LOCUS       NM_053654                808 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus platelet-activating factor acetylhydrolase 1b,
            catalytic subunit 3 (Pafah1b3), mRNA.
ACCESSION   NM_053654
VERSION     NM_053654.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 808)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   2  (bases 1 to 808)
  AUTHORS   Moriguchi,S., Shioda,N., Yamamoto,Y. and Fukunaga,K.
  TITLE     Platelet-activating factor-induced synaptic facilitation is
            associated with increased calcium/calmodulin-dependent protein
            kinase II, protein kinase C and extracellular signal-regulated
            kinase activities in the rat hippocampal CA1 region
  JOURNAL   Neuroscience 166 (4), 1158-1166 (2010)
   PUBMED   20074623
  REMARK    GeneRIF: These results suggest that PAF induces synaptic
            facilitation through activation of CaMKII, PKC and ERK in the
            hippocampal CA1 region.
REFERENCE   3  (bases 1 to 808)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 808)
  AUTHORS   Zhang,G., Assadi,A.H., McNeil,R.S., Beffert,U., Wynshaw-Boris,A.,
            Herz,J., Clark,G.D. and D'Arcangelo,G.
  TITLE     The Pafah1b complex interacts with the reelin receptor VLDLR
  JOURNAL   PLoS One 2 (2), e252 (2007)
   PUBMED   17330141
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 808)
  AUTHORS   Koizumi,H., Yamaguchi,N., Hattori,M., Ishikawa,T.O., Aoki,J.,
            Taketo,M.M., Inoue,K. and Arai,H.
  TITLE     Targeted disruption of intracellular type I platelet activating
            factor-acetylhydrolase catalytic subunits causes severe impairment
            in spermatogenesis
  JOURNAL   J Biol Chem 278 (14), 12489-12494 (2003)
   PUBMED   12551946
REFERENCE   6  (bases 1 to 808)
  AUTHORS   Kitagawa,M., Umezu,M., Aoki,J., Koizumi,H., Arai,H. and Inoue,K.
  TITLE     Direct association of LIS1, the lissencephaly gene product, with a
            mammalian homologue of a fungal nuclear distribution protein, rNUDE
  JOURNAL   FEBS Lett 479 (1-2), 57-62 (2000)
   PUBMED   10940388
REFERENCE   7  (bases 1 to 808)
  AUTHORS   Manya,H., Aoki,J., Watanabe,M., Adachi,T., Asou,H., Inoue,Y.,
            Arai,H. and Inoue,K.
  TITLE     Switching of platelet-activating factor acetylhydrolase catalytic
            subunits in developing rat brain
  JOURNAL   J Biol Chem 273 (29), 18567-18572 (1998)
   PUBMED   9660828
REFERENCE   8  (bases 1 to 808)
  AUTHORS   Watanabe,M., Aoki,J., Manya,H., Arai,H. and Inoue,K.
  TITLE     Molecular cloning of cDNAs encoding alpha1, alpha2, and beta
            subunits of rat brain platelet-activating factor acetylhydrolase
  JOURNAL   Biochim Biophys Acta 1401 (1), 73-79 (1998)
   PUBMED   9459487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053654.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016047.1, FM066029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000001.1  90011567-90011611   c
            46-143              JAXUCZ010000001.1  90011102-90011199   c
            144-233             JAXUCZ010000001.1  90010817-90010906   c
            234-350             JAXUCZ010000001.1  90010117-90010233   c
            351-473             JAXUCZ010000001.1  90009916-90010038   c
            474-808             JAXUCZ010000001.1  90009085-90009419   c
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..808
                     /gene="Pafah1b3"
                     /note="platelet-activating factor acetylhydrolase 1b,
                     catalytic subunit 3"
                     /db_xref="GeneID:114113"
                     /db_xref="RGD:620333"
     exon            1..45
                     /gene="Pafah1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            46..143
                     /gene="Pafah1b3"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..761
                     /gene="Pafah1b3"
                     /EC_number="3.1.1.47"
                     /note="platelet-activating factor acetylhydrolase IB
                     subunit gamma; PAF-AH alpha 1; PAFAH subunit gamma; PAF-AH
                     subunit gamma; PAF-AH 29 kDa subunit; PAF acetylhydrolase
                     29 kDa subunit; platelet-activating factor acetylhydrolase
                     alpha 1 subunit"
                     /codon_start=1
                     /product="platelet-activating factor acetylhydrolase IB
                     subunit alpha1"
                     /protein_id="NP_446106.1"
                     /db_xref="GeneID:114113"
                     /db_xref="RGD:620333"
                     /translation="MSGEGENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVF
                     IGDSLVQLMHQCEIWRELFSPLHALNFGIGGDSTQHVLWRLENGELEHIRPKIVVVWV
                     GTNNHSHTAEQVTGGIKAIVQLVNKLQPQARVVVLGLLPRGQHPNPLREKNRQVNELV
                     RAALAGYPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLA
                     QDQGQGIPLPETAP"
     exon            144..233
                     /gene="Pafah1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            234..350
                     /gene="Pafah1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            351..473
                     /gene="Pafah1b3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..808
                     /gene="Pafah1b3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagggaggg cgctaaattg tctctggtcc ctgtcggctt ttcaggagct gcggtgctga
       61 ggatgagcgg ggaaggggag aacccggcca gcaagcccac gcctgtgcag gacgtgcagg
      121 gcgacggacg ctggatgtct ctgcaccatc gatttgtggc agacagcaaa gacaaggaac
      181 ccgaagtcgt ctttatcggg gactccttgg ttcagctaat gcatcagtgt gagatctggc
      241 gggagctctt ctcacctctg catgcactta actttggcat tggcggtgac agcacacagc
      301 atgtactctg gcggcttgag aatggggagc tggagcacat ccggcccaag attgtggtgg
      361 tctgggtggg caccaacaac cacagccaca cagcagaaca agtgacaggt ggcatcaaag
      421 ccattgtaca actggtgaac aagctgcagc cccaggcccg ggtggttgtg ctgggcctgc
      481 ttccaagagg ccagcacccc aacccacttc gagagaaaaa ccgacaggtg aacgagctgg
      541 ttcgggcagc actagctggc tacccccgag cgcacttctt agatgcagac cctggctttg
      601 tgcactcgga cggtaccata agtcaccatg acatgtatga ctacctgcac ctgagccgcc
      661 tggggtacac acctgtctgc cgggccctgc actccttgct gcttcgtctc ctggcccaag
      721 atcagggcca aggcatccct ctgccagaga cagcacccta agcatctttc cttccttccc
      781 ttgacattaa attctcctct tccaccta
//
