LOCUS       NM_001024898            1973 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PAF1 homolog, Paf1/RNA polymerase II complex
            component (Paf1), mRNA.
ACCESSION   NM_001024898 XM_341816
VERSION     NM_001024898.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Strikoudis,A., Lazaris,C., Trimarchi,T., Galvao Neto,A.L., Yang,Y.,
            Ntziachristos,P., Rothbart,S., Buckley,S., Dolgalev,I.,
            Stadtfeld,M., Strahl,B.D., Dynlacht,B.D., Tsirigos,A. and
            Aifantis,I.
  TITLE     Regulation of transcriptional elongation in pluripotency and cell
            differentiation by the PHD-finger protein Phf5a
  JOURNAL   Nat Cell Biol 18 (11), 1127-1138 (2016)
   PUBMED   27749823
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Vethantham,V., Yang,Y., Bowman,C., Asp,P., Lee,J.H., Skalnik,D.G.
            and Dynlacht,B.D.
  TITLE     Dynamic loss of H2B ubiquitylation without corresponding changes in
            H3K4 trimethylation during myogenic differentiation
  JOURNAL   Mol Cell Biol 32 (6), 1044-1055 (2012)
   PUBMED   22252316
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   Nagaike,T., Logan,C., Hotta,I., Rozenblatt-Rosen,O., Meyerson,M.
            and Manley,J.L.
  TITLE     Transcriptional activators enhance polyadenylation of mRNA
            precursors
  JOURNAL   Mol Cell 41 (4), 409-418 (2011)
   PUBMED   21329879
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   Dey,P., Ponnusamy,M.P., Deb,S. and Batra,S.K.
  TITLE     Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates
            histone methylation and chromatin remodeling in pancreatic cancer
  JOURNAL   PLoS One 6 (10), e26926 (2011)
   PUBMED   22046413
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   Muntean,A.G., Tan,J., Sitwala,K., Huang,Y., Bronstein,J.,
            Connelly,J.A., Basrur,V., Elenitoba-Johnson,K.S. and Hess,J.L.
  TITLE     The PAF complex synergizes with MLL fusion proteins at HOX loci to
            promote leukemogenesis
  JOURNAL   Cancer Cell 17 (6), 609-621 (2010)
   PUBMED   20541477
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Jaehning,J.A.
  TITLE     The Paf1 complex: platform or player in RNA polymerase II
            transcription?
  JOURNAL   Biochim Biophys Acta 1799 (5-6), 379-388 (2010)
   PUBMED   20060942
  REMARK    Review article
REFERENCE   7  (bases 1 to 1973)
  AUTHORS   Ding,L., Paszkowski-Rogacz,M., Nitzsche,A., Slabicki,M.M.,
            Heninger,A.K., de Vries,I., Kittler,R., Junqueira,M.,
            Shevchenko,A., Schulz,H., Hubner,N., Doss,M.X., Sachinidis,A.,
            Hescheler,J., Iacone,R., Anastassiadis,K., Stewart,A.F.,
            Pisabarro,M.T., Caldarelli,A., Poser,I., Theis,M. and Buchholz,F.
  TITLE     A genome-scale RNAi screen for Oct4 modulators defines a role of
            the Paf1 complex for embryonic stem cell identity
  JOURNAL   Cell Stem Cell 4 (5), 403-415 (2009)
   PUBMED   19345177
REFERENCE   8  (bases 1 to 1973)
  AUTHORS   Youn,M.Y., Yoo,H.S., Kim,M.J., Hwang,S.Y., Choi,Y., Desiderio,S.V.
            and Yoo,J.Y.
  TITLE     hCTR9, a component of Paf1 complex, participates in the
            transcription of interleukin 6-responsive genes through regulation
            of STAT3-DNA interactions
  JOURNAL   J Biol Chem 282 (48), 34727-34734 (2007)
   PUBMED   17911113
REFERENCE   9  (bases 1 to 1973)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   10 (bases 1 to 1973)
  AUTHORS   Yart,A., Gstaiger,M., Wirbelauer,C., Pecnik,M., Anastasiou,D.,
            Hess,D. and Krek,W.
  TITLE     The HRPT2 tumor suppressor gene product parafibromin associates
            with human PAF1 and RNA polymerase II
  JOURNAL   Mol Cell Biol 25 (12), 5052-5060 (2005)
   PUBMED   15923622
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097494.1.
            
            On Jun 17, 2005 this sequence version replaced XM_341816.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1973
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /note="PAF1 homolog, Paf1/RNA polymerase II complex
                     component"
                     /db_xref="GeneID:361531"
                     /db_xref="RGD:1306219"
     exon            1..252
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1813
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /note="Paf1, RNA polymerase II associated factor, homolog"
                     /codon_start=1
                     /product="RNA polymerase II-associated factor 1 homolog"
                     /protein_id="NP_001020069.1"
                     /db_xref="GeneID:361531"
                     /db_xref="RGD:1306219"
                     /translation="MAPTIQTQAQREDGHRPNSHRTLPERSGVVCRVKYCNSLPDIPF
                     DPKFITYPFDQNRFVQYKATSLEKQHKHDLLTEPDLGVTIDLINPDTYRIDPNVLLDP
                     ADEKLLEEEIQAPTSSKRSQQHAKVVPWMRKTEYISTEFNRYGISNEKPEVKIGVSVK
                     QQFTEEEIYKDRDSQITAIEKTFEDAQKSISQHYSKPRVTPVEVMPVFPDFKMWINPC
                     AQVIFDSDPAPKDTSGAAALEMMSQAMIRGMMDEEGNQFVAYFLPVEETLKKRKRDQE
                     EEMDYAPDDVYDYKIAREYNWNVKNKASKGYEENYFFIFREGDGVYYNELETRVRLSK
                     RRAKAGVQSGTNALLVVKHRDMNEKELEAQEARKAQLENHEPEEEEEEEMEAEEKEAG
                     GSDEEHEKGSSSEKEGSEDERSGSESDREEGDRDEASDKSGSGEDESSEDEARAARDK
                     EEIFGSDADSEDDADSDDEDRGQAHRGSDNDSDSGSDGGGQRSRSQSRSRSRSASPFP
                     SGSEHSAQEDGSEAAASDSSEADSDSD"
     exon            253..282
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            283..375
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            376..497
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            498..564
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            565..666
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            667..772
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            773..841
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            842..945
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1062
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1191
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1297
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1388
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1947
                     /gene="Paf1"
                     /gene_synonym="RGD1306219"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagctgc gagtccgtgt ccgacgccgt ccacgcttta acttgagtca cacccgagcc
       61 tttctccccg gcccacttca tcccgccttt ctccgcagag cctgcgtctt gtccgcagat
      121 ccggcgtctc tcaaagtcgg cacgcccctc agcgtccgcc cgcggccagc ttggacgccg
      181 tccgcgccac cgtcgcctgg tcgcgatggc gcccaccatc cagacccagg cacagcggga
      241 agatggccat aggcccaatt cccaccggac cttgcctgag aggtctggag tggtctgccg
      301 agtcaagtac tgcaacagcc ttcctgacat cccatttgac cccaaattca tcacctaccc
      361 cttcgaccag aacaggtttg ttcagtacaa agcaacctcc ttggagaaac agcataaaca
      421 tgacctcctg actgaaccag atctgggggt caccatcgat ctcatcaacc ctgacaccta
      481 ccgcattgat cccaatgttc ttctggatcc ggctgatgaa aagcttttgg aagaggagat
      541 tcaggctccc accagctcca agagatccca gcagcatgcg aaggtggtgc cgtggatgcg
      601 taagacagag tatatttcca ctgagttcaa cagatatggc atctccaatg agaagcctga
      661 ggtcaagatt ggggtttctg tgaaacagca gttcacagag gaagaaatat acaaagacag
      721 ggacagccag atcacagcca ttgagaagac ttttgaagat gcccagaaat cgatctccca
      781 gcattacagc aagccccgag tgacaccagt ggaggtcatg cctgtcttcc cagactttaa
      841 gatgtggatc aacccatgtg ctcaggtcat ttttgattca gacccagccc ccaaggacac
      901 aagtggagca gctgcattag agatgatgtc tcaggccatg atcaggggca tgatggatga
      961 ggaagggaac cagtttgtgg cttattttct gcctgtggaa gagacactaa aaaaacgaaa
     1021 gcgggaccaa gaggaagaga tggactatgc accagatgat gtgtatgact acaagattgc
     1081 tcgagaatat aactggaatg tgaagaacaa ggccagtaag ggctacgagg aaaactactt
     1141 cttcatcttc agagagggtg atggtgtcta ctacaatgag ctagagacca gggtccgtct
     1201 cagtaagcgc cgggccaagg ctggggttca gtcgggtacc aatgccttgc ttgtggtcaa
     1261 acaccgtgac atgaatgaga aggaattaga agcccaggag gcacgcaagg cccagttgga
     1321 aaaccacgaa ccagaggaag aggaggagga ggagatggag gctgaagaga aagaagctgg
     1381 aggctcagat gaggaacatg agaagggcag cagcagcgaa aaggaaggca gcgaggatga
     1441 gcgctctggc agtgagagtg atcgagagga gggtgacagg gatgaggcaa gtgacaagag
     1501 tggcagcggt gaggatgaga gcagcgagga cgaagcacgt gctgcccggg acaaagagga
     1561 gattttcggt agtgatgctg attcagaaga tgatgctgac tctgatgatg aagacagagg
     1621 gcaggcccac aggggcagtg ataatgactc ggacagtggc agtgatggtg gtggccagcg
     1681 gagccgcagc cagagcagga gtcgtagccg gagtgccagc cccttcccca gtggtagtga
     1741 acactcagct caggaagatg gcagtgaagc tgcagcttct gattccagtg aggctgacag
     1801 tgacagtgac tgagcctcaa gaccttctaa tgaggtcagc acagacacca ttcttagggc
     1861 agggaagcac ttttctagtt gtctgttttg tgagcccttt gtccctaccc ttcaatcttt
     1921 gctgttaata aatctaactt ctctggaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
