LOCUS       NM_019210               2152 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus p21 (RAC1) activated kinase 3 (Pak3), mRNA.
ACCESSION   NM_019210
VERSION     NM_019210.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2152)
  AUTHORS   Hussain,N.K., Thomas,G.M., Luo,J. and Huganir,R.L.
  TITLE     Regulation of AMPA receptor subunit GluA1 surface expression by
            PAK3 phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 112 (43), E5883-E5890 (2015)
   PUBMED   26460013
  REMARK    GeneRIF: specific loss of PAK3 expression and pharmacological
            inhibition of PAK both disrupt activity-dependent phosphorylation
            of S863 in cortical neurons
REFERENCE   2  (bases 1 to 2152)
  AUTHORS   Jaudon,F., Raynaud,F., Wehrle,R., Bellanger,J.M., Doulazmi,M.,
            Vodjdani,G., Gasman,S., Fagni,L., Dusart,I., Debant,A. and
            Schmidt,S.
  TITLE     The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2112-2127 (2015)
   PUBMED   25851601
REFERENCE   3  (bases 1 to 2152)
  AUTHORS   Holderness Parker,N., Donninger,H., Birrer,M.J. and Leaner,V.D.
  TITLE     p21-activated kinase 3 (PAK3) is an AP-1 regulated gene
            contributing to actin organisation and migration of transformed
            fibroblasts
  JOURNAL   PLoS One 8 (6), e66892 (2013)
   PUBMED   23818969
  REMARK    GeneRIF: Results show elevated PAK3 expression at both the mRNA and
            protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as
            well as in transformed human fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2152)
  AUTHORS   Dolan,B.M., Duron,S.G., Campbell,D.A., Vollrath,B.,
            Shankaranarayana Rao,B.S., Ko,H.Y., Lin,G.G., Govindarajan,A.,
            Choi,S.Y. and Tonegawa,S.
  TITLE     Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the
            small-molecule PAK inhibitor FRAX486
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), 5671-5676 (2013)
   PUBMED   23509247
REFERENCE   5  (bases 1 to 2152)
  AUTHORS   Dubos,A., Combeau,G., Bernardinelli,Y., Barnier,J.V., Hartley,O.,
            Gaertner,H., Boda,B. and Muller,D.
  TITLE     Alteration of synaptic network dynamics by the intellectual
            disability protein PAK3
  JOURNAL   J Neurosci 32 (2), 519-527 (2012)
   PUBMED   22238087
  REMARK    GeneRIF: PAK3 regulates activity-mediated rearrangement of synaptic
            connectivity associated with learning, suggesting that defects in
            spine formation and refinement during development could account for
            intellectual disability.
REFERENCE   6  (bases 1 to 2152)
  AUTHORS   King,A.J., Sun,H., Diaz,B., Barnard,D., Miao,W., Bagrodia,S. and
            Marshall,M.S.
  TITLE     The protein kinase Pak3 positively regulates Raf-1 activity through
            phosphorylation of serine 338
  JOURNAL   Nature 396 (6707), 180-183 (1998)
   PUBMED   9823899
  REMARK    Erratum:[Nature 2000 Jul 27;406(6794):439]
REFERENCE   7  (bases 1 to 2152)
  AUTHORS   Kim,S.O., Irwin,P., Katz,S. and Pelech,S.L.
  TITLE     Expression of mitogen-activated protein kinase pathways during
            postnatal development of rat heart
  JOURNAL   J Cell Biochem 71 (2), 286-301 (1998)
   PUBMED   9779826
REFERENCE   8  (bases 1 to 2152)
  AUTHORS   Manser,E., Chong,C., Zhao,Z.S., Leung,T., Michael,G., Hall,C. and
            Lim,L.
  TITLE     Molecular cloning of a new member of the p21-Cdc42/Rac-activated
            kinase (PAK) family
  JOURNAL   J Biol Chem 270 (42), 25070-25078 (1995)
   PUBMED   7559638
REFERENCE   9  (bases 1 to 2152)
  AUTHORS   Manser,E., Leung,T., Salihuddin,H., Zhao,Z.S. and Lim,L.
  TITLE     A brain serine/threonine protein kinase activated by Cdc42 and Rac1
  JOURNAL   Nature 367 (6458), 40-46 (1994)
   PUBMED   8107774
REFERENCE   10 (bases 1 to 2152)
  AUTHORS   Williams,A.F., Barclay,A.N., Letarte-Muirhead,M. and Morris,R.J.
  TITLE     Rat thy-1 antigens from thymus and brain: their tissue
            distribution, purification, and chemical composition
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 51-61 (1977)
   PUBMED   70317
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019210.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U33314.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000021.1  112057602-112057634
            34-235              JAXUCZ010000021.1  112084586-112084787
            236-336             JAXUCZ010000021.1  112100457-112100557
            337-490             JAXUCZ010000021.1  112105911-112106064
            491-528             JAXUCZ010000021.1  112106893-112106930
            529-660             JAXUCZ010000021.1  112118218-112118349
            661-826             JAXUCZ010000021.1  112120450-112120615
            827-890             JAXUCZ010000021.1  112127299-112127362
            891-939             JAXUCZ010000021.1  112146285-112146333
            940-1052            JAXUCZ010000021.1  112146594-112146706
            1053-1170           JAXUCZ010000021.1  112148060-112148177
            1171-1270           JAXUCZ010000021.1  112149871-112149970
            1271-1467           JAXUCZ010000021.1  112150394-112150590
            1468-1605           JAXUCZ010000021.1  112162680-112162817
            1606-2152           JAXUCZ010000021.1  112164477-112165023
FEATURES             Location/Qualifiers
     source          1..2152
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33"
     gene            1..2152
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /note="p21 (RAC1) activated kinase 3"
                     /db_xref="GeneID:29433"
                     /db_xref="RGD:3251"
     exon            1..33
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            34..235
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1695
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /EC_number="2.7.11.1"
                     /note="p21 (CDKN1A)-activated kinase 3; PAK-3; p65-PAK;
                     p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3
                     (yeast Ste20-related); p21 protein (Cdc42/Rac)-activated
                     kinase 3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 3"
                     /protein_id="NP_062083.1"
                     /db_xref="GeneID:29433"
                     /db_xref="RGD:3251"
                     /translation="MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNK
                     KARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLL
                     QTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKT
                     ASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNK
                     EATPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQ
                     GASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLV
                     GDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDN
                     ILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGI
                     MAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRG
                     SAKELLQHPFLKLAKPLSSLTPLILAAKEAIKNSSR"
     exon            236..336
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            337..490
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            491..528
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            529..660
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            661..826
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            827..890
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            891..939
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1052
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1170
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1270
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1467
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1605
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..2152
                     /gene="Pak3"
                     /gene_synonym="beta-PAK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttactttta tgctcaccat ctgattggcc taggagctgt gaaatcagct gcaactgaaa
       61 atgtctgaca gcttggataa cgaagaaaaa cctccagctc ccccactgag gatgaacagt
      121 aacaaccgag attcttcagc actcaaccac agctccaaac cactgcccat ggccccggaa
      181 gagaagaata agaaagccag gcttcgctct atcttcccag gaggagggga taaaaccaat
      241 aagaagaaag agaaagaacg cccagagatc tctcttcctt cagactttga gcatacgatt
      301 catgtgggtt ttgatgcagt caccggggaa ttcactggaa ttcctgaaca atgggctcga
      361 ctgctccaaa cctccaacat tacaaaactg gaacagaaga agaacccaca ggctgttctg
      421 gatgttctca agttttacga ctccaaagaa acagtcaaca accagaaata catgagcttt
      481 acatcaggag ataaaagtgc ccatggatat atagcagcac atcagtcgaa taccaaaaca
      541 gcttcagaac ctcctttggc tcctcctgta tctgaagaag aggatgaaga agaggaagag
      601 gaagaagatg ataatgagcc cccgcctgtc attgcaccaa gaccagagca tacaaaatca
      661 atctatactc gttctgtggt tgagtcaatt gcttcaccag cagcaccaaa taaagaagcc
      721 accccacctt ctgctgagaa tgccaattcc agtactttgt acaggaatac agatcggcaa
      781 agaaaaaaat ccaagatgac agatgaggag atcctagaga agctaagaag cattgtgagt
      841 gttggggacc caaagaagaa atatacaaga tttgaaaaaa ttggccaagg ggcatcagga
      901 actgtttaca cagcactaga cattgcgaca ggacaagagg tggctataaa gcaaatgaac
      961 cttcaacagc agcccaaaaa ggaattaatt attaatgaaa ttcttgtcat gagggaaaat
     1021 aagaacccca atattgtcaa ttatttagat agctacttag tgggtgatga actgtgggta
     1081 gtcatggaat acttggctgg tggctctttg actgacgtgg tcacagaaac ctgtatggat
     1141 gaaggacaga tagcagccgt ctgtagagag tgcctccaag ctttggattt cttgcactca
     1201 aaccaagtga tccacagaga tataaagagt gacaatattc tcctcgggat ggatggttct
     1261 gttaaactga ctgattttgg attctgtgcc caaatcactc ctgagcaaag taaacgaagc
     1321 actatggtgg gaactcccta ttggatggca cctgaggtgg taactcgaaa agcttatggc
     1381 ccgaaagttg atatctggtc tctgggaatc atggccattg aaatggtgga aggtgaaccc
     1441 ccttacctta atgaaaatcc actcagggcc ttatatctga tagccactaa tggaacccca
     1501 gagctccaga atcccgagag actgtcagct gtattccgtg acttcttaaa tcgctgtctt
     1561 gagatggatg tggatagacg agggtctgcc aaggagcttt tgcagcatcc atttttaaaa
     1621 ttagccaagc ccctgtccag cctcactcct ctgattcttg ctgcaaagga agccattaag
     1681 aacagtagcc gttagaagtg caagccttac ccctcaccgt ctcccggatg agtaagactg
     1741 aactaaaact ctgctgcagg atccacagaa gaaaagacag tcaaatggag tgggggttct
     1801 ttaactttca agtgaataga aacttcttat aaaccttttt cctactccct cagattatgt
     1861 aatttatttg taagcctgaa ccgcagccca cacagggcag caatgtcgaa gtagccatta
     1921 agtggccact tccaccgtga agcgagagag ccagtagtga atcccctcat tcgtgcattt
     1981 actttgaaga aaaagagatt tctcaaagat gcacactccc tcttcatagt gctgtgtgtt
     2041 tttaagttag agagtagtcc cccttccatt caaacctctt tcaaaatccc ttacccaacg
     2101 tgatgttttt tcacttgcat tgtcattaga tgtccagaaa aaaagatgtc aa
//
