LOCUS       XM_006250852            1946 bp    mRNA    linear   ROD 22-FEB-2024
DEFINITION  PREDICTED: Rattus norvegicus phosphoribosylaminoimidazole
            carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide
            synthase (Paics), transcript variant X2, mRNA.
ACCESSION   XM_006250852
VERSION     XM_006250852.4
DBLINK      BioProject: PRJNA1074393
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086032) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Oct 16, 2024 this sequence was replaced by
            NM_001433942.1.
            
            On Jan 21, 2021 this sequence version replaced XM_006250852.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     gene            1..1946
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="phosphoribosylaminoimidazole carboxylase and
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 45 ESTs, 1687 long SRA reads, 12
                     Proteins"
                     /db_xref="GeneID:140946"
                     /db_xref="RGD:620066"
     CDS             168..1445
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /codon_start=1
                     /product="bifunctional phosphoribosylaminoimidazole
                     carboxylase/phosphoribosylaminoimidazole
                     succinocarboxamide synthetase isoform X2"
                     /protein_id="XP_006250914.1"
                     /db_xref="GeneID:140946"
                     /db_xref="RGD:620066"
                     /translation="MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNA
                     ARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRR
                     IATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQT
                     EVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWP
                     SGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTS
                     DLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNG
                     LGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFG
                     LNNHLVWAKLRASKLNTWISLKQADKKIRECNL"
     polyA_site      1946
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gggacggggg cggagctatg gagtcaaggg actggggtta attctccgcg gcagaggtca
       61 ggatcgctgc ttttccctgc acgtgggaga ctccgttatt ttcccgctcc caaggcatcg
      121 ctgcttcttt ttcccgcgcg gtctgctcct ctagttcacc taggataatg gcgacagctg
      181 aagtactgaa catcgggaga aagctgtatg agggtaaaac aaaggaagtc tatgaattgt
      241 tagacagtcc aggaagagtc ctcctgcagt ccaaggacca gattacagca ggaaatgcag
      301 ctagaaagaa ccacctggaa ggcaaagccg ccatctccaa taagatcacc agctgcatat
      361 ttcagttgtt acaggaagct ggtataaaaa ctgctttcac caagaaatgt ggggagactg
      421 ctttcattgc accccagtgt gaaatgattc caattgagtg ggtatgccga agaatcgcca
      481 ctggatcttt tctcaaaagg aaccctggtg tgaaggaggg gtataggttt tatccaccaa
      541 aagtagagat gttcttcaag gatgatgcca ataacgaccc acaatggtct gaggagcaac
      601 tcatcgctgc aaaattttgt tttgctggac tcgttatagg gcaaactgaa gtggatatca
      661 tgagtcatgc cacacaagct atttttgaaa ttctggagaa atcctggctg ccccaaaact
      721 gtacgctggt tgatatgaag attgagtttg gcgttgatgt aaccaccaaa gagattgttc
      781 ttgctgatgt catagataat gattcctgga gactatggcc atcaggagat cggagccagc
      841 agaaagacaa acagtcttat cgggatctca aagaagtaac tccggaagga ctccagatgg
      901 taaagaagaa ctttgagtgg gttgcagacc gagtggagtt gcttctcaag tcaaacagtc
      961 agtgcagggt ggtagtgctg atggggtcga cctctgacct tggtcactgt gaaaaaatta
     1021 agaaggcttg tggaaacttt gggattccat gtgaacttag agtaacatct gcacataaag
     1081 gaccagatga aactttgagg attaaagcag aatatgaagg ggatggcata cctactgtat
     1141 ttgtcgcagt ggcgggcagg agcaatggac tgggcccagt gatgtctggt aatactgcat
     1201 acccggttat cagctgtccc ccaatcacag cagactgggg tgctcaggat gtgtggtcat
     1261 ctctgcgact gcccagtggt attggctgtt caactatact ttctccagaa ggatcagccc
     1321 agtttgctgc tcagatattt gggttaaaca accatttggt gtgggccaaa cttcgagcga
     1381 gcaaactgaa cacgtggata tccttaaagc aggctgataa gaaaatcaga gagtgcaatt
     1441 tgtaataaag caatttaatt tgtaggagaa aagttacata ttcctagttt ggatttaaaa
     1501 aaaaaatcaa gcaaaatgat ttcacatcag agaaaacaat tcagtttatt ttctggctct
     1561 atgtagtgat atgtccctgt agcctgagca ctctagagga tcactaaatt caaggccagc
     1621 ctgaattgtg tattgagacc ctgtatttgc tggggagggg atcttggcac aacgctgcta
     1681 aattacatct cgctttctat atagtcattg ttgggtaaat atgtaattat ggaactggag
     1741 caatgtgtct gtggttcaag aaccagtatg gctctcctgc agatgccctg agtttggctc
     1801 ccagcatcca tgtagactgc ctcacaataa ataaccttta acccgggatc tgaccccgtg
     1861 gcttccttat gcacctgctc tcagattctg ttacattcct ccacccaaca cacacaattt
     1921 taaaaaataa acgttttcaa agagta
//
