LOCUS       NM_017227               2258 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus peptidyl arginine deiminase 4 (Padi4), mRNA.
ACCESSION   NM_017227
VERSION     NM_017227.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Christophorou,M.A., Castelo-Branco,G., Halley-Stott,R.P.,
            Oliveira,C.S., Loos,R., Radzisheuskaya,A., Mowen,K.A., Bertone,P.,
            Silva,J.C., Zernicka-Goetz,M., Nielsen,M.L., Gurdon,J.B. and
            Kouzarides,T.
  TITLE     Citrullination regulates pluripotency and histone H1 binding to
            chromatin
  JOURNAL   Nature 507 (7490), 104-108 (2014)
   PUBMED   24463520
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Guo,Q., Bedford,M.T. and Fast,W.
  TITLE     Discovery of peptidylarginine deiminase-4 substrates by protein
            array: antagonistic citrullination and methylation of human
            ribosomal protein S2
  JOURNAL   Mol Biosyst 7 (7), 2286-2295 (2011)
   PUBMED   21584310
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Arita,K., Shimizu,T., Hashimoto,H., Hidaka,Y., Yamada,M. and
            Sato,M.
  TITLE     Structural basis for histone N-terminal recognition by human
            peptidylarginine deiminase 4
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5291-5296 (2006)
   PUBMED   16567635
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Cuthbert,G.L., Daujat,S., Snowden,A.W., Erdjument-Bromage,H.,
            Hagiwara,T., Yamada,M., Schneider,R., Gregory,P.D., Tempst,P.,
            Bannister,A.J. and Kouzarides,T.
  TITLE     Histone deimination antagonizes arginine methylation
  JOURNAL   Cell 118 (5), 545-553 (2004)
   PUBMED   15339660
REFERENCE   5  (bases 1 to 2258)
  AUTHORS   Arita,K., Hashimoto,H., Shimizu,T., Nakashima,K., Yamada,M. and
            Sato,M.
  TITLE     Structural basis for Ca(2+)-induced activation of human PAD4
  JOURNAL   Nat Struct Mol Biol 11 (8), 777-783 (2004)
   PUBMED   15247907
REFERENCE   6  (bases 1 to 2258)
  AUTHORS   Ishigami,A., Ohsawa,T., Asaga,H., Akiyama,K., Kuramoto,M. and
            Maruyama,N.
  TITLE     Human peptidylarginine deiminase type II: molecular cloning, gene
            organization, and expression in human skin
  JOURNAL   Arch Biochem Biophys 407 (1), 25-31 (2002)
   PUBMED   12392711
REFERENCE   7  (bases 1 to 2258)
  AUTHORS   Ishigami,A., Kuramoto,M., Yamada,M., Watanabe,K. and Senshu,T.
  TITLE     Molecular cloning of two novel types of peptidylarginine deiminase
            cDNAs from retinoic acid-treated culture of a newborn rat
            keratinocyte cell line
  JOURNAL   FEBS Lett 433 (1-2), 113-118 (1998)
   PUBMED   9738944
REFERENCE   8  (bases 1 to 2258)
  AUTHORS   Yamakoshi,A., Ono,H., Nishijyo,T., Shiraiwa,M. and Takahara,H.
  TITLE     Cloning of cDNA encoding a novel isoform (type IV) of
            peptidylarginine deiminase from rat epidermis
  JOURNAL   Biochim Biophys Acta 1386 (1), 227-232 (1998)
   PUBMED   9675292
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB010999.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2258
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /note="peptidyl arginine deiminase 4"
                     /db_xref="GeneID:29512"
                     /db_xref="RGD:3290"
     exon            1..108
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2017
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /EC_number="3.5.3.15"
                     /note="PAD-R4; peptidylarginine deiminase IV; peptidyl
                     arginine deiminase, type IV; protein-arginine deiminase
                     type IV; peptidylarginine deiminase type alpha; peptidyl
                     arginine deiminase, type 4"
                     /codon_start=1
                     /product="protein-arginine deiminase type-4"
                     /protein_id="NP_058923.1"
                     /db_xref="GeneID:29512"
                     /db_xref="RGD:3290"
                     /translation="MAQGAVIHVAPEEPTHAVCVVGTATPLDIRGSAPRGSTSFSITA
                     SPEVVVDVIHGPPSKKSTTGASKWPLDPKLEVTLQMKAASSRIDDQKVRISYYGPKTS
                     STQALLYLTGVELSLSADVTRTGKAKPAPAGKDQSTWTWGPDGHGAILLVNCDKEDPK
                     SSGMDFEDDKVLDNKDLQDMSPMTLSTKTPKDFFDKYQLVLQVPKAKMNKVRVFRATR
                     GKLPSRYKVVLGPQQFSHRLELLGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSN
                     PELPEALVFQDTVMFRVAPWIMTPNTQPPQEVYVCRFSDNEDFLKSLATFTKKAKCKL
                     TVCPEEENQDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYV
                     TRGLYRAEVTGLDAFGNLEVSPPVTVRGKEYPLGRILIGSSGYSSSESRDMHQILQDF
                     LGAQQVQAPVRLFSDWLFVGHVDEFLSFVPARGKQGFRLLLSSPRACYQMFQELQTEG
                     HGEASLFEGLKRKRQTISDILSSQKLRDQNAYVESCIDWNREVLKRELGLTEGDIIDI
                     PQLFRIVGNSRGNPKAEAFFPNMVNMLVLGKHLGIPKPFGPIINGRCCLEEKVCSLLE
                     PLGLHCTFINDFYSYHMYHGEVHCGTNVRRKPFAFKWWHMVP"
     exon            109..289
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            290..356
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            357..424
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            425..542
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..668
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            669..847
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            848..951
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1063
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1171
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1326
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1471
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1574
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1642
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1783
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..2258
                     /gene="Padi4"
                     /gene_synonym="Pdi4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccctgctgc ccgaggatgg cccagggtgc ggtgatccat gtggcccctg aggagcccac
       61 ccatgccgtg tgtgtggtgg gcacggcgac cccgctggat atccgtggct ctgctccaag
      121 gggctccacg tccttcagca tcacagcctc cccagaagtt gttgtagatg tcatccatgg
      181 tcctccatcc aagaagagta ccacgggggc ctccaaatgg cctctggacc ccaagctgga
      241 ggtgacccta cagatgaaag cagccagcag taggatagat gaccagaagg ttcgaatttc
      301 ctattacgga cccaagacct catcaaccca agccctgctc tacctcaccg gggtggaact
      361 ctccctgagt gcggatgtca cccgcactgg caaagcgaag ccagccccag ctgggaagga
      421 tcagagcacc tggacctggg gcccggacgg tcacggcgcc atcctgttgg tgaactgtga
      481 caaggaggat cccaagtcct ccggaatgga cttcgaggac gacaaggtct tagacaacaa
      541 agacctgcag gacatgtcac caatgaccct aagcacgaag actcccaaag acttctttga
      601 caagtatcag ttggtgctgc aggtgccgaa ggccaagatg aacaaagtga gagtcttccg
      661 ggccacacgg ggcaaactgc catccagata caaggtggtc ctaggaccac agcagttctc
      721 ccaccgccta gagctgctgg gcggccagca cagcacggac ttctatgtgg aaggccttgc
      781 tttccctgac gccgacttca aggggctcat tcccctaacg atctccctgt tggacaaatc
      841 taacccggag ctccctgaag ccctggtgtt ccaagacacc gtgatgttcc gtgtggcccc
      901 ctggatcatg acgcccaaca ctcagccccc ccaggaggta tacgtgtgca ggttttccga
      961 caatgaagac ttcctaaagt cactggctac tttcaccaag aaagccaagt gcaaactgac
     1021 tgtgtgccca gaggaggaaa atcaagatga ccagtggatg caggatgaaa tggagattgg
     1081 ctacatacag gccccccaca agacgctgcc tgtggtcttt gactccccga gggacagagg
     1141 cctgaaggat ttccctgtca aacgagtcat gggtccaaat tttggctatg tgacccgagg
     1201 gctctataga gcagaggtca ctgggctgga tgcctttggg aacctggagg tgagtccccc
     1261 agtcactgtc agagggaagg aatacccact gggcaggatt ctcatcggga gcagcggtta
     1321 ttccagcagt gagagccggg acatgcacca gatcctgcag gacttcctgg gtgcccagca
     1381 ggtgcaggcc cctgtgagac tcttctccga ttggctcttt gtgggtcacg tggatgagtt
     1441 cttgagcttc gtcccggcac ggggcaagca gggctttcgg ctgctactgt ccagccccag
     1501 agcttgctac cagatgttcc aggagctgca gaccgagggc cacggggagg catcactgtt
     1561 cgaaggactc aagaggaaaa ggcagacaat cagtgacatt ctgtccagcc agaaactaag
     1621 agaccagaat gcctacgtgg agagctgtat tgactggaac cgtgaggtgc tgaagcgaga
     1681 gttgggcctg acggagggcg acatcattga tataccccag ctcttcagga ttgtgggaaa
     1741 ctccagaggg aacccgaagg ctgaggcctt cttcccaaac atggtgaaca tgctggtact
     1801 gggcaagcac ctgggcatcc ccaagccctt tgggcccatc atcaacggcc gctgctgcct
     1861 ggaggagaag gtgtgctccc tgctggagcc gctgggtctg cactgcacct tcatcaacga
     1921 cttctacagc tatcacatgt accacggaga ggttcactgt ggcaccaacg tgcgcaggaa
     1981 gcccttcgcc ttcaagtggt ggcacatggt tccctgagtc accgctcctg gcagcctccc
     2041 tcgaggactg ccctggctcc ctgcagggag atacagtgag agatctgggg ccttggggct
     2101 tccctagagg tggctacccc tccctgctgt gagttgcttt gcttcaccca catctggctc
     2161 ctgtcccacc tctgtatgtc ctaaaatggt ccttgcatag caaactcagt cctgcttaga
     2221 gatgctgcaa taaagatgtg gttttgtatc tttatttt
//
