LOCUS       NM_017226               4504 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus peptidyl arginine deiminase 2 (Padi2), mRNA.
ACCESSION   NM_017226
VERSION     NM_017226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4504)
  AUTHORS   Slade,D.J., Fang,P., Dreyton,C.J., Zhang,Y., Fuhrmann,J.,
            Rempel,D., Bax,B.D., Coonrod,S.A., Lewis,H.D., Guo,M., Gross,M.L.
            and Thompson,P.R.
  TITLE     Protein arginine deiminase 2 binds calcium in an ordered fashion:
            implications for inhibitor design
  JOURNAL   ACS Chem Biol 10 (4), 1043-1053 (2015)
   PUBMED   25621824
REFERENCE   2  (bases 1 to 4504)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   3  (bases 1 to 4504)
  AUTHORS   Zhang,X., Bolt,M., Guertin,M.J., Chen,W., Zhang,S.,
            Cherrington,B.D., Slade,D.J., Dreyton,C.J., Subramanian,V.,
            Bicker,K.L., Thompson,P.R., Mancini,M.A., Lis,J.T. and Coonrod,S.A.
  TITLE     Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26
            citrullination facilitates estrogen receptor alpha target gene
            activation
  JOURNAL   Proc Natl Acad Sci U S A 109 (33), 13331-13336 (2012)
   PUBMED   22853951
REFERENCE   4  (bases 1 to 4504)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 4504)
  AUTHORS   Arif,M. and Kato,T.
  TITLE     Increased expression of PAD2 after repeated intracerebroventricular
            infusions of soluble Abeta(25-35) in the Alzheimer's disease model
            rat brain: effect of memantine
  JOURNAL   Cell Mol Biol Lett 14 (4), 703-714 (2009)
   PUBMED   19641855
  REMARK    GeneRIF: These biochemical and immunohistochemical results suggest
            that PAD2 might play an important role in the pathology of early
            Alzheimer's disease
REFERENCE   6  (bases 1 to 4504)
  AUTHORS   Asaga,H. and Ishigami,A.
  TITLE     Microglial expression of peptidylarginine deiminase 2 in the
            prenatal rat brain
  JOURNAL   Cell Mol Biol Lett 12 (4), 536-544 (2007)
   PUBMED   17579814
  REMARK    GeneRIF: This report revealed the expression of PAD2 by microglia
            in the prenatal cerebrum at embryonic stages E19-E21.
REFERENCE   7  (bases 1 to 4504)
  AUTHORS   Nakayama-Hamada,M., Suzuki,A., Kubota,K., Takazawa,T., Ohsaka,M.,
            Kawaida,R., Ono,M., Kasuya,A., Furukawa,H., Yamada,R. and
            Yamamoto,K.
  TITLE     Comparison of enzymatic properties between hPADI2 and hPADI4
  JOURNAL   Biochem Biophys Res Commun 327 (1), 192-200 (2005)
   PUBMED   15629448
REFERENCE   8  (bases 1 to 4504)
  AUTHORS   Ishigami,A., Ohsawa,T., Asaga,H., Akiyama,K., Kuramoto,M. and
            Maruyama,N.
  TITLE     Human peptidylarginine deiminase type II: molecular cloning, gene
            organization, and expression in human skin
  JOURNAL   Arch Biochem Biophys 407 (1), 25-31 (2002)
   PUBMED   12392711
REFERENCE   9  (bases 1 to 4504)
  AUTHORS   Watanabe,K., Nomoto,M., Nagata,S., Itoh,Y., Hikichi,K.,
            Maruyama,N., Mita,T. and Senshu,T.
  TITLE     The rat peptidylarginine deiminase-encoding gene: structural
            analysis and the 5'-flanking sequence
  JOURNAL   Gene 114 (2), 261-265 (1992)
   PUBMED   1601308
REFERENCE   10 (bases 1 to 4504)
  AUTHORS   Watanabe,K. and Senshu,T.
  TITLE     Isolation and characterization of cDNA clones encoding rat skeletal
            muscle peptidylarginine deiminase
  JOURNAL   J Biol Chem 264 (26), 15255-15260 (1989)
   PUBMED   2768262
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017226.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05022.1, SRR22582419.730376.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000005.1  158492087-158492238
            153-336             JAXUCZ010000005.1  158501085-158501268
            337-409             JAXUCZ010000005.1  158502791-158502863
            410-471             JAXUCZ010000005.1  158510100-158510161
            472-589             JAXUCZ010000005.1  158511804-158511921
            590-715             JAXUCZ010000005.1  158512467-158512592
            716-894             JAXUCZ010000005.1  158517667-158517845
            895-998             JAXUCZ010000005.1  158518407-158518510
            999-1110            JAXUCZ010000005.1  158519367-158519478
            1111-1218           JAXUCZ010000005.1  158520870-158520977
            1219-1370           JAXUCZ010000005.1  158523646-158523797
            1371-1515           JAXUCZ010000005.1  158525005-158525149
            1516-1609           JAXUCZ010000005.1  158526589-158526682
            1610-1695           JAXUCZ010000005.1  158528940-158529025
            1696-1824           JAXUCZ010000005.1  158531482-158531610
            1825-4504           JAXUCZ010000005.1  158531983-158534662
FEATURES             Location/Qualifiers
     source          1..4504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4504
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /note="peptidyl arginine deiminase 2"
                     /db_xref="GeneID:29511"
                     /db_xref="RGD:3288"
     exon            1..152
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2058
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /EC_number="3.5.3.15"
                     /note="peptidylarginine deiminase II; protein-arginine
                     deiminase type II; peptidyl arginine deiminase, type 2;
                     peptidyl arginine deiminase, type II"
                     /codon_start=1
                     /product="protein-arginine deiminase type-2"
                     /protein_id="NP_058922.2"
                     /db_xref="GeneID:29511"
                     /db_xref="RGD:3288"
                     /translation="MLRERTVRLQYGSRVEAVYVLGTQLWTDVYSAAPAGAKTFSLKH
                     SEGVKVEVVGDGEAEEVVTNGKQRWALSPSTTLRLSMAQASTEASSDKVTVNYYEEDG
                     SAPIDQAGLFLTAIEISLDVDADRDGEVEKNNPKKASWTWGPEGQGAILLVNCDRDTP
                     WLPKEDCSDEKVYSKQDLQDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVE
                     NPFFGQRYIHILGRQKLYHVVKYTGGSAELLFFVEGLRFPDESFSGLVSIHVSLLEYM
                     AEDIPLTPIFTDTVTFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCE
                     LKVCFQYMNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPIKQLLGPDFGY
                     VTREPLFETVTSLDSFGNLEVSPPVTVNGKAYPLGRILIGSSFPLSGGRRMTKVVRDF
                     LQAQQVQAPVELYSDWLTVGHVDEFMTFVPIPGKKEFRLLMASTSACYQLFREKQKEG
                     HGEAIMFKGLGGMSSKRITINKILSNESLTQENQYFQRCLDWNRDILKKELALTEKDI
                     IDLPALFKMDEDRQARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLETHVRGLLEP
                     LGLACTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP"
     exon            153..336
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..409
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..471
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..589
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..715
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..894
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..998
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1110
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1218
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1370
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1515
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1609
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1695
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1824
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..4504
                     /gene="Padi2"
                     /gene_synonym="Pdi2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgtagcag gtgctcattc ccgggagcag cgcggactgc agccgcctct gcggggaaag
       61 atgctgcggg agcggaccgt acggctgcaa tacgggagcc gcgtggaggc ggtgtacgtg
      121 ctgggcacgc agctctggac cgatgtctac agtgcagcgc ctgctggggc caaaaccttc
      181 agcctgaagc actcggaggg tgtgaaagta gaggtcgtgg gcgatggaga ggcagaggag
      241 gtagtcacca acggcaagca gcgttgggcc ctgtcaccca gcaccacact gcgactcagc
      301 atggcccagg ccagcaccga ggccagcagc gacaaggtca ccgtcaacta ctatgaagag
      361 gatggcagtg cccccattga ccaggctggg ctcttcctca ctgccattga gatctcactg
      421 gatgtggacg cagaccggga cggagaagtg gagaagaata atcctaagaa ggcatcctgg
      481 acctggggtc ctgagggcca gggggccatc ctgctggtga actgtgaccg agacacaccc
      541 tggttgccca aggaggactg cagtgatgaa aaggtctaca gcaaacaaga ccttcaggac
      601 atgtctcaga tgatcctgag gaccaaaggc cctgaccgcc tgcccgccgg gtatgaaata
      661 gtcctctaca tttctatgtc ggactcggac aaagtgggcg tgttctacgt ggagaacccg
      721 ttctttggcc agcgctacat ccacatcctg ggccggcaga agctctacca cgtggtgaag
      781 tacaccggtg gctctgcaga gttgctgttc ttcgtggaag gcctccgttt cccagacgag
      841 agtttctcag gcctggtttc catccacgtc agtctgctgg agtatatggc cgaggacatc
      901 ccgttgacac ccatcttcac agacaccgtg acgttccgga ttgccccatg gattatgaca
      961 cccaacatcc tgcctcccgt gtcagtgttt gtgtgctgca tgaaggacaa ttacctgttc
     1021 ctgaaagagg tgaagaacct ggtggagaaa accaactgcg agctgaaagt ttgtttccag
     1081 tacatgaatc gtggcgaccg ctggatccag gatgaaattg agtttggcta cattgaggca
     1141 cctcacaaag gcttcccagt agtgctggac tcccctcgag atggaaacct gaaggacttc
     1201 cccattaagc aactcctggg cccagatttc ggctatgtga cccgggagcc cctctttgag
     1261 actgtcacca gccttgactc cttcgggaat ctggaggtca gtcccccagt gaccgtgaat
     1321 ggcaaggcat acccgcttgg ccggatcctc atcgggagca gtttccctct gtctggaggc
     1381 aggaggatga ccaaggtggt gcgtgacttc ctgcaggccc agcaggtgca ggcgcccgtg
     1441 gaactctact cggattggct gactgtgggc cacgtcgatg agttcatgac cttcgtcccc
     1501 atcccaggca aaaaggaatt tcggctgctc atggccagca cctcagcctg ctaccagctc
     1561 ttcagagaaa agcagaagga aggccacggg gaggccatta tgttcaaggg tctggggggc
     1621 atgagcagca aacgaatcac catcaacaag atcctgtcca atgagagcct cacgcaggaa
     1681 aaccagtact ttcagcgctg tctggattgg aaccgtgaca tccttaagaa ggagctggct
     1741 ctgactgaga aggacatcat tgacctgcct gctctcttca agatggatga agaccgtcag
     1801 gccagggctt tcttccctaa catggtgaac atgatcgtgc tagacaagga cctgggtatc
     1861 cccaagcctt tcgggcccca ggtcgaggag gagtgctgcc tggagacaca tgttcgaggc
     1921 ctgctggagc ccctgggcct tgcctgcacc ttcattgatg acatctctgc ataccacaag
     1981 tttctgggag aggttcactg tggtaccaac gtgcgcagga agcccttcac cttcaagtgg
     2041 tggcacatgg tgccctgact gccaggggcc ctggccttcc ttccttccct gcgatctcca
     2101 ggtccttcct gtgtccccaa gtccttcccc tacaagaagc gggtgggatt gggattgtgc
     2161 cttgctgtcc cctggagaag gactttagtg tccattgaag ccaccccgag taagtccaac
     2221 cgttccctac ccctgaaaat agctagacat gtggttagtg tgcagaactt tggaagggaa
     2281 aaccagactt caacaaatca tgtagtcgca ctgtcccccc aaagaattct cagcctctac
     2341 tccagatcag aaagagggga gagagaaggg agactctgag gtcattggct cgcccagcac
     2401 ccatctgaca ttcaagatag accaggagga ccagggccag ggtcctggcg tacctcggat
     2461 ggtaccatct tttcaagctt acctaccttg gggcctcctg gtggcatcct gcacccgttc
     2521 attccttaag gcttcccata cacactgtgt ccccacccta ccccaccccc accccctgag
     2581 ggtccaatca ttcagcttag aatcatccgg aaatgggtct tagcagagga gaggtcttca
     2641 ctttctgtgg attcgggctg cccaattttg ggaggacggg gaggtctcgg actagcatcc
     2701 gaggtccaaa gttcagtaga caaagatgca cctgtgtatc gacactattt ctgttctctc
     2761 ccccggtcct cagttctctg gccagtccgt gagcctctct ttccattgtt cttctgtttc
     2821 tgacactggc cttcctattc tggatgttgc ccctccagca gctacagttt cttcaccacc
     2881 agccagattc aggcctcccg agggcctgag aagtagccaa tcccactgtc caaggatgct
     2941 gaggatgctg gcaatgcccc agcctcactg atcacttccc ggctagctac tgctccagag
     3001 gcagaatttt ccagcacact ttccgaaggc cttccatcca gatacaggca aatggatccc
     3061 ccctccccca acccgcttca tttagaaagg cccccaggag ctgtagagat ggctcggcag
     3121 ttaaaaatgc tccctgctcc caagttcagt tcccaacacc ctcggctgtc tgtaactcca
     3181 gatccagagg atccaatacc cttttctggt ctctgagggc acttcacgca tgtgcacaaa
     3241 cccatagaca taaatcaatg tttgagagtc tggagagatg gcccagtggt taaaagcact
     3301 tgctgctctt gcagaggacc tgggttcagt tctcagcacc cagttggtgg ctcacaacca
     3361 actataactc tagtcccagg gggtccgatg ctctcctctg acctccatgg gcttctgcac
     3421 acaggtggtt cacatacaca ccctcaagca cacatacaag taaagtaaag taaacgatgc
     3481 ttaaaaaaat agaaacaagg aaaatatgtc tcttaaaata gagaaggtcc ttttaaggcc
     3541 aagaaggtag gaaatggtaa ttctgctttg gagggttaaa cggtcccatt ttatagctga
     3601 agaagagggt tacacccaca ttcttagggg aacaagattt ttaccttgca ttatttcctc
     3661 agtaggttgt atgctactga gtagtgggca cagacttgga cgctgataac acaagctagc
     3721 catagactcg cttgtcccaa cagacaaaac ccacgtctgc atagccaccc tccgcccttg
     3781 ctgtggtaac actacccagt atattcaaga agcattcagg acaacagtca ctgccttcaa
     3841 caattaggag gtgtcctctt ttctgtccag ctggcctaat gcaccatgcc aggtcaggcc
     3901 ccagagcctc caaagctgtc atcctctgtc tctggggaca gaggttcctg cccttgaggg
     3961 caaagcccca aatcctgtct cctgctccag agtggaaaac acaggcacct ctctgaggga
     4021 ggtggtctgg ggatgtggcg gtttgtcgtg tgtggtgttc cgttaaagtg gcttttactg
     4081 cttttatttt tatctgcgtt aagaggaagt gagccctccc cacgtggagg ccacgacgtg
     4141 tcttttgtag gttgtgttgg ttgtttgggg aatttctgga actccaggac tccgcctgtc
     4201 ccatctcact tactcaccca gtgtgacccc ctcaagtgtg gacgccccat cccgaggact
     4261 ccttgctcat ctccacctcc attgtttgtt gggttttttt ttttttaaac ttatgcccag
     4321 aggcttctgg gctatgccag ttcctgtttc aatgttaatt ttgaaatgct ctgctgaggg
     4381 cgggggtaac ggcaggaaga tggcgggaat ggggcagcat gaacttcctg gaaaagaagc
     4441 caagatggag tctgaggagt gtctggggga agagccaaaa taaagagcaa taaaataagc
     4501 cgtc
//
