LOCUS       NM_001191766            2350 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus peptidyl arginine deiminase 6 (Padi6), mRNA.
ACCESSION   NM_001191766 XM_233601
VERSION     NM_001191766.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Xu,Y., Shi,Y., Fu,J., Yu,M., Feng,R., Sang,Q., Liang,B., Chen,B.,
            Qu,R., Li,B., Yan,Z., Mao,X., Kuang,Y., Jin,L., He,L., Sun,X. and
            Wang,L.
  TITLE     Mutations in PADI6 Cause Female Infertility Characterized by Early
            Embryonic Arrest
  JOURNAL   Am J Hum Genet 99 (3), 744-752 (2016)
   PUBMED   27545678
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Kim,B., Kan,R., Anguish,L., Nelson,L.M. and Coonrod,S.A.
  TITLE     Potential role for MATER in cytoplasmic lattice formation in murine
            oocytes
  JOURNAL   PLoS One 5 (9), e12587 (2010)
   PUBMED   20830304
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Yurttas,P., Vitale,A.M., Fitzhenry,R.J., Cohen-Gould,L., Wu,W.,
            Gossen,J.A. and Coonrod,S.A.
  TITLE     Role for PADI6 and the cytoplasmic lattices in ribosomal storage in
            oocytes and translational control in the early mouse embryo
  JOURNAL   Development 135 (15), 2627-2636 (2008)
   PUBMED   18599511
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Esposito,G., Vitale,A.M., Leijten,F.P., Strik,A.M.,
            Koonen-Reemst,A.M., Yurttas,P., Robben,T.J., Coonrod,S. and
            Gossen,J.A.
  TITLE     Peptidylarginine deiminase (PAD) 6 is essential for oocyte
            cytoskeletal sheet formation and female fertility
  JOURNAL   Mol Cell Endocrinol 273 (1-2), 25-31 (2007)
   PUBMED   17587491
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Wright,P.W., Bolling,L.C., Calvert,M.E., Sarmento,O.F.,
            Berkeley,E.V., Shea,M.C., Hao,Z., Jayes,F.C., Bush,L.A., Shetty,J.,
            Shore,A.N., Reddi,P.P., Tung,K.S., Samy,E., Allietta,M.M.,
            Sherman,N.E., Herr,J.C. and Coonrod,S.A.
  TITLE     ePAD, an oocyte and early embryo-abundant peptidylarginine
            deiminase-like protein that localizes to egg cytoplasmic sheets
  JOURNAL   Dev Biol 256 (1), 73-88 (2003)
   PUBMED   12654293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 12, 2022 this sequence version replaced NM_001191766.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN09345329 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000005.1  158320350-158320508 c
            160-337             JAXUCZ010000005.1  158319659-158319836 c
            338-410             JAXUCZ010000005.1  158318789-158318861 c
            411-478             JAXUCZ010000005.1  158317683-158317750 c
            479-590             JAXUCZ010000005.1  158316713-158316824 c
            591-716             JAXUCZ010000005.1  158314558-158314683 c
            717-889             JAXUCZ010000005.1  158312717-158312889 c
            890-993             JAXUCZ010000005.1  158312400-158312503 c
            994-1105            JAXUCZ010000005.1  158311290-158311401 c
            1106-1213           JAXUCZ010000005.1  158310063-158310170 c
            1214-1368           JAXUCZ010000005.1  158309697-158309851 c
            1369-1525           JAXUCZ010000005.1  158308614-158308770 c
            1526-1649           JAXUCZ010000005.1  158308401-158308524 c
            1650-1720           JAXUCZ010000005.1  158307109-158307179 c
            1721-1882           JAXUCZ010000005.1  158306155-158306316 c
            1883-2350           JAXUCZ010000005.1  158304921-158305388 c
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2350
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /note="peptidyl arginine deiminase 6"
                     /db_xref="GeneID:298595"
                     /db_xref="RGD:1560424"
     exon            1..159
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2116
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /EC_number="3.5.3.15"
                     /note="peptidyl arginine deiminase, type VI"
                     /codon_start=1
                     /product="protein-arginine deiminase type-6"
                     /protein_id="NP_001178695.2"
                     /db_xref="GeneID:298595"
                     /db_xref="RGD:1560424"
                     /translation="MSFQSTLSLSLDSPTHAICMVGMEITLDISGCAPDKCESFTIRG
                     SPRVLIHISSSVITGKEDAVVWRPMKQPTEALVRMVSPSPTVDEDKVLVSYYCPDKEV
                     PTATAVLFLTGIEVSLEADIYRDGQLDMPSDKQAKKRWMWGLNGWGAILLVNCNPETP
                     SQSDEQSGAQESPREIQNLSQMTLTVEGPTSILRDYQLLLHTSKEEAKKTRVYWAHSA
                     SAYELVVGPDKPFHILPTFDTRGKETFYIEATEFPSPSFSGLISFSVSLIEQAHDQLI
                     PETPLYKDTVMFRVAPYIFLPSTQLPLEVYLCRELQLQGFVDSVTKLSEKSNVQVASV
                     YEDPNRQGRWLQDEMAFCYTQAPHKTLSFILDTPRVAKLEDFPMKYSLSPGVGYLIQE
                     TEDHRVASLDSVGNLIVSPPVKAQGKDYPLGRILIGGSFYPSFEGRDMSKALRDFVYA
                     QQVQAPVELFSDWLMTGHVDQFLCFVPVDDKNSDRKGFRLLLASPSACYELFEQKQKE
                     GFGDVTLFEDVRAEQLISNGREVKTISQILADENLREQNAYVEKCISLNRTLLKKELG
                     LVDNDFIRIPQLFCLEPLTNVPSNQQTSKLFARPYFPDMLQMIVLGKNIGIPKPFGPQ
                     IKGTCCLEETVCGLLEPLGLKCTFIDDFDCYLANIGDACASVIVNRVPFAFKWWKMNP
                     "
     exon            160..337
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            338..410
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            411..478
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            479..590
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            591..716
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            717..889
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            890..993
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1105
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1213
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1368
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1525
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1649
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1720
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1882
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2350
                     /gene="Padi6"
                     /gene_synonym="RGD1560424"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctagcca gctactctgg tgggttaaag gctgcgtctg acagggctag cttggttagg
       61 cctcgccatg tcttttcaga gtactctcag cctgtctctg gacagcccca cccatgctat
      121 ctgcatggtg ggtatggaaa tcaccttgga catcagtggg tgcgccccag ataagtgtga
      181 gtccttcacc atccgtggct cccccagggt cttgatccac atctccagct ccgtcattac
      241 cgggaaggag gatgctgtgg tctggcggcc aatgaaacaa cccacagagg cactggtgag
      301 gatggtgtca cccagcccca ctgtggacga agacaaggtg ctggtctcct actactgtcc
      361 tgacaaagag gtccccacgg ccacagctgt gctgttcctc actggtattg aggtctccct
      421 ggaggcagac atctatcggg atggacaact ggacatgcca agtgataaac aagctaagaa
      481 aagatggatg tggggtctga acggctgggg agccatcctg ctcgtgaatt gtaatcctga
      541 aaccccaagc cagtctgatg agcagtccgg ggctcaggag agccccagag aaatacagaa
      601 cctgtctcag atgacgctaa ctgtggaggg ccccaccagc atccttcggg actaccagtt
      661 gcttctacat acctccaagg aagaggcgaa gaagacaaga gtctactggg ctcacagcgc
      721 ctctgcctat gaactggtag taggacctga caaacctttc cacatcctgc ctacctttga
      781 cacccgtggg aaagagactt tctacataga agccacagag ttcccatctc ccagcttctc
      841 tggcctgatc tccttctcgg tctccctaat agaacaggct catgaccagt tgatcccaga
      901 gaccccgcta tataaggata cagtgatgtt ccgggtggca ccttacatct tcctgcccag
      961 tacccagctg cctctagagg tttacctgtg ccgggagcta cagctgcaag gctttgtgga
     1021 ctccgtgaca aagctgagtg agaagagcaa cgtgcaggtg gcatccgtct atgaggaccc
     1081 caaccgccag ggcaggtggc tacaggacga gatggctttc tgctatacgc aggctcctca
     1141 caagactctg tccttcatcc ttgacacccc gagggttgcc aagctggaag atttccccat
     1201 gaaatactca ctgagccctg gcgttggcta cctgatccaa gaaactgagg accaccgggt
     1261 ggctagcctg gattccgtcg ggaacctgat tgtatccccg cctgtcaagg ctcagggcaa
     1321 agactaccca ctaggaagga ttctcattgg tggcagcttt taccccagct ttgagggccg
     1381 ggacatgagc aaggccctac gagacttcgt gtacgcccaa caggtgcagg cccctgtgga
     1441 gctcttctcg gattggctga tgaccggtca cgtggatcag ttcctatgct ttgtccctgt
     1501 cgatgataag aacagtgaca ggaagggctt ccgcctgctg ctggccagtc ccagtgcctg
     1561 ctatgagctc tttgaacaga agcagaagga gggctttggg gacgtgacgc tgttcgaaga
     1621 tgtcagagca gaacagctca tttctaatgg gagggaggtc aaaaccatct cccaaatcct
     1681 ggctgatgag aatttgcgag agcagaacgc ctatgtggag aagtgcatca gcctgaaccg
     1741 cacccttctg aagaaggaac tgggactggt ggacaatgac ttcatcagga tcccacagct
     1801 cttctgcctg gagccgctga caaacgtccc ctccaaccag cagacctcaa aactctttgc
     1861 aaggccttac ttccccgaca tgctgcagat gatcgtgcta ggcaagaaca ttgggatccc
     1921 caagcccttc gggccccaaa tcaagggcac ctgctgcctg gaagagacgg tctgtggctt
     1981 actggagccc ctgggtctca agtgcacctt cattgatgac tttgactgct acttggccaa
     2041 cataggggac gcctgtgcca gtgtcatcgt aaaccgggtg ccatttgcat tcaagtggtg
     2101 gaagatgaac ccataaatcc tgggccccag agctgcccat ctgccccgga gcggatggcc
     2161 tttaccatag agccggagtg gtgtgtgagc attgttgttg gccactgggt tgaagggaca
     2221 gagagctggg gagatagggt ctctcagacc taccagtttg acacctctgg gggggggggt
     2281 ggggaagggg gaaggaaaag ctatatgtaa ccaaagtata gagccaataa actatggtgt
     2341 tctgagtgca
//
