LOCUS       NM_001135809             669 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus progestagen associated endometrial protein
            (Paep), mRNA.
ACCESSION   NM_001135809
VERSION     NM_001135809.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Gu,Y., Liu,Q., Chen,P., Guo,C., Liu,Y., Zhao,Y., Zhang,Y. and
            Lin,D.
  TITLE     Characterization of the oligomerization and ligand-binding
            properties of recombinant rat lipocalin 11
  JOURNAL   Biochim Biophys Acta 1834 (1), 1-7 (2013)
   PUBMED   23451353
  REMARK    GeneRIF: rLcn11 processes a moderate affinity for binding
            1-aminoanthracene (AMA), implying that Lcn11 might work as a
            dimeric chemoreception protein in male reproductive
REFERENCE   2  (bases 1 to 669)
  AUTHORS   Lee,C.L., Chiu,P.C., Lam,K.K., Chan,R.W., Chu,I.K., Koistinen,R.,
            Koistinen,H., Seppala,M., Lee,K.F. and Yeung,W.S.
  TITLE     Glycodelin-A modulates cytokine production of peripheral blood
            natural killer cells
  JOURNAL   Fertil Steril 94 (2), 769-771 (2010)
   PUBMED   19945098
REFERENCE   3  (bases 1 to 669)
  AUTHORS   Alok,A., Mukhopadhyay,D. and Karande,A.A.
  TITLE     Glycodelin A, an immunomodulatory protein in the endometrium,
            inhibits proliferation and induces apoptosis in monocytic cells
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1138-1147 (2009)
   PUBMED   18996219
REFERENCE   4  (bases 1 to 669)
  AUTHORS   Chiu,P.C., Chung,M.K., Koistinen,R., Koistinen,H., Seppala,M.,
            Ho,P.C., Ng,E.H., Lee,K.F. and Yeung,W.S.
  TITLE     Cumulus oophorus-associated glycodelin-C displaces sperm-bound
            glycodelin-A and -F and stimulates spermatozoa-zona pellucida
            binding
  JOURNAL   J Biol Chem 282 (8), 5378-5388 (2007)
   PUBMED   17192260
REFERENCE   5  (bases 1 to 669)
  AUTHORS   Chiu,P.C., Chung,M.K., Tsang,H.Y., Koistinen,R., Koistinen,H.,
            Seppala,M., Lee,K.F. and Yeung,W.S.
  TITLE     Glycodelin-S in human seminal plasma reduces cholesterol efflux and
            inhibits capacitation of spermatozoa
  JOURNAL   J Biol Chem 280 (27), 25580-25589 (2005)
   PUBMED   15883155
REFERENCE   6  (bases 1 to 669)
  AUTHORS   Chiu,P.C., Koistinen,R., Koistinen,H., Seppala,M., Lee,K.F. and
            Yeung,W.S.
  TITLE     Zona-binding inhibitory factor-1 from human follicular fluid is an
            isoform of glycodelin
  JOURNAL   Biol Reprod 69 (1), 365-372 (2003)
   PUBMED   12672671
REFERENCE   7  (bases 1 to 669)
  AUTHORS   Bell,S.C., Keyte,J.W. and Waites,G.T.
  TITLE     Pregnancy-associated endometrial alpha 2-globulin, the major
            secretory protein of the luteal phase and first trimester pregnancy
            endometrium, is not glycosylated prolactin but related to
            beta-lactoglobulins
  JOURNAL   J Clin Endocrinol Metab 65 (5), 1067-1071 (1987)
   PUBMED   3667877
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ537495.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ537495.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132275,
                                           SAMD00132279 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..669
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /note="progestagen associated endometrial protein"
                     /db_xref="GeneID:100169711"
                     /db_xref="RGD:2293817"
     exon            1..126
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..561
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /note="lipocalin 11"
                     /codon_start=1
                     /product="progestagen associated endometrial protein
                     precursor"
                     /protein_id="NP_001129281.1"
                     /db_xref="GeneID:100169711"
                     /db_xref="RGD:2293817"
                     /translation="MKGLLLLSMGLGLTWALQDQTNVPVAPYFVPEQVTGSWHTFKLA
                     ATDPSVVEEGDAYRCFMTGIVLLDNGTLNVTYLHREDGKCVEKFYIAEKTETPGRYTF
                     DYQGKNFLTFMDVTEDYTIIDLESKVGSLIVTELHARSLSTSDVGWDYYFSHTCRRGI
                     SPLDIEDLSFSRECDTL"
     exon            127..263
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /inference="alignment:Splign:2.1.0"
     exon            264..337
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /inference="alignment:Splign:2.1.0"
     exon            338..439
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /inference="alignment:Splign:2.1.0"
     exon            440..541
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /inference="alignment:Splign:2.1.0"
     exon            542..655
                     /gene="Paep"
                     /gene_synonym="Lcn11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagtccaa gaagacacag gagaggaatg aagggcctgc tgttgctcag tatggggctg
       61 ggcctgacct gggcacttca ggatcaaacc aatgttcccg tggcgccgta ctttgtacct
      121 gaacaggtga caggatcttg gcataccttc aagctggctg ccactgaccc atctgtcgtt
      181 gaggaaggag atgcttatcg gtgcttcatg actggcattg ttctcctgga caatggtacc
      241 ctgaacgtca cctacttgca cagagaagat ggaaaatgtg tggagaaatt ctacattgca
      301 gagaagactg agacacctgg acgctatacg tttgactacc aaggcaaaaa ctttctgact
      361 tttatggatg ttactgagga ttacaccatc atagatttgg aaagcaaagt gggcagctta
      421 attgtgactg agctccatgc caggagtctg tccacaagtg acgttggatg ggactactac
      481 ttctctcaca catgcagaag aggcatctca ccactggaca ttgaggacct ttccttctct
      541 cgtgagtgtg acacactcta gtcagcgttt ccacaaccca catctcctga agcttctgac
      601 gtcgtacact gacccacttt tctccaagta ataaataaac tcagtatctg ctcaaaaaaa
      661 aaaaaaaaa
//
