LOCUS       NM_080910               1994 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phosphoribosylaminoimidazole carboxylase and
            phosphoribosylaminoimidazolesuccinocarboxamide synthase (Paics),
            mRNA.
ACCESSION   NM_080910
VERSION     NM_080910.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Ikeda,M., Tomita,Y., Mouri,A., Koga,M., Okochi,T., Yoshimura,R.,
            Yamanouchi,Y., Kinoshita,Y., Hashimoto,R., Williams,H.J.,
            Takeda,M., Nakamura,J., Nabeshima,T., Owen,M.J., O'Donovan,M.C.,
            Honda,H., Arinami,T., Ozaki,N. and Iwata,N.
  TITLE     Identification of novel candidate genes for treatment response to
            risperidone and susceptibility for schizophrenia: integrated
            analysis among pharmacogenomics, mouse expression, and genetic
            case-control association approaches
  JOURNAL   Biol Psychiatry 67 (3), 263-269 (2010)
   PUBMED   19850283
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Iwahana,H., Honda,S., Tsujisawa,T., Takahashi,Y., Adzuma,K.,
            Katashima,R., Yamaoka,T., Moritani,M., Yoshimoto,K. and Itakura,M.
  TITLE     Rat genomic structure of amidophosphoribosyltransferase, cDNA
            sequence of aminoimidazole ribonucleotide carboxylase, and cell
            cycle-dependent expression of these two physically linked genes
  JOURNAL   Biochim Biophys Acta 1261 (3), 369-380 (1995)
   PUBMED   7742366
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Ichihara,Y., Sogawa,K., Morohashi,K., Fujii-Kuriyama,Y. and
            Takahashi,K.
  TITLE     Nucleotide sequence of a nearly full-length cDNA coding for
            pepsinogen of rat gastric mucosa
  JOURNAL   Eur J Biochem 161 (1), 7-12 (1986)
   PUBMED   3780741
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085711.1.
            
            [WARNING] On Oct 16, 2024 this sequence was replaced by
            NM_080910.4.
            
            On Nov 15, 2004 this sequence version replaced NM_080910.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085711.1, SRR8487226.29470.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1994
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="phosphoribosylaminoimidazole carboxylase and
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /db_xref="GeneID:140946"
                     /db_xref="RGD:620066"
     exon            1..44
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            45..111
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1373
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /EC_number="6.3.2.6"
                     /EC_number="4.1.1.21"
                     /note="multifunctional protein ADE2;
                     phosphoribosylaminoimidazole carboxylase,
                     phosphoribosylaminoribosylaminoimidazole
                     succinocarboxamide synthetase; multifunctional protein
                     ADE2-like; phosphoribosylaminoimidazole carboxylase,
                     phosphoribosylaminoimidazole succinocarboxamide
                     synthetase; AIR carboxylase-SAICAR synthetase;
                     phosphoribosylaminoimidazole carboxylase;
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /codon_start=1
                     /product="bifunctional phosphoribosylaminoimidazole
                     carboxylase/phosphoribosylaminoimidazole
                     succinocarboxamide synthetase"
                     /protein_id="NP_543186.1"
                     /db_xref="GeneID:140946"
                     /db_xref="RGD:620066"
                     /translation="MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNA
                     ARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRR
                     IATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQT
                     EVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWP
                     SGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTS
                     DLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNG
                     LGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFG
                     LNNHLVWAKLRASKLNTWISLKQADKKIRECNL"
     exon            112..309
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            310..488
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            489..668
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            669..782
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            783..866
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1047
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1206
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1966
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggttcctgc cctgagcagc cagccgagtg ctttgggttc gctgatcgct gcttcttttt
       61 cccgcgcggt ctgctcctct agttcaccta ggataatggc gacagctgaa gtactgaaca
      121 tcgggagaaa gctgtatgag ggtaaaacaa aggaagtcta tgaattgtta gacagtccag
      181 gaagagtcct cctgcagtcc aaggaccaga ttacagcagg aaatgcagct agaaagaacc
      241 acctggaagg caaagccgcc atctccaata agatcaccag ctgcatattt cagttgttac
      301 aggaagctgg tataaaaact gctttcacca agaaatgtgg ggagactgct ttcattgcac
      361 cccagtgtga aatgattcca attgagtggg tatgccgaag aatcgccact ggatcttttc
      421 tcaaaaggaa ccctggtgtg aaggaggggt ataggtttta tccaccaaaa gtagagatgt
      481 tcttcaagga tgatgccaat aacgacccac aatggtctga ggagcaactc atcgctgcaa
      541 aattttgttt tgctggactc gttatagggc aaactgaagt ggatatcatg agtcatgcca
      601 cacaagctat ttttgaaatt ctggagaaat cctggctgcc ccaaaactgt acgctggttg
      661 atatgaagat tgagtttggc gttgatgtaa ccaccaaaga gattgttctt gctgatgtca
      721 tagataatga ttcctggaga ctatggccat caggagatcg gagccagcag aaagacaaac
      781 agtcttatcg ggatctcaaa gaagtaactc cggaaggact ccagatggta aagaagaact
      841 ttgagtgggt tgcagaccga gtggagttgc ttctcaagtc aaacagtcag tgcagggtgg
      901 tagtgctgat ggggtcgacc tctgaccttg gtcactgtga aaaaattaag aaggcttgtg
      961 gaaactttgg gattccatgt gaacttagag taacatctgc acataaagga ccagatgaaa
     1021 ctttgaggat taaagcagaa tatgaagggg atggcatacc tactgtattt gtcgcagtgg
     1081 cgggcaggag caatggactg ggcccagtga tgtctggtaa tactgcatac ccggttatca
     1141 gctgtccccc aatcacagca gactggggtg ctcaggatgt gtggtcatct ctgcgactgc
     1201 ccagtggtat tggctgttca actatacttt ctccagaagg atcagcccag tttgctgctc
     1261 agatatttgg gttaaacaac catttggtgt gggccaaact tcgagcgagc aaactgaaca
     1321 cgtggatatc cttaaagcag gctgataaga aaatcagaga gtgcaatttg taataaagca
     1381 atttaatttg taggagaaaa gttacatatt cctagtttgg atttaaaaaa aaaatcaagc
     1441 aaaatgattt cacatcagag aaaacaattc agtttatttt ctggctctat gtagtgatat
     1501 gtccctgtag cctgagcact ctagaggatc actaaattca aggccagcct gaattgtgta
     1561 ttgagaccct gtatttgctg gggaggggat cttggcacaa cgctgctaaa ttacatctcg
     1621 ctttctatat agtcattgtt gggtaaatat gtaattatgg aactggagca atgtgtctgt
     1681 ggttcaagaa ccagtatggc tctcctgcag atgccctgag tttggctccc agcatccatg
     1741 tagactgcct cacaataaat aacctttaac ccgggatctg accccgtggc ttccttatgc
     1801 acctgctctc agattctgtt acattcctcc acccaacaca cacaatttta aaaaataaac
     1861 gttttcaaag agtattattt ctaagtggta ataacattta taaatcaata gtattgcttg
     1921 acatttggag ttgacacttt aaaaattaaa atattgtgcg tgttaaaaaa aaaaaaaaaa
     1981 aaaaaaaaaa aaaa
//
