LOCUS       NM_017230               3099 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus peptidyl arginine deiminase 3 (Padi3), mRNA.
ACCESSION   NM_017230
VERSION     NM_017230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3099)
  AUTHORS   U Basmanav,F.B., Cau,L., Tafazzoli,A., Mechin,M.C., Wolf,S.,
            Romano,M.T., Valentin,F., Wiegmann,H., Huchenq,A., Kandil,R.,
            Garcia Bartels,N., Kilic,A., George,S., Ralser,D.J., Bergner,S.,
            Ferguson,D.J.P., Oprisoreanu,A.M., Wehner,M., Thiele,H.,
            Altmuller,J., Nurnberg,P., Swan,D., Houniet,D., Buchner,A.,
            Weibel,L., Wagner,N., Grimalt,R., Bygum,A., Serre,G.,
            Blume-Peytavi,U., Sprecher,E., Schoch,S., Oji,V., Hamm,H.,
            Farrant,P., Simon,M. and Betz,R.C.
  TITLE     Mutations in Three Genes Encoding Proteins Involved in Hair Shaft
            Formation Cause Uncombable Hair Syndrome
  JOURNAL   Am J Hum Genet 99 (6), 1292-1304 (2016)
   PUBMED   27866708
REFERENCE   2  (bases 1 to 3099)
  AUTHORS   Ishigami,A., Ohsawa,T., Asaga,H., Akiyama,K., Kuramoto,M. and
            Maruyama,N.
  TITLE     Human peptidylarginine deiminase type II: molecular cloning, gene
            organization, and expression in human skin
  JOURNAL   Arch Biochem Biophys 407 (1), 25-31 (2002)
   PUBMED   12392711
REFERENCE   3  (bases 1 to 3099)
  AUTHORS   Nishijyo,T., Kawada,A., Kanno,T., Shiraiwa,M. and Takahara,H.
  TITLE     Isolation and molecular cloning of epidermal- and hair
            follicle-specific peptidylarginine deiminase (type III) from rat
  JOURNAL   J Biochem 121 (5), 868-875 (1997)
   PUBMED   9192727
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D88034.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017230.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88034.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3099              D88034.1           2-3100
FEATURES             Location/Qualifiers
     source          1..3099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3099
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /note="peptidyl arginine deiminase 3"
                     /db_xref="GeneID:29520"
                     /db_xref="RGD:3289"
     exon            1..133
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2036
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /EC_number="3.5.3.15"
                     /note="peptidylarginine deiminase III; protein-arginine
                     deiminase type III; peptidyl arginine deiminase, type III;
                     peptidyl arginine deiminase, type 3"
                     /codon_start=1
                     /product="protein-arginine deiminase type-3"
                     /protein_id="NP_058926.1"
                     /db_xref="GeneID:29520"
                     /db_xref="RGD:3289"
                     /translation="MSLQRTVRVSLEHPTSAVCVAGVETIVDIYGSVPEGTDMFEVYG
                     TPGVDIYVSPSMERNRERADTRRWCFNKGLEIIVVMNSPSNDLNDSHVQIAYHSSHEH
                     LPLAYAVLYLTCVDITLDCDMNCADRQDRSFVDKRQWMWGPDGYGAILLVNCDRDEVS
                     SDAQDNCDQCVRCLQDLEDMSVMVLRTQGPESLFDDHRLILHTSSCDAERARVFHVCG
                     PEDSCEAYRCVLGPDRMSYEVPRLKGYEERFYVEGLSFPDAGFPGILSFHITLLDDSN
                     EDYSETPIFTDTVVFRVAPWIMTPSTLPPLEVYVCQVRNNTCFVEAVEELARKAGCKL
                     TICPQAENRNDRWIQDEMELGYTQAPHKTLPVVFDSPRNGELQGFPYKRILGLDFGYV
                     TREPPDSSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSRGRRVTQVVRDFL
                     HAQKVQPLVELFVDWLAVGHVDEFLSFVPAPDGKGFRLLLASPGACFRLFQEKQKWGH
                     GRSLLFEGVIGDRRVQTISINQVLSNQSLINFNKFAQSCIDWNREVLKRELGLGESDI
                     IDIPQLFKSEKRKAVAFFPDLVNMLVLGKHLGIPKPFGPIINGRCCLEEKVRSLLEPL
                     GLHCTFIDDFTPYHMLHGEVHCGTNVRREPFAFKWWHMVP"
     exon            134..314
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..387
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..449
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            450..567
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..693
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            694..872
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            873..976
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1088
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1196
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1348
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1493
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1596
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1676
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1802
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..3099
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3099
                     /gene="Padi3"
                     /gene_synonym="Pdi3"
ORIGIN      
        1 agtgctgggt ttggtggcca aagcccccat cctaggccgg catgtctctg cagaggactg
       61 tacgtgtatc cctggaacac ccaaccagcg ctgtgtgtgt ggcaggggtt gagaccatcg
      121 tggacattta tgggtcggtt cctgagggca cagacatgtt tgaggtctat gggacaccgg
      181 gagtggacat ctacgtgtct cccagcatgg agaggaaccg agagcgagct gacaccaggc
      241 ggtggtgctt caacaagggg ctggagatca tcgtggtcat gaactctcct agcaatgacc
      301 tcaacgacag tcacgttcaa atagcttacc actccagtca cgagcatttg cccctggcct
      361 atgcagtact ctacctcacc tgtgtggaca tcaccctgga ctgtgacatg aactgtgctg
      421 accggcagga caggagcttc gtggataaga ggcagtggat gtggggacct gatgggtacg
      481 gagccatctt gctggtgaac tgtgatcggg acgaggtcag ctctgatgcc caagataact
      541 gtgaccaatg tgtgcgctgc ctgcaagatc tggaagacat gtccgtcatg gtcctacgga
      601 cccagggccc cgaatctctc tttgacgacc acaggcttat cctccacacc tccagctgtg
      661 atgcggagcg ggcacgggtc ttccacgtct gtggccccga ggattcctgc gaagcctata
      721 ggtgtgttct gggcccggac cggatgtcct atgaggtacc ccgcctgaag ggctatgagg
      781 agcgcttcta cgtggagggc ctctccttcc ctgatgcagg cttcccaggg atcctctcct
      841 tccatatcac cctgctggat gactccaatg aggactactc cgagaccccg atcttcacgg
      901 acacagtggt gttccgagtg gcaccctgga tcatgacgcc cagcaccctg ccacccctgg
      961 aggtgtacgt gtgccaggtg aggaataaca cctgctttgt ggaagctgtg gaggagctgg
     1021 ccaggaaggc aggctgcaaa ctcaccatct gtcctcaggc agagaaccgc aatgaccgat
     1081 ggatccagga tgagatggag ctggggtaca cgcaggcgcc acacaagact ttgcctgtgg
     1141 tctttgattc tccgaggaat ggggagctgc agggtttccc ttacaaaagg atcctgggtc
     1201 tagattttgg ctacgtgact cgagaacctc cagacagttc tgtgagcggt ctggactcct
     1261 ttggcaacct ggaggtcagc ccgcccgtgg tggccaatgg gaaggagtat ccactgggga
     1321 ggattctcat cgggggcaac ctgcctgggt cgagaggccg cagagttacc caggtggtac
     1381 gagacttcct ccatgcccag aaggtgcaac ctctggtgga gttgtttgtg gactggctgg
     1441 ctgtgggcca cgtggatgaa tttctgagct tcgtccctgc accagatgga aagggcttcc
     1501 ggctcctcct ggccagccct ggtgcctgct tcaggctatt ccaggaaaag cagaagtggg
     1561 gccatggccg gtccctcctt ttcgaggggg tcattggtga caggcgggtc cagaccatct
     1621 ccatcaatca ggttctttcc aaccagagcc ttatcaactt taataagttt gcacagagct
     1681 gtattgactg gaaccgtgag gtgctgaagc gggagctagg cctgggggag agcgacatca
     1741 ttgacatccc acagctcttc aagtcggaga agaggaaggc ggtggcgttc ttcccggacc
     1801 tggtgaacat gctggtactg ggcaagcacc tgggcatccc taagcccttc gggcccatca
     1861 tcaatggccg ctgctgcctg gaggagaagg tgcgctccct gctggagccg ctgggtctgc
     1921 actgcacctt cattgatgac ttcacaccgt accacatgct gcacggggag gttcactgtg
     1981 gcaccaacgt gcgccgggag ccctttgcct tcaagtggtg gcacatggtg ccctgagccg
     2041 cccgccaccc atcccccatc cgtcccccag gatagggcat ccgcccggca ggtggagact
     2101 gcgacagacc ccagagcacc cagagactcc cagtttctag actgaatgac ccaagcttct
     2161 cagaagcctt ttctcttgaa atgtccgcat ccacctgctg cccattcagt tcccagacat
     2221 gaatcctctt ggtgccccca aagaagggtc ccatgtcaac caaactctcc tgcgggtcga
     2281 gatgatccat ggggataact ttaaatacca ttcacccccc ccccaccccc gcaaactcca
     2341 aaactcctct ttgtggggaa aaatccgctt gggtatctag aagcattgac cttggcttgt
     2401 gcttcctatg gtggaaggcc tggggcggtg ggggttggtg gggttgtttt ggccattgcc
     2461 tcctgccctg caggggatgg ttgtaaagtc agactatttc acaccctcac tactcgacta
     2521 gagggagtct accctcccag gaagcacccc gggtccattc aggtcaaagt gtgtccatca
     2581 tgtccactgc aagctcccgg caggaccggc ctttactgca agccagcctg ggctatcaca
     2641 cggtggggac ctgtcacaca atggggacct ctagatgctt ttgcaatgac agatgtccct
     2701 tagctttcca ggcttcccat catccgatgt ctgggaatct ggttgtccaa atccttttgg
     2761 agtttctctg aagtgaatga ttggggggct ggattcccag gggagaacgc ctttcctaag
     2821 acaggattga ccctcggggt cccaccatct gaaggggttc ctccatcagc ttgcctgggg
     2881 gctctgtgca gaggagaccc caggctgact tagcccagag ccttctgcct atacagccat
     2941 cccgtagtag aggcccggga agtgccaccc tgggtgccat caaggcagga cttagaggga
     3001 cagttaagcc tctccacata ctgggagaag ggagggatgt ggctgtctca gtatgggtct
     3061 tctgtgagtt cagctggcca aaaaataaaa cagaggctc
//
