LOCUS       NM_019332               3740 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus peptidyl arginine deiminase 1 (Padi1), mRNA.
ACCESSION   NM_019332
VERSION     NM_019332.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3740)
  AUTHORS   Saijo,S., Nagai,A., Kinjo,S., Mashimo,R., Akimoto,M., Kizawa,K.,
            Yabe-Wada,T., Shimizu,N., Takahara,H. and Unno,M.
  TITLE     Monomeric Form of Peptidylarginine Deiminase Type I Revealed by
            X-ray Crystallography and Small-Angle X-ray Scattering
  JOURNAL   J Mol Biol 428 (15), 3058-3073 (2016)
   PUBMED   27393304
REFERENCE   2  (bases 1 to 3740)
  AUTHORS   Guerrin,M., Ishigami,A., Mechin,M.C., Nachat,R., Valmary,S.,
            Sebbag,M., Simon,M., Senshu,T. and Serre,G.
  TITLE     cDNA cloning, gene organization and expression analysis of human
            peptidylarginine deiminase type I
  JOURNAL   Biochem J 370 (Pt 1), 167-174 (2003)
   PUBMED   12416996
REFERENCE   3  (bases 1 to 3740)
  AUTHORS   Ishigami,A., Ohsawa,T., Asaga,H., Akiyama,K., Kuramoto,M. and
            Maruyama,N.
  TITLE     Human peptidylarginine deiminase type II: molecular cloning, gene
            organization, and expression in human skin
  JOURNAL   Arch Biochem Biophys 407 (1), 25-31 (2002)
   PUBMED   12392711
REFERENCE   4  (bases 1 to 3740)
  AUTHORS   Ishigami,A., Kuramoto,M., Yamada,M., Watanabe,K. and Senshu,T.
  TITLE     Molecular cloning of two novel types of peptidylarginine deiminase
            cDNAs from retinoic acid-treated culture of a newborn rat
            keratinocyte cell line
  JOURNAL   FEBS Lett 433 (1-2), 113-118 (1998)
   PUBMED   9738944
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB010998.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010998.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5756307
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3740
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /note="peptidyl arginine deiminase 1"
                     /db_xref="GeneID:54282"
                     /db_xref="RGD:3287"
     exon            1..222
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2119
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /EC_number="3.5.3.15"
                     /note="PAD-R11; peptidylarginine deiminase I;
                     protein-arginine deiminase type I; peptidyl arginine
                     deiminase, type 1; peptidyl arginine deiminase, type I"
                     /codon_start=1
                     /product="protein-arginine deiminase type-1"
                     /protein_id="NP_062205.1"
                     /db_xref="GeneID:54282"
                     /db_xref="RGD:3287"
                     /translation="MASQRAVQLSLRKPAHAVCVIGVGTLVDVYSDVPKGAKTFEVSG
                     SSEVKIYMVYDPSRVAEPAGPAHWPLDANVDVVVVADTVSKNLHDLKVKVSYFKSQDT
                     AALAHSLLYLTAVDVSLDVDTGRTGKVKKGSGDKKNWRWGSGGSGAILLVNCDRDVHG
                     SREDLHDSHLRSLEDLQDMSPMVLSCDGPDDLFKSHKPVLKASLPDSRRLGVFCARGG
                     TSLSNYKQVLGPRHNSYEVERHPGERDIQFYVEGLAFPDASFSGLLSLSVSLVDTRPL
                     SEVLVFTDSVTFRVAPWIMTPNTQPPLELYVCSVTDMHGSNDKFLEDMSHLATKANCK
                     LVVCPRLENRNDRWIQDEMEFGYIDAPHKSFPVVFDSPRNRGLRDFALKKILGPDFGY
                     VTREIQFAGASGLDSFGNLDVSPPVRVGNTEYPLGRILIGGNFPKSSGRRMARVVRDF
                     LHAQQVQAPVELYSDWLSVGHVDEFLSFVPTSDQKGFRLLLASPSACLQLFQEKKEEG
                     YGEAKQFDGLKHKTKRSINDILADRHLRRDSAHVQKCIDWNREVLKQELGLSESDIVD
                     IPQLFFLKGAYAEAFFPDMVNMVVLGKYLGIPKPFGPIINGRCCLEEKVRSLLEPLGL
                     RCVFIDDFLFYHQLLGEIHCGTNVRRKPFAFRWWNSVP"
     exon            223..403
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..476
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..538
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..653
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..779
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..952
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1056
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1180
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1288
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1440
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1585
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1679
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1759
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1885
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..3740
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagaacgc acgctcctac ccggcagccg ggtgtcccca agaagagctg gggatccggg
       61 gcacagctga ggcttgtggc tgctgggtac ccaagctgac ccgatcagga gactggaagc
      121 tgggcccagg atggcctccc agcgagctgt gcagctgtct ctgagaaagc ctgctcatgc
      181 cgtgtgtgtg ataggtgtgg ggacactggt ggatgtgtac agtgatgtgc ccaaaggcgc
      241 caagaccttt gaggtgtccg ggagctctga ggtgaagatc tacatggtct acgatccctc
      301 aagagtggca gagcccgcag gcccggccca ctggcccctg gatgccaatg tggatgtggt
      361 ggtggtggcg gacacagtca gtaagaactt acacgacctc aaggtaaagg tatcatactt
      421 caagtcccag gacactgccg ccctggccca cagccttctc tacctaaccg ctgttgatgt
      481 gtcccttgat gtcgacacag gccgcacagg caaggtgaag aaaggctctg gtgacaagaa
      541 aaactggcgc tggggctccg ggggctccgg ggctatcctg ttggtgaact gtgacagaga
      601 tgtgcatggg tccagagagg acctgcatga tagccatttg aggtcactgg aggacctgca
      661 ggacatgtcc ccaatggtgt tgagctgtga cggccctgat gatcttttta agagccacaa
      721 gccggtcttg aaggcatctt tgccggattc cagaagactg ggggtctttt gtgcccgggg
      781 tgggacctcc ctctccaact acaaacaggt gctggggccc cgtcataact cctatgaggt
      841 ggaaaggcat cctggggaga gggacattca gttctacgtg gaaggactcg ccttccctga
      901 tgccagtttc tcagggctgc tgtctctcag tgtcagcctg gtagacacac ggcccctctc
      961 cgaggtgttg gtcttcacgg acagcgtgac cttccgagtg gccccctgga tcatgacccc
     1021 caacacccag ccgcccctgg aactgtacgt gtgcagcgtg acagatatgc atggcagcaa
     1081 cgacaagttc ttggaggaca tgtcccacct ggccacgaag gccaactgca aactagtggt
     1141 ctgtccccgg ctagagaatc gcaatgatcg atggatccag gatgagatgg agtttggcta
     1201 cattgatgcc cctcacaaat cgttccctgt ggtctttgat tccccccgaa acagaggctt
     1261 gagggacttc gcccttaaga agatcctggg tcctgacttt ggatatgtga cccgggagat
     1321 ccagttcgca ggtgcctctg gcctggattc cttcggcaac ctggatgtga gcccgccagt
     1381 gagggtgggc aacacagagt accccctcgg cagaatcctc atcggtggca acttccctaa
     1441 gtccagcggg cggcggatgg ccagggtggt gcgtgacttc ctgcatgccc agcaggtgca
     1501 ggctccggtg gaactctact ctgactggct ctccgtgggc cacgtggatg agtttctgag
     1561 cttcgtgccc acctctgacc aaaagggctt ccggttactc ctggccagcc ccagcgcctg
     1621 cctccagctg ttccaggaga agaaggagga gggctacggg gaggccaagc agtttgatgg
     1681 cctcaagcat aagacaaaga gaagcatcaa tgacatctta gctgacaggc acctcaggag
     1741 ggacagtgca catgtgcaga aatgcatcga ctggaaccgt gaggtgctaa aacaggagct
     1801 gggcctctcc gagagcgaca tcgtggatat tccacagctc ttcttcctga agggagccta
     1861 cgctgaagcc ttctttcctg acatggtcaa tatggtggtc ctcggcaagt acctgggcat
     1921 ccccaagccc ttcgggccca tcatcaatgg ccgctgctgc ctggaagaga aggtgcgctc
     1981 cctgctggag ccgctgggtc tacgctgcgt ctttatcgac gactttctct tttaccacca
     2041 actgcttgga gagatccatt gtggcactaa tgtgcggagg aaaccttttg cctttaggtg
     2101 gtggaactcc gtgccctgag cctgcccgac caccaccctc gctgccctgc tgatgagaac
     2161 cccagagcaa gggcaagggc cacgaaccag cttccaccct cctggagcct gaaagcggac
     2221 tgactactgt ggtcagctgg gctcccggag gacaacacac ttcttcgttt ctggagtcgc
     2281 ctgtcctgcc caggagacta ttgacacttt tccttcaccc tttcccagcc agagccccca
     2341 gagggtcaag gtcggaagct aagcctgtag gccacgccct actttgagct gtttcccccc
     2401 tcccttctgg acacctctct gatgctgttt cagaaatgcc caccatgcca ggaccctggg
     2461 gcacgaacac catagtttcg tatgactcct ggattgcgca agatgaaaag gaagatttgg
     2521 ggcgtctttt tttcccagag gacctcaggc catggccccc tggcaccctt cagctcaacg
     2581 taggcaaaca aaggcaggaa atcccagtcc ttgaaagcgg gcaggcacaa aagcccctct
     2641 aatgccaaac tccatccagt cccacctctg cagaatgctt gttacctgtt ggggcagcct
     2701 ttaattacga gccctggtgc ttcctgttgg aagatgcttc ggggcatagg gaggccctcg
     2761 gaagtctgca agcgtgggtg ggggtgggga agggtgggca ggaaggtcgc accaggaagg
     2821 cagagaggtt gcccatctcg gggtggggga acctcgaagc ctggaactct tggctgggtg
     2881 tttggggccc ctgaacctga cggctgttgg tccagatgtg aaggggatgg ggcccaaggt
     2941 attagaagat ggtggggtag gccattaagt tacatctgga ggtgaggctt aatttcctct
     3001 aatagtctct aattactccc taacctgctg caggcagtgg gaggggaggg cccacactcc
     3061 cccagcagcc tgggacccta cacaacactt gtacagcccc agtaaacccc atggcaggcc
     3121 tgtgtccccc ctcccacagt aggacagaca gctggcctgg aggctaatag cattgggtga
     3181 ggtcacagag acatgtgtcg gcaagcaggc aggccaaccg gctgcagggc acggctggca
     3241 gaggcttcct ctggtcaagg agccacaaca ggctgctgga ttctgtcttt gtattttggt
     3301 agcttctggt gccacccctg acttgaggca gctgctgtca cttggtaacc actggacact
     3361 tagttagcaa aggcttcctt ggagctgtta ggataggcat ggccaggtag acattggctc
     3421 ttcccccttc cagaaggttc tgtggaactg gaacccccat ttgtaggctc cccacaccaa
     3481 caccctcctc tatgatcatg gcctggctga ggttaagcca tggagaagga gaagaagaag
     3541 aagataaagg gggatgagaa ggttgggggc ggggcctggc ctctgaagac tcaggagact
     3601 gactacagag cctcggcaag catgggagca agtcttctgc gccacatgag gtgggctctg
     3661 gagtcgctac tcagaccgtc tgggggcctg gctgactggc caccctctcc ctcatcaatt
     3721 aaaaacatcg ttgtgcattc
//
