LOCUS       NM_022387               1994 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus platelet-activating factor acetylhydrolase 1b,
            catalytic subunit 2 (Pafah1b2), mRNA.
ACCESSION   NM_022387 XM_346824
VERSION     NM_022387.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Kim,G.R., Zhao,T., Kee,H.J., Kee,S.J. and Jeong,M.H.
  TITLE     MicroRNA-212-5p and its target PAFAH1B2 suppress vascular
            proliferation and contraction via the downregulation of RhoA
  JOURNAL   PLoS One 16 (3), e0249146 (2021)
   PUBMED   33760887
  REMARK    GeneRIF: MicroRNA-212-5p and its target PAFAH1B2 suppress vascular
            proliferation and contraction via the downregulation of RhoA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Zhang,G., Assadi,A.H., McNeil,R.S., Beffert,U., Wynshaw-Boris,A.,
            Herz,J., Clark,G.D. and D'Arcangelo,G.
  TITLE     The Pafah1b complex interacts with the reelin receptor VLDLR
  JOURNAL   PLoS One 2 (2), e252 (2007)
   PUBMED   17330141
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Bonin,F., Ryan,S.D., Migahed,L., Mo,F., Lallier,J., Franks,D.J.,
            Arai,H. and Bennett,S.A.
  TITLE     Anti-apoptotic actions of the platelet-activating factor
            acetylhydrolase I alpha2 catalytic subunit
  JOURNAL   J Biol Chem 279 (50), 52425-52436 (2004)
   PUBMED   15456758
  REMARK    GeneRIF: the PAF receptor-independent death pathway is regulated by
            PAF-AH I alpha2
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Arai,H., Koizumi,H., Aoki,J. and Inoue,K.
  TITLE     Platelet-activating factor acetylhydrolase (PAF-AH)
  JOURNAL   J Biochem 131 (5), 635-640 (2002)
   PUBMED   11983068
  REMARK    Review article
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Kitagawa,M., Umezu,M., Aoki,J., Koizumi,H., Arai,H. and Inoue,K.
  TITLE     Direct association of LIS1, the lissencephaly gene product, with a
            mammalian homologue of a fungal nuclear distribution protein, rNUDE
  JOURNAL   FEBS Lett 479 (1-2), 57-62 (2000)
   PUBMED   10940388
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Shmueli,O., Cahana,A. and Reiner,O.
  TITLE     Platelet-activating factor (PAF) acetylhydrolase activity, LIS1
            expression, and seizures
  JOURNAL   J Neurosci Res 57 (2), 176-184 (1999)
   PUBMED   10398295
REFERENCE   9  (bases 1 to 1994)
  AUTHORS   Manya,H., Aoki,J., Watanabe,M., Adachi,T., Asou,H., Inoue,Y.,
            Arai,H. and Inoue,K.
  TITLE     Switching of platelet-activating factor acetylhydrolase catalytic
            subunits in developing rat brain
  JOURNAL   J Biol Chem 273 (29), 18567-18572 (1998)
   PUBMED   9660828
REFERENCE   10 (bases 1 to 1994)
  AUTHORS   Watanabe,M., Aoki,J., Manya,H., Arai,H. and Inoue,K.
  TITLE     Molecular cloning of cDNAs encoding alpha1, alpha2, and beta
            subunits of rat brain platelet-activating factor acetylhydrolase
  JOURNAL   Biochim Biophys Acta 1401 (1), 73-79 (1998)
   PUBMED   9459487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081714.1.
            
            On Sep 16, 2004 this sequence version replaced NM_022387.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081714.1, FQ212439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1994
                     /gene="Pafah1b2"
                     /note="platelet-activating factor acetylhydrolase 1b,
                     catalytic subunit 2"
                     /db_xref="GeneID:64189"
                     /db_xref="RGD:620332"
     exon            1..118
                     /gene="Pafah1b2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..206
                     /gene="Pafah1b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..815
                     /gene="Pafah1b2"
                     /EC_number="3.1.1.47"
                     /note="platelet-activating factor acetylhydrolase IB
                     subunit beta; PAF-AH alpha 2; PAFAH subunit beta; PAF-AH
                     subunit beta; PAF-AH 30 kDa subunit; PAF acetylhydrolase
                     30 kDa subunit; platelet-activating factor acetylhydrolase
                     alpha 2 subunit (PAF-AH alpha 2)"
                     /codon_start=1
                     /product="platelet-activating factor acetylhydrolase IB
                     subunit alpha2"
                     /protein_id="NP_071782.1"
                     /db_xref="GeneID:64189"
                     /db_xref="RGD:620332"
                     /translation="MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLF
                     VGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWV
                     GTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLL
                     KVSLPKLANVQLLDIDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLE
                     ETPEEKQTTIA"
     exon            207..296
                     /gene="Pafah1b2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..413
                     /gene="Pafah1b2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..536
                     /gene="Pafah1b2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1963
                     /gene="Pafah1b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggggcc cgaggagggg acgcgcgccg gaacgcggcc gtcgggatca agcgagcgac
       61 tgaagcgtaa ccagccgacg ccgcacccgc tgagggcccg tacggaccct ctgcctctgt
      121 gtagaatgag ccaaggagac tcaaacccag cagctattcc acatgcagca gaagatattc
      181 aaggagatga caggtggatg tctcagcaca ataggtttgt tctggactgc aaagacaaag
      241 agccggacgt gctgtttgtg ggagactcca tggtacagtt gatgcagcag tacgagatat
      301 ggcgggagct gttttcccca cttcatgctc ttaattttgg aattggggga gacacaacac
      361 gacatgtttt atggagacta aagaacggag agctggagaa cattaagcct aaggtcattg
      421 ttgtctgggt aggaacaaac aaccatgaaa atacagcaga agaagtagca ggtggaattg
      481 aggctatcgt acagcttata aacacgaggc agccacaggc caagatcatt gtactgggtc
      541 tgttacctcg aggtgagaag cccaaccctt taagacaaaa gaatgccaag gtgaaccagc
      601 ttctcaaggt ttccctgccg aagcttgcca atgtgcagct cctggatata gatgggggct
      661 tcgtgcactc ggacggtgcc atctcctgcc acgacatgtt tgattttctt catctcacag
      721 gagggggcta tgcaaagatc tgcaaacccc tccatgaact gatcatgcag ttgctggagg
      781 aaacaccaga ggagaagcag accaccattg cttgactggc ccatcagtgt taacagcatc
      841 ccagcttcct cagatcagtt agaccactgg cactacagaa tcctttctta aggcactttg
      901 cattgtacaa tgttcctgga tgcttgtatg tttgaagggg aggagggatt taaattggtc
      961 ctgtatataa aggtttgttt gaagagagga gaaaaattag ccaaggaaga ttcatttgaa
     1021 accagaaggg gactttttag ttgtttatgt cacacttgta gaattatcac tgtttttcct
     1081 aggacaacat caagcaagag tacaatatga agattctttt cttggccctt ttttctatgg
     1141 attatgtcat gtgtgataat tatcacagct acttggcttt aaacttattt ttggtccagt
     1201 tttaaggttc atgagttagt atgttgtgtt gtgttgtttg attcatgtat gctcggtatt
     1261 tttattaaca tatagcatca gattaaacat gcttgtcact ccagtatgcg agatgctata
     1321 gttacaagtg agtttgttcc tctcagtctt aagcagtggg aacaaggtct ggggactggg
     1381 atagagttct tactgctgct gaatatcatg tctgtaatag acccgtgcat gcagcctttc
     1441 cgcttcccct tcatctcttc acaggtgggt tatttacacc gcaaactttt aactcatttt
     1501 tgatctagga cttgcactgc cgtcaggacg atcttactaa tgtataactc actctgtggt
     1561 gttctgtgat gtagggtctg tgtaatgtta atcatccaga gttctgcttg tcatcatacc
     1621 cccaacctgt tgttttcctt tgttttgtag gaggtggggg tggtgtcaaa attgtttccc
     1681 attccataat gcctgatgtt atttcaagtt ttatattatt ttaaggtgta tatgtttgtt
     1741 ttcgttttat atatattata tataaataga tatattttac agtactggaa tcaaacccgg
     1801 ggcttagcac atactaagca agtgctctgc cgctgaggta atccctagac atgcttgttt
     1861 atttgcttgt ttgtttggtt ggttttttta ttggtttaat tcttaaattc tatcagtaaa
     1921 aaaatgtttt tccacgggaa acagtgaaac tgctctcaca ataaaaaaaa aaaaaaaaaa
     1981 aaaaaaaaaa aaaa
//
