LOCUS       NM_177932               1191 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus platelet-activating factor acetylhydrolase 2
            (Pafah2), mRNA.
ACCESSION   NM_177932
VERSION     NM_177932.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Bonin,F., Ryan,S.D., Migahed,L., Mo,F., Lallier,J., Franks,D.J.,
            Arai,H. and Bennett,S.A.
  TITLE     Anti-apoptotic actions of the platelet-activating factor
            acetylhydrolase I alpha2 catalytic subunit
  JOURNAL   J Biol Chem 279 (50), 52425-52436 (2004)
   PUBMED   15456758
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Karasawa,K., Qiu,X. and Lee,T.
  TITLE     Purification and characterization from rat kidney membranes of a
            novel platelet-activating factor (PAF)-dependent transacetylase
            that catalyzes the hydrolysis of PAF, formation of PAF analogs, and
            C2-ceramide
  JOURNAL   J Biol Chem 274 (13), 8655-8661 (1999)
   PUBMED   10085103
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY225592.1.
            
            On Jun 3, 2003 this sequence version replaced NM_177932.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY225592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1191
                     /gene="Pafah2"
                     /note="platelet-activating factor acetylhydrolase 2"
                     /db_xref="GeneID:313611"
                     /db_xref="RGD:631399"
     exon            1..104
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1187
                     /gene="Pafah2"
                     /EC_number="3.1.1.47"
                     /EC_number="2.3.1.149"
                     /note="serine-dependent phospholipase A2; SD-PLA2;
                     platelet-activating factor acetylhydrolase 2, 40kDa;
                     PAF:sphingosine transacetylase; PAF:lysophospholipid
                     transacetylase; platelet-activating factor
                     acetyltransferase PAFAH2"
                     /codon_start=1
                     /product="platelet-activating factor acetylhydrolase 2,
                     cytoplasmic"
                     /protein_id="NP_808793.1"
                     /db_xref="GeneID:313611"
                     /db_xref="RGD:631399"
                     /translation="MGAGQSICFPPISGPHHIGCTDVMEGHSLEGSLFRLFYPCEASE
                     TCEQPLWIPRYEYCVGLADYLQYNKRWVGLLFNVGIGSCRLPVSWNGPFKTKESGYPL
                     IILSHGLGGFRVSYSAFCMELASRGFVVAAIEHRDQSAAATYFCKQTSQESSPTESLE
                     EEWIPFRRIKEGEKEFHVRNPQVHQRAKECVRVLQILQDASAGKPVINVFPGGLDLMT
                     LKGSIDMSRVAVMGHSFGGATAILALTQEAQFRCAIALDAWMFPLEHDFYPKARGPVF
                     FINVEKFQTVESVNLMKKICAQHEQSRIVTVLGAVHRSQTDFAFVTGNMIGKLFSSGT
                     RGTLDPYEGQEVMVRAMLAFLQKHLDLKEDYDQWNSFIEGIGPSLIQGAPHYLSSL"
     exon            105..255
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..352
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..421
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            422..560
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..674
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..766
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..937
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1092
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1191
                     /gene="Pafah2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctggtga tgagatgggg gccggtcagt ctatatgctt cccgcccatc tccgggcccc
       61 accacattgg ctgcacggat gtgatggagg gtcacagtct tgaggggagc ctcttccgac
      121 tcttctaccc ctgcgaagca tcagagacgt gcgagcagcc cctgtggatt ccccgctatg
      181 agtactgcgt gggtctggct gactacctgc agtataacaa gcgctgggtg gggctgctgt
      241 tcaacgtggg catcggatcc tgtcgcttgc ctgttagctg gaacggcccc tttaagacaa
      301 aggaatctgg ataccctttg atcatcttgt cccatggcct agggggcttc agggtgtcat
      361 actcggcctt ctgcatggag ctggcctccc gtggctttgt ggttgctgcc atagagcaca
      421 gggaccagtc agctgcagcc acctacttct gcaagcagac ctcccaggag agttcgccca
      481 ctgagtctct ggaggaggaa tggatcccct tccgtcggat caaggaaggg gagaaggaat
      541 tccatgttag gaatccccag gtgcaccagc gggcgaaaga gtgtgtgcgc gtgctgcaga
      601 tccttcagga cgcctctgct ggcaagcctg tcatcaatgt cttcccagga ggactggatc
      661 tgatgacctt gaagggcagc atcgacatga gccgagtggc tgtgatggga cactccttcg
      721 gaggggctac ggctattctt gctttgaccc aggaggccca gtttcggtgt gctatagccc
      781 tggacgcttg gatgttccct ctggaacacg acttctaccc caaggcccgg ggccccgtgt
      841 tctttataaa cgttgagaaa ttccagacag tggagagcgt gaacttgatg aagaagatat
      901 gtgcccagca cgagcaatcc aggatcgtga ctgtcctagg cgctgttcat cggagtcaaa
      961 ctgactttgc ctttgtcacg ggcaacatga ttggtaaact cttttccagc ggcacacgtg
     1021 ggactttgga cccttatgaa ggtcaggaag tcatggtgcg ggccatgttg gccttcctgc
     1081 agaagcacct cgacctgaag gaggactatg atcagtggaa cagcttcatc gaaggcatcg
     1141 gaccgtcgct catccaaggg gccccacact atctgtccag cctctaggtt g
//
