LOCUS       NM_053306               4122 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus p21 (RAC1) activated kinase 2 (Pak2), transcript
            variant 1, mRNA.
ACCESSION   NM_053306
VERSION     NM_053306.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4122)
  AUTHORS   Binder,P., Wang,S., Radu,M., Zin,M., Collins,L., Khan,S., Li,Y.,
            Sekeres,K., Humphreys,N., Swanton,E., Reid,A., Pu,F., Oceandy,D.,
            Guan,K., Hille,S.S., Frey,N., Muller,O.J., Cartwright,E.J.,
            Chernoff,J., Wang,X. and Liu,W.
  TITLE     Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic
            Reticulum Stress Response
  JOURNAL   Circ Res 124 (5), 696-711 (2019)
   PUBMED   30620686
  REMARK    GeneRIF: Pak2 promotes a protective endoplasmic reticulum stress
            response, protecting the heart from disease.
REFERENCE   2  (bases 1 to 4122)
  AUTHORS   Chang,J.K., Ni,Y., Han,L., Sinnett-Smith,J., Jacamo,R., Rey,O.,
            Young,S.H. and Rozengurt,E.
  TITLE     Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I
            p21-activated kinase (PAK) regulates PKD1 localization
  JOURNAL   J Biol Chem 292 (23), 9523-9539 (2017)
   PUBMED   28408623
  REMARK    GeneRIF: PAK-mediated phosphorylation of PKD1 at Ser203 triggers
            its membrane dissociation and subsequent entry into the nucleus,
            thereby regulating the phosphorylation of PKD1 nuclear targets,
            including class IIa histone deacetylases.
REFERENCE   3  (bases 1 to 4122)
  AUTHORS   Nuche-Berenguer,B., Ramos-Alvarez,I. and Jensen,R.T.
  TITLE     The p21-activated kinase, PAK2, is important in the activation of
            numerous pancreatic acinar cell signaling cascades and in the onset
            of early pancreatitis events
  JOURNAL   Biochim Biophys Acta 1862 (6), 1122-1136 (2016)
   PUBMED   26912410
  REMARK    GeneRIF: PAK2 regulates cell death pathways in pancreatic acinar
            cells promoting cell death .
REFERENCE   4  (bases 1 to 4122)
  AUTHORS   Nuche-Berenguer,B. and Jensen,R.T.
  TITLE     Gastrointestinal hormones/neurotransmitters and growth factors can
            activate P21 activated kinase 2 in pancreatic acinar cells by novel
            mechanisms
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2371-2382 (2015)
   PUBMED   25979836
  REMARK    GeneRIF: These results show that PAK2 is important in signaling
            cascades activated by numerous pancreatic stimuli which mediate
            their various physiological/pathophysiological responses
REFERENCE   5  (bases 1 to 4122)
  AUTHORS   Tornavaca,O., Chia,M., Dufton,N., Almagro,L.O., Conway,D.E.,
            Randi,A.M., Schwartz,M.A., Matter,K. and Balda,M.S.
  TITLE     ZO-1 controls endothelial adherens junctions, cell-cell tension,
            angiogenesis, and barrier formation
  JOURNAL   J Cell Biol 208 (6), 821-838 (2015)
   PUBMED   25753039
REFERENCE   6  (bases 1 to 4122)
  AUTHORS   Kim,S.O., Irwin,P., Katz,S. and Pelech,S.L.
  TITLE     Expression of mitogen-activated protein kinase pathways during
            postnatal development of rat heart
  JOURNAL   J Cell Biochem 71 (2), 286-301 (1998)
   PUBMED   9779826
REFERENCE   7  (bases 1 to 4122)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   8  (bases 1 to 4122)
  AUTHORS   Teo,M., Manser,E. and Lim,L.
  TITLE     Identification and molecular cloning of a p21cdc42/rac1-activated
            serine/threonine kinase that is rapidly activated by thrombin in
            platelets
  JOURNAL   J Biol Chem 270 (44), 26690-26697 (1995)
   PUBMED   7592896
REFERENCE   9  (bases 1 to 4122)
  AUTHORS   Martin,G.A., Bollag,G., McCormick,F. and Abo,A.
  TITLE     A novel serine kinase activated by rac1/CDC42Hs-dependent
            autophosphorylation is related to PAK65 and STE20
  JOURNAL   EMBO J 14 (9), 1970-1978 (1995)
   PUBMED   7744004
  REMARK    Erratum:[EMBO J. 1995 Sep 1;14(17):4385. doi:
            10.1002/j.1460-2075.1995.tb00113.x.. PMID: 7556080]
REFERENCE   10 (bases 1 to 4122)
  AUTHORS   Manser,E., Leung,T., Salihuddin,H., Zhao,Z.S. and Lim,L.
  TITLE     A brain serine/threonine protein kinase activated by Cdc42 and Rac1
  JOURNAL   Nature 367 (6458), 40-46 (1994)
   PUBMED   8107774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Mar 4, 2021 this sequence version replaced NM_053306.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.41528.1,
                                           SRR26643288.45978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000011.1  82212935-82213155
            222-429             JAXUCZ010000011.1  82235209-82235416
            430-530             JAXUCZ010000011.1  82246126-82246226
            531-678             JAXUCZ010000011.1  82248528-82248675
            679-710             JAXUCZ010000011.1  82249576-82249607
            711-818             JAXUCZ010000011.1  82250599-82250706
            819-951             JAXUCZ010000011.1  82252058-82252190
            952-1015            JAXUCZ010000011.1  82254708-82254771
            1016-1064           JAXUCZ010000011.1  82257132-82257180
            1065-1177           JAXUCZ010000011.1  82257880-82257992
            1178-1295           JAXUCZ010000011.1  82260281-82260398
            1296-1395           JAXUCZ010000011.1  82264272-82264371
            1396-1592           JAXUCZ010000011.1  82267416-82267612
            1593-1730           JAXUCZ010000011.1  82269963-82270100
            1731-4122           JAXUCZ010000011.1  82271412-82273803
FEATURES             Location/Qualifiers
     source          1..4122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4122
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /note="p21 (RAC1) activated kinase 2"
                     /db_xref="GeneID:29432"
                     /db_xref="RGD:61953"
     exon            1..221
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..429
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1817
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /EC_number="2.7.11.1"
                     /note="p21 (CDKN1A)-activated kinase 2; p21-activated
                     kinase 2; serine/threonine-protein kinase PAK 2-like; p21
                     protein (Cdc42/Rac)-activated kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 2"
                     /protein_id="NP_445758.3"
                     /db_xref="GeneID:29432"
                     /db_xref="RGD:61953"
                     /translation="MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVP
                     EEKKPRNKIISIFSSTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQW
                     ARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNTK
                     GSETSAVVTEEDDDDEDAAPPVIAPRPDHTKSIYTRSVIDPIPAPVGDSNVDSGAKSS
                     DKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVA
                     IKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDV
                     VTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQ
                     ITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR
                     ALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSS
                     LTPLILAAKEAMKSNR"
     exon            430..530
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..678
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..710
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..818
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..951
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1015
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1064
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1177
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1295
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1395
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1592
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1730
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..4122
                     /gene="Pak2"
                     /gene_synonym="gamma-PAK; PAK-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccgcttc ccctccggcc cgggccgtcg ccattgccga aggctcctgc cctcccctcc
       61 ctggctcaag gggttctgcg cctcacagcc tcggtagcga cggccgcgcc ccgcgccgct
      121 cctctccgcc ctgccatcct ccctctctgc tccccagcac agtgctcgcc cgcgtcggcc
      181 cggcagcccg ccctgggtcg ggcggagacc tttcctctct ggccgtttcc taattctgaa
      241 tcatgtctga taacggggag ctagaggaca agcccccagc acctccagtg cggatgagca
      301 gcaccatttt tagcactgga ggaaaggatc ctttatcagc caatcacagt ttgaagcctt
      361 tgccttctgt tccagaggaa aaaaaaccga ggaacaaaat catctccata ttctcaagca
      421 cagaaaaagg aagtaaaaag aaagaaaaag aacggccaga gatttctccg ccgtctgatt
      481 ttgagcatac catccatgtt ggctttgatg ctgttacggg agagttcact ggcatgccag
      541 agcagtgggc acggctgttg cagacctcca acattaccaa actggagcag aagaagaacc
      601 cgcaggctgt gctggatgtc ttgaagttct acgactccaa cactgtgaag cagaagtacc
      661 tgagcttcac tcctcctgag aaagatggct ttccttctgg aacaccagca ctgaacacca
      721 aggggtcaga gacatcagct gtggtgacag aggaagacga tgacgatgaa gatgctgctc
      781 ctcccgtcat tgcccctcgg ccagatcata caaaatcaat ctacacaagg tctgtcatcg
      841 accctattcc tgctccagtt ggtgactcta atgtcgacag tggtgccaag tcttcagaca
      901 aacagaaaaa gaaagccaag atgaccgatg aagagattat ggagaaatta agaactattg
      961 tgagcatagg tgaccctaag aaaaaataca caagatatga aaaaatcggg caaggggctt
     1021 ctggtacagt ttttactgca actgatgtgg ccctggggca agaggttgct atcaagcaga
     1081 ttaatttaca gaaacaacca aagaaggaat tgatcattaa tgaaattctg gtgatgaaag
     1141 agttaaagaa tcccaacata gttaacttct tggacagtta cctggtagga gacgagttgt
     1201 ttgtggtaat ggagtacctt gctggtgggt ccctcactga tgtcgtgaca gaaacctgca
     1261 tggatgaagc gcagatcgca gctgtgtgca gagagtgttt acaggcgttg gagtttttac
     1321 atgctaatca agtgatccac agagacatca aaagtgacaa tgtgcttttg ggaatggaag
     1381 gctcagttaa actcactgat tttggcttct gtgcccagat cacccctgaa cagagcaaac
     1441 gcagtactat ggttggaaca ccatactgga tggcaccgga ggtagtcacg cggaaagcct
     1501 atggccccaa agttgacata tggtctctgg gcatcatggc tatcgaaatg gtggaaggag
     1561 agcctccata cctcaatgaa aatcctttac gggcattata cctgatagca acgaatggaa
     1621 cacctgagct ccagaatcca gaaaaacttt cccccatatt tcgggatttc ttaaatcggt
     1681 gtttggaaat ggatgtggag aagaggggtt cagccaaaga actattacag catcctttcc
     1741 tgaaactggc caaaccatta tccagcttga cgcctctgat cctggcagct aaagaagcaa
     1801 tgaagagtaa ccgctaacgt cgtcagcgag gcctcatgtt cctttatcca ttttctaaag
     1861 aagtctttta atacatgaaa ttgttactct gaggggtgta aagagacagt ttgcatcaca
     1921 tggagaaaag caagcaaact tattattttc taaagatgac caagagaaaa ttgcagtaaa
     1981 agagttacaa ctttgcaatg agcccctgct ttagggtcca aaaggagttg tggactgcat
     2041 cactagcctt acatttccca gcagacagtg cttgacgttt gcatattgtt ttaatgactc
     2101 ttagtatggt agatcctgct cagtgtctcc tttgggtctt tcccatactt gaatgtcaga
     2161 ttcgagtttt tcctagattg catctgctgg tcttacctct cctttgtaac cttcccttcc
     2221 tctaacccgt tcctttcaag ttgttgcttt gagtttttct tatgcctaaa tccaagagag
     2281 atgtgataaa aattatgtag ttctttatat tgggaaagga gcttgacatg ttttaacttt
     2341 ttatagaagt taggaccagc tgttgtacgt gtagtatttc agttagagct taaactgaag
     2401 gggaaagaaa gtatgtgatt tttacctttt ttaacaaatg tgaaagagtc agctttagaa
     2461 atttcatggt agtgagtttg acatttgtta catgtataga aaaaagacta ataatctata
     2521 tttatagcta aatcattgat acagagaaaa aaatcccact gactgtatgt tctcaccatt
     2581 ttgtcttctt ctctgcctgt ttctcctcat actcggctct aggaaccaaa gtgatctgtg
     2641 cttgttcaca caagctttat ggctttggtg ccactgcctc cctgcacttc cttgggaatg
     2701 ggtgtctgtg tatgttctga tttaggtgtc agttttgaat caacccttat ttcacatatt
     2761 tcaccccctc taccctctag ggcaaataac aaccattgaa ttgtcagaat ttaaaagtta
     2821 aaagacttcc tgtttaaaag gaaaaaatat ttgggactag cagaaaccaa ggaagatttg
     2881 aaccttggta ggttctaggc tagttgtaat aatgaaatgt caatattgta gaggtgaagc
     2941 ttatggcagt aaactgtaaa gactcatcta atctacagta ttcccagccc attgtcagtg
     3001 tttactgttc acgagaggtg aagcttgatg gatcatctgg ggtgttgggt actttgtttt
     3061 tccaatgagt agggtattca ttgtaaaaca aacaaacaaa caaactggag aaagaactgc
     3121 agtgttcata ttgttagtaa tactttttat tttaaagatt taataaaagg tctgtgacct
     3181 gtagtattag ctgttagctg ccctttcccc ctcctgtctt tccttctctc tgctttgttg
     3241 ctttgcctgt ggaggaggtg ttactgtctg ttctacgttc ctgccgccat agaaaagaaa
     3301 tctctgtggt tggttcaggt ttgtccccac catccccttt caaagaactt gacacatgct
     3361 tgccactctg cagagtacga accatggatg agtcacgaat gctcttcagg gtattagggg
     3421 aagggcaggg cttcatctcc tgttgttccc attaaaatac aggagtaaga agagatcact
     3481 gggggttttt gataacagat tttcagcgaa agtcaacatc cagagaactt cctggcctgt
     3541 tttccatgag ttctttctcc tatggactat atttttctac aactgtcact aaattacaga
     3601 ggcaaactgg tctgtttgtg gtgggacgct gtgctgcctc atgctctggc tgtgtgcact
     3661 gtttgtaaac agctgtctgg gtggattgtg gtgacagtgc tgccacacag tagaaagcca
     3721 gccacacagt gggactgctt gtcttggact gctcaaggag gtgctccatc ctacgtcaga
     3781 gacagcgcag gggacacgtg cccctgcccc tcctgtgctg tgactccaca agggctttta
     3841 ggcaacagag cagtctgggg tttgtatttt cactttcttg gatggttatc tgcgtgtcca
     3901 ttgctggcga cggactctgt cattcaaacc tgactccgag gttaagggag ctgcactgtg
     3961 gtttattctt tctgacctgg ataaactaac ctggaatagc aaagagaaat ggctaatgtt
     4021 gagatgtgtc atttttaaac aaaaataatc tttaaagcaa tatagaattg tgatttatta
     4081 gttaatttta aattaaaatg ttgagatcct gttgaaagac aa
//
