1347
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1481
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1608
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1734
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1869
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2857
                     /gene="Pak4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcag tagccgcggc ggcggcggct cgagacagct gagggcggta cgcgggcgca
       61 gagttctggg cccggcagct aggccgcgag cgaccgcggc gccaagccga tgagtaactc
      121 aaagcctcag gaggagacgt cacccacaca agggtgtttc tagcccagcc acttcagacc
      181 aggtgcctgt aagagcccag gccaccccac cattcacaca ctttgtgcta aggtcctgga
      241 accatgtttg gaaagaagaa gaagcgggtg gagatctcgg ccccatccaa cttcgagcac
      301 cgcgtacaca caggcttcga tcagcatgag cagaagttca cagggctgcc ccgccagtgg
      361 cagagcctga ttgaggagtc agcgcgcaga cccaagcccc tgatcgaccc tgcttgcatc
      421 acttccatcc agcctggagc ccccaagacc atcgtgcggg gcagcaaagg tgccaaggat
      481 ggggctctca cactgctgct tgacgaattt gagaacatgt cggtgacacg ctccaactcc
      541 ctgcgcagag agagtcctcc accccctgcc cgcgcccatc aggaaaatgg aatgctggag
      601 gagcgggcag ctctggccag aatggcccct gacaaagctg gaggcagggg ccgggccaca
      661 ggccacagtg aggcaggcag tggcagtggt gacagacggc gggtggggcc agagaagagg
      721 cccaagtcat caagggaggg cccaggaggg ccccaggagg tctcccgtga taagcgcccc
      781 ctctctggtc ctgatgtcag cactcctcag cctggcagtc tggccagcga gacaaaacta
      841 gcagctggca gaccctttaa cacataccct cgggctgaca cggaccaccc accccggggt
      901 acccaggggg agccacacac catggcccct aatgggccat cagccatagg cctggctgct
      961 cctcagtctt cctcctcctc ccggcctccc acccgagccc gtggtgctcc cagcccggga
     1021 gtgctgggtc cccatgcctc tgagccccag ttggcccccc cagcacgtgc ccttgctgcc
     1081 cctgctgtac cccctgctcc tgggccccct gggcctcggt caccacagcg ggagccccaa
     1141 cgagtatccc atgagcagtt ccgggccgcc ctgcagctag tggtggaccc aggggaccct
     1201 cgttcctatc tagacaactt catcaagatt ggcgagggct ctacaggtat tgtgtgcata
     1261 gccactgtgc gaagctcggg caaactggtg gccgtcaaga agatggactt gcgtaagcag
     1321 cagagacgtg agctgctctt caatgaggtg gtgatcatga gggactaccg gcatgaaaac
     1381 gtggtggaga tgtacaacag ctacctggta ggcgatgagc tctgggtggt catggagttc
     1441 ctggagggag gcgccctcac ggatattgtc acccacacca ggatgaatga ggaacagatt
     1501 gccgccgtgt gcctggctgt gcttcaggcg ctgtctgtgc tccatgccca gggcgtcatc
     1561 caccgtgaca tcaagagtga ctccatcctg ctgacccacg atggccgggt gaagctgtcc
     1621 gacttcgggt tttgtgccca ggtgagcaag gaggtgcctc ggaggaagtc gctggtgggc
     1681 accccatact ggatggcccc agagctcatc tcccgccttc cctacgggcc agaggtggat
     1741 atctggtcac tgggggtaat ggtgatcgag atggtggatg gggaaccccc ctacttcaac
     1801 gagccacccc tgaaagccat gaagatgatt cgggacaacc tgccgccccg actgaagaac
     1861 ctgcacaagg cctcaccatc tctgaaaggc ttcttggatc gcctgctggt gcgtgaccca
     1921 gcccagcggg ccactgctgc tgagctgctg aagcacccgt tcctcaccaa ggcggggccg
     1981 ccagccagca ttgtgcccct tatgcgccag caccgaaaca gatgagccag aacctagtcc
     2041 tgaaccaaag agccctgggc taccctgcct gtcagaggcc agtagagggc tgcccagctc
     2101 ccacagccca cgagacactc tagggcacca ccgtcactgt gctggggcct tcatgggacc
     2161 ctactactga tctctgggtt tgattccatg acttgtaaag ccacaccgca caccaggaca
     2221 catgggagcg attgaggctc ccaggaccca ggacaggccc ctcccctgga ctgcctacag
     2281 gagagaaggt ggctgccatt gtggaaatct gcatcagcgg ccactggggc agagatgaca
     2341 ccatgagaaa ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2401 tgtgtgtgtg tgtgtgcgtg cgcgcgcgca cgagcactct cacgccaaga aagtccacct
     2461 ctgtcctcag cctgcctggt gcccagcccc tgaccctgag ccattgatgg gtcaatcatg
     2521 aatgtttgaa gagtggcctt ttcccagagc cccacaccct ctttccacag gagaaacatg
     2581 gggcctcccc ttccccaacc tctgcagcaa atgactactg catccagaca gcctccgttt
     2641 tctagaagtc tatttatatt gtcattttat aacactagtt gtgtctctat ctcagcctgg
     2701 gaacagatga tccctgacct atggggtggc tggcctgggg acagagccac tttgaagaat
     2761 caggctcctg tccctcaccc tgccgccaat ccctcaagtt agttttacaa ttaaagtatt
     2821 ttcttggttt ttgttgtgtt gtgttgtgtt gtgttgt
//
