LOCUS       NM_001393856            1440 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Paxip1-associated glutamate-rich protein 1
            (Pagr1), mRNA.
ACCESSION   NM_001393856
VERSION     NM_001393856.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1440)
  AUTHORS   Han,X., Zhu,Y., Shen,L., Zhou,Y., Pang,L., Zhou,W., Gu,H., Han,K.,
            Yang,Y., Jiang,C., Xie,J., Zhang,C. and Ding,L.
  TITLE     PTIP Inhibits Cell Invasion in Esophageal Squamous Cell Carcinoma
            via Modulation of EphA2 Expression
  JOURNAL   Front Oncol 11, 629916 (2021)
   PUBMED   33833989
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1440)
  AUTHORS   Starnes,L.M., Su,D., Pikkupeura,L.M., Weinert,B.T., Santos,M.A.,
            Mund,A., Soria,R., Cho,Y.W., Pozdnyakova,I., Kubec Hojfeldt,M.,
            Vala,A., Yang,W., Lopez-Mendez,B., Lee,J.E., Peng,W., Yuan,J.,
            Ge,K., Montoya,G., Nussenzweig,A., Choudhary,C. and Daniel,J.A.
  TITLE     A PTIP-PA1 subcomplex promotes transcription for IgH class
            switching independently from the associated MLL3/MLL4
            methyltransferase complex
  JOURNAL   Genes Dev 30 (2), 149-163 (2016)
   PUBMED   26744420
REFERENCE   3  (bases 1 to 1440)
  AUTHORS   Kumar,A., Lualdi,M., Loncarek,J., Cho,Y.W., Lee,J.E., Ge,K. and
            Kuehn,M.R.
  TITLE     Loss of function of mouse Pax-Interacting Protein 1-associated
            glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression
            and defects in chorion and amnion development
  JOURNAL   Dev Dyn 243 (7), 937-947 (2014)
   PUBMED   24633704
REFERENCE   4  (bases 1 to 1440)
  AUTHORS   Wang,C., Lee,J.E., Cho,Y.W., Xiao,Y., Jin,Q., Liu,C. and Ge,K.
  TITLE     UTX regulates mesoderm differentiation of embryonic stem cells
            independent of H3K27 demethylase activity
  JOURNAL   Proc Natl Acad Sci U S A 109 (38), 15324-15329 (2012)
   PUBMED   22949634
REFERENCE   5  (bases 1 to 1440)
  AUTHORS   Shilatifard,A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   6  (bases 1 to 1440)
  AUTHORS   Gong,Z., Cho,Y.W., Kim,J.E., Ge,K. and Chen,J.
  TITLE     Accumulation of Pax2 transactivation domain interaction protein
            (PTIP) at sites of DNA breaks via RNF8-dependent pathway is
            required for cell survival after DNA damage
  JOURNAL   J Biol Chem 284 (11), 7284-7293 (2009)
   PUBMED   19124460
REFERENCE   7  (bases 1 to 1440)
  AUTHORS   Liang,J., Zhang,H., Zhang,Y., Zhang,Y. and Shang,Y.
  TITLE     GAS, a new glutamate-rich protein, interacts differentially with
            SRCs and is involved in oestrogen receptor function
  JOURNAL   EMBO Rep 10 (1), 51-57 (2009)
   PUBMED   19039327
REFERENCE   8  (bases 1 to 1440)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO404699.1, SRR26643289.2959.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840117
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-897               JAXUCZ010000001.1  191054658-191055554 c
            898-980             JAXUCZ010000001.1  191054415-191054497 c
            981-1440            JAXUCZ010000001.1  191053228-191053687 c
FEATURES             Location/Qualifiers
     source          1..1440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1440
                     /gene="Pagr1"
                     /gene_synonym="Pa1; RGD1305592"
                     /note="Paxip1-associated glutamate-rich protein 1"
                     /db_xref="GeneID:293500"
                     /db_xref="RGD:1305592"
     exon            1..897
                     /gene="Pagr1"
                     /gene_synonym="Pa1; RGD1305592"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1180
                     /gene="Pagr1"
                     /gene_synonym="Pa1; RGD1305592"
                     /note="PAXIP1-associated protein 1; PTIP-associated
                     protein 1"
                     /codon_start=1
                     /product="PAXIP1-associated glutamate-rich protein 1"
                     /protein_id="NP_001380785.1"
                     /db_xref="GeneID:293500"
                     /db_xref="RGD:1305592"
                     /translation="MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSAS
                     KAEEEGKGSQEEAGREASRAEEALEASSAVSDERAEGESEDWCVPCSDEEVELPANGQ
                     SWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEK
                     PHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQIL
                     RTGRDLFSLDSEGPSPASPPLRSSGNSLFPRQRKY"
     exon            898..980
                     /gene="Pagr1"
                     /gene_synonym="Pa1; RGD1305592"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1440
                     /gene="Pagr1"
                     /gene_synonym="Pa1; RGD1305592"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttctctgc gcctgcgtac tgcgatcctg cgcagccagg gaggcgggtt ttagctccag
       61 gtttgtaccg ctgctgagta gacgcgaact aggtttgccg ggtttaaaaa aatggcttcc
      121 atccaggtga tggagaaggc gatgtgaaag cgagaaagca ggcccttccc tttccagctc
      181 cgagcgtgtc tcctgccggt ccctgggaac ggcagaattc tggatccgtg gggtggggtc
      241 tgtcctagca gggacctgag cgccccctcc tggggaccgt gctctggccg cagtcagttg
      301 ttggactgcc tcgttggtga tttcttagac ccccacttga tctaaagcct tttgggtgag
      361 gcaccctggt ttggtactcc agagtctcct atattgctgg gctcttctct agtactctat
      421 gtcccttgcc ctgggccatg gaaccattgc aggcagcaca gcggcgcctc tgtctgaaga
      481 aggggaagtg acttccggcc tccaggctct ggcggtggag gacactggag gtccctctgt
      541 ctcggctagt aaggccgagg aagaggggaa aggcagtcag gaggaggccg ggcgtgaggc
      601 atccagggct gaggaggcac tagaagcttc cagcgctgtg agcgacgagc gtgccgaggg
      661 agaatccgaa gactggtgcg tgccctgcag cgacgaggag gtggagctgc cggccaatgg
      721 gcagtcctgg atgcccccac cctccgaaat ccagcggctc tatgaactgc tggctaccca
      781 aggtactctg gagcttcaag cggagatcct accccgccgg ccgcctactc ctgaggccca
      841 gagtgaagag gagagatcag atgaggagcc agaggccaaa gaggaggagg aggaaaagcc
      901 gcacatgcct acagagtttg actttgatga tgagccagtg acacccaagg actcactgat
      961 tgacagaaga cgtacaccag gaagctcagc ccggagccag aaacgggagg cgcgtctgga
     1021 taaagtcctc tcagacatga agcgacataa gaaactagag gagcagatcc ttcggaccgg
     1081 gagagacctc ttcagcttag actcagaagg ccccagccct gccagccctc cactccgatc
     1141 ctcaggaaat agtctctttc ccaggcagcg aaagtactga ctgttgctgc tctggcctac
     1201 aggtgcagac tgttttgtgc tgagcatggc cggcctttcc catcccaggc tcttgtaaca
     1261 gaaaaagcct caagctccca gcgcagtgcc ttgcaggaga gtgtgtgtgt gtgtgtgtgt
     1321 gtgtgcgtgt gcgtgtgtgt gtgttgttgt tgttgttgtt gttgtttagt gtctgtttac
     1381 agttttgagc tggatatgct gaatctaata aaagatgcct gatgatcttt tcagaggaga
//
